SrasV1, PascalFrancis, Curation, bibRecord, 000551

Human memory T cell responses to SARS-CoV E protein

Identifieur interne : 000551 ( PascalFrancis/Curation ); précédent : 000550; suivant : 000552

Human memory T cell responses to SARS-CoV E protein

Auteurs : HUI PENG [République populaire de Chine] ; Li-Tao Yang [République populaire de Chine] ; JIAN LI [République populaire de Chine] ; Zhi-Qiang Lu [République populaire de Chine] ; Ling-Yun Wang [République populaire de Chine] ; Richard A. Koup [États-Unis] ; Robert T. Bailer [États-Unis] ; Chang-You Wu [République populaire de Chine]

Source :

Microbes and infection [ 1286-4579 ] ; 2006.

RBID : Pascal:06-0518406

Descripteurs français

Pascal (Inist)
- Homme, Virus syndrome respiratoire aigu sévère, Immunité cellulaire, Protéine, Lymphocyte T, Déterminant antigénique, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antigenic determinant, Cellular immunity, Human, Protein, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, T-Lymphocyte.

Abstract

E protein is a membrane component of severe acute respiratory syndrome coronavirus (SARS-CoV). Disruption of E protein may reduce viral infectivity. Thus, the SARS-CoV E protein is considered a potential target for the development of antiviral drugs. However, the cellular immune responses to E protein remain unclear in humans. In this study, we found that peripheral blood mononuclear cells (PBMCs) from fully recovered SARS individuals rapidly produced IFN-y and IL-2 following stimulation with a pool of 9 peptides overlapping the entire E protein sequence. Analysis of the immune responses by flow cytometry showed that both CD4⁺ and CD8⁺T cells were involved in the SARS-CoV E-specific immune responses after stimulation with SARS-CoV E peptides. Moreover, the majority of IFN-γ⁺CD4+T cells were central memory cells expressing CD45RO⁺CCR7+CD62L^-; whereas IFN-γ⁺CD8⁺ memory T cells were mostly effector memory cells expressing CD45RO^-CCR7^-CD62L^-. The results of T-cell responses to 9 individual peptides indicated that the E protein contained at least two major T cell epitopes (E2 amino acid [aa] 9-26 and E5-6: aa 33-57) which were important in eliciting cellular immune response to SARS-CoV E protein in humans.

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A08	`01`	`1`	`ENG`	`@1 Human memory T cell responses to SARS-CoV E protein`
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A11	`02`	`1`		`@1 YANG (Li-Tao)`
A11	`03`	`1`		`@1 JIAN LI`
A11	`04`	`1`		`@1 LU (Zhi-Qiang)`
A11	`05`	`1`		`@1 WANG (Ling-Yun)`
A11	`06`	`1`		`@1 KOUP (Richard A.)`
A11	`07`	`1`		`@1 BAILER (Robert T.)`
A11	`08`	`1`		`@1 WU (Chang-You)`
A14	`01`			`@1 Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, No. 74 Zhongshan Road II @2 Guangzhou 510089 @3 CHN @Z 1 aut. @Z 2 aut. @Z 8 aut.`
A14	`02`			`@1 Department of Cardiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 111 Dade Road @2 Guangzhou 510020 @3 CHN @Z 3 aut.`
A14	`03`			`@1 Department of Respiratory Disease, the Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road @2 Guangzhou 510020 @3 CHN @Z 4 aut.`
A14	`04`			`@1 Department of Digestive Diseases, the Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road @2 Guangzhou 510020 @3 CHN @Z 5 aut.`
A14	`05`			`@1 Vaccine Research Center, NIAID/NIH @2 Bethesda, MD 20892 @3 USA @Z 6 aut. @Z 7 aut.`
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C01	`01`		`ENG`	@0 E protein is a membrane component of severe acute respiratory syndrome coronavirus (SARS-CoV). Disruption of E protein may reduce viral infectivity. Thus, the SARS-CoV E protein is considered a potential target for the development of antiviral drugs. However, the cellular immune responses to E protein remain unclear in humans. In this study, we found that peripheral blood mononuclear cells (PBMCs) from fully recovered SARS individuals rapidly produced IFN-y and IL-2 following stimulation with a pool of 9 peptides overlapping the entire E protein sequence. Analysis of the immune responses by flow cytometry showed that both CD4⁺ and CD8⁺T cells were involved in the SARS-CoV E-specific immune responses after stimulation with SARS-CoV E peptides. Moreover, the majority of IFN-γ⁺CD4+T cells were central memory cells expressing CD45RO⁺CCR7+CD62L^-; whereas IFN-γ⁺CD8⁺ memory T cells were mostly effector memory cells expressing CD45RO^-CCR7^-CD62L^-. The results of T-cell responses to 9 individual peptides indicated that the E protein contained at least two major T cell epitopes (E2 amino acid [aa] 9-26 and E5-6: aa 33-57) which were important in eliciting cellular immune response to SARS-CoV E protein in humans.
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C03	`07`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 14`
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C07	`01`	`X`	`ENG`	`@0 Coronavirus @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW`
C07	`02`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Nidovirales @2 NW`
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C07	`05`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 13`
C07	`06`	`X`	`FRE`	`@0 Virose`
C07	`06`	`X`	`ENG`	`@0 Viral disease`
C07	`06`	`X`	`SPA`	`@0 Virosis`
C07	`07`	`X`	`FRE`	`@0 Infection`
C07	`07`	`X`	`ENG`	`@0 Infection`
C07	`07`	`X`	`SPA`	`@0 Infección`
C07	`08`	`X`	`FRE`	`@0 Poumon pathologie @5 16`
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C07	`08`	`X`	`SPA`	`@0 Pulmón patología @5 16`
N21				`@1 338`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:06-0518406

