SrasV1, PascalFrancis, Curation, bibRecord, 000108

Probing the structure of the SARS coronavirus using scanning electron microscopy

Identifieur interne : 000108 ( PascalFrancis/Curation ); précédent : 000107; suivant : 000109

Probing the structure of the SARS coronavirus using scanning electron microscopy

Auteurs : YUN LIN [République populaire de Chine] ; XIYUN YAN [République populaire de Chine] ; WUCHUN CAO [République populaire de Chine] ; CHAOYING WANG [République populaire de Chine] ; JING FENG [République populaire de Chine] ; JINZHU DUAN [République populaire de Chine] ; SISHEN XIE [République populaire de Chine]

Source :

Antiviral therapy : (London) [ 1359-6535 ] ; 2004.

RBID : Pascal:04-0309340

Descripteurs français

Pascal (Inist)
- Coronavirus, Microscopie électronique, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Electron microscopy, Severe acute respiratory syndrome.

Abstract

A novel coronavirus, SARS-CoV, has been confirmed to be the aetiological agent of SARS. Transmission electron microscope (TEM) images played an important role in initial identification of the pathogen. In order to obtain greater morphological detail of SARS-CoV than could be obtained by TEM, we used ultra-high resolution scanning electron microscopy (SEM) to image the virus particles. We show here the three-dimensional appearance of SARS-CoV. Enhanced detail of the ultrastructure reveals the trimeric structure of the 10-20 nm spikes on the virion surface. These results contribute to characterization of the SARS agent and development of new antiviral strategies.

A01	`01`	`1`		`@0 1359-6535`
A03		`1`		`@0 Antivir. ther. : (Lond.)`
A05				`@2 9`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Probing the structure of the SARS coronavirus using scanning electron microscopy`
A11	`01`	`1`		`@1 YUN LIN`
A11	`02`	`1`		`@1 XIYUN YAN`
A11	`03`	`1`		`@1 WUCHUN CAO`
A11	`04`	`1`		`@1 CHAOYING WANG`
A11	`05`	`1`		`@1 JING FENG`
A11	`06`	`1`		`@1 JINZHU DUAN`
A11	`07`	`1`		`@1 SISHEN XIE`
A14	`01`			`@1 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS) @2 Beijing @3 CHN @Z 1 aut. @Z 2 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 State Key Laboratory of Microbial Resources, Institute of Microbiology, CAS @2 Beijing @3 CHN @Z 1 aut. @Z 5 aut. @Z 6 aut.`
A14	`03`			`@1 Department of Epidemiology, Institute of Microbiology and Epidemiology @2 Beijing @3 CHN @Z 3 aut.`
A14	`04`			`@1 Center for Condensed Matter Physics, Institute of Physics, CAS @2 Beijing @3 CHN @Z 4 aut. @Z 7 aut.`
A20				`@1 287-289`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 27047 @5 354000110084150150`
A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 6 ref.`
A47	`01`	`1`		`@0 04-0309340`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Antiviral therapy : (London)`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 A novel coronavirus, SARS-CoV, has been confirmed to be the aetiological agent of SARS. Transmission electron microscope (TEM) images played an important role in initial identification of the pathogen. In order to obtain greater morphological detail of SARS-CoV than could be obtained by TEM, we used ultra-high resolution scanning electron microscopy (SEM) to image the virus particles. We show here the three-dimensional appearance of SARS-CoV. Enhanced detail of the ultrastructure reveals the trimeric structure of the 10-20 nm spikes on the virion surface. These results contribute to characterization of the SARS agent and development of new antiviral strategies.
C02	`01`	`X`		`@0 002B02S05`
C03	`01`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 11`
C03	`01`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 11`
C03	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 11`
C03	`02`	`X`	`FRE`	`@0 Microscopie électronique @5 12`
C03	`02`	`X`	`ENG`	`@0 Electron microscopy @5 12`
C03	`02`	`X`	`SPA`	`@0 Microscopía electrónica @5 12`
C03	`03`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @4 CD @5 96`
C03	`03`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @4 CD @5 96`
C03	`03`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 61`
C07	`04`	`X`	`ENG`	`@0 Respiratory disease @5 61`
C07	`04`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 61`
C07	`05`	`X`	`FRE`	`@0 Poumon pathologie @5 62`
C07	`05`	`X`	`ENG`	`@0 Lung disease @5 62`
C07	`05`	`X`	`SPA`	`@0 Pulmón patología @5 62`
C07	`06`	`X`	`FRE`	`@0 Virose @2 NM @5 63`
C07	`06`	`X`	`ENG`	`@0 Viral disease @2 NM @5 63`
C07	`06`	`X`	`SPA`	`@0 Virosis @2 NM @5 63`
C07	`07`	`X`	`FRE`	`@0 Infection @2 NM`
C07	`07`	`X`	`ENG`	`@0 Infection @2 NM`
C07	`07`	`X`	`SPA`	`@0 Infección @2 NM`
N21				`@1 187`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<front><div type="abstract" xml:lang="en">A novel coronavirus, SARS-CoV, has been confirmed to be the aetiological agent of SARS. Transmission electron microscope (TEM) images played an important role in initial identification of the pathogen. In order to obtain greater morphological detail of SARS-CoV than could be obtained by TEM, we used ultra-high resolution scanning electron microscopy (SEM) to image the virus particles. We show here the three-dimensional appearance of SARS-CoV. Enhanced detail of the ultrastructure reveals the trimeric structure of the 10-20 nm spikes on the virion surface. These results contribute to characterization of the SARS agent and development of new antiviral strategies.</div>
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<fC03 i1="02" i2="X" l="SPA"><s0>Microscopía electrónica</s0>
<s5>12</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
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<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>61</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>61</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>61</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>62</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>62</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>62</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0>
<s2>NM</s2>
<s5>63</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0>
<s2>NM</s2>
<s5>63</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0>
<s2>NM</s2>
<s5>63</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fN21><s1>187</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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Probing the structure of the SARS coronavirus using scanning electron microscopy

Probing the structure of the SARS coronavirus using scanning electron microscopy

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