SrasV1, PascalFrancis, Curation, bibRecord, 000275

Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus

Identifieur interne : 000275 ( PascalFrancis/Curation ); précédent : 000274; suivant : 000276

Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus

Auteurs : Gabriella A. Farcas [Canada] ; Susan M. Poutanen [Canada] ; Tony Mazzulli [Canada] ; Barbara M. Willey [Canada] ; Jagdish Butany [Canada] ; Sylvia L. Asa [Canada] ; Peter Faure [Canada] ; Poolak Akhavan [Canada] ; Donald E. Low [Canada] ; Kevin C. Kain [Canada]

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2005.

RBID : Pascal:05-0144473

Descripteurs français

Pascal (Inist)
- Coronavirus, Microbiologie, Infection, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Infection, Microbiology, Severe acute respiratory syndrome.

Abstract

Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patients who died of SARS during the Toronto outbreak. SARS-CoV was detected in lung (100%), bowel (73%), liver (41%), and kidney (38%) in 19 patients who died of SARS, with the highest viral loads observed in lung (1.0 X 10¹⁰ copies/g) and bowel (2.7 X 10⁹ copies/g). Fatal SARS was associated with multiorgan viral dissemination in a distribution that has implications for disease manifestation, viral shedding, and transmission.

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A08	`01`	`1`	`ENG`	`@1 Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus`
A11	`01`	`1`		`@1 FARCAS (Gabriella A.)`
A11	`02`	`1`		`@1 POUTANEN (Susan M.)`
A11	`03`	`1`		`@1 MAZZULLI (Tony)`
A11	`04`	`1`		`@1 WILLEY (Barbara M.)`
A11	`05`	`1`		`@1 BUTANY (Jagdish)`
A11	`06`	`1`		`@1 ASA (Sylvia L.)`
A11	`07`	`1`		`@1 FAURE (Peter)`
A11	`08`	`1`		`@1 AKHAVAN (Poolak)`
A11	`09`	`1`		`@1 LOW (Donald E.)`
A11	`10`	`1`		`@1 KAIN (Kevin C.)`
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A64	`01`	`1`		`@0 The Journal of infectious diseases`
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C01	`01`		`ENG`	@0 Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patients who died of SARS during the Toronto outbreak. SARS-CoV was detected in lung (100%), bowel (73%), liver (41%), and kidney (38%) in 19 patients who died of SARS, with the highest viral loads observed in lung (1.0 X 10¹⁰ copies/g) and bowel (2.7 X 10⁹ copies/g). Fatal SARS was associated with multiorgan viral dissemination in a distribution that has implications for disease manifestation, viral shedding, and transmission.
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C03	`02`	`X`	`FRE`	`@0 Microbiologie @5 05`
C03	`02`	`X`	`ENG`	`@0 Microbiology @5 05`
C03	`02`	`X`	`SPA`	`@0 Microbiología @5 05`
C03	`03`	`X`	`FRE`	`@0 Infection @5 06`
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C03	`03`	`X`	`SPA`	`@0 Infección @5 06`
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C03	`04`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 14`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 13`
C07	`04`	`X`	`ENG`	`@0 Respiratory disease @5 13`
C07	`04`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 13`
C07	`05`	`X`	`FRE`	`@0 Virose`
C07	`05`	`X`	`ENG`	`@0 Viral disease`
C07	`05`	`X`	`SPA`	`@0 Virosis`
C07	`06`	`X`	`FRE`	`@0 Poumon pathologie @5 16`
C07	`06`	`X`	`ENG`	`@0 Lung disease @5 16`
C07	`06`	`X`	`SPA`	`@0 Pulmón patología @5 16`
N21				`@1 094`
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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus</title>
<author><name sortKey="Farcas, Gabriella A" sort="Farcas, Gabriella A" uniqKey="Farcas G" first="Gabriella A." last="Farcas">Gabriella A. Farcas</name>
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<author><name sortKey="Poutanen, Susan M" sort="Poutanen, Susan M" uniqKey="Poutanen S" first="Susan M." last="Poutanen">Susan M. Poutanen</name>
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<series><title level="j" type="main">The Journal of infectious diseases</title>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patients who died of SARS during the Toronto outbreak. SARS-CoV was detected in lung (100%), bowel (73%), liver (41%), and kidney (38%) in 19 patients who died of SARS, with the highest viral loads observed in lung (1.0 X 10<sup>10</sup>
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HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000275 | SxmlIndent | more

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{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:05-0144473
   |texte=   Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus
}}

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Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus

Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus

Source :

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Abstract

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