Probing the structure of the SARS coronavirus using scanning electron microscopy
Identifieur interne : 000882 ( PascalFrancis/Corpus ); précédent : 000881; suivant : 000883Probing the structure of the SARS coronavirus using scanning electron microscopy
Auteurs : YUN LIN ; XIYUN YAN ; WUCHUN CAO ; CHAOYING WANG ; JING FENG ; JINZHU DUAN ; SISHEN XIESource :
- Antiviral therapy : (London) [ 1359-6535 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
A novel coronavirus, SARS-CoV, has been confirmed to be the aetiological agent of SARS. Transmission electron microscope (TEM) images played an important role in initial identification of the pathogen. In order to obtain greater morphological detail of SARS-CoV than could be obtained by TEM, we used ultra-high resolution scanning electron microscopy (SEM) to image the virus particles. We show here the three-dimensional appearance of SARS-CoV. Enhanced detail of the ultrastructure reveals the trimeric structure of the 10-20 nm spikes on the virion surface. These results contribute to characterization of the SARS agent and development of new antiviral strategies.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 04-0309340 INIST |
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ET : | Probing the structure of the SARS coronavirus using scanning electron microscopy |
AU : | YUN LIN; XIYUN YAN; WUCHUN CAO; CHAOYING WANG; JING FENG; JINZHU DUAN; SISHEN XIE |
AF : | National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS)/Beijing/Chine (1 aut., 2 aut., 5 aut., 6 aut.); State Key Laboratory of Microbial Resources, Institute of Microbiology, CAS/Beijing/Chine (1 aut., 5 aut., 6 aut.); Department of Epidemiology, Institute of Microbiology and Epidemiology/Beijing/Chine (3 aut.); Center for Condensed Matter Physics, Institute of Physics, CAS/Beijing/Chine (4 aut., 7 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Antiviral therapy : (London); ISSN 1359-6535; Royaume-Uni; Da. 2004; Vol. 9; No. 2; Pp. 287-289; Bibl. 6 ref. |
LA : | Anglais |
EA : | A novel coronavirus, SARS-CoV, has been confirmed to be the aetiological agent of SARS. Transmission electron microscope (TEM) images played an important role in initial identification of the pathogen. In order to obtain greater morphological detail of SARS-CoV than could be obtained by TEM, we used ultra-high resolution scanning electron microscopy (SEM) to image the virus particles. We show here the three-dimensional appearance of SARS-CoV. Enhanced detail of the ultrastructure reveals the trimeric structure of the 10-20 nm spikes on the virion surface. These results contribute to characterization of the SARS agent and development of new antiviral strategies. |
CC : | 002B02S05 |
FD : | Coronavirus; Microscopie électronique; Syndrome respiratoire aigu sévère |
FG : | Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie; Virose; Infection |
ED : | Coronavirus; Electron microscopy; Severe acute respiratory syndrome |
EG : | Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease; Viral disease; Infection |
SD : | Coronavirus; Microscopía electrónica; Síndrome respiratorio agudo severo |
LO : | INIST-27047.354000110084150150 |
ID : | 04-0309340 |
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Pascal:04-0309340Le document en format XML
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<server><NO>PASCAL 04-0309340 INIST</NO>
<ET>Probing the structure of the SARS coronavirus using scanning electron microscopy</ET>
<AU>YUN LIN; XIYUN YAN; WUCHUN CAO; CHAOYING WANG; JING FENG; JINZHU DUAN; SISHEN XIE</AU>
<AF>National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS)/Beijing/Chine (1 aut., 2 aut., 5 aut., 6 aut.); State Key Laboratory of Microbial Resources, Institute of Microbiology, CAS/Beijing/Chine (1 aut., 5 aut., 6 aut.); Department of Epidemiology, Institute of Microbiology and Epidemiology/Beijing/Chine (3 aut.); Center for Condensed Matter Physics, Institute of Physics, CAS/Beijing/Chine (4 aut., 7 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Antiviral therapy : (London); ISSN 1359-6535; Royaume-Uni; Da. 2004; Vol. 9; No. 2; Pp. 287-289; Bibl. 6 ref.</SO>
<LA>Anglais</LA>
<EA>A novel coronavirus, SARS-CoV, has been confirmed to be the aetiological agent of SARS. Transmission electron microscope (TEM) images played an important role in initial identification of the pathogen. In order to obtain greater morphological detail of SARS-CoV than could be obtained by TEM, we used ultra-high resolution scanning electron microscopy (SEM) to image the virus particles. We show here the three-dimensional appearance of SARS-CoV. Enhanced detail of the ultrastructure reveals the trimeric structure of the 10-20 nm spikes on the virion surface. These results contribute to characterization of the SARS agent and development of new antiviral strategies.</EA>
<CC>002B02S05</CC>
<FD>Coronavirus; Microscopie électronique; Syndrome respiratoire aigu sévère</FD>
<FG>Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie; Virose; Infection</FG>
<ED>Coronavirus; Electron microscopy; Severe acute respiratory syndrome</ED>
<EG>Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease; Viral disease; Infection</EG>
<SD>Coronavirus; Microscopía electrónica; Síndrome respiratorio agudo severo</SD>
<LO>INIST-27047.354000110084150150</LO>
<ID>04-0309340</ID>
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