Nucleoside analogues for the treatment of coronavirus infections
Identifieur interne : 000439 ( Pmc/Checkpoint ); précédent : 000438; suivant : 000440Nucleoside analogues for the treatment of coronavirus infections
Auteurs : Andrea J. Pruijssers [États-Unis] ; Mark R. Denison [États-Unis]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2019.
Abstract
Coronaviruses (CoV) represent current and future risk for pandemic zoonotic infections. Nucleoside analogues are highly active across multiple virus families. CoVs encode a proofreading exoribonuclease that opposes inhibition by many nucleoside analogues. Remdesivir is an adenosine analogue that acts against a broad spectrum of CoVs. Other nucleoside analogues show promise against CoVs.
Url:
DOI: 10.1016/j.coviro.2019.04.002
PubMed: 31125806
PubMed Central: 7102703
Affiliations:
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Pruijssers</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0010">Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronaviruses (CoV) represent current and future risk for pandemic zoonotic infections.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Nucleoside analogues are highly active across multiple virus families.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">CoVs encode a proofreading exoribonuclease that opposes inhibition by many nucleoside analogues.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Remdesivir is an adenosine analogue that acts against a broad spectrum of CoVs.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Other nucleoside analogues show promise against CoVs.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S. Su</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G. Wong</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W. Shi</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author><author><name sortKey="Lai, A C K" uniqKey="Lai A">A.C.K. Lai</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J. Zhou</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Bi, Y" uniqKey="Bi Y">Y. Bi</name></author><author><name sortKey="Gao, G F" uniqKey="Gao G">G.F. Gao</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Y M" uniqKey="Arabi Y">Y.M. Arabi</name></author><author><name sortKey="Balkhy, H H" uniqKey="Balkhy H">H.H. Balkhy</name></author><author><name sortKey="Hayden, F G" uniqKey="Hayden F">F.G. Hayden</name></author><author><name sortKey="Bouchama, A" uniqKey="Bouchama A">A. Bouchama</name></author><author><name sortKey="Luke, T" uniqKey="Luke T">T. Luke</name></author><author><name sortKey="Baillie, J K" uniqKey="Baillie J">J.K. Baillie</name></author><author><name sortKey="Al Omari, A" uniqKey="Al Omari A">A. Al-Omari</name></author><author><name sortKey="Hajeer, A H" uniqKey="Hajeer A">A.H. Hajeer</name></author><author><name sortKey="Senga, M" uniqKey="Senga M">M. Senga</name></author><author><name sortKey="Denison, M R" uniqKey="Denison M">M.R. Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, C M" uniqKey="Luo C">C.-M. Luo</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Yang, X L" uniqKey="Yang X">X.-L. Yang</name></author><author><name sortKey="Liu, H Z" uniqKey="Liu H">H.-Z. Liu</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Li, B" uniqKey="Li B">B. Li</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B. Hu</name></author><author><name sortKey="Peng, C" uniqKey="Peng C">C. Peng</name></author><author><name sortKey="Geng, Q B" uniqKey="Geng Q">Q.-B. Geng</name></author><author><name sortKey="Zhu, G J" uniqKey="Zhu G">G.-J. Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, H" uniqKey="Chu H">H. Chu</name></author><author><name sortKey="Chan, C M" uniqKey="Chan C">C.-M. Chan</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Yuan, S" uniqKey="Yuan S">S. Yuan</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J. Zhou</name></author><author><name sortKey="Au Yeung, R K H" uniqKey="Au Yeung R">R.K.-H. Au-Yeung</name></author><author><name sortKey="Sze, K H" uniqKey="Sze K">K.