Nucleoside analogues for the treatment of coronavirus infections
Identifieur interne : 003050 ( Ncbi/Merge ); précédent : 003049; suivant : 003051Nucleoside analogues for the treatment of coronavirus infections
Auteurs : Andrea J. Pruijssers [États-Unis] ; Mark R. Denison [États-Unis]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Association de médicaments, Coronavirus (), Coronavirus du syndrome respiratoire du Moyen-Orient (), Exoribonucleases (métabolisme), Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Nucléosides (analogues et dérivés), Nucléosides (pharmacologie), Réplication virale (), Virus du SRAS ().
- MESH :
- analogues et dérivés : Nucléosides.
- métabolisme : Exoribonucleases.
- pharmacologie : Antiviraux, Nucléosides.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Infections à coronavirus.
- Animaux, Association de médicaments, Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Coronavirus (drug effects), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Drug Therapy, Combination, Exoribonucleases (metabolism), Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Nucleosides (analogs & derivatives), Nucleosides (pharmacology), SARS Virus (drug effects), Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Nucleosides.
- chemical , metabolism : Exoribonucleases.
- chemical , pharmacology : Antiviral Agents, Nucleosides.
- drug effects : Coronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus, Virus Replication.
- drug therapy : Coronavirus Infections.
- virology : Coronavirus Infections.
- Animals, Drug Therapy, Combination, Humans.
Abstract
Coronaviruses (CoV) represent current and future risk for pandemic zoonotic infections. Nucleoside analogues are highly active across multiple virus families. CoVs encode a proofreading exoribonuclease that opposes inhibition by many nucleoside analogues. Remdesivir is an adenosine analogue that acts against a broad spectrum of CoVs. Other nucleoside analogues show promise against CoVs.
Url:
DOI: 10.1016/j.coviro.2019.04.002
PubMed: 31125806
PubMed Central: 7102703
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PMC:7102703Le document en format XML
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Pruijssers</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Coronavirus (drug effects)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Drug Therapy, Combination</term><term>Exoribonucleases (metabolism)</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Nucleosides (analogs & derivatives)</term><term>Nucleosides (pharmacology)</term><term>SARS Virus (drug effects)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Association de médicaments</term><term>Coronavirus ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Exoribonucleases (métabolisme)</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Nucléosides (analogues et dérivés)</term><term>Nucléosides (pharmacologie)</term><term>Réplication virale ()</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Nucleosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Exoribonucleases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Nucleosides</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Nucléosides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Exoribonucleases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Nucléosides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Therapy, Combination</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association de médicaments</term><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Réplication virale</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronaviruses (CoV) represent current and future risk for pandemic zoonotic infections.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Nucleoside analogues are highly active across multiple virus families.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">CoVs encode a proofreading exoribonuclease that opposes inhibition by many nucleoside analogues.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Remdesivir is an adenosine analogue that acts against a broad spectrum of CoVs.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Other nucleoside analogues show promise against CoVs.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S. 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Pruijssers</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31125806</idno><idno type="pmc">7102703</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102703</idno><idno type="RBID">PMC:7102703</idno><idno type="doi">10.1016/j.coviro.2019.04.002</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">001737</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001737</idno><idno type="wicri:Area/Pmc/Curation">001737</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001737</idno><idno type="wicri:Area/Pmc/Checkpoint">000439</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000439</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nucleoside analogues for the treatment of coronavirus infections</title><author><name sortKey="Pruijssers, Andrea J" sort="Pruijssers, Andrea J" uniqKey="Pruijssers A" first="Andrea J" last="Pruijssers">Andrea J. Pruijssers</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronaviruses (CoV) represent current and future risk for pandemic zoonotic infections.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Nucleoside analogues are highly active across multiple virus families.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">CoVs encode a proofreading exoribonuclease that opposes inhibition by many nucleoside analogues.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Remdesivir is an adenosine analogue that acts against a broad spectrum of CoVs.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Other nucleoside analogues show promise against CoVs.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S. 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Pruijssers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address: mark.denison@vumc.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31125806</idno><idno type="pmid">31125806</idno><idno type="doi">10.1016/j.coviro.2019.04.002</idno><idno type="wicri:Area/PubMed/Corpus">000902</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000902</idno><idno type="wicri:Area/PubMed/Curation">000902</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000902</idno><idno type="wicri:Area/PubMed/Checkpoint">000875</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000875</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nucleoside analogues for the treatment of coronavirus infections.</title><author><name sortKey="Pruijssers, Andrea J" sort="Pruijssers, Andrea J" uniqKey="Pruijssers A" first="Andrea J" last="Pruijssers">Andrea J. Pruijssers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address: mark.denison@vumc.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Current opinion in virology</title><idno type="eISSN">1879-6265</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Coronavirus (drug effects)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Drug Therapy, Combination</term><term>Exoribonucleases (metabolism)</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Nucleosides (analogs & derivatives)</term><term>Nucleosides (pharmacology)</term><term>SARS Virus (drug effects)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Association de médicaments</term><term>Coronavirus ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Exoribonucleases (métabolisme)</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Nucléosides (analogues et dérivés)</term><term>Nucléosides (pharmacologie)</term><term>Réplication virale ()</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Nucleosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Exoribonucleases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Nucleosides</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Nucléosides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Exoribonucleases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Nucléosides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Therapy, Combination</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association de médicaments</term><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Réplication virale</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent outbreaks of SARS-Coronavirus and MERS-Coronavirus (CoV) have heightened awareness about the lack of vaccines or antiviral compounds approved for prevention or treatment of human or potential zoonotic CoVs. Anti-CoV drug development has long been challenged by the activity of a 3' to 5' proofreading exoribonuclease unique to CoVs. Recently, a promising nucleoside analogue with broad-spectrum activity against CoVs has been identified. This review will discuss progress made in the development of antiviral nucleoside and nucleotide analogues targeting viral RNA synthesis as effective therapeutics against CoV infections and propose promising strategies for combination therapy.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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