SrasV1, PascalFrancis, Corpus, bibRecord, 000717

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus

Identifieur interne : 000717 ( PascalFrancis/Corpus ); précédent : 000716; suivant : 000718

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus

Auteurs : Sara Akerström ; Mehrdad Mousavi-Jazi ; Jonas Klingström ; Mikael Leijon ; Ake Lundkvist ; Ali Mirazimi

Source :

Journal of virology [ 0022-538X ] ; 2005.

RBID : Pascal:05-0134586

Descripteurs français

Pascal (Inist)
- Coronavirus, Azote monoxyde, Réplication, Microbiologie, Virologie, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Microbiology, Nitric oxide, Replication, Severe acute respiratory syndrome, Virology.

Abstract

Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.
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Format Inist (serveur)

NO :	PASCAL 05-0134586 INIST
ET :	Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus
AU :	AKERSTRÖM (Sara); MOUSAVI-JAZI (Mehrdad); KLINGSTRÖM (Jonas); LEIJON (Mikael); LUNDKVIST (Ake); MIRAZIMI (Ali)
AF :	Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control/Solna/Suède (1 aut., 3 aut., 5 aut., 6 aut.); LightUp Technologies/Huddinge/Suède (2 aut., 4 aut.); MTC/Karolinska Institutet/Stockholm/Suède (3 aut., 5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of virology; ISSN 0022-538X; Etats-Unis; Da. 2005; Vol. 79; No. 3; Pp. 1966-1969; Bibl. 34 ref.
LA :	Anglais
EA :	Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.
CC :	002A05C10
FD :	Coronavirus; Azote monoxyde; Réplication; Microbiologie; Virologie; Syndrome respiratoire aigu sévère
FG :	Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Infection; Poumon pathologie
ED :	Coronavirus; Nitric oxide; Replication; Microbiology; Virology; Severe acute respiratory syndrome
EG :	Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Infection; Lung disease
SD :	Coronavirus; Nitrógeno monóxido; Replicación; Microbiología; Virología; Síndrome respiratorio agudo severo
LO :	INIST-13592.354000127060900660
ID :	05-0134586

Links to Exploration step

Pascal:05-0134586

Le document en format XML

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<front><div type="abstract" xml:lang="en">Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.</div>
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<server><NO>PASCAL 05-0134586 INIST</NO>
<ET>Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus</ET>
<AU>AKERSTRÖM (Sara); MOUSAVI-JAZI (Mehrdad); KLINGSTRÖM (Jonas); LEIJON (Mikael); LUNDKVIST (Ake); MIRAZIMI (Ali)</AU>
<AF>Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control/Solna/Suède (1 aut., 3 aut., 5 aut., 6 aut.); LightUp Technologies/Huddinge/Suède (2 aut., 4 aut.); MTC/Karolinska Institutet/Stockholm/Suède (3 aut., 5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of virology; ISSN 0022-538X; Etats-Unis; Da. 2005; Vol. 79; No. 3; Pp. 1966-1969; Bibl. 34 ref.</SO>
<LA>Anglais</LA>
<EA>Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.</EA>
<CC>002A05C10</CC>
<FD>Coronavirus; Azote monoxyde; Réplication; Microbiologie; Virologie; Syndrome respiratoire aigu sévère</FD>
<FG>Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Infection; Poumon pathologie</FG>
<ED>Coronavirus; Nitric oxide; Replication; Microbiology; Virology; Severe acute respiratory syndrome</ED>
<EG>Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Infection; Lung disease</EG>
<SD>Coronavirus; Nitrógeno monóxido; Replicación; Microbiología; Virología; Síndrome respiratorio agudo severo</SD>
<LO>INIST-13592.354000127060900660</LO>
<ID>05-0134586</ID>
</server>
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Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus

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