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Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

Identifieur interne : 000747 ( PascalFrancis/Curation ); précédent : 000746; suivant : 000748

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

Auteurs : Arun K. Ghosh [États-Unis] ; GANGLI GONG [États-Unis] ; Valerie Grum-Tokars [États-Unis] ; Debbie C. Mulhearn [États-Unis] ; Susan C. Baker [États-Unis] ; Melissa Coughlin [États-Unis] ; Bellur S. Prabhakar [États-Unis] ; Katrina Sleeman [États-Unis] ; Michael E. Johnson [États-Unis] ; Andrew D. Mesecar [États-Unis]

Source :

RBID : Pascal:09-0033367

Descripteurs français

English descriptors

Abstract

Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to potency. Inhibitor 10 with a 5-chloropyridinyl ester at position 4 of the indole ring is the most potent inhibitor with a SARS-CoV 3CLpro IC50 value of 30 nM and an antiviral EC50 value of 6.9 μM. Molecular docking studies have provided possible binding modes of these inhibitors.
pA  
A01 01  1    @0 0960-894X
A03   1    @0 Bioorg. med. chem. lett. : (Print)
A05       @2 18
A06       @2 20
A08 01  1  ENG  @1 Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors
A11 01  1    @1 GHOSH (Arun K.)
A11 02  1    @1 GANGLI GONG
A11 03  1    @1 GRUM-TOKARS (Valerie)
A11 04  1    @1 MULHEARN (Debbie C.)
A11 05  1    @1 BAKER (Susan C.)
A11 06  1    @1 COUGHLIN (Melissa)
A11 07  1    @1 PRABHAKAR (Bellur S.)
A11 08  1    @1 SLEEMAN (Katrina)
A11 09  1    @1 JOHNSON (Michael E.)
A11 10  1    @1 MESECAR (Andrew D.)
A14 01      @1 Departments of Chemistry and Medicinal Chemistry. Purdue University, 560 Oval drive @2 West Lafayette, IN 47907 @3 USA @Z 1 aut. @Z 2 aut.
A14 02      @1 Center for Pharmaceutical Biotechnology, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S @2 Ashland, IL 60607 @3 USA @Z 3 aut. @Z 4 aut. @Z 9 aut. @Z 10 aut.
A14 03      @1 Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine @2 Maywood, IL @3 USA @Z 5 aut. @Z 8 aut.
A14 04      @1 Department of Microbiology and Immunology, University of Illinois @2 Chicago, IL 60607 @3 USA @Z 6 aut. @Z 7 aut.
A20       @1 5684-5688
A21       @1 2008
A23 01      @0 ENG
A43 01      @1 INIST @2 22446 @5 354000184446880790
A44       @0 0000 @1 © 2009 INIST-CNRS. All rights reserved.
A45       @0 24 ref.
A47 01  1    @0 09-0033367
A60       @1 P
A61       @0 A
A64 01  1    @0 Bioorganic & medicinal chemistry letters : (Print)
A66 01      @0 GBR
C01 01    ENG  @0 Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to potency. Inhibitor 10 with a 5-chloropyridinyl ester at position 4 of the indole ring is the most potent inhibitor with a SARS-CoV 3CLpro IC50 value of 30 nM and an antiviral EC50 value of 6.9 μM. Molecular docking studies have provided possible binding modes of these inhibitors.
C02 01  X    @0 002B02S05
C03 01  X  FRE  @0 Synthèse chimique @5 01
C03 01  X  ENG  @0 Chemical synthesis @5 01
