Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development
Identifieur interne : 002D09 ( Ncbi/Merge ); précédent : 002D08; suivant : 002D10Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development
Auteurs : Oi-Wing Ng [Singapour] ; Yee-Joo Tan [Singapour]Source :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Chiroptera (virologie), Flambées de maladies, Génétique inverse, Humains, Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Séquençage nucléotidique à haut débit, Vaccins antiviraux (immunologie), Vaccins antiviraux (isolement et purification), Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Virus du SRAS.
- immunologie : Vaccins antiviraux, Virus du SRAS.
- isolement et purification : Vaccins antiviraux, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- virologie : Chiroptera, Syndrome respiratoire aigu sévère.
- épidémiologie : Syndrome respiratoire aigu sévère.
- Animaux, Flambées de maladies, Génétique inverse, Humains, Séquençage nucléotidique à haut débit.
English descriptors
- KwdEn :
- Animals, Chiroptera (virology), Disease Outbreaks, High-Throughput Nucleotide Sequencing, Humans, Reverse Genetics, SARS Virus (genetics), SARS Virus (immunology), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology), Viral Vaccines (immunology), Viral Vaccines (isolation & purification).
- MESH :
- chemical , immunology : Viral Vaccines.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- immunology : SARS Virus.
- isolation & purification : SARS Virus, Viral Vaccines.
- pathogenicity : SARS Virus.
- virology : Chiroptera, Severe Acute Respiratory Syndrome.
- Animals, Disease Outbreaks, High-Throughput Nucleotide Sequencing, Humans, Reverse Genetics.
Abstract
The severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, causing the SARS epidemic which resulted in a 10% fatality rate. The advancements in metagenomic techniques have allowed the identification of SARS-like coronaviruses (SL-CoVs) sequences that share high homology to the human SARS-CoV epidemic strains from wildlife bats, presenting concrete evidence that bats are the origin and natural reservoir of SARS-CoV. The application of reverse genetics further enabled that characterization of these bat CoVs and the prediction of their potential to cause disease in humans. The knowledge gained from such studies is valuable in the surveillance and preparation of a possible future outbreak caused by a spill-over of these bat SL-CoVs.
Url:
DOI: 10.1080/21645515.2016.1228500
PubMed: 27644155
PubMed Central: 5287300
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PMC:5287300Le document en format XML
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<term>SARS Virus (genetics)</term>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>The severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, causing the SARS epidemic which resulted in a 10% fatality rate. The advancements in metagenomic techniques have allowed the identification of SARS-like coronaviruses (SL-CoVs) sequences that share high homology to the human SARS-CoV epidemic strains from wildlife bats, presenting concrete evidence that bats are the origin and natural reservoir of SARS-CoV. The application of reverse genetics further enabled that characterization of these bat CoVs and the prediction of their potential to cause disease in humans. The knowledge gained from such studies is valuable in the surveillance and preparation of a possible future outbreak caused by a spill-over of these bat SL-CoVs.</p>
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<double pmid="27644155"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development</title>
<author><name sortKey="Ng, Oi Wing" sort="Ng, Oi Wing" uniqKey="Ng O" first="Oi-Wing" last="Ng">Oi-Wing Ng</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</institution>
,<country>Singapore</country>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</institution>
,<country>Singapore</country>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)</institution>
,<country>Singapore</country>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">27644155</idno>
<idno type="pmc">5287300</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287300</idno>
<idno type="RBID">PMC:5287300</idno>
<idno type="doi">10.1080/21645515.2016.1228500</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000789</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000789</idno>
<idno type="wicri:Area/Pmc/Curation">000789</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000789</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000657</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000657</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development</title>
<author><name sortKey="Ng, Oi Wing" sort="Ng, Oi Wing" uniqKey="Ng O" first="Oi-Wing" last="Ng">Oi-Wing Ng</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</institution>
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<country xml:lang="fr">Singapour</country>
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<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)</institution>
,<country>Singapore</country>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">Human Vaccines & Immunotherapeutics</title>
<idno type="ISSN">2164-5515</idno>
<idno type="eISSN">2164-554X</idno>
<imprint><date when="2016">2016</date>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>The severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, causing the SARS epidemic which resulted in a 10% fatality rate. The advancements in metagenomic techniques have allowed the identification of SARS-like coronaviruses (SL-CoVs) sequences that share high homology to the human SARS-CoV epidemic strains from wildlife bats, presenting concrete evidence that bats are the origin and natural reservoir of SARS-CoV. The application of reverse genetics further enabled that characterization of these bat CoVs and the prediction of their potential to cause disease in humans. The knowledge gained from such studies is valuable in the surveillance and preparation of a possible future outbreak caused by a spill-over of these bat SL-CoVs.</p>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks - Implications for coronavirus vaccine development.</title>
<author><name sortKey="Ng, Oi Wing" sort="Ng, Oi Wing" uniqKey="Ng O" first="Oi-Wing" last="Ng">Oi-Wing Ng</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore , Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore </wicri:regionArea>
<wicri:noRegion>National University of Singapore </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore , Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore </wicri:regionArea>
<wicri:noRegion>National University of Singapore </wicri:noRegion>
</affiliation>
</author>
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<date when="2017">2017</date>
<idno type="RBID">pubmed:27644155</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks - Implications for coronavirus vaccine development.</title>
<author><name sortKey="Ng, Oi Wing" sort="Ng, Oi Wing" uniqKey="Ng O" first="Oi-Wing" last="Ng">Oi-Wing Ng</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore , Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore </wicri:regionArea>
<wicri:noRegion>National University of Singapore </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name>
<affiliation wicri:level="1"><nlm:affiliation>a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore , Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore </wicri:regionArea>
<wicri:noRegion>National University of Singapore </wicri:noRegion>
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</author>
</analytic>
<series><title level="j">Human vaccines & immunotherapeutics</title>
<idno type="eISSN">2164-554X</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Chiroptera (virology)</term>
<term>Disease Outbreaks</term>
<term>High-Throughput Nucleotide Sequencing</term>
<term>Humans</term>
<term>Reverse Genetics</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (immunology)</term>
<term>SARS Virus (isolation & purification)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Viral Vaccines (immunology)</term>
<term>Viral Vaccines (isolation & purification)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chiroptera (virologie)</term>
<term>Flambées de maladies</term>
<term>Génétique inverse</term>
<term>Humains</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Syndrome respiratoire aigu sévère (épidémiologie)</term>
<term>Séquençage nucléotidique à haut débit</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins antiviraux (isolement et purification)</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (immunologie)</term>
<term>Virus du SRAS (isolement et purification)</term>
<term>Virus du SRAS (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antiviraux</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Vaccins antiviraux</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Outbreaks</term>
<term>High-Throughput Nucleotide Sequencing</term>
<term>Humans</term>
<term>Reverse Genetics</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Flambées de maladies</term>
<term>Génétique inverse</term>
<term>Humains</term>
<term>Séquençage nucléotidique à haut débit</term>
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<front><div type="abstract" xml:lang="en">The severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, causing the SARS epidemic which resulted in a 10% fatality rate. The advancements in metagenomic techniques have allowed the identification of SARS-like coronaviruses (SL-CoVs) sequences that share high homology to the human SARS-CoV epidemic strains from wildlife bats, presenting concrete evidence that bats are the origin and natural reservoir of SARS-CoV. The application of reverse genetics further enabled that characterization of these bat CoVs and the prediction of their potential to cause disease in humans. The knowledge gained from such studies is valuable in the surveillance and preparation of a possible future outbreak caused by a spill-over of these bat SL-CoVs.</div>
</front>
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