-H. Sze</name></author><author><name sortKey="Yang, D" uniqKey="Yang D">D. Yang</name></author><author><name sortKey="Shuai, H" uniqKey="Shuai H">H. Shuai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K. Modjarrad</name></author><author><name sortKey="Moorthy, V S" uniqKey="Moorthy V">V.S. Moorthy</name></author><author><name sortKey="Ben Embarek, P" uniqKey="Ben Embarek P">P. Ben Embarek</name></author><author><name sortKey="Van Kerkhove, M" uniqKey="Van Kerkhove M">M. Van Kerkhove</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J. Kim</name></author><author><name sortKey="Kieny, M P" uniqKey="Kieny M">M.-P. Kieny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brende, B" uniqKey="Brende B">B. Brende</name></author><author><name sortKey="Farrar, J" uniqKey="Farrar J">J. Farrar</name></author><author><name sortKey="Gashumba, D" uniqKey="Gashumba D">D. Gashumba</name></author><author><name sortKey="Moedas, C" uniqKey="Moedas C">C. Moedas</name></author><author><name sortKey="Mundel, T" uniqKey="Mundel T">T. Mundel</name></author><author><name sortKey="Shiozaki, Y" uniqKey="Shiozaki Y">Y. Shiozaki</name></author><author><name sortKey="Vardhan, H" uniqKey="Vardhan H">H. Vardhan</name></author><author><name sortKey="Wanka, J" uniqKey="Wanka J">J. Wanka</name></author><author><name sortKey="R Ttingen, J A" uniqKey="R Ttingen J">J.-A. Røttingen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehand, M S" uniqKey="Mehand M">M.S. Mehand</name></author><author><name sortKey="Al Shorbaji, F" uniqKey="Al Shorbaji F">F. Al-Shorbaji</name></author><author><name sortKey="Millett, P" uniqKey="Millett P">P. Millett</name></author><author><name sortKey="Murgue, B" uniqKey="Murgue B">B. Murgue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perales, C" uniqKey="Perales C">C. Perales</name></author><author><name sortKey="Domingo, E" uniqKey="Domingo E">E. Domingo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckerle, L D" uniqKey="Eckerle L">L.D. Eckerle</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Sperry, S M" uniqKey="Sperry S">S.M. Sperry</name></author><author><name sortKey="Choi, L" uniqKey="Choi L">L. Choi</name></author><author><name sortKey="Denison, M R" uniqKey="Denison M">M.R. Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, E C" uniqKey="Smith E">E.C. Smith</name></author><author><name sortKey="Blanc, H" uniqKey="Blanc H">H. Blanc</name></author><author><name sortKey="Vignuzzi, M" uniqKey="Vignuzzi M">M. Vignuzzi</name></author><author><name sortKey="Denison, M R" uniqKey="Denison M">M.R. Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferron, F" uniqKey="Ferron F">F. Ferron</name></author><author><name sortKey="Subissi, L" uniqKey="Subissi L">L. Subissi</name></author><author><name sortKey="Silveira De Morais, A T" uniqKey="Silveira De Morais A">A.T. Silveira De Morais</name></author><author><name sortKey="Le, N T T" uniqKey="Le N">N.T.T. Le</name></author><author><name sortKey="Sevajol, M" uniqKey="Sevajol M">M. Sevajol</name></author><author><name sortKey="Gluais, L" uniqKey="Gluais L">L. Gluais</name></author><author><name sortKey="Decroly, E" uniqKey="Decroly E">E. Decroly</name></author><author><name sortKey="Vonrhein, C" uniqKey="Vonrhein C">C. Vonrhein</name></author><author><name sortKey="Bricogne, G" uniqKey="Bricogne G">G. Bricogne</name></author><author><name sortKey="Canard, B" uniqKey="Canard B">B. Canard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tejero, H" uniqKey="Tejero H">H. Tejero</name></author><author><name sortKey="Montero, F" uniqKey="Montero F">F. Montero</name></author><author><name sortKey="Nu O, J C" uniqKey="Nu O J">J.C. Nuño</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Te, H S" uniqKey="Te H">H.S. Te</name></author><author><name sortKey="Randall, G" uniqKey="Randall G">G. Randall</name></author><author><name sortKey="Jensen, D M" uniqKey="Jensen D">D.M. Jensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jordan, P C" uniqKey="Jordan P">P.C. Jordan</name></author><author><name sortKey="Stevens, S K" uniqKey="Stevens S">S.K. Stevens</name></author><author><name sortKey="Deval, J" uniqKey="Deval J">J. Deval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheahan, T P" uniqKey="Sheahan T">T.P. Sheahan</name></author><author><name sortKey="Sims, A C" uniqKey="Sims A">A.C. Sims</name></author><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author><author><name sortKey="Menachery, V D" uniqKey="Menachery V">V.D. Menachery</name></author><author><name sortKey="Gralinski, L E" uniqKey="Gralinski L">L.E. Gralinski</name></author><author><name sortKey="Case, J B" uniqKey="Case J">J.B. Case</name></author><author><name sortKey="Leist, S R" uniqKey="Leist S">S.R. Leist</name></author><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K. Pyrc</name></author><author><name sortKey="Feng, J Y" uniqKey="Feng J">J.Y. Feng</name></author><author><name sortKey="Trantcheva, I" uniqKey="Trantcheva I">I. Trantcheva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saijo, M" uniqKey="Saijo M">M. Saijo</name></author><author><name sortKey="Morikawa, S" uniqKey="Morikawa S">S. Morikawa</name></author><author><name sortKey="Fukushi, S" uniqKey="Fukushi S">S. Fukushi</name></author><author><name sortKey="Mizutani, T" uniqKey="Mizutani T">T. Mizutani</name></author><author><name sortKey="Hasegawa, H" uniqKey="Hasegawa H">H. Hasegawa</name></author><author><name sortKey="Nagata, N" uniqKey="Nagata N">N. Nagata</name></author><author><name sortKey="Iwata, N" uniqKey="Iwata N">N. Iwata</name></author><author><name sortKey="Kurane, I" uniqKey="Kurane I">I. Kurane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feld, J J" uniqKey="Feld J">J.J. Feld</name></author><author><name sortKey="Hoofnagle, J H" uniqKey="Hoofnagle J">J.H. Hoofnagle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cameron, C E" uniqKey="Cameron C">C.E. Cameron</name></author><author><name sortKey="Castro, C" uniqKey="Castro C">C. Castro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J F W" uniqKey="Chan J">J.F.W. Chan</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.-H. Chan</name></author><author><name sortKey="Kao, R Y T" uniqKey="Kao R">R.Y.T. Kao</name></author><author><name sortKey="To, K K W" uniqKey="To K">K.K.W. To</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.-J. Zheng</name></author><author><name sortKey="Li, C P Y" uniqKey="Li C">C.P.Y. Li</name></author><author><name sortKey="Li, P T W" uniqKey="Li P">P.T.W. Li</name></author><author><name sortKey="Dai, J" uniqKey="Dai J">J. Dai</name></author><author><name sortKey="Mok, F K Y" uniqKey="Mok F">F.K.Y. Mok</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author><author><name sortKey="Day, C W" uniqKey="Day C">C.W. Day</name></author><author><name sortKey="Bailey, K" uniqKey="Bailey K">K. Bailey</name></author><author><name sortKey="Heiner, M" uniqKey="Heiner M">M. Heiner</name></author><author><name sortKey="Montgomery, R" uniqKey="Montgomery R">R. Montgomery</name></author><author><name sortKey="Lauridsen, L" uniqKey="Lauridsen L">L. Lauridsen</name></author><author><name sortKey="Winslow, S" uniqKey="Winslow S">S. Winslow</name></author><author><name sortKey="Hoopes, J" uniqKey="Hoopes J">J. Hoopes</name></author><author><name sortKey="Jk K, Li" uniqKey="Jk K L">Li JK-K</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Booth, C M" uniqKey="Booth C">C.M. Booth</name></author><author><name sortKey="Matukas, L M" uniqKey="Matukas L">L.M. Matukas</name></author><author><name sortKey="Tomlinson, G A" uniqKey="Tomlinson G">G.A. Tomlinson</name></author><author><name sortKey="Rachlis, A R" uniqKey="Rachlis A">A.R. Rachlis</name></author><author><name sortKey="Rose, D B" uniqKey="Rose D">D.B. Rose</name></author><author><name sortKey="Dwosh, H A" uniqKey="Dwosh H">H.A. Dwosh</name></author><author><name sortKey="Walmsley, S L" uniqKey="Walmsley S">S.L. Walmsley</name></author><author><name sortKey="Mazzulli, T" uniqKey="Mazzulli T">T. Mazzulli</name></author><author><name sortKey="Avendano, M" uniqKey="Avendano M">M. Avendano</name></author><author><name sortKey="Derkach, P" uniqKey="Derkach P">P. Derkach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gross, A E" uniqKey="Gross A">A.E. Gross</name></author><author><name sortKey="Bryson, M L" uniqKey="Bryson M">M.L. Bryson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name></author><author><name sortKey="Rasmussen, A L" uniqKey="Rasmussen