COVID-19: A promising cure for the global panic.
Identifieur interne : 000715 ( PubMed/Checkpoint ); précédent : 000714; suivant : 000716COVID-19: A promising cure for the global panic.
Auteurs : Balachandar Vellingiri [Inde] ; Kaavya Jayaramayya [Inde] ; Mahalaxmi Iyer [Inde] ; Arul Narayanasamy [Inde] ; Vivekanandhan Govindasamy [Inde] ; Bupesh Giridharan [Inde] ; Singaravelu Ganesan [Inde] ; Anila Venugopal [Inde] ; Dhivya Venkatesan [Inde] ; Harsha Ganesan [Inde] ; Kamarajan Rajagopalan [Inde] ; Pattanathu K S M. Rahman [Royaume-Uni] ; Ssang-Goo Cho [Corée du Sud] ; Nachimuthu Senthil Kumar [Inde] ; Mohana Devi Subramaniam [Inde]Source :
- The Science of the total environment [ 1879-1026 ] ; 2020.
Abstract
The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.
DOI: 10.1016/j.scitotenv.2020.138277
PubMed: 32278175
Affiliations:
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<author><name sortKey="Venugopal, Anila" sort="Venugopal, Anila" uniqKey="Venugopal A" first="Anila" last="Venugopal">Anila Venugopal</name>
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<author><name sortKey="Govindasamy, Vivekanandhan" sort="Govindasamy, Vivekanandhan" uniqKey="Govindasamy V" first="Vivekanandhan" last="Govindasamy">Vivekanandhan Govindasamy</name>
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<author><name sortKey="Venugopal, Anila" sort="Venugopal, Anila" uniqKey="Venugopal A" first="Anila" last="Venugopal">Anila Venugopal</name>
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<author><name sortKey="Venkatesan, Dhivya" sort="Venkatesan, Dhivya" uniqKey="Venkatesan D" first="Dhivya" last="Venkatesan">Dhivya Venkatesan</name>
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<author><name sortKey="Ganesan, Harsha" sort="Ganesan, Harsha" uniqKey="Ganesan H" first="Harsha" last="Ganesan">Harsha Ganesan</name>
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<author><name sortKey="Rajagopalan, Kamarajan" sort="Rajagopalan, Kamarajan" uniqKey="Rajagopalan K" first="Kamarajan" last="Rajagopalan">Kamarajan Rajagopalan</name>
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<author><name sortKey="Rahman, Pattanathu K S M" sort="Rahman, Pattanathu K S M" uniqKey="Rahman P" first="Pattanathu K S M" last="Rahman">Pattanathu K S M. Rahman</name>
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<author><name sortKey="Kumar, Nachimuthu Senthil" sort="Kumar, Nachimuthu Senthil" uniqKey="Kumar N" first="Nachimuthu Senthil" last="Kumar">Nachimuthu Senthil Kumar</name>
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<author><name sortKey="Subramaniam, Mohana Devi" sort="Subramaniam, Mohana Devi" uniqKey="Subramaniam M" first="Mohana Devi" last="Subramaniam">Mohana Devi Subramaniam</name>
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<front><div type="abstract" xml:lang="en">The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.</div>
</front>
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<Day>20</Day>
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<ArticleTitle>COVID-19: A promising cure for the global panic.</ArticleTitle>
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<ELocationID EIdType="pii" ValidYN="Y">S0048-9697(20)31790-3</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.scitotenv.2020.138277</ELocationID>
<Abstract><AbstractText>The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vellingiri</LastName>
<ForeName>Balachandar</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India. Electronic address: geneticbala@buc.edu.in.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jayaramayya</LastName>
<ForeName>Kaavya</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Iyer</LastName>
<ForeName>Mahalaxmi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Narayanasamy</LastName>
<ForeName>Arul</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Govindasamy</LastName>
<ForeName>Vivekanandhan</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Giridharan</LastName>
