Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease
Identifieur interne : 000663 ( PascalFrancis/Checkpoint ); précédent : 000662; suivant : 000664Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease
Auteurs : Jiun-Jie Shie [Taïwan] ; Jim-Min Fang [Taïwan] ; Chih-Jung Kuo [Taïwan] ; Tun-Hsun Kuo [Taïwan] ; Po-Huang Liang [Taïwan] ; Hung-Jyun Huang [Taïwan] ; Wen-Bin Yang [Taïwan] ; Chun-Hung Lin [Taïwan] ; Jiun-Ling Chen [Taïwan] ; Yin-Ta Wu [Taïwan] ; Chi-Huey Wong [Taïwan, États-Unis]Source :
- Journal of medicinal chemistry : (Print) [ 0022-2623 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Anilide, Inhibiteur enzyme, Virus syndrome respiratoire aigu sévère, Peptidases, Antiviral, Peptide, Composé non peptide, Aminoamide, Benzène dérivé, Composé nitro, Relation structure activité, Tripeptide, Tétrapeptide, In vitro, Carboxamide, Phénylalanamide(N-[2-chloro-4-nitrophényl]-N-[4-(diméthylamino)benzoyl]).
English descriptors
- KwdEn :
Abstract
A diversified library of peptide anilides was prepared, and their inhibition activities against the SARS-CoV 3CL protease were examined by a fluorogenic tetradecapeptide substrate. The most potent inhibitor is an anilide derived from 2-chloro-4-nitroaniline, L-phenylalanine and 4-(dimethylamino)benzoic acid. This anilide is a competitive inhibitor of the SARS-CoV 3CL protease with Ki = 0.03 μM. The molecular docking experiment indicates that the PI residue of this anilide inhibitor is distant from the nucleophilic SH of Cys145 in the active site.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:05-0450262Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease</title><author><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei, 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 106</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei, 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 106</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genomics Research Center, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Kuo, Chih Jung" sort="Kuo, Chih Jung" uniqKey="Kuo C" first="Chih-Jung" last="Kuo">Chih-Jung Kuo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Kuo, Tun Hsun" sort="Kuo, Tun Hsun" uniqKey="Kuo T" first="Tun-Hsun" last="Kuo">Tun-Hsun Kuo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Hung Jyun" sort="Huang, Hung Jyun" uniqKey="Huang H" first="Hung-Jyun" last="Huang">Hung-Jyun Huang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei, 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 106</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Wen Bin" sort="Yang, Wen Bin" uniqKey="Yang W" first="Wen-Bin" last="Yang">Wen-Bin Yang</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genomics Research Center, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Chun Hung" sort="Lin, Chun Hung" uniqKey="Lin C" first="Chun-Hung" last="Lin">Chun-Hung Lin</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jiun Ling" sort="Chen, Jiun Ling" uniqKey="Chen J" first="Jiun-Ling" last="Chen">Jiun-Ling Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei, 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 106</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yin Ta" sort="Wu, Yin Ta" uniqKey="Wu Y" first="Yin-Ta" last="Wu">Yin-Ta Wu</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genomics Research Center, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genomics Research Center, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0450262</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0450262 INIST</idno><idno type="RBID">Pascal:05-0450262</idno><idno type="wicri:Area/PascalFrancis/Corpus">000595</idno><idno type="wicri:Area/PascalFrancis/Curation">000395</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000663</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000663</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease</title><author><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei, 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 106</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei, 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 106</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genomics Research Center, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Kuo, Chih Jung" sort="Kuo, Chih Jung" uniqKey="Kuo C" first="Chih-Jung" last="Kuo">Chih-Jung Kuo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Kuo, Tun Hsun" sort="Kuo, Tun Hsun" uniqKey="Kuo T" first="Tun-Hsun" last="Kuo">Tun-Hsun Kuo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Hung Jyun" sort="Huang, Hung Jyun" uniqKey="Huang H" first="Hung-Jyun" last="Huang">Hung-Jyun Huang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei, 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 106</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Wen Bin" sort="Yang, Wen Bin" uniqKey="Yang W" first="Wen-Bin" last="Yang">Wen-Bin Yang</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genomics Research Center, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Chun Hung" sort="Lin, Chun Hung" uniqKey="Lin