COVID-19: A promising cure for the global panic.
Identifieur interne : 003898 ( Ncbi/Merge ); précédent : 003897; suivant : 003899COVID-19: A promising cure for the global panic.
Auteurs : Balachandar Vellingiri [Inde] ; Kaavya Jayaramayya [Inde] ; Mahalaxmi Iyer [Inde] ; Arul Narayanasamy [Inde] ; Vivekanandhan Govindasamy [Inde] ; Bupesh Giridharan [Inde] ; Singaravelu Ganesan [Inde] ; Anila Venugopal [Inde] ; Dhivya Venkatesan [Inde] ; Harsha Ganesan [Inde] ; Kamarajan Rajagopalan [Inde] ; Pattanathu K S M. Rahman [Royaume-Uni] ; Ssang-Goo Cho [Corée du Sud] ; Nachimuthu Senthil Kumar [Inde] ; Mohana Devi Subramaniam [Inde]Source :
- The Science of the total environment [ 1879-1026 ] ; 2020.
Abstract
The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.
DOI: 10.1016/j.scitotenv.2020.138277
PubMed: 32278175
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19: A promising cure for the global panic.</title><author><name sortKey="Vellingiri, Balachandar" sort="Vellingiri, Balachandar" uniqKey="Vellingiri B" first="Balachandar" last="Vellingiri">Balachandar Vellingiri</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India. Electronic address: geneticbala@buc.edu.in.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Jayaramayya, Kaavya" sort="Jayaramayya, Kaavya" uniqKey="Jayaramayya K" first="Kaavya" last="Jayaramayya">Kaavya Jayaramayya</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Iyer, Mahalaxmi" sort="Iyer, Mahalaxmi" uniqKey="Iyer M" first="Mahalaxmi" last="Iyer">Mahalaxmi Iyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Narayanasamy, Arul" sort="Narayanasamy, Arul" uniqKey="Narayanasamy A" first="Arul" last="Narayanasamy">Arul Narayanasamy</name><affiliation wicri:level="1"><nlm:affiliation>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Govindasamy, Vivekanandhan" sort="Govindasamy, Vivekanandhan" uniqKey="Govindasamy V" first="Vivekanandhan" last="Govindasamy">Vivekanandhan Govindasamy</name><affiliation wicri:level="1"><nlm:affiliation>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Giridharan, Bupesh" sort="Giridharan, Bupesh" uniqKey="Giridharan B" first="Bupesh" last="Giridharan">Bupesh Giridharan</name><affiliation wicri:level="1"><nlm:affiliation>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto</wicri:regionArea><wicri:noRegion>Zunhebeto</wicri:noRegion></affiliation></author><author><name sortKey="Ganesan, Singaravelu" sort="Ganesan, Singaravelu" uniqKey="Ganesan S" first="Singaravelu" last="Ganesan">Singaravelu Ganesan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Thiruvalluvar University, Vellore 632115, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Thiruvalluvar University, Vellore 632115</wicri:regionArea><wicri:noRegion>Vellore 632115</wicri:noRegion></affiliation></author><author><name sortKey="Venugopal, Anila" sort="Venugopal, Anila" uniqKey="Venugopal A" first="Anila" last="Venugopal">Anila Venugopal</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Venkatesan, Dhivya" sort="Venkatesan, Dhivya" uniqKey="Venkatesan D" first="Dhivya" last="Venkatesan">Dhivya Venkatesan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Ganesan, Harsha" sort="Ganesan, Harsha" uniqKey="Ganesan H" first="Harsha" last="Ganesan">Harsha Ganesan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Rajagopalan, Kamarajan" sort="Rajagopalan, Kamarajan" uniqKey="Rajagopalan K" first="Kamarajan" last="Rajagopalan">Kamarajan Rajagopalan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Pattanathu K S M" sort="Rahman, Pattanathu K S M" uniqKey="Rahman P" first="Pattanathu K S M" last="Rahman">Pattanathu K S M. Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY</wicri:regionArea><wicri:noRegion>Portsmouth PO1 2DY</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Ssang Goo" sort="Cho, Ssang Goo" uniqKey="Cho S" first="Ssang-Goo" last="Cho">Ssang-Goo Cho</name><affiliation wicri:level="3"><nlm:affiliation>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kumar, Nachimuthu Senthil" sort="Kumar, Nachimuthu Senthil" uniqKey="Kumar N" first="Nachimuthu Senthil" last="Kumar">Nachimuthu Senthil Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram</wicri:regionArea><wicri:noRegion>Mizoram</wicri:noRegion></affiliation></author><author><name sortKey="Subramaniam, Mohana Devi" sort="Subramaniam, Mohana Devi" uniqKey="Subramaniam M" first="Mohana Devi" last="Subramaniam">Mohana Devi Subramaniam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006</wicri:regionArea><wicri:noRegion>Chennai 600 006</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32278175</idno><idno type="pmid">32278175</idno><idno type="doi">10.1016/j.scitotenv.2020.138277</idno><idno type="wicri:Area/PubMed/Corpus">000219</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000219</idno><idno type="wicri:Area/PubMed/Curation">000219</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000219</idno><idno type="wicri:Area/PubMed/Checkpoint">000715</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000715</idno><idno type="wicri:Area/Ncbi/Merge">003898</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19: A promising cure for the global panic.