SrasV1, PascalFrancis, Curation, bibRecord, 000219

Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design

Identifieur interne : 000219 ( PascalFrancis/Curation ); précédent : 000218; suivant : 000220

Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design

Auteurs : XUE WU ZHANG [Hong Kong] ; YEE LENG YAP [Hong Kong]

Source :

Bioorganic & medicinal chemistry [ 0968-0896 ] ; 2004.

RBID : Pascal:04-0571083

Descripteurs français

Pascal (Inist)
- Relation structure activité, Antiviral, Coronavirus, Inhibiteur enzyme, Peptidases, Inhibiteur protease, Syndrome respiratoire aigu sévère, Interaction moléculaire, Fixation biologique, Etude comparative, Virus artérite virale équine, Virus hépatite C, Virus hépatite A, Virus dengue, Complexe enzyme inhibiteur, Aminocétone, Fluor composé organique, Composé benzénique, Cétoacide, Aminoamide.

English descriptors

KwdEn :
- Aminoamide, Aminoketone, Antiviral, Benzenic compound, Biological fixation, Comparative study, Coronavirus, Dengue virus, Enzyme inhibitor, Equine arteritis virus, Hepatitis A virus, Hepatitis C virus, Inhibitor enzyme complex, Ketoacid, Molecular interaction, Organic fluorine compounds, Peptidases, Protease inhibitor, Severe acute respiratory syndrome, Structure activity relation.

Abstract

The main proteinase of SARS-associated coronavirus (SARS-CoV) plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development. The important thing is to understand its binding mechanism with possible ligands. In this study, we investigated possible noncanonical interactions, potential inhibitors, and binding pockets in the main proteinase of SARS-CoV based on its recently determined crystal structure. These findings provide a wide clue to searching for anti-SARS drug. Interestingly, we found that similar structure patterns exist in SARS-CoV main proteinase with Poliovirus 3c Proteinase, Rhinovirus 3c Protease, Nsp4 Proteinase From Equine Arteritis Virus, Hepatitis C Virus Ns3 Protease, Hepatitis A Virus 3c Protease, and Dengue Virus Ns3 Protease. It suggests that the available drugs in these viruses could be used to fight SARS disease.