A">A.L. Rasmussen</name></author><author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F. Feldmann</name></author><author><name sortKey="Okumura, A" uniqKey="Okumura A">A. Okumura</name></author><author><name sortKey="Scott, D P" uniqKey="Scott D">D.P. Scott</name></author><author><name sortKey="Brining, D" uniqKey="Brining D">D. Brining</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T. Bushmaker</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C. Martellaro</name></author><author><name sortKey="Baseler, L" uniqKey="Baseler L">L. Baseler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C. Martellaro</name></author><author><name sortKey="Callison, J" uniqKey="Callison J">J. Callison</name></author><author><name sortKey="Munster, V J" uniqKey="Munster V">V.J. Munster</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H. Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. Al-Tawfiq</name></author><author><name sortKey="Momattin, H" uniqKey="Momattin H">H. Momattin</name></author><author><name sortKey="Dib, J" uniqKey="Dib J">J. Dib</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name></author><author><name sortKey="Saad, M M" uniqKey="Saad M">M.M. Saad</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K. Baig</name></author><author><name sortKey="Bahloul, A" uniqKey="Bahloul A">A. Bahloul</name></author><author><name sortKey="Abdul Matin, M" uniqKey="Abdul Matin M">M. Abdul-Matin</name></author><author><name sortKey="Alaidaroos, A Y" uniqKey="Alaidaroos A">A.Y. Alaidaroos</name></author><author><name sortKey="Almakhlafi, G A" uniqKey="Almakhlafi G">G.A. Almakhlafi</name></author><author><name sortKey="Albarrak, M M" uniqKey="Albarrak M">M.M. Albarrak</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name></author><author><name sortKey="Albarrak, A M" uniqKey="Albarrak A">A.M. Albarrak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shalhoub, S" uniqKey="Shalhoub S">S. Shalhoub</name></author><author><name sortKey="Farahat, F" uniqKey="Farahat F">F. Farahat</name></author><author><name sortKey="Al Jiffri, A" uniqKey="Al Jiffri A">A. Al-Jiffri</name></author><author><name sortKey="Simhairi, R" uniqKey="Simhairi R">R. Simhairi</name></author><author><name sortKey="Shamma, O" uniqKey="Shamma O">O. Shamma</name></author><author><name sortKey="Siddiqi, N" uniqKey="Siddiqi N">N. Siddiqi</name></author><author><name sortKey="Mushtaq, A" uniqKey="Mushtaq A">A. Mushtaq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo, M K" uniqKey="Lo M">M.K. Lo</name></author><author><name sortKey="Jordan, R" uniqKey="Jordan R">R. Jordan</name></author><author><name sortKey="Arvey, A" uniqKey="Arvey A">A. Arvey</name></author><author><name sortKey="Sudhamsu, J" uniqKey="Sudhamsu J">J. Sudhamsu</name></author><author><name sortKey="Shrivastava Ranjan, P" uniqKey="Shrivastava Ranjan P">P. Shrivastava-Ranjan</name></author><author><name sortKey="Hotard, A L" uniqKey="Hotard A">A.L. Hotard</name></author><author><name sortKey="Flint, M" uniqKey="Flint M">M. Flint</name></author><author><name sortKey="Mcmullan, L K" uniqKey="Mcmullan L">L.K. McMullan</name></author><author><name sortKey="Siegel, D" uniqKey="Siegel D">D. Siegel</name></author><author><name sortKey="Clarke, M O" uniqKey="Clarke M">M.O. Clarke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warren, T K" uniqKey="Warren T">T.K. Warren</name></author><author><name sortKey="Wells, J" uniqKey="Wells J">J. Wells</name></author><author><name sortKey="Panchal, R G" uniqKey="Panchal R">R.G. Panchal</name></author><author><name sortKey="Stuthman, K S" uniqKey="Stuthman K">K.S. Stuthman</name></author><author><name sortKey="Garza, N L" uniqKey="Garza N">N.L. Garza</name></author><author><name sortKey="Van Tongeren, S A" uniqKey="Van Tongeren S">S.A. Van Tongeren</name></author><author><name sortKey="Dong, L" uniqKey="Dong L">L. Dong</name></author><author><name sortKey="Retterer, C J" uniqKey="Retterer C">C.J. Retterer</name></author><author><name sortKey="Eaton, B P" uniqKey="Eaton B">B.P. Eaton</name></author><author><name sortKey="Pegoraro, G" uniqKey="Pegoraro G">G. Pegoraro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agostini, M L" uniqKey="Agostini