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Human memory T cell responses to SARS-CoV E protein</title>
<author><name sortKey="Hui Peng" sort="Hui Peng" uniqKey="Hui Peng" last="Hui Peng">HUI PENG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, No. 74 Zhongshan Road II</s1>
<s2>Guangzhou 510089</s2>
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<country>République populaire de Chine</country>
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<author><name sortKey="Yang, Li Tao" sort="Yang, Li Tao" uniqKey="Yang L" first="Li-Tao" last="Yang">Li-Tao Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, No. 74 Zhongshan Road II</s1>
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<author><name sortKey="Jian Li" sort="Jian Li" uniqKey="Jian Li" last="Jian Li">JIAN LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 111 Dade Road</s1>
<s2>Guangzhou 510020</s2>
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<author><name sortKey="Lu, Zhi Qiang" sort="Lu, Zhi Qiang" uniqKey="Lu Z" first="Zhi-Qiang" last="Lu">Zhi-Qiang Lu</name>
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<s3>CHN</s3>
<sZ>4 aut.</sZ>
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<country>République populaire de Chine</country>
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<author><name sortKey="Wang, Ling Yun" sort="Wang, Ling Yun" uniqKey="Wang L" first="Ling-Yun" last="Wang">Ling-Yun Wang</name>
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<author><name sortKey="Koup, Richard A" sort="Koup, Richard A" uniqKey="Koup R" first="Richard A." last="Koup">Richard A. Koup</name>
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<author><name sortKey="Wu, Chang You" sort="Wu, Chang You" uniqKey="Wu C" first="Chang-You" last="Wu">Chang-You Wu</name>
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<s2>Guangzhou 510089</s2>
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<country>République populaire de Chine</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Human memory T cell responses to SARS-CoV E protein</title>
<author><name sortKey="Hui Peng" sort="Hui Peng" uniqKey="Hui Peng" last="Hui Peng">HUI PENG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, No. 74 Zhongshan Road II</s1>
<s2>Guangzhou 510089</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yang, Li Tao" sort="Yang, Li Tao" uniqKey="Yang L" first="Li-Tao" last="Yang">Li-Tao Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, No. 74 Zhongshan Road II</s1>
<s2>Guangzhou 510089</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jian Li" sort="Jian Li" uniqKey="Jian Li" last="Jian Li">JIAN LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 111 Dade Road</s1>
<s2>Guangzhou 510020</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Lu, Zhi Qiang" sort="Lu, Zhi Qiang" uniqKey="Lu Z" first="Zhi-Qiang" last="Lu">Zhi-Qiang Lu</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Respiratory Disease, the Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road</s1>
<s2>Guangzhou 510020</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Wang, Ling Yun" sort="Wang, Ling Yun" uniqKey="Wang L" first="Ling-Yun" last="Wang">Ling-Yun Wang</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Digestive Diseases, the Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road</s1>
<s2>Guangzhou 510020</s2>
<s3>CHN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Koup, Richard A" sort="Koup, Richard A" uniqKey="Koup R" first="Richard A." last="Koup">Richard A. Koup</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Vaccine Research Center, NIAID/NIH</s1>
<s2>Bethesda, MD 20892</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Bailer, Robert T" sort="Bailer, Robert T" uniqKey="Bailer R" first="Robert T." last="Bailer">Robert T. Bailer</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Vaccine Research Center, NIAID/NIH</s1>
<s2>Bethesda, MD 20892</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Wu, Chang You" sort="Wu, Chang You" uniqKey="Wu C" first="Chang-You" last="Wu">Chang-You Wu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, No. 74 Zhongshan Road II</s1>
<s2>Guangzhou 510089</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Microbes and infection</title>
<title level="j" type="abbreviated">Microbes infect.</title>
<idno type="ISSN">1286-4579</idno>
<imprint><date when="2006">2006</date>
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<seriesStmt><title level="j" type="main">Microbes and infection</title>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigenic determinant</term>
<term>Cellular immunity</term>
<term>Human</term>
<term>Protein</term>
<term>Severe acute respiratory syndrome</term>
<term>Severe acute respiratory syndrome virus</term>
<term>T-Lymphocyte</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homme</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Immunité cellulaire</term>
<term>Protéine</term>
<term>Lymphocyte T</term>
<term>Déterminant antigénique</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">E protein is a membrane component of severe acute respiratory syndrome coronavirus (SARS-CoV). Disruption of E protein may reduce viral infectivity. Thus, the SARS-CoV E protein is considered a potential target for the development of antiviral drugs. However, the cellular immune responses to E protein remain unclear in humans. In this study, we found that peripheral blood mononuclear cells (PBMCs) from fully recovered SARS individuals rapidly produced IFN-y and IL-2 following stimulation with a pool of 9 peptides overlapping the entire E protein sequence. Analysis of the immune responses by flow cytometry showed that both CD4<sup>+</sup>