A01	`01`	`1`		`@0 0968-0896`
A03		`1`		`@0 Bioorg. med. chem.`
A05				`@2 12`
A06				`@2 9`
A08	`01`	`1`	`ENG`	`@1 Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design`
A11	`01`	`1`		`@1 XUE WU ZHANG`
A11	`02`	`1`		`@1 YEE LENG YAP`
A14	`01`			`@1 HKU-Pasteur Research Center, Bioinformatics, 8 Sassoon Road @3 HKG @Z 1 aut. @Z 2 aut.`
A20				`@1 2219-2223`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 26564 @5 354000117106140210`
A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 19 ref.`
A47	`01`	`1`		`@0 04-0571083`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Bioorganic & medicinal chemistry`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 The main proteinase of SARS-associated coronavirus (SARS-CoV) plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development. The important thing is to understand its binding mechanism with possible ligands. In this study, we investigated possible noncanonical interactions, potential inhibitors, and binding pockets in the main proteinase of SARS-CoV based on its recently determined crystal structure. These findings provide a wide clue to searching for anti-SARS drug. Interestingly, we found that similar structure patterns exist in SARS-CoV main proteinase with Poliovirus 3c Proteinase, Rhinovirus 3c Protease, Nsp4 Proteinase From Equine Arteritis Virus, Hepatitis C Virus Ns3 Protease, Hepatitis A Virus 3c Protease, and Dengue Virus Ns3 Protease. It suggests that the available drugs in these viruses could be used to fight SARS disease.
C02	`01`	`X`		`@0 002B02S05`
C03	`01`	`X`	`FRE`	`@0 Relation structure activité @5 01`
C03	`01`	`X`	`ENG`	`@0 Structure activity relation @5 01`
C03	`01`	`X`	`SPA`	`@0 Relación estructura actividad @5 01`
C03	`02`	`X`	`FRE`	`@0 Antiviral @5 02`
C03	`02`	`X`	`ENG`	`@0 Antiviral @5 02`
C03	`02`	`X`	`SPA`	`@0 Antiviral @5 02`
C03	`03`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 03`
C03	`03`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 03`
C03	`03`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 03`
C03	`04`	`X`	`FRE`	`@0 Inhibiteur enzyme @5 04`
C03	`04`	`X`	`ENG`	`@0 Enzyme inhibitor @5 04`
C03	`04`	`X`	`SPA`	`@0 Inhibidor enzima @5 04`
C03	`05`	`X`	`FRE`	`@0 Peptidases @2 FE @5 05`
C03	`05`	`X`	`ENG`	`@0 Peptidases @2 FE @5 05`
C03	`05`	`X`	`SPA`	`@0 Peptidases @2 FE @5 05`
C03	`06`	`X`	`FRE`	`@0 Inhibiteur protease @2 FR @5 06`
C03	`06`	`X`	`ENG`	`@0 Protease inhibitor @2 FR @5 06`
C03	`06`	`X`	`SPA`	`@0 Inhibidor proteasa @2 FR @5 06`
C03	`07`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 07`
C03	`07`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 07`
C03	`07`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 07`
C03	`08`	`X`	`FRE`	`@0 Interaction moléculaire @5 09`
C03	`08`	`X`	`ENG`	`@0 Molecular interaction @5 09`
C03	`08`	`X`	`SPA`	`@0 Interacción molecular @5 09`
C03	`09`	`X`	`FRE`	`@0 Fixation biologique @5 10`
C03	`09`	`X`	`ENG`	`@0 Biological fixation @5 10`
C03	`09`	`X`	`SPA`	`@0 Fijación biológica @5 10`
C03	`10`	`X`	`FRE`	`@0 Etude comparative @5 12`
C03	`10`	`X`	`ENG`	`@0 Comparative study @5 12`