C03 01  X  SPA  @0 Síntesis química @5 01
C03 02  X  FRE  @0 Antiviral @5 02
C03 02  X  ENG  @0 Antiviral @5 02
C03 02  X  SPA  @0 Antiviral @5 02
C03 03  X  FRE  @0 Relation structure activité @5 03
C03 03  X  ENG  @0 Structure activity relation @5 03
C03 03  X  SPA  @0 Relación estructura actividad @5 03
C03 04  X  FRE  @0 In vitro @5 04
C03 04  X  ENG  @0 In vitro @5 04
C03 04  X  SPA  @0 In vitro @5 04
C03 05  X  FRE  @0 Cysteine endopeptidases @2 FE @5 05
C03 05  X  ENG  @0 Cysteine endopeptidases @2 FE @5 05
C03 05  X  SPA  @0 Cysteine endopeptidases @2 FE @5 05
C03 06  X  FRE  @0 Virus syndrome respiratoire aigu sévère @2 NW @5 06
C03 06  X  ENG  @0 Severe acute respiratory syndrome virus @2 NW @5 06
C03 06  X  SPA  @0 Severe acute respiratory syndrome virus @2 NW @5 06
C03 07  X  FRE  @0 Hétérocycle azote @5 07
C03 07  X  ENG  @0 Nitrogen heterocycle @5 07
C03 07  X  SPA  @0 Heterociclo nitrógeno @5 07
C03 08  X  FRE  @0 Composé bicyclique @5 08
C03 08  X  ENG  @0 Bicyclic compound @5 08
C03 08  X  SPA  @0 Compuesto bicíclico @5 08
C03 09  X  FRE  @0 Composé aromatique @5 09
C03 09  X  ENG  @0 Aromatic compound @5 09
C03 09  X  SPA  @0 Compuesto aromático @5 09
C03 10  X  FRE  @0 Dérivé de la pyridine @5 11
C03 10  X  ENG  @0 Pyridine derivatives @5 11
C03 10  X  SPA  @0 Piridina derivado @5 11
C03 11  X  FRE  @0 Modèle moléculaire @5 12
C03 11  X  ENG  @0 Molecular model @5 12
C03 11  X  SPA  @0 Modelo molecular @5 12
C03 12  X  FRE  @0 Complexe enzyme inhibiteur @5 13
C03 12  X  ENG  @0 Inhibitor enzyme complex @5 13
C03 12  X  SPA  @0 Complejo enzima inhibidor @5 13
C03 13  X  FRE  @0 Modélisation @5 32
C03 13  X  ENG  @0 Modeling @5 32
C03 13  X  SPA  @0 Modelización @5 32
C03 14  X  FRE  @0 Inhibiteur enzyme @5 33
C03 14  X  ENG  @0 Enzyme inhibitor @5 33
C03 14  X  SPA  @0 Inhibidor enzima @5 33
C03 15  X  FRE  @0 Indole-4-carboxylique acide ester 5-chloro-3-pyridyle @2 NK @2 FR @4 INC @5 76
C07 01  X  FRE  @0 Peptidases @2 FE
C07 01  X  ENG  @0 Peptidases @2 FE
C07 01  X  SPA  @0 Peptidases @2 FE
C07 02  X  FRE  @0 Hydrolases @2 FE
C07 02  X  ENG  @0 Hydrolases @2 FE
C07 02  X  SPA  @0 Hydrolases @2 FE
C07 03  X  FRE  @0 Enzyme @2 FE
C07 03  X  ENG  @0 Enzyme @2 FE
C07 03  X  SPA  @0 Enzima @2 FE
C07 04  X  FRE  @0 Coronavirus @2 NW
C07 04  X  ENG  @0 Coronavirus @2 NW
C07 04  X  SPA  @0 Coronavirus @2 NW
C07 05  X  FRE  @0 Coronaviridae @2 NW
C07 05  X  ENG  @0 Coronaviridae @2 NW
C07 05  X  SPA  @0 Coronaviridae @2 NW
C07 06  X  FRE  @0 Nidovirales @2 NW
C07 06  X  ENG  @0 Nidovirales @2 NW
C07 06  X  SPA  @0 Nidovirales @2 NW
C07 07  X  FRE  @0 Virus @2 NW
C07 07  X  ENG  @0 Virus @2 NW
C07 07  X  SPA  @0 Virus @2 NW
C07 08  X  FRE  @0 Chlore Composé organique @2 NC @2 FX @2 NA @5 10
C07 08  X  ENG  @0 Chlorine Organic compounds @2 NC @2 FX @2 NA @5 10
C07 08  X  SPA  @0 Cloro Compuesto orgánico @2 NC @2 FX @2 NA @5 10
N21       @1 022

