Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development
Identifieur interne : 000657 ( Pmc/Checkpoint ); précédent : 000656; suivant : 000658Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development
Auteurs : Oi-Wing Ng [Singapour] ; Yee-Joo Tan [Singapour]Source :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2016.
Abstract
The severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, causing the SARS epidemic which resulted in a 10% fatality rate. The advancements in metagenomic techniques have allowed the identification of SARS-like coronaviruses (SL-CoVs) sequences that share high homology to the human SARS-CoV epidemic strains from wildlife bats, presenting concrete evidence that bats are the origin and natural reservoir of SARS-CoV. The application of reverse genetics further enabled that characterization of these bat CoVs and the prediction of their potential to cause disease in humans. The knowledge gained from such studies is valuable in the surveillance and preparation of a possible future outbreak caused by a spill-over of these bat SL-CoVs.
Url:
DOI: 10.1080/21645515.2016.1228500
PubMed: 27644155
PubMed Central: 5287300
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development</title><author><name sortKey="Ng, Oi Wing" sort="Ng, Oi Wing" uniqKey="Ng O" first="Oi-Wing" last="Ng">Oi-Wing Ng</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27644155</idno><idno type="pmc">5287300</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287300</idno><idno type="RBID">PMC:5287300</idno><idno type="doi">10.1080/21645515.2016.1228500</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000789</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000789</idno><idno type="wicri:Area/Pmc/Curation">000789</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000789</idno><idno type="wicri:Area/Pmc/Checkpoint">000657</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000657</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development</title><author><name sortKey="Ng, Oi Wing" sort="Ng, Oi Wing" uniqKey="Ng O" first="Oi-Wing" last="Ng">Oi-Wing Ng</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Vaccines & Immunotherapeutics</title><idno type="ISSN">2164-5515</idno><idno type="eISSN">2164-554X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>The severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, causing the SARS epidemic which resulted in a 10% fatality rate. The advancements in metagenomic techniques have allowed the identification of SARS-like coronaviruses (SL-CoVs) sequences that share high homology to the human SARS-CoV epidemic strains from wildlife bats, presenting concrete evidence that bats are the origin and natural reservoir of SARS-CoV. The application of reverse genetics further enabled that characterization of these bat CoVs and the prediction of their potential to cause disease in humans. The knowledge gained from such studies is valuable in the surveillance and preparation of a possible future outbreak caused by a spill-over of these bat SL-CoVs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="He, Yq" uniqKey="He Y">YQ He</name></author><author><name sortKey="Liu, Xl" uniqKey="Liu X">XL Liu</name></author><author><name sortKey="Zhuang, Zx" uniqKey="Zhuang Z">ZX Zhuang</name></author><author><name sortKey="Cheung, Cl" uniqKey="Cheung C">CL Cheung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kan, B" uniqKey="Kan B">B Kan</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Jing, H" uniqKey="Jing H">H Jing</name></author><author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name></author><author><name sortKey="Jiang, X" uniqKey="Jiang X">X Jiang</name></author><author><name sortKey="Yan, M" uniqKey="Yan M">M Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Hd" uniqKey="Song H">HD Song</name></author><author><name sortKey="Tu, Cc" uniqKey="Tu C">CC Tu</name></author><author><name sortKey="Zhang, Gw" uniqKey="Zhang G">GW Zhang</name></author><author><name sortKey="Wang, Sy" uniqKey="Wang S">SY Wang</name></author><author><name sortKey="Zheng, K" uniqKey="Zheng K">K Zheng</name></author><author><name sortKey="Lei, Lc" uniqKey="Lei L">LC Lei</name></author><author><name sortKey="Chen, Qx" uniqKey="Chen Q">QX Chen</name></author><author><name sortKey="Gao, Yw" uniqKey="Gao Y">YW Gao</name></author><author><name sortKey="Zhou, Hq" uniqKey="Zhou H">HQ Zhou</name></author><author><name sortKey="Xiang, H" uniqKey="Xiang H">H Xiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mokili, Jl" uniqKey="Mokili J">JL Mokili</name></author><author><name sortKey="Rohwer, F" uniqKey="Rohwer F">F Rohwer</name></author><author><name sortKey="Dutilh, Be" uniqKey="Dutilh B">BE Dutilh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willner, D" uniqKey="Willner D">D Willner</name></author><author><name sortKey="Hugenholtz, P" uniqKey="Hugenholtz P">P Hugenholtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drexler, Jf" uniqKey="Drexler J">JF Drexler</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almazan, F" uniqKey="Almazan F">F Almazan</name></author><author><name sortKey="Sola, I" uniqKey="Sola I">I Sola</name></author><author><name sortKey="Zuniga, S" uniqKey="Zuniga S">S Zuniga</name></author><author><name sortKey="Marquez Jurado, S" uniqKey="Marquez Jurado S">S Marquez-Jurado</name></author><author><name