 and CD8<sup>+</sup>
T cells were involved in the SARS-CoV E-specific immune responses after stimulation with SARS-CoV E peptides. Moreover, the majority of IFN-γ<sup>+</sup>
CD4+T cells were central memory cells expressing CD45RO<sup>+</sup>
CCR7+CD62L<sup>-</sup>
; whereas IFN-γ<sup>+</sup>
CD8<sup>+</sup>
 memory T cells were mostly effector memory cells expressing CD45RO<sup>-</sup>
CCR7<sup>-</sup>
CD62L<sup>-</sup>
. The results of T-cell responses to 9 individual peptides indicated that the E protein contained at least two major T cell epitopes (E2 amino acid [aa] 9-26 and E5-6: aa 33-57) which were important in eliciting cellular immune response to SARS-CoV E protein in humans.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Human memory T cell responses to SARS-CoV E protein</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>HUI PENG</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>YANG (Li-Tao)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>JIAN LI</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>LU (Zhi-Qiang)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>WANG (Ling-Yun)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>KOUP (Richard A.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>BAILER (Robert T.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>WU (Chang-You)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, No. 74 Zhongshan Road II</s1>
<s2>Guangzhou 510089</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Cardiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 111 Dade Road</s1>
<s2>Guangzhou 510020</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Respiratory Disease, the Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road</s1>
<s2>Guangzhou 510020</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Digestive Diseases, the Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road</s1>
<s2>Guangzhou 510020</s2>
<s3>CHN</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Vaccine Research Center, NIAID/NIH</s1>
<s2>Bethesda, MD 20892</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>2424-2431</s1>
</fA20>
<fA21><s1>2006</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>26816</s2>
<s5>354000158788210120</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>35 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0518406</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Microbes and infection</s0>
</fA64>
<fA66 i1="01"><s0>FRA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>E protein is a membrane component of severe acute respiratory syndrome coronavirus (SARS-CoV). Disruption of E protein may reduce viral infectivity. Thus, the SARS-CoV E protein is considered a potential target for the development of antiviral drugs. However, the cellular immune responses to E protein remain unclear in humans. In this study, we found that peripheral blood mononuclear cells (PBMCs) from fully recovered SARS individuals rapidly produced IFN-y and IL-2 following stimulation with a pool of 9 peptides overlapping the entire E protein sequence. Analysis of the immune responses by flow cytometry showed that both CD4<sup>+</sup>
 and CD8<sup>+</sup>
T cells were involved in the SARS-CoV E-specific immune responses after stimulation with SARS-CoV E peptides. Moreover, the majority of IFN-γ<sup>+</sup>
CD4+T cells were central memory cells expressing CD45RO<sup>+</sup>
CCR7+CD62L<sup>-</sup>
; whereas IFN-γ<sup>+</sup>
CD8<sup>+</sup>
 memory T cells were mostly effector memory cells expressing CD45RO<sup>-</sup>
CCR7<sup>-</sup>
CD62L<sup>-</sup>
. The results of T-cell responses to 9 individual peptides indicated that the E protein contained at least two major T cell epitopes (E2 amino acid [aa] 9-26 and E5-6: aa 33-57) which were important in eliciting cellular immune response to SARS-CoV E protein in humans.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Homme</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Human</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Immunité cellulaire</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Cellular immunity</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Inmunidad celular</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Protéine</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Protein</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Proteína</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Lymphocyte T</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>T-Lymphocyte</s0>
<s5>07</s5>
<s6>«T»-Lymphocyte</s6>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Linfocito T</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Déterminant antigénique</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Antigenic determinant</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Determinante antigénico</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>14</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>13</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>16</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>16</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>16</s5>
</fC07>
<fN21><s1>338</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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Human memory T cell responses to SARS-CoV E protein

Human memory T cell responses to SARS-CoV E protein

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