Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors
Identifieur interne : 000539 ( PascalFrancis/Corpus ); précédent : 000538; suivant : 000540Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors
Auteurs : Arun K. Ghosh ; KAI XI ; Kiira Ratia ; Bernard D. Santarsiero ; WENTAO FU ; Brian H. Harcourt ; Paul A. Rota ; Susan C. Baker ; Michael E. Johnson ; Andrew D. MesecarSource :
- Journal of medicinal chemistry : (Print) [ 0022-2623 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Synthèse chimique, Composé peptidomimétique, Virus syndrome respiratoire aigu sévère, Inhibiteur protease, Composé non peptide, Cétoamide, Carboxamide, Lactame, Hétérocycle oxygène azote, Hétérocycle azote, In vitro, Complexe enzyme inhibiteur, Modèle moléculaire, Activité biologique, Composé vinylique, Peptidases, Inhibiteur enzyme, Antiviral, Modélisation, Pyrrolidine-3-pent-2-énoïque acide(γ-[(5-méthyl-2-[4-méthyl-3-([(5-méthylisoxazol-3-yl)carbonyl]amino)-2-oxopentyl]hex-4-énoyl)amino]-2-oxo) ester éthyle, Pyrrolidin-2-one dérivé, Isoxazole-3-carboxamide dérivé.
English descriptors
- KwdEn :
- Antiviral, Biological activity, Carboxamide, Chemical synthesis, Enzyme inhibitor, In vitro, Inhibitor enzyme complex, Ketoamide, Lactam, Modeling, Molecular model, Nitrogen heterocycle, Non peptide compound, Oxygen nitrogen heterocycle, Peptidases, Peptidomimetic compound, Protease inhibitor, Severe acute respiratory syndrome virus, Vinylic compound.
Abstract
Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
|
---|
Format Inist (serveur)
NO : | PASCAL 06-0152064 INIST |
---|---|
ET : | Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors |
AU : | GHOSH (Arun K.); KAI XI; RATIA (Kiira); SANTARSIERO (Bernard D.); WENTAO FU; HARCOURT (Brian H.); ROTA (Paul A.); BAKER (Susan C.); JOHNSON (Michael E.); MESECAR (Andrew D.) |
AF : | Departments of Chemistry and Medicinal Chemistry, Purdue University/West Lafayette, Indiana 47907/Etats-Unis (1 aut., 2 aut.); Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S/Ashland, Illinois 60607/Etats-Unis (3 aut., 4 aut., 5 aut., 9 aut., 10 aut.); Center for Disease Control and Prevention/Atlanta, Georgia/Etats-Unis (6 aut.); Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine/Maywood, Illinois/Etats-Unis (7 aut., 8 aut.); Department of Chemistry, University of Illinois at Chicago/Chicago, Illinois 60607/Etats-Unis |
DT : | Publication en série; Correspondance, lettre; Niveau analytique |
SO : | Journal of medicinal chemistry : (Print); ISSN 0022-2623; Coden JMCMAR; Etats-Unis; Da. 2005; Vol. 48; No. 22; Pp. 6767-6771; Bibl. 18 ref. |
LA : | Anglais |
EA : | Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors. |
CC : | 002B02S05 |
FD : | Synthèse chimique; Composé peptidomimétique; Virus syndrome respiratoire aigu sévère; Inhibiteur protease; Composé non peptide; Cétoamide; Carboxamide; Lactame; Hétérocycle oxygène azote; Hétérocycle azote; In vitro; Complexe enzyme inhibiteur; Modèle moléculaire; Activité biologique; Composé vinylique; Peptidases; Inhibiteur enzyme; Antiviral; Modélisation; Pyrrolidine-3-pent-2-énoïque acide(γ-[(5-méthyl-2-[4-méthyl-3-([(5- méthylisoxazol-3-yl)carbonyl]amino)-2-oxopentyl]hex-4- énoyl)amino]-2-oxo) ester éthyle; Pyrrolidin-2-one dérivé; Isoxazole-3-carboxamide dérivé |
FG : | Coronavirus; Coronaviridae; Nidovirales; Virus; Hydrolases; Enzyme |
ED : | Chemical synthesis; Peptidomimetic compound; Severe acute respiratory syndrome virus; Protease inhibitor; Non peptide compound; Ketoamide; Carboxamide; Lactam; Oxygen nitrogen heterocycle; Nitrogen heterocycle; In vitro; Inhibitor enzyme complex; Molecular model; Biological activity; Vinylic compound; Peptidases; Enzyme inhibitor; Antiviral; Modeling |
EG : | Coronavirus; Coronaviridae; Nidovirales; Virus; Hydrolases; Enzyme |
SD : | Síntesis química; Compuesto peptidomimético; Severe acute respiratory syndrome virus; Inhibidor proteasa; Compuesto no péptido; Cetoamida; Carboxamida; Lactamo; Heterociclo oxígeno nitrógeno; Heterociclo nitrógeno; In vitro; Complejo enzima inhibidor; Modelo molecular; Actividad biológica; Compuesto vinílico; Peptidases; Inhibidor enzima; Antiviral; Modelización |