sortKey="Morales, L" uniqKey="Morales L">L Morales</name></author><author><name sortKey="Becares, M" uniqKey="Becares M">M Becares</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z Shi</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M Yu</name></author><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C Smith</name></author><author><name sortKey="Epstein, Jh" uniqKey="Epstein J">JH Epstein</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Crameri, G" uniqKey="Crameri G">G Crameri</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z Hu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Tsoi, Hw" uniqKey="Tsoi H">HW Tsoi</name></author><author><name sortKey="Wong, Bh" uniqKey="Wong B">BH Wong</name></author><author><name sortKey="Wong, Ss" uniqKey="Wong S">SS Wong</name></author><author><name sortKey="Leung, Sy" uniqKey="Leung S">SY Leung</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author><author><name sortKey="Qu, X" uniqKey="Qu X">X Qu</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Han, Z" uniqKey="Han Z">Z Han</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M Yu</name></author><author><name sortKey="Zhou, P" uniqKey="Zhou P">P Zhou</name></author><author><name sortKey="Zhang, Sy" uniqKey="Zhang S">SY Zhang</name></author><author><name sortKey="Wang, Lf" uniqKey="Wang L">LF Wang</name></author><author><name sortKey="Deng, H" uniqKey="Deng H">H Deng</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name></author><author><name sortKey="Li, Jl" uniqKey="Li J">JL Li</name></author><author><name sortKey="Yang, Xl" uniqKey="Yang X">XL Yang</name></author><author><name sortKey="Chmura, Aa" uniqKey="Chmura A">AA Chmura</name></author><author><name sortKey="Zhu, G" uniqKey="Zhu G">G Zhu</name></author><author><name sortKey="Epstein, Jh" uniqKey="Epstein J">JH Epstein</name></author><author><name sortKey="Mazet, Jk" uniqKey="Mazet J">JK Mazet</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Peng, C" uniqKey="Peng C">C Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Debbink, K" uniqKey="Debbink K">K Debbink</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name></author><author><name sortKey="Plante, Ja" uniqKey="Plante J">JA Plante</name></author><author><name sortKey="Royal, Sr" uniqKey="Royal S">SR Royal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Debbink, K" uniqKey="Debbink K">K Debbink</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Plante, Ja" uniqKey="Plante J">JA Plante</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name></author><author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name></author><author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, X" uniqKey="Qiu X">X Qiu</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name></author><author><name sortKey="Audet, J" uniqKey="Audet J">J Audet</name></author><author><name sortKey="Bello, A" uniqKey="Bello A">A Bello</name></author><author><name sortKey="Fernando, L" uniqKey="Fernando L">L Fernando</name></author><author><name sortKey="Alimonti, Jb" uniqKey="Alimonti J">JB Alimonti</name></author><author><name sortKey="Fausther Bovendo, H" uniqKey="Fausther Bovendo H">H Fausther-Bovendo</name></author><author><name sortKey="Wei, H" uniqKey="Wei H">H Wei</name></author><author><name sortKey="Aviles, J" uniqKey="Aviles J">J Aviles</name></author><author><name sortKey="Hiatt, E" uniqKey="Hiatt E">E Hiatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Groothuis, Jr" uniqKey="Groothuis J">JR Groothuis</name></author><author><name sortKey="Simoes, Ea" uniqKey="Simoes E">EA Simoes</name></author><author><name sortKey="Levin, Mj" uniqKey="Levin M">MJ Levin</name></author><author><name sortKey="Hall, Cb" uniqKey="Hall C">CB Hall</name></author><author><name sortKey="Long, Ce" uniqKey="Long C">CE Long</name></author><author><name sortKey="Rodriguez, Wj" uniqKey="Rodriguez W">WJ Rodriguez</name></author><author><name sortKey="Arrobio, J" uniqKey="Arrobio J">J Arrobio</name></author><author><name sortKey="Meissner, Hc" uniqKey="Meissner H">HC Meissner</name></author><author><name sortKey="Fulton, Dr" uniqKey="Fulton D">DR Fulton</name></author><author><name sortKey="Welliver, Rc" uniqKey="Welliver R">RC Welliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coughlin, Mm" uniqKey="Coughlin M">MM Coughlin</name></author><author><name sortKey="Prabhakar, Bs" uniqKey="Prabhakar B">BS Prabhakar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elshabrawy, Ha" uniqKey="Elshabrawy H">HA Elshabrawy</name></author><author><name sortKey="Coughlin, Mm" uniqKey="Coughlin M">MM Coughlin</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Prabhakar, Bs" uniqKey="Prabhakar B">BS Prabhakar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Ow" uniqKey="Ng O">OW Ng</name></author><author><name sortKey="Keng, Ct" uniqKey="Keng C">CT Keng</name></author><author><name sortKey="Leung, Cs" uniqKey="Leung C">CS Leung</name></author><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Tan, Yj" uniqKey="Tan Y">YJ Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilianski, A" uniqKey="Kilianski A">A Kilianski</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohd, Ha" uniqKey="Mohd H">HA Mohd</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Kw" uniqKey="Cheng K">KW Cheng</name></author><author><name sortKey="Cheng, Sc" uniqKey="Cheng S">SC Cheng</name></author><author><name