Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression
Identifieur interne : 002985 ( Ncbi/Merge ); précédent : 002984; suivant : 002986Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression
Auteurs : Krishna Narayanan [États-Unis] ; Sydney I. Ramirez [États-Unis] ; Kumari G. Lokugamage [États-Unis] ; Shinji Makino [États-Unis]Source :
- Virus Research [ 0168-1702 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus (croissance et développement), Coronavirus (pathogénicité), Coronavirus (physiologie), Facteurs de virulence (métabolisme), Humains, Interactions hôte-pathogène, Mammifères, Protéines virales non structurales (métabolisme), Régulation de l'expression des gènes, Régulation de l'expression des gènes viraux, Virulence.
- MESH :
- croissance et développement : Coronavirus.
- métabolisme : Facteurs de virulence, Protéines virales non structurales.
- pathogénicité : Coronavirus.
- physiologie : Coronavirus.
- Animaux, Humains, Interactions hôte-pathogène, Mammifères, Régulation de l'expression des gènes, Régulation de l'expression des gènes viraux, Virulence.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Viral Nonstructural Proteins, Virulence Factors.
- growth & development : Coronavirus.
- pathogenicity : Coronavirus.
- physiology : Coronavirus.
- Animals, Gene Expression Regulation, Gene Expression Regulation, Viral, Host-Pathogen Interactions, Humans, Mammals, Virulence.
Abstract
Novel strategies to inhibit host gene expression by coronavirus nonstructural protein 1. Summarizes the conserved and divergent functions of Alpha and Betacoronavirus nsp1. Provides a mechanistic insight into the unique properties of SARS coronavirus nsp1.
Url:
DOI: 10.1016/j.virusres.2014.11.019
PubMed: 25432065
PubMed Central: 4444399
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PMC:4444399Le document en format XML
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Ramirez</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G." last="Lokugamage">Kumari G. Lokugamage</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus (growth & development)</term><term>Coronavirus (pathogenicity)</term><term>Coronavirus (physiology)</term><term>Gene Expression Regulation</term><term>Gene Expression Regulation, Viral</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Mammals</term><term>Viral Nonstructural Proteins (metabolism)</term><term>Virulence</term><term>Virulence Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Coronavirus (croissance et développement)</term><term>Coronavirus (pathogénicité)</term><term>Coronavirus (physiologie)</term><term>Facteurs de virulence (métabolisme)</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Mammifères</term><term>Protéines virales non structurales (métabolisme)</term><term>Régulation de l'expression des gènes</term><term>Régulation de l'expression des gènes viraux</term><term>Virulence</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Nonstructural Proteins</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de virulence</term><term>Protéines virales non structurales</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Expression Regulation</term><term>Gene Expression Regulation, Viral</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Mammals</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Mammifères</term><term>Régulation de l'expression des gènes</term><term>Régulation de l'expression des gènes viraux</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Novel strategies to inhibit host gene expression by coronavirus nonstructural protein 1.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Summarizes the conserved and divergent functions of Alpha and Betacoronavirus nsp1.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Provides a mechanistic insight into the unique properties of SARS coronavirus nsp1.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Almeida, M S" uniqKey="Almeida M">M.S. 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Thiel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="25432065"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression</title><author><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ramirez, Sydney I" sort="Ramirez, Sydney I" uniqKey="Ramirez S" first="Sydney I." last="Ramirez">Sydney I. Ramirez</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G." last="Lokugamage">Kumari G. Lokugamage</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25432065</idno><idno type="pmc">4444399</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444399</idno><idno type="RBID">PMC:4444399</idno><idno type="doi">10.1016/j.virusres.2014.11.019</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001602</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001602</idno><idno type="wicri:Area/Pmc/Curation">001602</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001602</idno><idno type="wicri:Area/Pmc/Checkpoint">000913</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000913</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression</title><author><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ramirez, Sydney I" sort="Ramirez, Sydney I" uniqKey="Ramirez S" first="Sydney I." last="Ramirez">Sydney I. Ramirez</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G." last="Lokugamage">Kumari G. Lokugamage</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Novel strategies to inhibit host gene expression by coronavirus nonstructural protein 1.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Summarizes the conserved and divergent functions of Alpha and Betacoronavirus nsp1.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Provides a mechanistic insight into the unique properties of SARS coronavirus nsp1.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Almeida, M S" uniqKey="Almeida M">M.S. 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Kuri</name></author><author><name sortKey="Blakqori, G" uniqKey="Blakqori G">G. Blakqori</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F. Weber</name></author><author><name sortKey="Ludewig, B" uniqKey="Ludewig B">B. Ludewig</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression.</title><author><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: krnaraya@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ramirez, Sydney I" sort="Ramirez, Sydney I" uniqKey="Ramirez S" first="Sydney I" last="Ramirez">Sydney I. Ramirez</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: syiramir@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G" last="Lokugamage">Kumari G. Lokugamage</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: kglokuga@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: shmakino@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25432065</idno><idno type="pmid">25432065</idno><idno type="doi">10.1016/j.virusres.2014.11.019</idno><idno type="wicri:Area/PubMed/Corpus">000F06</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F06</idno><idno type="wicri:Area/PubMed/Curation">000F06</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F06</idno><idno type="wicri:Area/PubMed/Checkpoint">000E42</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression.</title><author><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: krnaraya@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ramirez, Sydney I" sort="Ramirez, Sydney I" uniqKey="Ramirez S" first="Sydney I" last="Ramirez">Sydney I. Ramirez</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: syiramir@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G" last="Lokugamage">Kumari G. Lokugamage</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: kglokuga@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: shmakino@utmb.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">Virus research</title><idno type="eISSN">1872-7492</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus (growth & development)</term><term>Coronavirus (pathogenicity)</term><term>Coronavirus (physiology)</term><term>Gene Expression Regulation</term><term>Gene Expression Regulation, Viral</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Mammals</term><term>Viral Nonstructural Proteins (metabolism)</term><term>Virulence</term><term>Virulence Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Coronavirus (croissance et développement)</term><term>Coronavirus (pathogénicité)</term><term>Coronavirus (physiologie)</term><term>Facteurs de virulence (métabolisme)</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Mammifères</term><term>Protéines virales non structurales (métabolisme)</term><term>Régulation de l'expression des gènes</term><term>Régulation de l'expression des gènes viraux</term><term>Virulence</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Nonstructural Proteins</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de virulence</term><term>Protéines virales non structurales</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Expression Regulation</term><term>Gene Expression Regulation, Viral</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Mammals</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Mammifères</term><term>Régulation de l'expression des gènes</term><term>Régulation de l'expression des gènes viraux</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong interest in the identification of viral factors that determine the virulence and pathogenesis of CoVs. The nonstructural protein 1 (nsp1) of CoVs has attracted considerable attention in this regard as a potential virulence factor and a target for CoV vaccine development because of accumulating evidence that point to its role in the downregulation of host innate immune responses to CoV infection. Studies have revealed both functional conservation and mechanistic divergence among the nsp1 of different mammalian CoVs in perturbing host gene expression and antiviral responses. This review summarizes the current knowledge about the biological functions of CoV nsp1 that provides an insight into the novel strategies utilized by this viral protein to modulate host and viral gene expression during CoV infection. </div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002985 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002985 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:4444399
|texte= Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:25432065" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |