SrasV1, PascalFrancis, Checkpoint, bibRecord, 000383

Evaluation of the safety, immunogenicity and pharmacokinetics of equine anti-SARS-CoV F(ab')2 in macaques

Identifieur interne : 000383 ( PascalFrancis/Checkpoint ); précédent : 000382; suivant : 000384

Evaluation of the safety, immunogenicity and pharmacokinetics of equine anti-SARS-CoV F(ab')2 in macaques

Auteurs : YUNSHENG XU [République populaire de Chine] ; ZHENGCAI JIA [République populaire de Chine] ; LIYUN ZHOU [République populaire de Chine] ; LI WANG [République populaire de Chine] ; JINTAO LI [République populaire de Chine] ; YUNFEI LIANG [République populaire de Chine] ; TINGTING ZHAO [République populaire de Chine] ; BING NI [République populaire de Chine] ; YUZHANG WU [République populaire de Chine]

Source :

International immunopharmacology [ 1567-5769 ] ; 2007.

RBID : Pascal:08-0012795

Descripteurs français

Pascal (Inist)
- Evaluation, Toxicité, Sécurité, Immunogénicité, Réponse immune, Pharmacocinétique, Coronavirus, Syndrome respiratoire aigu sévère, Primates, Pharmacologie.
Wicri :
- topic : Pharmacologie.

English descriptors

KwdEn :
- Coronavirus, Evaluation, Immune response, Immunogenicity, Pharmacokinetics, Pharmacology, Primates, Safety, Severe acute respiratory syndrome, Toxicity.

Abstract

To warrant potential clinical testing, the equine anti-SARS-CoV F(ab')₂ requires evaluation in as many animal models as possible and a safety test in a primate model. In this study, we evaluated the pharmacokinetics, tolerance and immunity of this kind of antibody in macaques and rats. Results showed that the F(ab')₂ fragments had a normal metabolism in injected animals. The general physiological indexes did not differ between animals injected with anti-SARS-CoV F(ab')₂ or saline. However, a mild inflammatory response in local injection site and a moderate immune response against this antibody in the successively injected animals were observed, which however recovered 3 weeks after the last injection. The antibody titring from 1:100 to 400 against the equine anti-SARS-CoV F(ab')₂ in the inoculated hosts could be detected at week 2 during the successive injections of the equine F(ab')₂. The considerable safety of this antibody used in primates and the fact that the immune system of the host can be motivated by post-injection of the F(ab')₂ indicate that this type of anti-SARS-CoV antibody can be used for prevention and treatment of SASR, especially at the early stage of this virus infection. In addition, it can also provide the precious time for the combined use of other anti-SARS-CoV agents such as antiviral drug and vaccine.

Affiliations:

République populaire de Chine

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Le document en format XML

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<term>Primates</term>
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<front><div type="abstract" xml:lang="en">To warrant potential clinical testing, the equine anti-SARS-CoV F(ab')<sub>2</sub>
 requires evaluation in as many animal models as possible and a safety test in a primate model. In this study, we evaluated the pharmacokinetics, tolerance and immunity of this kind of antibody in macaques and rats. Results showed that the F(ab')<sub>2</sub>
 fragments had a normal metabolism in injected animals. The general physiological indexes did not differ between animals injected with anti-SARS-CoV F(ab')<sub>2</sub>
 or saline. However, a mild inflammatory response in local injection site and a moderate immune response against this antibody in the successively injected animals were observed, which however recovered 3 weeks after the last injection. The antibody titring from 1:100 to 400 against the equine anti-SARS-CoV F(ab')<sub>2</sub>
 in the inoculated hosts could be detected at week 2 during the successive injections of the equine F(ab')<sub>2</sub>
. The considerable safety of this antibody used in primates and the fact that the immune system of the host can be motivated by post-injection of the F(ab')<sub>2</sub>
 indicate that this type of anti-SARS-CoV antibody can be used for prevention and treatment of SASR, especially at the early stage of this virus infection. In addition, it can also provide the precious time for the combined use of other anti-SARS-CoV agents such as antiviral drug and vaccine.</div>
</front>
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<fA11 i1="01" i2="1"><s1>YUNSHENG XU</s1>
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<fA11 i1="03" i2="1"><s1>LIYUN ZHOU</s1>
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<fA11 i1="05" i2="1"><s1>JINTAO LI</s1>
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<fA11 i1="08" i2="1"><s1>BING NI</s1>
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<fA11 i1="09" i2="1"><s1>YUZHANG WU</s1>
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<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA20><s1>1834-1840</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>27109</s2>
<s5>354000162128710290</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>25 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>08-0012795</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>International immunopharmacology</s0>
</fA64>
<fA66 i1="01"><s0>NLD</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>To warrant potential clinical testing, the equine anti-SARS-CoV F(ab')<sub>2</sub>
 requires evaluation in as many animal models as possible and a safety test in a primate model. In this study, we evaluated the pharmacokinetics, tolerance and immunity of this kind of antibody in macaques and rats. Results showed that the F(ab')<sub>2</sub>
 fragments had a normal metabolism in injected animals. The general physiological indexes did not differ between animals injected with anti-SARS-CoV F(ab')<sub>2</sub>
 or saline. However, a mild inflammatory response in local injection site and a moderate immune response against this antibody in the successively injected animals were observed, which however recovered 3 weeks after the last injection. The antibody titring from 1:100 to 400 against the equine anti-SARS-CoV F(ab')<sub>2</sub>
 in the inoculated hosts could be detected at week 2 during the successive injections of the equine F(ab')<sub>2</sub>
. The considerable safety of this antibody used in primates and the fact that the immune system of the host can be motivated by post-injection of the F(ab')<sub>2</sub>
 indicate that this type of anti-SARS-CoV antibody can be used for prevention and treatment of SASR, especially at the early stage of this virus infection. In addition, it can also provide the precious time for the combined use of other anti-SARS-CoV agents such as antiviral drug and vaccine.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Evaluation</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Evaluation</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Evaluación</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Toxicité</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Toxicity</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Toxicidad</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Sécurité</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Safety</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Seguridad</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Immunogénicité</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Immunogenicity</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Inmunogenicidad</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Réponse immune</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Immune response</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Respuesta inmune</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Pharmacocinétique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Pharmacokinetics</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Farmacocinética</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Primates</s0>
<s2>NS</s2>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Primates</s0>
<s2>NS</s2>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Primates</s0>
<s2>NS</s2>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Pharmacologie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Pharmacology</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Farmacología</s0>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Pathologie des poumons</s0>
<s5>38</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>009</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Yunsheng Xu" sort="Yunsheng Xu" uniqKey="Yunsheng Xu" last="Yunsheng Xu">YUNSHENG XU</name>
</noRegion>
<name sortKey="Bing Ni" sort="Bing Ni" uniqKey="Bing Ni" last="Bing Ni">BING NI</name>
<name sortKey="Jintao Li" sort="Jintao Li" uniqKey="Jintao Li" last="Jintao Li">JINTAO LI</name>
<name sortKey="Li Wang" sort="Li Wang" uniqKey="Li Wang" last="Li Wang">LI WANG</name>
<name sortKey="Liyun Zhou" sort="Liyun Zhou" uniqKey="Liyun Zhou" last="Liyun Zhou">LIYUN ZHOU</name>
<name sortKey="Tingting Zhao" sort="Tingting Zhao" uniqKey="Tingting Zhao" last="Tingting Zhao">TINGTING ZHAO</name>
<name sortKey="Yunfei Liang" sort="Yunfei Liang" uniqKey="Yunfei Liang" last="Yunfei Liang">YUNFEI LIANG</name>
<name sortKey="Yunsheng Xu" sort="Yunsheng Xu" uniqKey="Yunsheng Xu" last="Yunsheng Xu">YUNSHENG XU</name>
<name sortKey="Yuzhang Wu" sort="Yuzhang Wu" uniqKey="Yuzhang Wu" last="Yuzhang Wu">YUZHANG WU</name>
<name sortKey="Zhengcai Jia" sort="Zhengcai Jia" uniqKey="Zhengcai Jia" last="Zhengcai Jia">ZHENGCAI JIA</name>
</country>
</tree>
</affiliations>
</record>

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Evaluation of the safety, immunogenicity and pharmacokinetics of equine anti-SARS-CoV F(ab')2 in macaques

Evaluation of the safety, immunogenicity and pharmacokinetics of equine anti-SARS-CoV F(ab')2 in macaques

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