LO : | INIST-9165.354000131970830010 |
ID : | 06-0152064 |
Links to Exploration step
Pascal:06-0152064Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors</title>
<author><name sortKey="Ghosh, Arun K" sort="Ghosh, Arun K" uniqKey="Ghosh A" first="Arun K." last="Ghosh">Arun K. Ghosh</name>
<affiliation><inist:fA14 i1="01"><s1>Departments of Chemistry and Medicinal Chemistry, Purdue University</s1>
<s2>West Lafayette, Indiana 47907</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="05"><s1>Department of Chemistry, University of Illinois at Chicago</s1>
<s2>Chicago, Illinois 60607</s2>
<s3>USA</s3>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kai Xi" sort="Kai Xi" uniqKey="Kai Xi" last="Kai Xi">KAI XI</name>
<affiliation><inist:fA14 i1="01"><s1>Departments of Chemistry and Medicinal Chemistry, Purdue University</s1>
<s2>West Lafayette, Indiana 47907</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ratia, Kiira" sort="Ratia, Kiira" uniqKey="Ratia K" first="Kiira" last="Ratia">Kiira Ratia</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Santarsiero, Bernard D" sort="Santarsiero, Bernard D" uniqKey="Santarsiero B" first="Bernard D." last="Santarsiero">Bernard D. Santarsiero</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Wentao Fu" sort="Wentao Fu" uniqKey="Wentao Fu" last="Wentao Fu">WENTAO FU</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Harcourt, Brian H" sort="Harcourt, Brian H" uniqKey="Harcourt B" first="Brian H." last="Harcourt">Brian H. Harcourt</name>
<affiliation><inist:fA14 i1="03"><s1>Center for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rota, Paul A" sort="Rota, Paul A" uniqKey="Rota P" first="Paul A." last="Rota">Paul A. Rota</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine</s1>
<s2>Maywood, Illinois</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Baker, Susan C" sort="Baker, Susan C" uniqKey="Baker S" first="Susan C." last="Baker">Susan C. Baker</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine</s1>
<s2>Maywood, Illinois</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Johnson, Michael E" sort="Johnson, Michael E" uniqKey="Johnson M" first="Michael E." last="Johnson">Michael E. Johnson</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0152064</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 06-0152064 INIST</idno>
<idno type="RBID">Pascal:06-0152064</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000539</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors</title>
<author><name sortKey="Ghosh, Arun K" sort="Ghosh, Arun K" uniqKey="Ghosh A" first="Arun K." last="Ghosh">Arun K. Ghosh</name>
<affiliation><inist:fA14 i1="01"><s1>Departments of Chemistry and Medicinal Chemistry, Purdue University</s1>
<s2>West Lafayette, Indiana 47907</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="05"><s1>Department of Chemistry, University of Illinois at Chicago</s1>
<s2>Chicago, Illinois 60607</s2>
<s3>USA</s3>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kai Xi" sort="Kai Xi" uniqKey="Kai Xi" last="Kai Xi">KAI XI</name>
<affiliation><inist:fA14 i1="01"><s1>Departments of Chemistry and Medicinal Chemistry, Purdue University</s1>
<s2>West Lafayette, Indiana 47907</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ratia, Kiira" sort="Ratia, Kiira" uniqKey="Ratia K" first="Kiira" last="Ratia">Kiira Ratia</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Santarsiero, Bernard D" sort="Santarsiero, Bernard D" uniqKey="Santarsiero B" first="Bernard D." last="Santarsiero">Bernard D. Santarsiero</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Wentao Fu" sort="Wentao Fu" uniqKey="Wentao Fu" last="Wentao Fu">WENTAO FU</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Harcourt, Brian H" sort="Harcourt, Brian H" uniqKey="Harcourt B" first="Brian H." last="Harcourt">Brian H. Harcourt</name>