M">M.L. Agostini</name></author><author><name sortKey="Andres, E L" uniqKey="Andres E">E.L. Andres</name></author><author><name sortKey="Sims, A C" uniqKey="Sims A">A.C. Sims</name></author><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author><author><name sortKey="Sheahan, T P" uniqKey="Sheahan T">T.P. Sheahan</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Smith, E C" uniqKey="Smith E">E.C. Smith</name></author><author><name sortKey="Case, J B" uniqKey="Case J">J.B. Case</name></author><author><name sortKey="Feng, J Y" uniqKey="Feng J">J.Y. Feng</name></author><author><name sortKey="Jordan, R" uniqKey="Jordan R">R. Jordan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Urakova, N" uniqKey="Urakova N">N. Urakova</name></author><author><name sortKey="Kuznetsova, V" uniqKey="Kuznetsova V">V. Kuznetsova</name></author><author><name sortKey="Crossman, D K" uniqKey="Crossman D">D.K. Crossman</name></author><author><name sortKey="Sokratian, A" uniqKey="Sokratian A">A. Sokratian</name></author><author><name sortKey="Guthrie, D B" uniqKey="Guthrie D">D.B. Guthrie</name></author><author><name sortKey="Kolykhalov, A A" uniqKey="Kolykhalov A">A.A. Kolykhalov</name></author><author><name sortKey="Lockwood, M A" uniqKey="Lockwood M">M.A. Lockwood</name></author><author><name sortKey="Natchus, M G" uniqKey="Natchus M">M.G. Natchus</name></author><author><name sortKey="Crowley, M R" uniqKey="Crowley M">M.R. Crowley</name></author><author><name sortKey="Painter, G R" uniqKey="Painter G">G.R. Painter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ehteshami, M" uniqKey="Ehteshami M">M. Ehteshami</name></author><author><name sortKey="Tao, S" uniqKey="Tao S">S. Tao</name></author><author><name sortKey="Zandi, K" uniqKey="Zandi K">K. Zandi</name></author><author><name sortKey="Hsiao, H M" uniqKey="Hsiao H">H.-M. Hsiao</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y. Jiang</name></author><author><name sortKey="Hammond, E" uniqKey="Hammond E">E. Hammond</name></author><author><name sortKey="Amblard, F" uniqKey="Amblard F">F. Amblard</name></author><author><name sortKey="Russell, O O" uniqKey="Russell O">O.O. Russell</name></author><author><name sortKey="Merits, A" uniqKey="Merits A">A. Merits</name></author><author><name sortKey="Schinazi, R F" uniqKey="Schinazi R">R.F. Schinazi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoon, J J" uniqKey="Yoon J">J.-J. Yoon</name></author><author><name sortKey="Toots, M" uniqKey="Toots M">M. Toots</name></author><author><name sortKey="Lee, S" uniqKey="Lee S">S. Lee</name></author><author><name sortKey="Lee, M E" uniqKey="Lee M">M.-E. Lee</name></author><author><name sortKey="Ludeke, B" uniqKey="Ludeke B">B. Ludeke</name></author><author><name sortKey="Luczo, J M" uniqKey="Luczo J">J.M. Luczo</name></author><author><name sortKey="Ganti, K" uniqKey="Ganti K">K. Ganti</name></author><author><name sortKey="Cox, R M" uniqKey="Cox R">R.M. Cox</name></author><author><name sortKey="Sticher, Z M" uniqKey="Sticher Z">Z.M. Sticher</name></author><author><name sortKey="Edpuganti, V" uniqKey="Edpuganti V">V. Edpuganti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K. Pyrc</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author><author><name sortKey="Berkhout, B" uniqKey="Berkhout B">B. Berkhout</name></author><author><name sortKey="Jebbink, M F" uniqKey="Jebbink M">M.F. Jebbink</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R. Dijkman</name></author><author><name sortKey="Rottier, P" uniqKey="Rottier P">P. Rottier</name></author><author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L. van der Hoek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stuyver, L J" uniqKey="Stuyver L">L.J. Stuyver</name></author><author><name sortKey="Whitaker, T" uniqKey="Whitaker T">T. Whitaker</name></author><author><name sortKey="Mcbrayer, T R" uniqKey="Mcbrayer T">T.R. McBrayer</name></author><author><name sortKey="Hernandez Santiago, B I" uniqKey="Hernandez Santiago B">B.I. Hernandez-Santiago</name></author><author><name sortKey="Lostia, S" uniqKey="Lostia S">S. Lostia</name></author><author><name sortKey="Tharnish, P M" uniqKey="Tharnish P">P.M. Tharnish</name></author><author><name sortKey="Ramesh, M" uniqKey="Ramesh M">M. Ramesh</name></author><author><name sortKey="Chu, C K" uniqKey="Chu C">C.K. Chu</name></author><author><name sortKey="Jordan, R" uniqKey="Jordan R">R. Jordan</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J. Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author><author><name sortKey="Hubbard, V D" uniqKey="Hubbard V">V.D. Hubbard</name></author><author><name sortKey="Burton, J" uniqKey="Burton J">J. Burton</name></author><author><name sortKey="Smee, D F" uniqKey="Smee D">D.F. Smee</name></author><author><name sortKey="Morrey, J D" uniqKey="Morrey J">J.D. Morrey</name></author><author><name sortKey="Otto, M J" uniqKey="Otto M">M.J. Otto</name></author><author><name sortKey="Sidwell, R W" uniqKey="Sidwell R">R.W. Sidwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, R" uniqKey="Taylor R">R. Taylor</name></author><author><name sortKey="Kotian, P" uniqKey="Kotian P">P. Kotian</name></author><author><name sortKey="Warren, T" uniqKey="Warren T">T. Warren</name></author><author><name sortKey="Panchal, R" uniqKey="Panchal R">R. Panchal</name></author><author><name sortKey="Bavari, S" uniqKey="Bavari S">S. Bavari</name></author><author><name sortKey="Julander, J" uniqKey="Julander J">J. Julander</name></author><author><name sortKey="Dobo, S" uniqKey="Dobo S">S. Dobo</name></author><author><name sortKey="Rose, A" uniqKey="Rose A">A. Rose</name></author><author><name sortKey="El Kattan, Y" uniqKey="El Kattan Y">Y. El-Kattan</name></author><author><name sortKey="Taubenheim, B" uniqKey="Taubenheim B">B. Taubenheim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dyall, J" uniqKey="Dyall J">J. Dyall</name></author><author><name sortKey="Coleman, C M" uniqKey="Coleman C">C.M. Coleman</name></author><author><name sortKey="Hart, B J" uniqKey="Hart B">B.J. Hart</name></author><author><name sortKey="Venkataraman, T" uniqKey="Venkataraman T">T. Venkataraman</name></author><author><name sortKey="Holbrook, M R" uniqKey="Holbrook M">M.R. Holbrook</name></author><author><name sortKey="Kindrachuk, J" uniqKey="Kindrachuk J">J. Kindrachuk</name></author><author><name sortKey="Johnson, R F" uniqKey="Johnson R">R.F. Johnson</name></author><author><name sortKey="Olinger, G G" uniqKey="Olinger G">G.G. Olinger</name></author><author><name sortKey="Jahrling, P B" uniqKey="Jahrling P">P.B. Jahrling</name></author><author><name sortKey="Laidlaw, M" uniqKey="Laidlaw M">M. Laidlaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peters, H L" uniqKey="Peters H">H.L. Peters</name></author><author><name sortKey="Jochmans, D" uniqKey="Jochmans D">D. Jochmans</name></author><author><name sortKey="De Wilde, A H" uniqKey="De Wilde A">A.H. de Wilde</name></author><author><name sortKey="Posthuma, C C" uniqKey="Posthuma C">C.C. Posthuma</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Neyts, J" uniqKey="Neyts J">J. Neyts</name></author><author><name sortKey="Seley Radtke, K L" uniqKey="Seley Radtke K">K.L. Seley-Radtke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deval, J" uniqKey="Deval J">J. Deval</name></author><author><name sortKey="Fung, A" uniqKey="Fung A">A. Fung</name></author><author><name sortKey="Stevens, S K" uniqKey="Stevens S">S.K. Stevens</name></author><author><name sortKey="Jordan, P C" uniqKey="Jordan P">P.C. Jordan</name></author><author><name sortKey="Gromova, T" uniqKey="Gromova T">T. Gromova</name></author><author><name sortKey="Taylor, J S" uniqKey="Taylor J">J.S. Taylor</name></author><author><name sortKey="Hong, J" uniqKey="Hong J">J. Hong</name></author><author><name sortKey="Meng, J" uniqKey="Meng J">J. Meng</name></author><author><name sortKey="Wang, G" uniqKey="Wang G">G. Wang</name></author><author><name sortKey="Dyatkina, N" uniqKey="Dyatkina N">N. Dyatkina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eyer, L" uniqKey="Eyer L">L. Eyer</name></author><author><name sortKey="Kondo, H" uniqKey="Kondo H">H. Kondo</name></author><author><name sortKey="Zouharova, D" uniqKey="Zouharova D">D. Zouharova</name></author><author><name sortKey="Hirano, M" uniqKey="Hirano M">M. Hirano</name></author><author><name sortKey="Valdes, J