Antiviral drugs specific for coronaviruses in preclinical development
Identifieur interne : 002917 ( Ncbi/Merge ); précédent : 002916; suivant : 002918Antiviral drugs specific for coronaviruses in preclinical development
Auteurs : Adeyemi O. Adedeji [États-Unis] ; Stefan G. Sarafianos [États-Unis]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- isolement et purification : Antiviraux.
- pharmacologie : Antiviraux.
- tendances : Découverte de médicament.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Virus du SRAS, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- MESH :
- chemical , isolation & purification : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents.
- drug effects : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- trends : Drug Discovery.
- Drug Evaluation, Preclinical, Humans.
Abstract
Coronaviruses are RNA viruses that cause systemic diseases in humans and animals. There are no approved drugs for the treatment of coronavirus infections. Several SARS-CoV inhibitors, with known mechanisms of action, have been identified. These inhibitors stand as promising leads for coronavirus therapeutics.
Url:
DOI: 10.1016/j.coviro.2014.06.002
PubMed: 24997250
PubMed Central: 4195804
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Links to Exploration step
PMC:4195804Le document en format XML
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Adedeji</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0020">Department of Biochemistry, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Drug Discovery (trends)</term><term>Drug Evaluation, Preclinical</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>SARS Virus (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Découverte de médicament (tendances)</term><term>Humains</term><term>Virus du SRAS ()</term><term>Évaluation préclinique de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Découverte de médicament</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Evaluation, Preclinical</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Virus du SRAS</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronaviruses are RNA viruses that cause systemic diseases in humans and animals.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">There are no approved drugs for the treatment of coronavirus infections.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Several SARS-CoV inhibitors, with known mechanisms of action, have been identified.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">These inhibitors stand as promising leads for coronavirus therapeutics.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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Sarafianos</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0020">Department of Biochemistry, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24997250</idno><idno type="pmc">4195804</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195804</idno><idno type="RBID">PMC:4195804</idno><idno type="doi">10.1016/j.coviro.2014.06.002</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001731</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001731</idno><idno type="wicri:Area/Pmc/Curation">001731</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001731</idno><idno type="wicri:Area/Pmc/Checkpoint">000923</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000923</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antiviral drugs specific for coronaviruses in preclinical development</title><author><name sortKey="Adedeji, Adeyemi O" sort="Adedeji, Adeyemi O" uniqKey="Adedeji A" first="Adeyemi O" last="Adedeji">Adeyemi O. Adedeji</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0020">Department of Biochemistry, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronaviruses are RNA viruses that cause systemic diseases in humans and animals.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">There are no approved drugs for the treatment of coronavirus infections.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Several SARS-CoV inhibitors, with known mechanisms of action, have been identified.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">These inhibitors stand as promising leads for coronavirus therapeutics.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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Adedeji</name><affiliation wicri:level="2"><nlm:affiliation>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, United States. Electronic address: aoadedeji@ucdavis.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. 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Electronic address: sarafianoss@missouri.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States; Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States; Department of Biochemistry, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24997250</idno><idno type="pmid">24997250</idno><idno type="doi">10.1016/j.coviro.2014.06.002</idno><idno type="wicri:Area/PubMed/Corpus">000F69</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F69</idno><idno type="wicri:Area/PubMed/Curation">000F69</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F69</idno><idno type="wicri:Area/PubMed/Checkpoint">001043</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001043</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiviral drugs specific for coronaviruses in preclinical development.</title><author><name sortKey="Adedeji, Adeyemi O" sort="Adedeji, Adeyemi O" uniqKey="Adedeji A" first="Adeyemi O" last="Adedeji">Adeyemi O. Adedeji</name><affiliation wicri:level="2"><nlm:affiliation>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, United States. Electronic address: aoadedeji@ucdavis.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name><affiliation wicri:level="2"><nlm:affiliation>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States; Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States; Department of Biochemistry, University of Missouri, Columbia, MO 65211, United States. Electronic address: sarafianoss@missouri.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States; Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States; Department of Biochemistry, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></analytic><series><title level="j">Current opinion in virology</title><idno type="eISSN">1879-6265</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Drug Discovery (trends)</term><term>Drug Evaluation, Preclinical</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>SARS Virus (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Découverte de médicament (tendances)</term><term>Humains</term><term>Virus du SRAS ()</term><term>Évaluation préclinique de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Découverte de médicament</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Evaluation, Preclinical</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Virus du SRAS</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronaviruses are positive stranded RNA viruses that cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses impeded the development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV), and more recently, Middle East respiratory syndrome coronavirus (MERS-CoV), has impelled the development of such drugs. This review focuses on some newly identified SARS-CoV inhibitors, with known mechanisms of action and their potential to inhibit the novel MERS-CoV. The clinical development of optimized versions of such compounds could be beneficial for the treatment and control of SARS-CoV, the current MERS-CoV and other future SARS-like epidemics. </div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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