<affiliation><inist:fA14 i1="03"><s1>Center for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rota, Paul A" sort="Rota, Paul A" uniqKey="Rota P" first="Paul A." last="Rota">Paul A. Rota</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine</s1>
<s2>Maywood, Illinois</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Baker, Susan C" sort="Baker, Susan C" uniqKey="Baker S" first="Susan C." last="Baker">Susan C. Baker</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine</s1>
<s2>Maywood, Illinois</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Johnson, Michael E" sort="Johnson, Michael E" uniqKey="Johnson M" first="Michael E." last="Johnson">Michael E. Johnson</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of medicinal chemistry : (Print)</title>
<title level="j" type="abbreviated">J. med. chem. : (Print)</title>
<idno type="ISSN">0022-2623</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of medicinal chemistry : (Print)</title>
<title level="j" type="abbreviated">J. med. chem. : (Print)</title>
<idno type="ISSN">0022-2623</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term>
<term>Biological activity</term>
<term>Carboxamide</term>
<term>Chemical synthesis</term>
<term>Enzyme inhibitor</term>
<term>In vitro</term>
<term>Inhibitor enzyme complex</term>
<term>Ketoamide</term>
<term>Lactam</term>
<term>Modeling</term>
<term>Molecular model</term>
<term>Nitrogen heterocycle</term>
<term>Non peptide compound</term>
<term>Oxygen nitrogen heterocycle</term>
<term>Peptidases</term>
<term>Peptidomimetic compound</term>
<term>Protease inhibitor</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Vinylic compound</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Synthèse chimique</term>
<term>Composé peptidomimétique</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Inhibiteur protease</term>
<term>Composé non peptide</term>
<term>Cétoamide</term>
<term>Carboxamide</term>
<term>Lactame</term>
<term>Hétérocycle oxygène azote</term>
<term>Hétérocycle azote</term>
<term>In vitro</term>
<term>Complexe enzyme inhibiteur</term>
<term>Modèle moléculaire</term>
<term>Activité biologique</term>
<term>Composé vinylique</term>
<term>Peptidases</term>
<term>Inhibiteur enzyme</term>
<term>Antiviral</term>
<term>Modélisation</term>
<term>Pyrrolidine-3-pent-2-énoïque acide(γ-[(5-méthyl-2-[4-méthyl-3-([(5-méthylisoxazol-3-yl)carbonyl]amino)-2-oxopentyl]hex-4-énoyl)amino]-2-oxo) ester éthyle</term>
<term>Pyrrolidin-2-one dérivé</term>
<term>Isoxazole-3-carboxamide dérivé</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-2623</s0>
</fA01>
<fA02 i1="01"><s0>JMCMAR</s0>
</fA02>
<fA03 i2="1"><s0>J. med. chem. : (Print)</s0>
</fA03>
<fA05><s2>48</s2>
</fA05>
<fA06><s2>22</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>GHOSH (Arun K.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>KAI XI</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>RATIA (Kiira)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>SANTARSIERO (Bernard D.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>WENTAO FU</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>HARCOURT (Brian H.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>ROTA (Paul A.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>BAKER (Susan C.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>JOHNSON (Michael E.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>MESECAR (Andrew D.)</s1>
</fA11>
<fA14 i1="01"><s1>Departments of Chemistry and Medicinal Chemistry, Purdue University</s1>
<s2>West Lafayette, Indiana 47907</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S</s1>
<s2>Ashland, Illinois 60607</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Center for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine</s1>
<s2>Maywood, Illinois</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Chemistry, University of Illinois at Chicago</s1>
<s2>Chicago, Illinois 60607</s2>
<s3>USA</s3>
</fA14>
<fA20><s1>6767-6771</s1>
</fA20>
<fA21><s1>2005</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>9165</s2>