J" uniqKey="Valdes J">J.J. Valdés</name></author><author><name sortKey="Muto, M" uniqKey="Muto M">M. Muto</name></author><author><name sortKey="Kastl, T" uniqKey="Kastl T">T. Kastl</name></author><author><name sortKey="Kobayashi, S" uniqKey="Kobayashi S">S. Kobayashi</name></author><author><name sortKey="Haviernik, J" uniqKey="Haviernik J">J. Haviernik</name></author><author><name sortKey="Igarashi, M" uniqKey="Igarashi M">M. Igarashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diphoko, T" uniqKey="Diphoko T">T. Diphoko</name></author><author><name sortKey="Gaseitsiwe, S" uniqKey="Gaseitsiwe S">S. Gaseitsiwe</name></author><author><name sortKey="Kasvosve, I" uniqKey="Kasvosve I">I. Kasvosve</name></author><author><name sortKey="Moyo, S" uniqKey="Moyo S">S. Moyo</name></author><author><name sortKey="Okatch, H" uniqKey="Okatch H">H. Okatch</name></author><author><name sortKey="Musonda, R" uniqKey="Musonda R">R. Musonda</name></author><author><name sortKey="Wainberg, M" uniqKey="Wainberg M">M. Wainberg</name></author><author><name sortKey="Makhema, J" uniqKey="Makhema J">J. Makhema</name></author><author><name sortKey="Marlink, R" uniqKey="Marlink R">R. Marlink</name></author><author><name sortKey="Novitsky, V" uniqKey="Novitsky V">V. Novitsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valdes, J J" uniqKey="Valdes J">J.J. Valdés</name></author><author><name sortKey="Butterill, P T" uniqKey="Butterill P">P.T. Butterill</name></author><author><name sortKey="Ruzek, D" uniqKey="Ruzek D">D. Růžek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A. Zumla</name></author><author><name sortKey="Chan, J F W" uniqKey="Chan J">J.F.W. Chan</name></author><author><name sortKey="Azhar, E I" uniqKey="Azhar E">E.I. Azhar</name></author><author><name sortKey="Hui, D S C" uniqKey="Hui D">D.S.C. Hui</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.-Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, R" uniqKey="Liang R">R. Liang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Zhang, N" uniqKey="Zhang N">N. Zhang</name></author><author><name sortKey="Deng, X" uniqKey="Deng X">X. Deng</name></author><author><name sortKey="Su, M" uniqKey="Su M">M. Su</name></author><author><name sortKey="Su, Y" uniqKey="Su Y">Y. Su</name></author><author><name sortKey="Hu, L" uniqKey="Hu L">L. Hu</name></author><author><name sortKey="He, C" uniqKey="He C">C. He</name></author><author><name sortKey="Ying, T" uniqKey="Ying T">T. Ying</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, K W" uniqKey="Huang K">K.-W. Huang</name></author><author><name sortKey="Hsu, K C" uniqKey="Hsu K">K.-C. Hsu</name></author><author><name sortKey="Chu, L Y" uniqKey="Chu L">L.-Y. Chu</name></author><author><name sortKey="Yang, J M" uniqKey="Yang J">J.-M. Yang</name></author><author><name sortKey="Yuan, H S" uniqKey="Yuan H">H.S. Yuan</name></author><author><name sortKey="Hsiao, Y Y" uniqKey="Hsiao Y">Y.-Y. Hsiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gralinski, L E" uniqKey="Gralinski L">L.E. Gralinski</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Y M" uniqKey="Arabi Y">Y.M. Arabi</name></author><author><name sortKey="Alothman, A" uniqKey="Alothman A">A. Alothman</name></author><author><name sortKey="Balkhy, H H" uniqKey="Balkhy H">H.H. Balkhy</name></author><author><name sortKey="Al Dawood, A" uniqKey="Al Dawood A">A. Al-Dawood</name></author><author><name sortKey="Aljohani, S" uniqKey="Aljohani S">S. AlJohani</name></author><author><name sortKey="Al Harbi, S" uniqKey="Al Harbi S">S. Al Harbi</name></author><author><name sortKey="Kojan, S" uniqKey="Kojan S">S. Kojan</name></author><author><name sortKey="Al Jeraisy, M" uniqKey="Al Jeraisy M">M. Al Jeraisy</name></author><author><name sortKey="Deeb, A M" uniqKey="Deeb A">A.M. Deeb</name></author><author><name sortKey="Assiri, A M" uniqKey="Assiri A">A.M. Assiri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, F" uniqKey="Chen F">F. Chen</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y. Jiang</name></author><author><name sortKey="Kao, R Y T" uniqKey="Kao R">R.Y.T. Kao</name></author><author><name sortKey="Lu, H T" uniqKey="Lu H">H.T. Lu</name></author><author><name