Accessory proteins of SARS-CoV and other coronaviruses
Identifieur interne : 002915 ( Ncbi/Merge ); précédent : 002914; suivant : 002916Accessory proteins of SARS-CoV and other coronaviruses
Auteurs : Ding Xiang Liu [Singapour] ; To Sing Fung [Singapour] ; Kelvin Kian-Long Chong [Singapour] ; Aditi Shukla [Allemagne] ; Rolf Hilgenfeld [Allemagne]Source :
- Antiviral Research [ 0166-3542 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cadres ouverts de lecture, Coronavirus (), Coronavirus (génétique), Coronavirus (métabolisme), Humains, Infections à coronavirus (virologie), Protéines virales régulatrices ou accessoires (génétique), Protéines virales régulatrices ou accessoires (métabolisme), Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- génétique : Coronavirus, Protéines virales régulatrices ou accessoires, Virus du SRAS.
- métabolisme : Coronavirus, Protéines virales régulatrices ou accessoires, Virus du SRAS.
- virologie : Infections à coronavirus.
- Animaux, Cadres ouverts de lecture, Coronavirus, Humains.
English descriptors
- KwdEn :
- Animals, Coronavirus (classification), Coronavirus (genetics), Coronavirus (metabolism), Coronavirus Infections (virology), Humans, Open Reading Frames, SARS Virus (genetics), SARS Virus (metabolism), Viral Regulatory and Accessory Proteins (genetics), Viral Regulatory and Accessory Proteins (metabolism).
- MESH :
- chemical , genetics : Viral Regulatory and Accessory Proteins.
- classification : Coronavirus.
- genetics : Coronavirus, SARS Virus.
- metabolism : Coronavirus, SARS Virus, Viral Regulatory and Accessory Proteins.
- virology : Coronavirus Infections.
- Animals, Humans, Open Reading Frames.
Abstract
The SARS-CoV genome encodes eight accessory proteins; none is essential for RNA replication. Several appear to be involved in virus–host interactions and to influence the pathogenicity of the virus. Some of these accessory proteins modulate the interferon pathway and the production of pro-inflammatory cytokines. Five of the accessory proteins are incorporated into virions as minor structural proteins. Other coronaviruses including MERS-CoV also encode accessory proteins.
Url:
DOI: 10.1016/j.antiviral.2014.06.013
PubMed: 24995382
PubMed Central: 7113789
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PMC:7113789Le document en format XML
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Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Fung, To Sing" sort="Fung, To Sing" uniqKey="Fung T" first="To Sing" last="Fung">To Sing Fung</name><affiliation wicri:level="1"><nlm:aff id="af005">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Chong, Kelvin Kian Long" sort="Chong, Kelvin Kian Long" uniqKey="Chong K" first="Kelvin Kian-Long" last="Chong">Kelvin Kian-Long Chong</name><affiliation wicri:level="1"><nlm:aff id="af005">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Shukla, Aditi" sort="Shukla, Aditi" uniqKey="Shukla A" first="Aditi" last="Shukla">Aditi Shukla</name><affiliation wicri:level="1"><nlm:aff id="af010">Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 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of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), University of Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus (classification)</term><term>Coronavirus (genetics)</term><term>Coronavirus (metabolism)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Open Reading Frames</term><term>SARS Virus (genetics)</term><term>SARS Virus (metabolism)</term><term>Viral Regulatory and Accessory Proteins (genetics)</term><term>Viral Regulatory and Accessory Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Coronavirus ()</term><term>Coronavirus (génétique)</term><term>Coronavirus (métabolisme)</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Protéines virales régulatrices ou accessoires (génétique)</term><term>Protéines virales régulatrices ou accessoires (métabolisme)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Protéines virales régulatrices ou accessoires</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronavirus</term><term>Protéines virales régulatrices ou accessoires</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Open Reading Frames</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Coronavirus</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0255">The SARS-CoV genome encodes eight accessory proteins; none is essential for RNA replication.</p></list-item><list-item id="o0010"><label>•</label><p id="p0260">Several appear to be involved in virus–host interactions and to influence the pathogenicity of the virus.</p></list-item><list-item id="o0015"><label>•</label><p id="p0265">Some of these accessory proteins modulate the interferon pathway and the production of pro-inflammatory cytokines.