SrasV1, PascalFrancis, Checkpoint, bibRecord, 000894

Animal coronavirus vaccines : Lessons for SARS

Identifieur interne : 000894 ( PascalFrancis/Checkpoint ); précédent : 000893; suivant : 000895

Animal coronavirus vaccines : Lessons for SARS

Auteurs : L. J. Saif [États-Unis]

Source :

Developments in biologicals [ 1424-6074 ] ; 2004.

RBID : Pascal:05-0154089

Descripteurs français

Pascal (Inist)
- Virus syndrome respiratoire aigu sévère, Homme, Porcin, Vaccin, Chine, Origine, Transmission, Réservoir, Santé publique, Muqueuse, Immunité locale, Syndrome respiratoire aigu sévère, Maladie émergente, Adjuvant immunologique, Complication, Echec, Article synthèse.
Wicri :
- topic : Homme, Porcin, Vaccin, Santé publique.

English descriptors

KwdEn :
- China, Complication, Emerging disease, Failure, Human, Immunological adjuvant, Local immunity, Mucosa, Origin, Public health, Reservoir, Review, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Swine, Transmission, Vaccine.

Abstract

Severe acute respiratory syndrome (SARS) emerged in China and spread globally as a human pandemic. It is caused by a new coronavirus (CoV) of suspect animal origin. The emergence of SARS stunned medical scientists, but veterinary virologists had previously recognized CoVs as causing fatal respiratory or enteric disease in animals with interspecies transmission and wildlife reservoirs. Because of its public health impact, major efforts are focused on development of SARS vaccines. Occurrence of CoV disease at mucosal surfaces necessitates the stimulation of local immunity, having an impact on the vaccine type, delivery and adjuvant needed to achieve mucosal immunity. Such immunity is often short-lived, requires frequent boosting and may not prevent re-infection, all factors complicating CoV vaccine design. SARS vaccine efforts should be enhanced by understanding the correlates of protection and reasons for the success or failure of animal CoV vaccines. This review will focus on studies of immunity and protection in swine to the enteric CoV, transmissible gastroenteritis (TGEV) versus the respiratory variant, porcine respiratory CoV (PRCV), comparing live, inactivated and subunit vaccines, various vaccine vectors, routes and adjuvants. In addition avian infectious bronchitis CoV (IBV) vaccines targeted for protection of the upper respiratory tract of chickens are discussed. Unfortunately, despite long-term efforts, effective vaccines to prevent enteric CoV infections remain elusive, and generally live, but not killed vaccines, have induced the most consistent protection against animal CoVs. Confirmation of the pathogenesis of SARS in humans or animals models that mimic SARS may further aid in vaccine design and evaluation.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) emerged in China and spread globally as a human pandemic. It is caused by a new coronavirus (CoV) of suspect animal origin. The emergence of SARS stunned medical scientists, but veterinary virologists had previously recognized CoVs as causing fatal respiratory or enteric disease in animals with interspecies transmission and wildlife reservoirs. Because of its public health impact, major efforts are focused on development of SARS vaccines. Occurrence of CoV disease at mucosal surfaces necessitates the stimulation of local immunity, having an impact on the vaccine type, delivery and adjuvant needed to achieve mucosal immunity. Such immunity is often short-lived, requires frequent boosting and may not prevent re-infection, all factors complicating CoV vaccine design. SARS vaccine efforts should be enhanced by understanding the correlates of protection and reasons for the success or failure of animal CoV vaccines. This review will focus on studies of immunity and protection in swine to the enteric CoV, transmissible gastroenteritis (TGEV) versus the respiratory variant, porcine respiratory CoV (PRCV), comparing live, inactivated and subunit vaccines, various vaccine vectors, routes and adjuvants. In addition avian infectious bronchitis CoV (IBV) vaccines targeted for protection of the upper respiratory tract of chickens are discussed. Unfortunately, despite long-term efforts, effective vaccines to prevent enteric CoV infections remain elusive, and generally live, but not killed vaccines, have induced the most consistent protection against animal CoVs. Confirmation of the pathogenesis of SARS in humans or animals models that mimic SARS may further aid in vaccine design and evaluation.</div>
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<pR><fA30 i1="01" i2="1" l="ENG"><s1>Control of Infectious Animal Diseases by Vaccination. Conference</s1>
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<tree><country name="États-Unis"><region name="Ohio"><name sortKey="Saif, L J" sort="Saif, L J" uniqKey="Saif L" first="L. J." last="Saif">L. J. Saif</name>
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   |texte=   Animal coronavirus vaccines : Lessons for SARS
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Animal coronavirus vaccines : Lessons for SARS

Animal coronavirus vaccines : Lessons for SARS

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