<s5>354000131970830010</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>18 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0152064</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CR</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of medicinal chemistry : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Synthèse chimique</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Chemical synthesis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Síntesis química</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Composé peptidomimétique</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Peptidomimetic compound</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Compuesto peptidomimético</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Inhibiteur protease</s0>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Protease inhibitor</s0>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Inhibidor proteasa</s0>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Composé non peptide</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Non peptide compound</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Compuesto no péptido</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Cétoamide</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Ketoamide</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Cetoamida</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Carboxamide</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Carboxamide</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Carboxamida</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Lactame</s0>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Lactam</s0>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Lactamo</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Hétérocycle oxygène azote</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Oxygen nitrogen heterocycle</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Heterociclo oxígeno nitrógeno</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Hétérocycle azote</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Nitrogen heterocycle</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Heterociclo nitrógeno</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>In vitro</s0>
<s5>13</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>In vitro</s0>
<s5>13</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>In vitro</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Complexe enzyme inhibiteur</s0>
<s5>14</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Inhibitor enzyme complex</s0>
<s5>14</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Complejo enzima inhibidor</s0>
<s5>14</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Modèle moléculaire</s0>
<s5>15</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Molecular model</s0>
<s5>15</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Modelo molecular</s0>
<s5>15</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Activité biologique</s0>
<s5>16</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Biological activity</s0>
<s5>16</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Actividad biológica</s0>
<s5>16</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Composé vinylique</s0>
<s5>17</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Vinylic compound</s0>
<s5>17</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Compuesto vinílico</s0>
<s5>17</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Peptidases</s0>
<s2>FE</s2>
<s5>32</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Peptidases</s0>
<s2>FE</s2>
<s5>32</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Peptidases</s0>
<s2>FE</s2>
<s5>32</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0>
<s5>33</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG"><s0>Enzyme inhibitor</s0>
<s5>33</s5>
</fC03>
<fC03 i1="17" i2="X" l="SPA"><s0>Inhibidor enzima</s0>
<s5>33</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>34</s5>