<ForeName>Bupesh</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ganesan</LastName>
<ForeName>Singaravelu</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Zoology, Thiruvalluvar University, Vellore 632115, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Venugopal</LastName>
<ForeName>Anila</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Venkatesan</LastName>
<ForeName>Dhivya</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ganesan</LastName>
<ForeName>Harsha</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rajagopalan</LastName>
<ForeName>Kamarajan</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rahman</LastName>
<ForeName>Pattanathu K S M</ForeName>
<Initials>PKSM</Initials>
<AffiliationInfo><Affiliation>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cho</LastName>
<ForeName>Ssang-Goo</ForeName>
<Initials>SG</Initials>
<AffiliationInfo><Affiliation>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kumar</LastName>
<ForeName>Nachimuthu Senthil</ForeName>
<Initials>NS</Initials>
<AffiliationInfo><Affiliation>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Subramaniam</LastName>
<ForeName>Mohana Devi</ForeName>
<Initials>MD</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006, India.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>04</Month>
<Day>04</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Sci Total Environ</MedlineTA>
<NlmUniqueID>0330500</NlmUniqueID>
<ISSNLinking>0048-9697</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Coronavirus disease 2019 (COVID-19)</Keyword>
<Keyword MajorTopicYN="N">Indian traditional medicine</Keyword>
<Keyword MajorTopicYN="N">Mechanism of action</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">Therapeutic approach</Keyword>
</KeywordList>
<CoiStatement>Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>03</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>03</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
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<PublicationStatus>aheadofprint</PublicationStatus>
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<ArticleId IdType="pii">S0048-9697(20)31790-3</ArticleId>
<ArticleId IdType="doi">10.1016/j.scitotenv.2020.138277</ArticleId>
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<affiliations><list><country><li>Corée du Sud</li>
<li>Inde</li>
<li>Royaume-Uni</li>
</country>
<region><li>Région capitale de Séoul</li>
</region>
<settlement><li>Séoul</li>
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<name sortKey="Jayaramayya, Kaavya" sort="Jayaramayya, Kaavya" uniqKey="Jayaramayya K" first="Kaavya" last="Jayaramayya">Kaavya Jayaramayya</name>
<name sortKey="Kumar, Nachimuthu Senthil" sort="Kumar, Nachimuthu Senthil" uniqKey="Kumar N" first="Nachimuthu Senthil" last="Kumar">Nachimuthu Senthil Kumar</name>
<name sortKey="Narayanasamy, Arul" sort="Narayanasamy, Arul" uniqKey="Narayanasamy A" first="Arul" last="Narayanasamy">Arul Narayanasamy</name>
<name sortKey="Rajagopalan, Kamarajan" sort="Rajagopalan, Kamarajan" uniqKey="Rajagopalan K" first="Kamarajan" last="Rajagopalan">Kamarajan Rajagopalan</name>
<name sortKey="Subramaniam, Mohana Devi" sort="Subramaniam, Mohana Devi" uniqKey="Subramaniam M" first="Mohana Devi" last="Subramaniam">Mohana Devi Subramaniam</name>
<name sortKey="Venkatesan, Dhivya" sort="Venkatesan, Dhivya" uniqKey="Venkatesan D" first="Dhivya" last="Venkatesan">Dhivya Venkatesan</name>
<name sortKey="Venugopal, Anila" sort="Venugopal, Anila" uniqKey="Venugopal A" first="Anila" last="Venugopal">Anila Venugopal</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Rahman, Pattanathu K S M" sort="Rahman, Pattanathu K S M" uniqKey="Rahman P" first="Pattanathu K S M" last="Rahman">Pattanathu K S M. Rahman</name>
</noRegion>
</country>
<country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Cho, Ssang Goo" sort="Cho, Ssang Goo" uniqKey="Cho S" first="Ssang-Goo" last="Cho">Ssang-Goo Cho</name>
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