sortKey="Fan, K W" uniqKey="Fan K">K.W. Fan</name></author><author><name sortKey="Cheng, V C C" uniqKey="Cheng V">V.C.C. Cheng</name></author><author><name sortKey="Tsui, W H W" uniqKey="Tsui W">W.H.W. Tsui</name></author><author><name sortKey="Hung, I F N" uniqKey="Hung I">I.F.N. Hung</name></author><author><name sortKey="Lee, T S W" uniqKey="Lee T">T.S.W. Lee</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Curr Opin Virol</journal-id><journal-id journal-id-type="iso-abbrev">Curr Opin Virol</journal-id><journal-title-group><journal-title>Current Opinion in Virology</journal-title></journal-title-group><issn pub-type="ppub">1879-6257</issn><issn pub-type="epub">1879-6265</issn><publisher><publisher-name>Published by Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31125806</article-id><article-id pub-id-type="pmc">7102703</article-id><article-id pub-id-type="publisher-id">S1879-6257(19)30001-X</article-id><article-id pub-id-type="doi">10.1016/j.coviro.2019.04.002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Nucleoside analogues for the treatment of coronavirus infections</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Pruijssers</surname><given-names>Andrea J</given-names></name><xref rid="aff0005" ref-type="aff">1</xref><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Denison</surname><given-names>Mark R</given-names></name><email>mark.denison@vumc.org</email><xref rid="aff0005" ref-type="aff">1</xref><xref rid="aff0010" ref-type="aff">2</xref><xref rid="aff0015" ref-type="aff">3</xref></contrib></contrib-group><aff id="aff0005"><label>1</label>Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States</aff><aff id="aff0010"><label>2</label>Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, United States</aff><aff id="aff0015"><label>3</label>Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States</aff><pub-date pub-type="pmc-release"><day>21</day><month>5</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>4</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>21</day><month>5</month><year>2019</year></pub-date><volume>35</volume><fpage>57</fpage><lpage>62</lpage><permissions><copyright-statement>© 2019 Published by Elsevier B.V.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronaviruses (CoV) represent current and future risk for pandemic zoonotic infections.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Nucleoside analogues are highly active across multiple virus families.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">CoVs encode a proofreading exoribonuclease that opposes inhibition by many nucleoside analogues.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Remdesivir is an adenosine analogue that acts against a broad spectrum of CoVs.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Other nucleoside analogues show promise against CoVs.</p></list-item></list></p></abstract><abstract id="abs0010"><p>Recent outbreaks of SARS-Coronavirus and MERS-Coronavirus (CoV) have heightened awareness about the lack of vaccines or antiviral compounds approved for prevention or treatment of human or potential zoonotic CoVs. Anti-CoV drug development has long been challenged by the activity of a 3′ to 5′ proofreading exoribonuclease unique to CoVs. Recently, a promising nucleoside analogue with broad-spectrum activity against CoVs has been identified. This review will discuss progress made in the development of antiviral nucleoside and nucleotide analogues targeting viral RNA synthesis as effective therapeutics against CoV infections and propose promising strategies for combination therapy.</p></abstract></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Pruijssers, Andrea J" sort="Pruijssers, Andrea J" uniqKey="Pruijssers A" first="Andrea J" last="Pruijssers">Andrea J. Pruijssers</name></region><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R" last="Denison">Mark R. Denison</name><name sortKey="Pruijssers, Andrea J" sort="Pruijssers, Andrea J" uniqKey="Pruijssers A" first="Andrea J" last="Pruijssers">Andrea J. Pruijssers</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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