</fC03>
<fC03 i1="18" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>34</s5>
</fC03>
<fC03 i1="18" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>34</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>Modélisation</s0>
<s5>35</s5>
</fC03>
<fC03 i1="19" i2="X" l="ENG"><s0>Modeling</s0>
<s5>35</s5>
</fC03>
<fC03 i1="19" i2="X" l="SPA"><s0>Modelización</s0>
<s5>35</s5>
</fC03>
<fC03 i1="20" i2="X" l="FRE"><s0>Pyrrolidine-3-pent-2-énoïque acide(γ-[(5-méthyl-2-[4-méthyl-3-([(5-méthylisoxazol-3-yl)carbonyl]amino)-2-oxopentyl]hex-4-énoyl)amino]-2-oxo) ester éthyle</s0>
<s2>NK</s2>
<s2>FR</s2>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC03 i1="21" i2="X" l="FRE"><s0>Pyrrolidin-2-one dérivé</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>77</s5>
</fC03>
<fC03 i1="22" i2="X" l="FRE"><s0>Isoxazole-3-carboxamide dérivé</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fN21><s1>093</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 06-0152064 INIST</NO>
<ET>Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors</ET>
<AU>GHOSH (Arun K.); KAI XI; RATIA (Kiira); SANTARSIERO (Bernard D.); WENTAO FU; HARCOURT (Brian H.); ROTA (Paul A.); BAKER (Susan C.); JOHNSON (Michael E.); MESECAR (Andrew D.)</AU>
<AF>Departments of Chemistry and Medicinal Chemistry, Purdue University/West Lafayette, Indiana 47907/Etats-Unis (1 aut., 2 aut.); Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 S/Ashland, Illinois 60607/Etats-Unis (3 aut., 4 aut., 5 aut., 9 aut., 10 aut.); Center for Disease Control and Prevention/Atlanta, Georgia/Etats-Unis (6 aut.); Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine/Maywood, Illinois/Etats-Unis (7 aut., 8 aut.); Department of Chemistry, University of Illinois at Chicago/Chicago, Illinois 60607/Etats-Unis</AF>
<DT>Publication en série; Correspondance, lettre; Niveau analytique</DT>
<SO>Journal of medicinal chemistry : (Print); ISSN 0022-2623; Coden JMCMAR; Etats-Unis; Da. 2005; Vol. 48; No. 22; Pp. 6767-6771; Bibl. 18 ref.</SO>
<LA>Anglais</LA>
<EA>Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.</EA>
<CC>002B02S05</CC>
<FD>Synthèse chimique; Composé peptidomimétique; Virus syndrome respiratoire aigu sévère; Inhibiteur protease; Composé non peptide; Cétoamide; Carboxamide; Lactame; Hétérocycle oxygène azote; Hétérocycle azote; In vitro; Complexe enzyme inhibiteur; Modèle moléculaire; Activité biologique; Composé vinylique; Peptidases; Inhibiteur enzyme; Antiviral; Modélisation; Pyrrolidine-3-pent-2-énoïque acide(γ-[(5-méthyl-2-[4-méthyl-3-([(5- méthylisoxazol-3-yl)carbonyl]amino)-2-oxopentyl]hex-4- énoyl)amino]-2-oxo) ester éthyle; Pyrrolidin-2-one dérivé; Isoxazole-3-carboxamide dérivé</FD>
<FG>Coronavirus; Coronaviridae; Nidovirales; Virus; Hydrolases; Enzyme</FG>
<ED>Chemical synthesis; Peptidomimetic compound; Severe acute respiratory syndrome virus; Protease inhibitor; Non peptide compound; Ketoamide; Carboxamide; Lactam; Oxygen nitrogen heterocycle; Nitrogen heterocycle; In vitro; Inhibitor enzyme complex; Molecular model; Biological activity; Vinylic compound; Peptidases; Enzyme inhibitor; Antiviral; Modeling</ED>
<EG>Coronavirus; Coronaviridae; Nidovirales; Virus; Hydrolases; Enzyme</EG>
<SD>Síntesis química; Compuesto peptidomimético; Severe acute respiratory syndrome virus; Inhibidor proteasa; Compuesto no péptido; Cetoamida; Carboxamida; Lactamo; Heterociclo oxígeno nitrógeno; Heterociclo nitrógeno; In vitro; Complejo enzima inhibidor; Modelo molecular; Actividad biológica; Compuesto vinílico; Peptidases; Inhibidor enzima; Antiviral; Modelización</SD>
<LO>INIST-9165.354000131970830010</LO>
<ID>06-0152064</ID>
</server>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PascalFrancis/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000539 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 000539 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PascalFrancis |étape= Corpus |type= RBID |clé= Pascal:06-0152064 |texte= Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |