Cytoplasmic tail of coronavirus spike protein has intracellular targeting signals.
Identifieur interne : 002E06 ( Ncbi/Merge ); précédent : 002E05; suivant : 002E07Cytoplasmic tail of coronavirus spike protein has intracellular targeting signals.
Auteurs : Jibin Sadasivan [Inde] ; Manmeet Singh ; Jayasri Das SarmaSource :
- Journal of biosciences [ 0973-7138 ] ; 2017.
Descripteurs français
- KwdFr :
- Cellules HeLa, Conformation des protéines, Coronavirus (métabolisme), Cytoplasme, Glycoprotéine de spicule des coronavirus (), Glycoprotéine de spicule des coronavirus (métabolisme), Glycoprotéines membranaires (), Glycoprotéines membranaires (physiologie), Humains, Motifs d'acides aminés, Mutation, Régulation de l'expression des gènes viraux (physiologie), Signaux de triage des protéines, Séquence d'acides aminés, Transport de protéines.
- MESH :
- métabolisme : Coronavirus, Glycoprotéine de spicule des coronavirus.
- physiologie : Glycoprotéines membranaires, Régulation de l'expression des gènes viraux.
- Cellules HeLa, Conformation des protéines, Cytoplasme, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Humains, Motifs d'acides aminés, Mutation, Signaux de triage des protéines, Séquence d'acides aminés, Transport de protéines.
English descriptors
- KwdEn :
- Amino Acid Motifs, Amino Acid Sequence, Coronavirus (metabolism), Cytoplasm, Gene Expression Regulation, Viral (physiology), HeLa Cells, Humans, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (physiology), Mutation, Protein Conformation, Protein Sorting Signals, Protein Transport, Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (metabolism).
- MESH :
- chemical , chemistry : Membrane Glycoproteins, Spike Glycoprotein, Coronavirus.
- metabolism : Coronavirus, Spike Glycoprotein, Coronavirus.
- physiology : Gene Expression Regulation, Viral, Membrane Glycoproteins.
- Amino Acid Motifs, Amino Acid Sequence, Cytoplasm, HeLa Cells, Humans, Mutation, Protein Conformation, Protein Sorting Signals, Protein Transport.
Abstract
Intracellular trafficking and localization studies of spike protein from SARS and OC43 showed that SARS spike protein is localized in the ER or ERGIC compartment and OC43 spike protein is predominantly localized in the lysosome. Differential localization can be explained by signal sequence. The sequence alignment using Clustal W shows that the signal sequence present at the cytoplasmic tail plays an important role in spike protein localization. A unique GYQEL motif is identified at the cytoplasmic terminal of OC43 spike protein which helps in localization in the lysosome, and a novel KLHYT motif is identified in the cytoplasmic tail of SARS spike protein which helps in ER or ERGIC localization. This study sheds some light on the role of cytoplasmic tail of spike protein in cell-to-cell fusion, coronavirus host cell fusion and subsequent pathogenicity.
DOI: 10.1007/s12038-017-9676-7
PubMed: 28569247
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pubmed:28569247Le document en format XML
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<front><div type="abstract" xml:lang="en">Intracellular trafficking and localization studies of spike protein from SARS and OC43 showed that SARS spike protein is localized in the ER or ERGIC compartment and OC43 spike protein is predominantly localized in the lysosome. Differential localization can be explained by signal sequence. The sequence alignment using Clustal W shows that the signal sequence present at the cytoplasmic tail plays an important role in spike protein localization. A unique GYQEL motif is identified at the cytoplasmic terminal of OC43 spike protein which helps in localization in the lysosome, and a novel KLHYT motif is identified in the cytoplasmic tail of SARS spike protein which helps in ER or ERGIC localization. This study sheds some light on the role of cytoplasmic tail of spike protein in cell-to-cell fusion, coronavirus host cell fusion and subsequent pathogenicity.</div>
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<Abstract><AbstractText>Intracellular trafficking and localization studies of spike protein from SARS and OC43 showed that SARS spike protein is localized in the ER or ERGIC compartment and OC43 spike protein is predominantly localized in the lysosome. Differential localization can be explained by signal sequence. The sequence alignment using Clustal W shows that the signal sequence present at the cytoplasmic tail plays an important role in spike protein localization. A unique GYQEL motif is identified at the cytoplasmic terminal of OC43 spike protein which helps in localization in the lysosome, and a novel KLHYT motif is identified in the cytoplasmic tail of SARS spike protein which helps in ER or ERGIC localization. This study sheds some light on the role of cytoplasmic tail of spike protein in cell-to-cell fusion, coronavirus host cell fusion and subsequent pathogenicity.</AbstractText>
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