C" first="Chun-Hung" last="Lin">Chun-Hung Lin</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jiun Ling" sort="Chen, Jiun Ling" uniqKey="Chen J" first="Jiun-Ling" last="Chen">Jiun-Ling Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei, 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 106</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yin Ta" sort="Wu, Yin Ta" uniqKey="Wu Y" first="Yin-Ta" last="Wu">Yin-Ta Wu</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genomics Research Center, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genomics Research Center, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei, 115</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of medicinal chemistry : (Print)</title><title level="j" type="abbreviated">J. med. chem. : (Print)</title><idno type="ISSN">0022-2623</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of medicinal chemistry : (Print)</title><title level="j" type="abbreviated">J. med. chem. : (Print)</title><idno type="ISSN">0022-2623</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminoamide</term><term>Anilide</term><term>Antiviral</term><term>Benzene derivatives</term><term>Carboxamide</term><term>Enzyme inhibitor</term><term>In vitro</term><term>Nitro compound</term><term>Non peptide compound</term><term>Peptidases</term><term>Peptides</term><term>Severe acute respiratory syndrome virus</term><term>Structure activity relation</term><term>Tetrapeptide</term><term>Tripeptide</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anilide</term><term>Inhibiteur enzyme</term><term>Virus syndrome respiratoire aigu sévère</term><term>Peptidases</term><term>Antiviral</term><term>Peptide</term><term>Composé non peptide</term><term>Aminoamide</term><term>Benzène dérivé</term><term>Composé nitro</term><term>Relation structure activité</term><term>Tripeptide</term><term>Tétrapeptide</term><term>In vitro</term><term>Carboxamide</term><term>Phénylalanamide(N-[2-chloro-4-nitrophényl]-N-[4-(diméthylamino)benzoyl])</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A diversified library of peptide anilides was prepared, and their inhibition activities against the SARS-CoV 3CL protease were examined by a fluorogenic tetradecapeptide substrate. The most potent inhibitor is an anilide derived from 2-chloro-4-nitroaniline, L-phenylalanine and 4-(dimethylamino)benzoic acid. This anilide is a competitive inhibitor of the SARS-CoV 3CL protease with K<sub>i</sub> = 0.03 μM. The molecular docking experiment indicates that the PI residue of this anilide inhibitor is distant from the nucleophilic SH of Cys145 in the active site.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-2623</s0></fA01><fA02 i1="01"><s0>JMCMAR</s0></fA02><fA03 i2="1"><s0>J. med. chem. : (Print)</s0></fA03><fA05><s2>48</s2></fA05><fA06><s2>13</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease</s1></fA08><fA11 i1="01" i2="1"><s1>SHIE (Jiun-Jie)</s1></fA11><fA11 i1="02" i2="1"><s1>FANG (Jim-Min)</s1></fA11><fA11 i1="03" i2="1"><s1>KUO (Chih-Jung)</s1></fA11><fA11 i1="04" i2="1"><s1>KUO (Tun-Hsun)</s1></fA11><fA11 i1="05" i2="1"><s1>LIANG (Po-Huang)</s1></fA11><fA11 i1="06" i2="1"><s1>HUANG (Hung-Jyun)</s1></fA11><fA11 i1="07" i2="1"><s1>YANG (Wen-Bin)</s1></fA11><fA11 i1="08" i2="1"><s1>LIN (Chun-Hung)</s1></fA11><fA11 i1="09" i2="1"><s1>CHEN (Jiun-Ling)</s1></fA11><fA11 i1="10" i2="1"><s1>WU (Yin-Ta)</s1></fA11><fA11 i1="11" i2="1"><s1>WONG (Chi-Huey)</s1></fA11><fA14 i1="01"><s1>Department of Chemistry, National Taiwan University</s1><s2>Taipei, 106</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="02"><s1>Genomics Research Center, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="03"><s1>Institute of Biological Chemistry, Academia Sinica</s1><s2>Taipei, 115</s2><s3>TWN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>11 aut.</sZ></fA14><fA20><s1>4469-4473</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>9165</s2><s5>354000138558210310</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>18 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0450262</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of medicinal chemistry : (Print)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>A diversified library of peptide anilides was prepared, and their inhibition activities against the SARS-CoV 3CL protease were examined by a fluorogenic tetradecapeptide substrate. The most potent inhibitor is an anilide derived from 2-chloro-4-nitroaniline, L-phenylalanine and 4-(dimethylamino)benzoic acid. This anilide is a competitive inhibitor of the SARS-CoV 3CL protease with K<sub>i</sub> = 0.03 μM. The molecular docking experiment indicates that the PI residue of this anilide inhibitor is distant from the nucleophilic SH of Cys145 in the active site.