sortKey="Chen, Wy" uniqKey="Chen W">WY Chen</name></author><author><name sortKey="Lin, Mh" uniqKey="Lin M">MH Lin</name></author><author><name sortKey="Chuang, Sj" uniqKey="Chuang S">SJ Chuang</name></author><author><name sortKey="Cheng, Ih" uniqKey="Cheng I">IH Cheng</name></author><author><name sortKey="Sun, Cy" uniqKey="Sun C">CY Sun</name></author><author><name sortKey="Chou, Cy" uniqKey="Chou C">CY Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, N" uniqKey="Zhou N">N Zhou</name></author><author><name sortKey="Pan, T" uniqKey="Pan T">T Pan</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Bai, C" uniqKey="Bai C">C Bai</name></author><author><name sortKey="Huang, F" uniqKey="Huang F">F Huang</name></author><author><name sortKey="Peng, T" uniqKey="Peng T">T Peng</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Mangalam, Ak" uniqKey="Mangalam A">AK Mangalam</name></author><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C Fett</name></author><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="David, Cs" uniqKey="David C">CS David</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S Su</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Lai, Ac" uniqKey="Lai A">AC Lai</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="article-commentary"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Vaccin Immunother</journal-id><journal-id journal-id-type="iso-abbrev">Hum Vaccin Immunother</journal-id><journal-id journal-id-type="publisher-id">KHVI</journal-id><journal-id journal-id-type="publisher-id">khvi20</journal-id><journal-title-group><journal-title>Human Vaccines & Immunotherapeutics</journal-title></journal-title-group><issn pub-type="ppub">2164-5515</issn><issn pub-type="epub">2164-554X</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27644155</article-id><article-id pub-id-type="pmc">5287300</article-id><article-id pub-id-type="publisher-id">1228500</article-id><article-id pub-id-type="doi">10.1080/21645515.2016.1228500</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group></article-categories><title-group><article-title>Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development</article-title><alt-title alt-title-type="running-authors">O.-W. NG AND Y.-J. TAN</alt-title><alt-title alt-title-type="running-title">HUMAN VACCINES & IMMUNOTHERAPEUTICS</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ng</surname><given-names>Oi-Wing</given-names></name><xref ref-type="aff" rid="af0001"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Yee-Joo</given-names></name><xref ref-type="aff" rid="af0001"><sup>a</sup></xref><xref ref-type="aff" rid="af0002"><sup>b</sup></xref><xref ref-type="corresp" rid="an0001"></xref></contrib><aff id="af0001"><label>a</label><institution>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore</institution>,<country>Singapore</country></aff><aff id="af0002"><label>b</label><institution>Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)</institution>,<country>Singapore</country></aff></contrib-group><author-notes><corresp id="an0001"><bold>CONTACT</bold> Yee Joo Tan <email xlink:href="Yee_Joo_Tan@nuhs.edu.sg">Yee_Joo_Tan@nuhs.edu.sg</email><addr-line>MD4, 5 Science Drive 2</addr-line>, <country>Singapore</country> 117597</corresp></author-notes><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>10</day><month>11</month><year>2016</year></pub-date><volume>13</volume><issue>1</issue><fpage seq="26">186</fpage><lpage>189</lpage><history><date date-type="received"><day>29</day><month>7</month><year>2016</year></date><date date-type="rev-recd"><day>07</day><month>8</month><year>2016</year></date><date date-type="accepted"><day>22</day><month>8</month><year>2016</year></date></history><permissions><copyright-statement>© 2017 Taylor & Francis</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Taylor & Francis</copyright-holder><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="KHVI_13_1228500.pdf"></self-uri><abstract><title>ABSTRACT</title><p>The severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, causing the SARS epidemic which resulted in a 10% fatality rate. The advancements in metagenomic techniques have allowed the identification of SARS-like coronaviruses (SL-CoVs) sequences that share high homology to the human SARS-CoV epidemic strains from wildlife bats, presenting concrete evidence that bats are the origin and natural reservoir of SARS-CoV. The application of reverse genetics further enabled that characterization of these bat CoVs and the prediction of their potential to cause disease in humans. The knowledge gained from such studies is valuable in the surveillance and preparation of a possible future outbreak caused by a spill-over of these bat SL-CoVs.</p></abstract><kwd-group kwd-group-type="author"><title>KEYWORDS</title><kwd>Bats</kwd><kwd>Emerging and re-emerging virus</kwd><kwd>Severe acute respiratory syndrome coronavirus</kwd><kwd>SARS-like coronavirus</kwd><kwd>Zoonotic virus</kwd></kwd-group><counts><fig-count count="0"></fig-count><table-count count="0"></table-count><ref-count count="29"></ref-count><page-count count="4"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Ng, Oi Wing" sort="Ng, Oi Wing" uniqKey="Ng O" first="Oi-Wing" last="Ng">Oi-Wing Ng</name></noRegion><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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