Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus
Identifieur interne : 000715 ( PascalFrancis/Corpus ); précédent : 000714; suivant : 000716Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus
Auteurs : Gabriella A. Farcas ; Susan M. Poutanen ; Tony Mazzulli ; Barbara M. Willey ; Jagdish Butany ; Sylvia L. Asa ; Peter Faure ; Poolak Akhavan ; Donald E. Low ; Kevin C. KainSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patients who died of SARS during the Toronto outbreak. SARS-CoV was detected in lung (100%), bowel (73%), liver (41%), and kidney (38%) in 19 patients who died of SARS, with the highest viral loads observed in lung (1.0 X 1010 copies/g) and bowel (2.7 X 109 copies/g). Fatal SARS was associated with multiorgan viral dissemination in a distribution that has implications for disease manifestation, viral shedding, and transmission.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 05-0144473 INIST |
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ET : | Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus |
AU : | FARCAS (Gabriella A.); POUTANEN (Susan M.); MAZZULLI (Tony); WILLEY (Barbara M.); BUTANY (Jagdish); ASA (Sylvia L.); FAURE (Peter); AKHAVAN (Poolak); LOW (Donald E.); KAIN (Kevin C.) |
AF : | McLaughlin-Rotman Center for Global Health, McLaughlin Center for Molecular Medicine,/Toronto/Canada (1 aut., 10 aut.); Faculty of Medicine,, University of Toronto/Toronto/Canada (1 aut., 3 aut., 9 aut., 10 aut.); Institute of Medical Science, University of Toronto/Toronto/Canada (1 aut., 10 aut.); Department of Laboratory Medicine and Pathobiology, University of Toronto/Toronto/Canada (2 aut., 3 aut., 9 aut., 10 aut.); Department of Microbiology, Mount Sinai Hospital/Toronto/Canada (2 aut., 3 aut., 4 aut., 8 aut., 9 aut.); Toronto Medical Laboratories/Toronto/Canada (2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 8 aut., 9 aut., 10 aut.); Department of Pathology, University Health Network/Toronto/Canada (5 aut., 6 aut., 7 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Etats-Unis; Da. 2005; Vol. 191; No. 2; Pp. 193-197; Bibl. 15 ref. |
LA : | Anglais |
EA : | Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patients who died of SARS during the Toronto outbreak. SARS-CoV was detected in lung (100%), bowel (73%), liver (41%), and kidney (38%) in 19 patients who died of SARS, with the highest viral loads observed in lung (1.0 X 1010 copies/g) and bowel (2.7 X 109 copies/g). Fatal SARS was associated with multiorgan viral dissemination in a distribution that has implications for disease manifestation, viral shedding, and transmission. |
CC : | 002A05C10; 002B05 |
FD : | Coronavirus; Microbiologie; Infection; Syndrome respiratoire aigu sévère |
FG : | Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Poumon pathologie |
ED : | Coronavirus; Microbiology; Infection; Severe acute respiratory syndrome |
EG : | Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Lung disease |
SD : | Coronavirus; Microbiología; Infección; Síndrome respiratorio agudo severo |
LO : | INIST-2052.354000127078410060 |
ID : | 05-0144473 |
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Pascal:05-0144473Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus</title>
<author><name sortKey="Farcas, Gabriella A" sort="Farcas, Gabriella A" uniqKey="Farcas G" first="Gabriella A." last="Farcas">Gabriella A. Farcas</name>
<affiliation><inist:fA14 i1="01"><s1>McLaughlin-Rotman Center for Global Health, McLaughlin Center for Molecular Medicine,</s1>
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<affiliation><inist:fA14 i1="02"><s1>Faculty of Medicine,, University of Toronto</s1>
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<author><name sortKey="Faure, Peter" sort="Faure, Peter" uniqKey="Faure P" first="Peter" last="Faure">Peter Faure</name>
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<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
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<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patients who died of SARS during the Toronto outbreak. SARS-CoV was detected in lung (100%), bowel (73%), liver (41%), and kidney (38%) in 19 patients who died of SARS, with the highest viral loads observed in lung (1.0 X 10<sup>10</sup>
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<ET>Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus</ET>
<AU>FARCAS (Gabriella A.); POUTANEN (Susan M.); MAZZULLI (Tony); WILLEY (Barbara M.); BUTANY (Jagdish); ASA (Sylvia L.); FAURE (Peter); AKHAVAN (Poolak); LOW (Donald E.); KAIN (Kevin C.)</AU>
<AF>McLaughlin-Rotman Center for Global Health, McLaughlin Center for Molecular Medicine,/Toronto/Canada (1 aut., 10 aut.); Faculty of Medicine,, University of Toronto/Toronto/Canada (1 aut., 3 aut., 9 aut., 10 aut.); Institute of Medical Science, University of Toronto/Toronto/Canada (1 aut., 10 aut.); Department of Laboratory Medicine and Pathobiology, University of Toronto/Toronto/Canada (2 aut., 3 aut., 9 aut., 10 aut.); Department of Microbiology, Mount Sinai Hospital/Toronto/Canada (2 aut., 3 aut., 4 aut., 8 aut., 9 aut.); Toronto Medical Laboratories/Toronto/Canada (2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 8 aut., 9 aut., 10 aut.); Department of Pathology, University Health Network/Toronto/Canada (5 aut., 6 aut., 7 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Etats-Unis; Da. 2005; Vol. 191; No. 2; Pp. 193-197; Bibl. 15 ref.</SO>
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<EA>Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patients who died of SARS during the Toronto outbreak. SARS-CoV was detected in lung (100%), bowel (73%), liver (41%), and kidney (38%) in 19 patients who died of SARS, with the highest viral loads observed in lung (1.0 X 10<sup>10</sup>
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<ED>Coronavirus; Microbiology; Infection; Severe acute respiratory syndrome</ED>
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<SD>Coronavirus; Microbiología; Infección; Síndrome respiratorio agudo severo</SD>
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