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Pascal:09-0033367

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<term>Cysteine endopeptidases</term>
<term>Enzyme inhibitor</term>
<term>In vitro</term>
<term>Inhibitor enzyme complex</term>
<term>Modeling</term>
<term>Molecular model</term>
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<term>Synthèse chimique</term>
<term>Antiviral</term>
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<term>In vitro</term>
<term>Cysteine endopeptidases</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Hétérocycle azote</term>
<term>Composé bicyclique</term>
<term>Composé aromatique</term>
<term>Dérivé de la pyridine</term>
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<term>Complexe enzyme inhibiteur</term>
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</teiHeader>
<front>
<div type="abstract" xml:lang="en">Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to potency. Inhibitor 10 with a 5-chloropyridinyl ester at position 4 of the indole ring is the most potent inhibitor with a SARS-CoV 3CLpro IC
<sub>50</sub>
value of 30 nM and an antiviral EC
<sub>50</sub>
value of 6.9 μM. Molecular docking studies have provided possible binding modes of these inhibitors.</div>
</front>
</TEI>
<inist>
<standard h6="B">
<pA>
<fA01 i1="01" i2="1">
<s0>0960-894X</s0>
</fA01>
<fA03 i2="1">
<s0>Bioorg. med. chem. lett. : (Print)</s0>
</fA03>
<fA05>
<s2>18</s2>
</fA05>
<fA06>
<s2>20</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG">
<s1>Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors</s1>
</fA08>
<fA11 i1="01" i2="1">
<s1>GHOSH (Arun K.)</s1>
</fA11>
<fA11 i1="02" i2="1">
<s1>GANGLI GONG</s1>
</fA11>
<fA11 i1="03" i2="1">
<s1>GRUM-TOKARS (Valerie)</s1>
</fA11>
<fA11 i1="04" i2="1">
<s1>MULHEARN (Debbie C.)</s1>
</fA11>
<fA11 i1="05" i2="1">
<s1>BAKER (Susan C.)</s1>
</fA11>
<fA11 i1="06" i2="1">
<s1>COUGHLIN (Melissa)</s1>
</fA11>
<fA11 i1="07" i2="1">
<s1>PRABHAKAR (Bellur S.)</s1>
</fA11>
<fA11 i1="08" i2="1">
<s1>SLEEMAN (Katrina)</s1>
</fA11>
<fA11 i1="09" i2="1">
<s1>JOHNSON (Michael E.)</s1>
</fA11>
<fA11 i1="10" i2="1">
<s1>MESECAR (Andrew D.)</s1>
</fA11>
<fA14 i1="01">
<s1>Departments of Chemistry and Medicinal Chemistry. Purdue University, 560 Oval drive</s1>
<s2>West Lafayette, IN 47907</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>Center for Pharmaceutical Biotechnology, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, IL 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine</s1>
<s2>Maywood, IL</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>Department of Microbiology and Immunology, University of Illinois</s1>
<s2>Chicago, IL 60607</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA20>
<s1>5684-5688</s1>
</fA20>
<fA21>
<s1>2008</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>22446</s2>
<s5>354000184446880790</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>24 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>09-0033367</s0>
</fA47>
<fA60>
<s1>P</s1>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Bioorganic & medicinal chemistry letters : (Print)</s0>
</fA64>
<fA66 i1="01">
<s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to potency. Inhibitor 10 with a 5-chloropyridinyl ester at position 4 of the indole ring is the most potent inhibitor with a SARS-CoV 3CLpro IC
<sub>50</sub>
value of 30 nM and an antiviral EC
<sub>50</sub>
value of 6.9 μM. Molecular docking studies have provided possible binding modes of these inhibitors.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B02S05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Synthèse chimique</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Chemical synthesis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Síntesis química</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Antiviral</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Antiviral</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Antiviral</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Relation structure activité</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Structure activity relation</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Relación estructura actividad</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>In vitro</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>In vitro</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>In vitro</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Cysteine endopeptidases</s0>
<s2>FE</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Cysteine endopeptidases</s0>
<s2>FE</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Cysteine endopeptidases</s0>
<s2>FE</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Virus syndrome respiratoire aigu sévère</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Hétérocycle azote</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Nitrogen heterocycle</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Heterociclo nitrógeno</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Composé bicyclique</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Bicyclic compound</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Compuesto bicíclico</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Composé aromatique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Aromatic compound</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Compuesto aromático</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Dérivé de la pyridine</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Pyridine derivatives</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Piridina derivado</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Modèle moléculaire</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Molecular model</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Modelo molecular</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE">
<s0>Complexe enzyme inhibiteur</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG">
<s0>Inhibitor enzyme complex</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA">
<s0>Complejo enzima inhibidor</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE">
<s0>Modélisation</s0>
<s5>32</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG">
<s0>Modeling</s0>
<s5>32</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA">
<s0>Modelización</s0>
<s5>32</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE">
<s0>Inhibiteur enzyme</s0>
<s5>33</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG">
<s0>Enzyme inhibitor</s0>
<s5>33</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA">
<s0>Inhibidor enzima</s0>
<s5>33</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE">
<s0>Indole-4-carboxylique acide ester 5-chloro-3-pyridyle</s0>
<s2>NK</s2>
<s2>FR</s2>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Peptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE">
<s0>Chlore Composé organique</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>10</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG">
<s0>Chlorine Organic compounds</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>10</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA">
<s0>Cloro Compuesto orgánico</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>10</s5>
</fC07>
<fN21>
<s1>022</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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