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02S05</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Anilide</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Anilide</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Anilido</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Enzyme inhibitor</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Inhibidor enzima</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0><s2>NW</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Peptidases</s0><s2>FE</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Peptidases</s0><s2>FE</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Peptidases</s0><s2>FE</s2><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Antiviral</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Antiviral</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Antiviral</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Peptide</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Peptides</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Péptido</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Composé non peptide</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Non peptide compound</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Compuesto no péptido</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Aminoamide</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Aminoamide</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Aminoamida</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Benzène dérivé</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Benzene derivatives</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Benceno derivado</s0><s5>09</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Composé nitro</s0><s2>FX</s2><s5>11</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Nitro compound</s0><s2>FX</s2><s5>11</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Compuesto nitro</s0><s2>FX</s2><s5>11</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Relation structure activité</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Structure activity relation</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Relación estructura actividad</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Tripeptide</s0><s5>13</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Tripeptide</s0><s5>13</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Tripéptido</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Tétrapeptide</s0><s5>14</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Tetrapeptide</s0><s5>14</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Tetrapéptido</s0><s5>14</s5></fC03><fC03 i1="14" i2="X" l="FRE"><s0>In vitro</s0><s5>15</s5></fC03><fC03 i1="14" i2="X" l="ENG"><s0>In vitro</s0><s5>15</s5></fC03><fC03 i1="14" i2="X" l="SPA"><s0>In vitro</s0><s5>15</s5></fC03><fC03 i1="15" i2="X" l="FRE"><s0>Carboxamide</s0><s5>32</s5></fC03><fC03 i1="15" i2="X" l="ENG"><s0>Carboxamide</s0><s5>32</s5></fC03><fC03 i1="15" i2="X" l="SPA"><s0>Carboxamida</s0><s5>32</s5></fC03><fC03 i1="16" i2="X" l="FRE"><s0>Phénylalanamide(N-[2-chloro-4-nitrophényl]-N-[4-(diméthylamino)benzoyl])</s0><s2>NK</s2><s2>FR</s2><s4>INC</s4><s5>76</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Hydrolases</s0><s2>FE</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Hydrolases</s0><s2>FE</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Hydrolases</s0><s2>FE</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Enzima</s0><s2>FE</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Chlore Composé organique</s0><s2>NC</s2><s2>FX</s2><s2>NA</s2><s5>10</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Chlorine Organic compounds</s0><s2>NC</s2><s2>FX</s2><s2>NA</s2><s5>10</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Cloro Compuesto orgánico</s0><s2>NC</s2><s2>FX</s2><s2>NA</s2><s5>10</s5></fC07><fN21><s1>318</s1></fN21></pA></standard></inist><affiliations><list><country><li>Taïwan</li><li>États-Unis</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name></noRegion><name sortKey="Chen, Jiun Ling" sort="Chen, Jiun Ling" uniqKey="Chen J" first="Jiun-Ling" last="Chen">Jiun-Ling Chen</name><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name><name sortKey="Huang, Hung Jyun" sort="Huang, Hung Jyun" uniqKey="Huang H" first="Hung-Jyun" last="Huang">Hung-Jyun Huang</name><name sortKey="Kuo, Chih Jung" sort="Kuo, Chih Jung" uniqKey="Kuo C" first="Chih-Jung" last="Kuo">Chih-Jung Kuo</name><name sortKey="Kuo, Tun Hsun" sort="Kuo, Tun Hsun" uniqKey="Kuo T" first="Tun-Hsun" last="Kuo">Tun-Hsun Kuo</name><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name><name sortKey="Lin, Chun Hung" sort="Lin, Chun Hung" uniqKey="Lin C" first="Chun-Hung" last="Lin">Chun-Hung Lin</name><name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name><name sortKey="Wu, Yin Ta" sort="Wu, Yin Ta" uniqKey="Wu Y" first="Yin-Ta" last="Wu">Yin-Ta Wu</name><name sortKey="Yang, Wen Bin" sort="Yang, Wen Bin" uniqKey="Yang W" first="Wen-Bin" last="Yang">Wen-Bin Yang</name></country><country name="États-Unis"><noRegion><name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000663 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000663 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:05-0450262
|texte= Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease
}}
| This area was generated with Dilib version V0.6.33. |  |