SrasV1, Ncbi, Merge, bibRecord, 002E06

Cytoplasmic tail of coronavirus spike protein has intracellular targeting signals.

Identifieur interne : 002E06 ( Ncbi/Merge ); précédent : 002E05; suivant : 002E07

Cytoplasmic tail of coronavirus spike protein has intracellular targeting signals.

Auteurs : Jibin Sadasivan [Inde] ; Manmeet Singh ; Jayasri Das Sarma

Source :

Journal of biosciences [ 0973-7138 ] ; 2017.

RBID : pubmed:28569247

Descripteurs français

KwdFr :
- Cellules HeLa, Conformation des protéines, Coronavirus (métabolisme), Cytoplasme, Glycoprotéine de spicule des coronavirus (), Glycoprotéine de spicule des coronavirus (métabolisme), Glycoprotéines membranaires (), Glycoprotéines membranaires (physiologie), Humains, Motifs d'acides aminés, Mutation, Régulation de l'expression des gènes viraux (physiologie), Signaux de triage des protéines, Séquence d'acides aminés, Transport de protéines.
MESH :

English descriptors

KwdEn :
- Amino Acid Motifs, Amino Acid Sequence, Coronavirus (metabolism), Cytoplasm, Gene Expression Regulation, Viral (physiology), HeLa Cells, Humans, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (physiology), Mutation, Protein Conformation, Protein Sorting Signals, Protein Transport, Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (metabolism).
MESH :
- chemical , chemistry : Membrane Glycoproteins, Spike Glycoprotein, Coronavirus.
- metabolism : Coronavirus, Spike Glycoprotein, Coronavirus.
- physiology : Gene Expression Regulation, Viral, Membrane Glycoproteins.
- Amino Acid Motifs, Amino Acid Sequence, Cytoplasm, HeLa Cells, Humans, Mutation, Protein Conformation, Protein Sorting Signals, Protein Transport.

Abstract

Intracellular trafficking and localization studies of spike protein from SARS and OC43 showed that SARS spike protein is localized in the ER or ERGIC compartment and OC43 spike protein is predominantly localized in the lysosome. Differential localization can be explained by signal sequence. The sequence alignment using Clustal W shows that the signal sequence present at the cytoplasmic tail plays an important role in spike protein localization. A unique GYQEL motif is identified at the cytoplasmic terminal of OC43 spike protein which helps in localization in the lysosome, and a novel KLHYT motif is identified in the cytoplasmic tail of SARS spike protein which helps in ER or ERGIC localization. This study sheds some light on the role of cytoplasmic tail of spike protein in cell-to-cell fusion, coronavirus host cell fusion and subsequent pathogenicity.

DOI: 10.1007/s12038-017-9676-7
PubMed: 28569247

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pubmed:28569247

Le document en format XML

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<term>Séquence d'acides aminés</term>
<term>Transport de protéines</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Spike Glycoprotein, Coronavirus</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronavirus</term>
<term>Spike Glycoprotein, Coronavirus</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronavirus</term>
<term>Glycoprotéine de spicule des coronavirus</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Glycoprotéines membranaires</term>
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<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires</term>
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<term>Motifs d'acides aminés</term>
<term>Mutation</term>
<term>Signaux de triage des protéines</term>
<term>Séquence d'acides aminés</term>
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<front><div type="abstract" xml:lang="en">Intracellular trafficking and localization studies of spike protein from SARS and OC43 showed that SARS spike protein is localized in the ER or ERGIC compartment and OC43 spike protein is predominantly localized in the lysosome. Differential localization can be explained by signal sequence. The sequence alignment using Clustal W shows that the signal sequence present at the cytoplasmic tail plays an important role in spike protein localization. A unique GYQEL motif is identified at the cytoplasmic terminal of OC43 spike protein which helps in localization in the lysosome, and a novel KLHYT motif is identified in the cytoplasmic tail of SARS spike protein which helps in ER or ERGIC localization. This study sheds some light on the role of cytoplasmic tail of spike protein in cell-to-cell fusion, coronavirus host cell fusion and subsequent pathogenicity.</div>
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<Abstract><AbstractText>Intracellular trafficking and localization studies of spike protein from SARS and OC43 showed that SARS spike protein is localized in the ER or ERGIC compartment and OC43 spike protein is predominantly localized in the lysosome. Differential localization can be explained by signal sequence. The sequence alignment using Clustal W shows that the signal sequence present at the cytoplasmic tail plays an important role in spike protein localization. A unique GYQEL motif is identified at the cytoplasmic terminal of OC43 spike protein which helps in localization in the lysosome, and a novel KLHYT motif is identified in the cytoplasmic tail of SARS spike protein which helps in ER or ERGIC localization. This study sheds some light on the role of cytoplasmic tail of spike protein in cell-to-cell fusion, coronavirus host cell fusion and subsequent pathogenicity.</AbstractText>
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Cytoplasmic tail of coronavirus spike protein has intracellular targeting signals.

Cytoplasmic tail of coronavirus spike protein has intracellular targeting signals.

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