</title><author><name sortKey="Vellingiri, Balachandar" sort="Vellingiri, Balachandar" uniqKey="Vellingiri B" first="Balachandar" last="Vellingiri">Balachandar Vellingiri</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India. Electronic address: geneticbala@buc.edu.in.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Jayaramayya, Kaavya" sort="Jayaramayya, Kaavya" uniqKey="Jayaramayya K" first="Kaavya" last="Jayaramayya">Kaavya Jayaramayya</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Iyer, Mahalaxmi" sort="Iyer, Mahalaxmi" uniqKey="Iyer M" first="Mahalaxmi" last="Iyer">Mahalaxmi Iyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Narayanasamy, Arul" sort="Narayanasamy, Arul" uniqKey="Narayanasamy A" first="Arul" last="Narayanasamy">Arul Narayanasamy</name><affiliation wicri:level="1"><nlm:affiliation>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Govindasamy, Vivekanandhan" sort="Govindasamy, Vivekanandhan" uniqKey="Govindasamy V" first="Vivekanandhan" last="Govindasamy">Vivekanandhan Govindasamy</name><affiliation wicri:level="1"><nlm:affiliation>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Giridharan, Bupesh" sort="Giridharan, Bupesh" uniqKey="Giridharan B" first="Bupesh" last="Giridharan">Bupesh Giridharan</name><affiliation wicri:level="1"><nlm:affiliation>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto</wicri:regionArea><wicri:noRegion>Zunhebeto</wicri:noRegion></affiliation></author><author><name sortKey="Ganesan, Singaravelu" sort="Ganesan, Singaravelu" uniqKey="Ganesan S" first="Singaravelu" last="Ganesan">Singaravelu Ganesan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Thiruvalluvar University, Vellore 632115, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Thiruvalluvar University, Vellore 632115</wicri:regionArea><wicri:noRegion>Vellore 632115</wicri:noRegion></affiliation></author><author><name sortKey="Venugopal, Anila" sort="Venugopal, Anila" uniqKey="Venugopal A" first="Anila" last="Venugopal">Anila Venugopal</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Venkatesan, Dhivya" sort="Venkatesan, Dhivya" uniqKey="Venkatesan D" first="Dhivya" last="Venkatesan">Dhivya Venkatesan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Ganesan, Harsha" sort="Ganesan, Harsha" uniqKey="Ganesan H" first="Harsha" last="Ganesan">Harsha Ganesan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Rajagopalan, Kamarajan" sort="Rajagopalan, Kamarajan" uniqKey="Rajagopalan K" first="Kamarajan" last="Rajagopalan">Kamarajan Rajagopalan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Pattanathu K S M" sort="Rahman, Pattanathu K S M" uniqKey="Rahman P" first="Pattanathu K S M" last="Rahman">Pattanathu K S M. Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY</wicri:regionArea><wicri:noRegion>Portsmouth PO1 2DY</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Ssang Goo" sort="Cho, Ssang Goo" uniqKey="Cho S" first="Ssang-Goo" last="Cho">Ssang-Goo Cho</name><affiliation wicri:level="3"><nlm:affiliation>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kumar, Nachimuthu Senthil" sort="Kumar, Nachimuthu Senthil" uniqKey="Kumar N" first="Nachimuthu Senthil" last="Kumar">Nachimuthu Senthil Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram</wicri:regionArea><wicri:noRegion>Mizoram</wicri:noRegion></affiliation></author><author><name sortKey="Subramaniam, Mohana Devi" sort="Subramaniam, Mohana Devi" uniqKey="Subramaniam M" first="Mohana Devi" last="Subramaniam">Mohana Devi Subramaniam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006</wicri:regionArea><wicri:noRegion>Chennai 600 006</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Science of the total environment</title><idno type="eISSN">1879-1026</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32278175</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1026</ISSN><JournalIssue CitedMedium="Internet"><Volume>725</Volume><PubDate><Year>2020</Year><Month>Apr</Month><Day>04</Day></PubDate></JournalIssue><Title>The Science of the total environment</Title><ISOAbbreviation>Sci. Total Environ.</ISOAbbreviation></Journal><ArticleTitle>COVID-19: A promising cure for the global panic.</ArticleTitle><Pagination><MedlinePgn>138277</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0048-9697(20)31790-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.scitotenv.2020.138277</ELocationID><Abstract><AbstractText>The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vellingiri</LastName><ForeName>Balachandar</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India. Electronic address: geneticbala@buc.edu.in.