SrasV1, PascalFrancis, Curation, bibRecord, 000103

The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein

Identifieur interne : 000103 ( PascalFrancis/Curation ); précédent : 000102; suivant : 000104

The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein

Auteurs : Martin Spiegel [Allemagne] ; Andreas Pichlmair [Allemagne] ; Elke Mühlberger [Allemagne] ; Otto Haller [Allemagne] ; Friedemann Weber [Allemagne]

Source :

Journal of clinical virology [ 1386-6532 ] ; 2004.

RBID : Pascal:04-0289429

Descripteurs français

Pascal (Inist)
- Coronavirus, Antiviral, Interféron bêta, Protéine, Microbiologie, Virologie, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Antiviral, Beta interferon, Coronavirus, Microbiology, Protein, Severe acute respiratory syndrome, Virology.

Abstract

Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus termed SARS-CoV. No antiviral treatment has been established so far. Interferons are cytokines which induce the synthesis of several antivirally active proteins in the cell. In this study, we demonstrated that multiplication of SARS-CoV in cell culture can be strongly inhibited by pretreatment with interferon-beta. Interferon-alpha and interferon-gamma, by contrast, were less effective. The human MxA protein is one of the most prominent proteins induced by interferon-beta. Nevertheless, no interference with SARS-CoV replication was observed in Vero cells stably expressing MxA. Therefore, other interferon-induced proteins must be responsible for the strong inhibitory effect of interferon-beta against SARS-CoV.

A01	`01`	`1`		`@0 1386-6532`
A03		`1`		`@0 J. clin. virol.`
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A08	`01`	`1`	`ENG`	`@1 The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein`
A11	`01`	`1`		`@1 SPIEGEL (Martin)`
A11	`02`	`1`		`@1 PICHLMAIR (Andreas)`
A11	`03`	`1`		`@1 MÜHLBERGER (Elke)`
A11	`04`	`1`		`@1 HALLER (Otto)`
A11	`05`	`1`		`@1 WEBER (Friedemann)`
A14	`01`			`@1 Abteilung Virologie, Institut für Medizinische Mikrobiologie und, Hygiene, Universität Freiburg @2 79008 Freiburg @3 DEU @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut.`
A14	`02`			`@1 Institut für Virologie der Philipps-Universität Marhurg @2 35037 Marburg @3 DEU @Z 3 aut.`
A20				`@1 211-213`
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C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
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C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
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C07	`04`	`X`	`FRE`	`@0 Virose @2 NM`
C07	`04`	`X`	`ENG`	`@0 Viral disease @2 NM`
C07	`04`	`X`	`SPA`	`@0 Virosis @2 NM`
C07	`05`	`X`	`FRE`	`@0 Infection @2 NM`
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C07	`05`	`X`	`SPA`	`@0 Infección @2 NM`
C07	`06`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 19`
C07	`06`	`X`	`ENG`	`@0 Respiratory disease @5 19`
C07	`06`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 19`
C07	`07`	`X`	`FRE`	`@0 Poumon pathologie @5 20`
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C07	`07`	`X`	`SPA`	`@0 Pulmón patología @5 20`
N21				`@1 180`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<fC07 i1="04" i2="X" l="FRE"><s0>Virose</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Viral disease</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virosis</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>19</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>19</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>19</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>20</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>20</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>20</s5>
</fC07>
<fN21><s1>180</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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   |wiki=    Sante
   |area=    SrasV1
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   |clé=     Pascal:04-0289429
   |texte=   The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein
}}

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The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein

The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein

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