Antiviral drugs specific for coronaviruses in preclinical development
Identifieur interne : 001731 ( Pmc/Curation ); précédent : 001730; suivant : 001732Antiviral drugs specific for coronaviruses in preclinical development
Auteurs : Adeyemi O. Adedeji [États-Unis] ; Stefan G. Sarafianos [États-Unis]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2014.
Abstract
Coronaviruses are RNA viruses that cause systemic diseases in humans and animals. There are no approved drugs for the treatment of coronavirus infections. Several SARS-CoV inhibitors, with known mechanisms of action, have been identified. These inhibitors stand as promising leads for coronavirus therapeutics.
Url:
DOI: 10.1016/j.coviro.2014.06.002
PubMed: 24997250
PubMed Central: 4195804
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiviral drugs specific for coronaviruses in preclinical development</title><author><name sortKey="Adedeji, Adeyemi O" sort="Adedeji, Adeyemi O" uniqKey="Adedeji A" first="Adeyemi O" last="Adedeji">Adeyemi O. Adedeji</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616</wicri:regionArea></affiliation></author><author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0020">Department of Biochemistry, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Missouri, Columbia, MO 65211</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24997250</idno><idno type="pmc">4195804</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195804</idno><idno type="RBID">PMC:4195804</idno><idno type="doi">10.1016/j.coviro.2014.06.002</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001731</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001731</idno><idno type="wicri:Area/Pmc/Curation">001731</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001731</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antiviral drugs specific for coronaviruses in preclinical development</title><author><name sortKey="Adedeji, Adeyemi O" sort="Adedeji, Adeyemi O" uniqKey="Adedeji A" first="Adeyemi O" last="Adedeji">Adeyemi O. Adedeji</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616</wicri:regionArea></affiliation></author><author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0020">Department of Biochemistry, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Missouri, Columbia, MO 65211</wicri:regionArea></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronaviruses are RNA viruses that cause systemic diseases in humans and animals.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">There are no approved drugs for the treatment of coronavirus infections.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Several SARS-CoV inhibitors, with known mechanisms of action, have been identified.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">These inhibitors stand as promising leads for coronavirus therapeutics.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Curr Opin Virol</journal-id><journal-id journal-id-type="iso-abbrev">Curr Opin Virol</journal-id><journal-title-group><journal-title>Current Opinion in Virology</journal-title></journal-title-group><issn pub-type="ppub">1879-6257</issn><issn pub-type="epub">1879-6265</issn><publisher><publisher-name>Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24997250</article-id><article-id pub-id-type="pmc">4195804</article-id><article-id pub-id-type="publisher-id">S1879-6257(14)00137-0</article-id><article-id pub-id-type="doi">10.1016/j.coviro.2014.06.002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Antiviral drugs specific for coronaviruses in preclinical development</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Adedeji</surname><given-names>Adeyemi O</given-names></name><email>aoadedeji@ucdavis.edu</email><xref rid="aff0005" ref-type="aff">1</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Sarafianos</surname><given-names>Stefan G</given-names></name><email>sarafianoss@missouri.edu</email><email>stefansarafianos@gmail.com</email><xref rid="aff0010" ref-type="aff">2</xref><xref rid="aff0015" ref-type="aff">3</xref><xref rid="aff0020" ref-type="aff">4</xref></contrib></contrib-group><aff id="aff0005"><label>1</label>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, United States</aff><aff id="aff0010"><label>2</label>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States</aff><aff id="aff0015"><label>3</label>Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States</aff><aff id="aff0020"><label>4</label>Department of Biochemistry, University of Missouri, Columbia, MO 65211, United States</aff><pub-date pub-type="pmc-release"><day>2</day><month>7</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>10</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>2</day><month>7</month><year>2014</year></pub-date><volume>8</volume><fpage>45</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright © 2014 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Elsevier B.V.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronaviruses are RNA viruses that cause systemic diseases in humans and animals.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">There are no approved drugs for the treatment of coronavirus infections.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Several SARS-CoV inhibitors, with known mechanisms of action, have been identified.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">These inhibitors stand as promising leads for coronavirus therapeutics.</p></list-item></list></p></abstract><abstract id="abs0010"><p>Coronaviruses are positive stranded RNA viruses that cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses impeded the development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV), and more recently, Middle East respiratory syndrome coronavirus (MERS-CoV), has impelled the development of such drugs. This review focuses on some newly identified SARS-CoV inhibitors, with known mechanisms of action and their potential to inhibit the novel MERS-CoV. The clinical development of optimized versions of such compounds could be beneficial for the treatment and control of SARS-CoV, the current MERS-CoV and other future SARS-like epidemics.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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