C03	`10`	`X`	`SPA`	`@0 Estudio comparativo @5 12`
C03	`11`	`X`	`FRE`	`@0 Virus artérite virale équine @2 NW @5 13`
C03	`11`	`X`	`ENG`	`@0 Equine arteritis virus @2 NW @5 13`
C03	`11`	`X`	`SPA`	`@0 Equine arteritis virus @2 NW @5 13`
C03	`12`	`X`	`FRE`	`@0 Virus hépatite C @2 NW @5 14`
C03	`12`	`X`	`ENG`	`@0 Hepatitis C virus @2 NW @5 14`
C03	`12`	`X`	`SPA`	`@0 Hepatitis C virus @2 NW @5 14`
C03	`13`	`X`	`FRE`	`@0 Virus hépatite A @2 NW @5 15`
C03	`13`	`X`	`ENG`	`@0 Hepatitis A virus @2 NW @5 15`
C03	`13`	`X`	`SPA`	`@0 Hepatitis A virus @2 NW @5 15`
C03	`14`	`X`	`FRE`	`@0 Virus dengue @2 NW @5 16`
C03	`14`	`X`	`ENG`	`@0 Dengue virus @2 NW @5 16`
C03	`14`	`X`	`SPA`	`@0 Dengue virus @2 NW @5 16`
C03	`15`	`X`	`FRE`	`@0 Complexe enzyme inhibiteur @5 17`
C03	`15`	`X`	`ENG`	`@0 Inhibitor enzyme complex @5 17`
C03	`15`	`X`	`SPA`	`@0 Complejo enzima inhibidor @5 17`
C03	`16`	`X`	`FRE`	`@0 Aminocétone @5 18`
C03	`16`	`X`	`ENG`	`@0 Aminoketone @5 18`
C03	`16`	`X`	`SPA`	`@0 Aminocetona @5 18`
C03	`17`	`3`	`FRE`	`@0 Fluor composé organique @5 19`
C03	`17`	`3`	`ENG`	`@0 Organic fluorine compounds @5 19`
C03	`18`	`X`	`FRE`	`@0 Composé benzénique @5 20`
C03	`18`	`X`	`ENG`	`@0 Benzenic compound @5 20`
C03	`18`	`X`	`SPA`	`@0 Compuesto bencénico @5 20`
C03	`19`	`X`	`FRE`	`@0 Cétoacide @5 21`
C03	`19`	`X`	`ENG`	`@0 Ketoacid @5 21`
C03	`19`	`X`	`SPA`	`@0 Cetoácido @5 21`
C03	`20`	`X`	`FRE`	`@0 Aminoamide @5 22`
C03	`20`	`X`	`ENG`	`@0 Aminoamide @5 22`
C03	`20`	`X`	`SPA`	`@0 Aminoamida @5 22`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Hydrolases @2 FE`
C07	`04`	`X`	`ENG`	`@0 Hydrolases @2 FE`
C07	`04`	`X`	`SPA`	`@0 Hydrolases @2 FE`
C07	`05`	`X`	`FRE`	`@0 Enzyme @2 FE`
C07	`05`	`X`	`ENG`	`@0 Enzyme @2 FE`
C07	`05`	`X`	`SPA`	`@0 Enzima @2 FE`
C07	`06`	`X`	`FRE`	`@0 Virose @2 NM`
C07	`06`	`X`	`ENG`	`@0 Viral disease @2 NM`
C07	`06`	`X`	`SPA`	`@0 Virosis @2 NM`
C07	`07`	`X`	`FRE`	`@0 Infection @2 NM`
C07	`07`	`X`	`ENG`	`@0 Infection @2 NM`
C07	`07`	`X`	`SPA`	`@0 Infección @2 NM`
C07	`08`	`X`	`FRE`	`@0 Arterivirus @2 NW`
C07	`08`	`X`	`ENG`	`@0 Arterivirus @2 NW`
C07	`08`	`X`	`SPA`	`@0 Arterivirus @2 NW`
C07	`09`	`X`	`FRE`	`@0 Arteriviridae @2 NW`
C07	`09`	`X`	`ENG`	`@0 Arteriviridae @2 NW`
C07	`09`	`X`	`SPA`	`@0 Arteriviridae @2 NW`
C07	`10`	`X`	`FRE`	`@0 Hepacivirus @2 NW`
C07	`10`	`X`	`ENG`	`@0 Hepacivirus @2 NW`
C07	`10`	`X`	`SPA`	`@0 Hepacivirus @2 NW`
C07	`11`	`X`	`FRE`	`@0 Flaviviridae @2 NW`
C07	`11`	`X`	`ENG`	`@0 Flaviviridae @2 NW`
C07	`11`	`X`	`SPA`	`@0 Flaviviridae @2 NW`
C07	`12`	`X`	`FRE`	`@0 Hepatovirus @2 NW`
C07	`12`	`X`	`ENG`	`@0 Hepatovirus @2 NW`
C07	`12`	`X`	`SPA`	`@0 Hepatovirus @2 NW`
C07	`13`	`X`	`FRE`	`@0 Picornaviridae @2 NW`
C07	`13`	`X`	`ENG`	`@0 Picornaviridae @2 NW`
C07	`13`	`X`	`SPA`	`@0 Picornaviridae @2 NW`
C07	`14`	`X`	`FRE`	`@0 Virus groupe dengue @2 NW`
C07	`14`	`X`	`ENG`	`@0 Dengue group virus @2 NW`
C07	`14`	`X`	`SPA`	`@0 Dengue group virus @2 NW`
C07	`15`	`X`	`FRE`	`@0 Flavivirus @2 NW`
C07	`15`	`X`	`ENG`	`@0 Flavivirus @2 NW`
C07	`15`	`X`	`SPA`	`@0 Flavivirus @2 NW`
N21				`@1 327`
N44	`01`			`@1 PSI`
N82				`@1 PSI`