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jayaramayya</LastName><ForeName>Kaavya</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iyer</LastName><ForeName>Mahalaxmi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Narayanasamy</LastName><ForeName>Arul</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Govindasamy</LastName><ForeName>Vivekanandhan</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giridharan</LastName><ForeName>Bupesh</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ganesan</LastName><ForeName>Singaravelu</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Zoology, Thiruvalluvar University, Vellore 632115, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venugopal</LastName><ForeName>Anila</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venkatesan</LastName><ForeName>Dhivya</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ganesan</LastName><ForeName>Harsha</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajagopalan</LastName><ForeName>Kamarajan</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rahman</LastName><ForeName>Pattanathu K S M</ForeName><Initials>PKSM</Initials><AffiliationInfo><Affiliation>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Ssang-Goo</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Nachimuthu Senthil</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Subramaniam</LastName><ForeName>Mohana Devi</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006, India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Sci Total Environ</MedlineTA><NlmUniqueID>0330500</NlmUniqueID><ISSNLinking>0048-9697</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Coronavirus disease 2019 (COVID-19)</Keyword><Keyword MajorTopicYN="N">Indian traditional medicine</Keyword><Keyword MajorTopicYN="N">Mechanism of action</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Therapeutic approach</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>03</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32278175</ArticleId><ArticleId IdType="pii">S0048-9697(20)31790-3</ArticleId><ArticleId IdType="doi">10.1016/j.scitotenv.2020.138277</ArticleId><ArticleId IdType="pmc">PMC7128376</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li><li>Inde</li><li>Royaume-Uni</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Inde"><noRegion><name sortKey="Vellingiri, Balachandar" sort="Vellingiri, Balachandar" uniqKey="Vellingiri B" first="Balachandar" last="Vellingiri">Balachandar Vellingiri</name></noRegion><name sortKey="Ganesan, Harsha" sort="Ganesan, Harsha" uniqKey="Ganesan H" first="Harsha" last="Ganesan">Harsha Ganesan</name><name sortKey="Ganesan, Singaravelu" sort="Ganesan, Singaravelu" uniqKey="Ganesan S" first="Singaravelu" last="Ganesan">Singaravelu Ganesan</name><name sortKey="Giridharan, Bupesh" sort="Giridharan, Bupesh" uniqKey="Giridharan B" first="Bupesh" last="Giridharan">Bupesh Giridharan</name><name sortKey="Govindasamy, Vivekanandhan" sort="Govindasamy, Vivekanandhan" uniqKey="Govindasamy V" first="Vivekanandhan" last="Govindasamy">Vivekanandhan Govindasamy</name><name sortKey="Iyer, Mahalaxmi" sort="Iyer, Mahalaxmi" uniqKey="Iyer M" first="Mahalaxmi" last="Iyer">Mahalaxmi Iyer</name><name sortKey="Jayaramayya, Kaavya" sort="Jayaramayya, Kaavya" uniqKey="Jayaramayya K" first="Kaavya" last="Jayaramayya">Kaavya Jayaramayya</name><name sortKey="Kumar, Nachimuthu Senthil" sort="Kumar, Nachimuthu Senthil" uniqKey="Kumar N" first="Nachimuthu Senthil" last="Kumar">Nachimuthu Senthil Kumar</name><name sortKey="Narayanasamy, Arul" sort="Narayanasamy, Arul" uniqKey="Narayanasamy A" first="Arul" last="Narayanasamy">Arul Narayanasamy</name><name sortKey="Rajagopalan, Kamarajan" sort="Rajagopalan, Kamarajan" uniqKey="Rajagopalan K" first="Kamarajan" last="Rajagopalan">Kamarajan Rajagopalan</name><name sortKey="Subramaniam, Mohana Devi" sort="Subramaniam, Mohana Devi" uniqKey="Subramaniam M" first="Mohana Devi" last="Subramaniam">Mohana Devi Subramaniam</name><name sortKey="Venkatesan, Dhivya" sort="Venkatesan, Dhivya" uniqKey="Venkatesan D" first="Dhivya" last="Venkatesan">Dhivya Venkatesan</name><name sortKey="Venugopal, Anila" sort="Venugopal, Anila" uniqKey="Venugopal A" first="Anila" last="Venugopal">Anila Venugopal</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Rahman, Pattanathu K S M" sort="Rahman, Pattanathu K S M" uniqKey="Rahman P" first="Pattanathu K S M" last="Rahman">Pattanathu K S M. Rahman</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Cho, Ssang Goo" sort="Cho, Ssang Goo" uniqKey="Cho S" first="Ssang-Goo" last="Cho">Ssang-Goo Cho</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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