SrasV1, PascalFrancis, Checkpoint, bibRecord, 000971

Development of a standard treatment protocol for severe acute respiratory syndrome

Identifieur interne : 000971 ( PascalFrancis/Checkpoint ); précédent : 000970; suivant : 000972

Development of a standard treatment protocol for severe acute respiratory syndrome

Auteurs : Loletta K-Y So [Hong Kong] ; Arthur C. W. Lau [Hong Kong] ; Loretta Y. C. Yam [Hong Kong] ; Thomas M. T. Cheung [Hong Kong] ; Edwin Poon [Hong Kong] ; Raymond W. H. Yung [Hong Kong] ; K. Y. Yuen [Hong Kong]

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2003.

RBID : Pascal:03-0295939

Descripteurs français

Pascal (Inist)
- Détresse respiratoire adulte syndrome, Homme, Coronavirus, Protocole thérapeutique, Traitement, Ribavirine, Antibactérien, Association médicamenteuse, Méthylprednisolone, Chimiothérapie, Ventilation assistée, Hong Kong, Efficacité traitement, Corticostéroïde.
Wicri :
- geographic : Hong Kong.
- topic : Homme.

English descriptors

KwdEn :
- Adult respiratory distress syndrome, Antibacterial agent, Assisted ventilation, Chemotherapy, Coronavirus, Corticosteroid, Drug combination, Hong Kong, Human, Methylprednisolone, Ribavirin, Therapeutic protocol, Treatment, Treatment efficiency.

Abstract

A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.

Affiliations:

Hong Kong

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Le document en format XML

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<front><div type="abstract" xml:lang="en">A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.</div>
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</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Quimioterapia</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Ventilation assistée</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Assisted ventilation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Ventilación asistida</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Efficacité traitement</s0>
<s5>17</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Treatment efficiency</s0>
<s5>17</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Eficacia tratamiento</s0>
<s5>17</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Corticostéroïde</s0>
<s5>31</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Corticosteroid</s0>
<s5>31</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Corticoesteroide</s0>
<s5>31</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Chine</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Asie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Virose</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Viral disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Virosis</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>53</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>53</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>53</s5>
</fC07>
<fN21><s1>195</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Hong Kong</li>
</country>
</list>
<tree><country name="Hong Kong"><noRegion><name sortKey="So, Loletta K Y" sort="So, Loletta K Y" uniqKey="So L" first="Loletta K-Y" last="So">Loletta K-Y So</name>
</noRegion>
<name sortKey="Cheung, Thomas M T" sort="Cheung, Thomas M T" uniqKey="Cheung T" first="Thomas M. T." last="Cheung">Thomas M. T. Cheung</name>
<name sortKey="Lau, Arthur C W" sort="Lau, Arthur C W" uniqKey="Lau A" first="Arthur C. W." last="Lau">Arthur C. W. Lau</name>
<name sortKey="Poon, Edwin" sort="Poon, Edwin" uniqKey="Poon E" first="Edwin" last="Poon">Edwin Poon</name>
<name sortKey="Yam, Loretta Y C" sort="Yam, Loretta Y C" uniqKey="Yam L" first="Loretta Y. C." last="Yam">Loretta Y. C. Yam</name>
<name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name>
<name sortKey="Yung, Raymond W H" sort="Yung, Raymond W H" uniqKey="Yung R" first="Raymond W. H." last="Yung">Raymond W. H. Yung</name>
</country>
</tree>
</affiliations>
</record>

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Development of a standard treatment protocol for severe acute respiratory syndrome

Development of a standard treatment protocol for severe acute respiratory syndrome

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