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Pascal:04-0571083

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminoamide</term>
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<term>Benzenic compound</term>
<term>Biological fixation</term>
<term>Comparative study</term>
<term>Coronavirus</term>
<term>Dengue virus</term>
<term>Enzyme inhibitor</term>
<term>Equine arteritis virus</term>
<term>Hepatitis A virus</term>
<term>Hepatitis C virus</term>
<term>Inhibitor enzyme complex</term>
<term>Ketoacid</term>
<term>Molecular interaction</term>
<term>Organic fluorine compounds</term>
<term>Peptidases</term>
<term>Protease inhibitor</term>
<term>Severe acute respiratory syndrome</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Relation structure activité</term>
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<term>Virus hépatite C</term>
<term>Virus hépatite A</term>
<term>Virus dengue</term>
<term>Complexe enzyme inhibiteur</term>
<term>Aminocétone</term>
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<front><div type="abstract" xml:lang="en">The main proteinase of SARS-associated coronavirus (SARS-CoV) plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development. The important thing is to understand its binding mechanism with possible ligands. In this study, we investigated possible noncanonical interactions, potential inhibitors, and binding pockets in the main proteinase of SARS-CoV based on its recently determined crystal structure. These findings provide a wide clue to searching for anti-SARS drug. Interestingly, we found that similar structure patterns exist in SARS-CoV main proteinase with Poliovirus 3c Proteinase, Rhinovirus 3c Protease, Nsp4 Proteinase From Equine Arteritis Virus, Hepatitis C Virus Ns3 Protease, Hepatitis A Virus 3c Protease, and Dengue Virus Ns3 Protease. It suggests that the available drugs in these viruses could be used to fight SARS disease.</div>
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</fA11>
<fA11 i1="02" i2="1"><s1>YEE LENG YAP</s1>
</fA11>
<fA14 i1="01"><s1>HKU-Pasteur Research Center, Bioinformatics, 8 Sassoon Road</s1>
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<fC01 i1="01" l="ENG"><s0>The main proteinase of SARS-associated coronavirus (SARS-CoV) plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development. The important thing is to understand its binding mechanism with possible ligands. In this study, we investigated possible noncanonical interactions, potential inhibitors, and binding pockets in the main proteinase of SARS-CoV based on its recently determined crystal structure. These findings provide a wide clue to searching for anti-SARS drug. Interestingly, we found that similar structure patterns exist in SARS-CoV main proteinase with Poliovirus 3c Proteinase, Rhinovirus 3c Protease, Nsp4 Proteinase From Equine Arteritis Virus, Hepatitis C Virus Ns3 Protease, Hepatitis A Virus 3c Protease, and Dengue Virus Ns3 Protease. It suggests that the available drugs in these viruses could be used to fight SARS disease.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Relation structure activité</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Structure activity relation</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Relación estructura actividad</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Enzyme inhibitor</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Inhibidor enzima</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Peptidases</s0>
<s2>FE</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Peptidases</s0>
<s2>FE</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Peptidases</s0>
<s2>FE</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Inhibiteur protease</s0>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Protease inhibitor</s0>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Inhibidor proteasa</s0>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Interaction moléculaire</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Molecular interaction</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Interacción molecular</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Fixation biologique</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Biological fixation</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Fijación biológica</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Etude comparative</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Comparative study</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Estudio comparativo</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Virus artérite virale équine</s0>
<s2>NW</s2>
<s5>13</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Equine arteritis virus</s0>
<s2>NW</s2>
<s5>13</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Equine arteritis virus</s0>
<s2>NW</s2>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Virus hépatite C</s0>
<s2>NW</s2>
<s5>14</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Hepatitis C virus</s0>
<s2>NW</s2>
<s5>14</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Hepatitis C virus</s0>
<s2>NW</s2>
<s5>14</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Virus hépatite A</s0>
<s2>NW</s2>
<s5>15</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Hepatitis A virus</s0>
<s2>NW</s2>
<s5>15</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Hepatitis A virus</s0>
<s2>NW</s2>
<s5>15</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Virus dengue</s0>
<s2>NW</s2>
<s5>16</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Dengue virus</s0>
<s2>NW</s2>
<s5>16</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Dengue virus</s0>
<s2>NW</s2>
<s5>16</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Complexe enzyme inhibiteur</s0>
<s5>17</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Inhibitor enzyme complex</s0>
<s5>17</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Complejo enzima inhibidor</s0>
<s5>17</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Aminocétone</s0>
<s5>18</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Aminoketone</s0>
<s5>18</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Aminocetona</s0>
<s5>18</s5>
</fC03>
<fC03 i1="17" i2="3" l="FRE"><s0>Fluor composé organique</s0>
<s5>19</s5>
</fC03>
<fC03 i1="17" i2="3" l="ENG"><s0>Organic fluorine compounds</s0>
<s5>19</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Composé benzénique</s0>
<s5>20</s5>
</fC03>
<fC03 i1="18" i2="X" l="ENG"><s0>Benzenic compound</s0>
<s5>20</s5>
</fC03>
<fC03 i1="18" i2="X" l="SPA"><s0>Compuesto bencénico</s0>
<s5>20</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>Cétoacide</s0>
<s5>21</s5>
</fC03>
<fC03 i1="19" i2="X" l="ENG"><s0>Ketoacid</s0>
<s5>21</s5>
</fC03>
<fC03 i1="19" i2="X" l="SPA"><s0>Cetoácido</s0>
<s5>21</s5>
</fC03>
<fC03 i1="20" i2="X" l="FRE"><s0>Aminoamide</s0>
<s5>22</s5>
</fC03>
<fC03 i1="20" i2="X" l="ENG"><s0>Aminoamide</s0>
<s5>22</s5>
</fC03>
<fC03 i1="20" i2="X" l="SPA"><s0>Aminoamida</s0>
<s5>22</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Arterivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Arterivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Arterivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Arteriviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Arteriviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Arteriviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Hepacivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Hepacivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Hepacivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Flaviviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Flaviviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Flaviviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Hepatovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Hepatovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Hepatovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Picornaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Picornaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Picornaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="14" i2="X" l="FRE"><s0>Virus groupe dengue</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="14" i2="X" l="ENG"><s0>Dengue group virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="14" i2="X" l="SPA"><s0>Dengue group virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="15" i2="X" l="FRE"><s0>Flavivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="15" i2="X" l="ENG"><s0>Flavivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="15" i2="X" l="SPA"><s0>Flavivirus</s0>
<s2>NW</s2>
</fC07>
<fN21><s1>327</s1>
</fN21>
<fN44 i1="01"><s1>PSI</s1>
</fN44>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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   |texte=   Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design
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Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design

Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design

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