</p></list-item><list-item id="o0020"><label>•</label><p id="p0270">Five of the accessory proteins are incorporated into virions as minor structural proteins.</p></list-item><list-item id="o0025"><label>•</label><p id="p0275">Other coronaviruses including MERS-CoV also encode accessory proteins.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey=" Kerstrom, S" uniqKey=" Kerstrom S">S. 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Shao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="24995382"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Accessory proteins of SARS-CoV and other coronaviruses</title><author><name sortKey="Liu, Ding Xiang" sort="Liu, Ding Xiang" uniqKey="Liu D" first="Ding Xiang" last="Liu">Ding Xiang Liu</name><affiliation wicri:level="1"><nlm:aff id="af005">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Fung, To Sing" sort="Fung, To Sing" uniqKey="Fung T" first="To Sing" last="Fung">To Sing Fung</name><affiliation wicri:level="1"><nlm:aff id="af005">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Chong, Kelvin Kian Long" sort="Chong, Kelvin Kian Long" uniqKey="Chong K" first="Kelvin Kian-Long" last="Chong">Kelvin Kian-Long Chong</name><affiliation wicri:level="1"><nlm:aff id="af005">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Shukla, Aditi" sort="Shukla, Aditi" uniqKey="Shukla A" first="Aditi" last="Shukla">Aditi Shukla</name><affiliation wicri:level="1"><nlm:aff id="af010">Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), University of Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name><affiliation wicri:level="1"><nlm:aff id="af010">Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), University of Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24995382</idno><idno type="pmc">7113789</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113789</idno><idno type="RBID">PMC:7113789</idno><idno type="doi">10.1016/j.antiviral.2014.06.013</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001690</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001690</idno><idno type="wicri:Area/Pmc/Curation">001690</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001690</idno><idno type="wicri:Area/Pmc/Checkpoint">000926</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000926</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Accessory proteins of SARS-CoV and other coronaviruses</title><author><name sortKey="Liu, Ding Xiang" sort="Liu, Ding Xiang" uniqKey="Liu D" first="Ding Xiang" last="Liu">Ding Xiang Liu</name><affiliation wicri:level="1"><nlm:aff id="af005">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Fung, To Sing" sort="Fung, To Sing" uniqKey="Fung T" first="To Sing" last="Fung">To Sing Fung</name><affiliation wicri:level="1"><nlm:aff id="af005">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Chong, Kelvin Kian Long" sort="Chong, Kelvin Kian Long" uniqKey="Chong K" first="Kelvin Kian-Long" last="Chong">Kelvin Kian-Long Chong</name><affiliation wicri:level="1"><nlm:aff id="af005">School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Shukla, Aditi" sort="Shukla, Aditi" uniqKey="Shukla A" first="Aditi" last="Shukla">Aditi Shukla</name><affiliation wicri:level="1"><nlm:aff id="af010">Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), University of Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name><affiliation wicri:level="1"><nlm:aff id="af010">Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">German Center for Infection Research (DZIF), University of Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0255">The SARS-CoV genome encodes eight accessory proteins; none is essential for RNA replication.</p></list-item><list-item id="o0010"><label>•</label><p id="p0260">Several appear to be involved in virus–host interactions and to influence the pathogenicity of the virus.</p></list-item><list-item id="o0015"><label>•</label><p id="p0265">Some of these accessory proteins modulate the interferon pathway and the production of pro-inflammatory cytokines.</p></list-item><list-item id="o0020"><label>•</label><p id="p0270">Five of the accessory proteins are incorporated into virions as minor structural proteins.</p></list-item><list-item id="o0025"><label>•</label><p id="p0275">Other coronaviruses including MERS-CoV also encode accessory proteins.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey=" Kerstrom, S" uniqKey=" Kerstrom S">S. 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Shao</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Accessory proteins of SARS-CoV and other coronaviruses.</title><author><name sortKey="Liu, Ding Xiang" sort="Liu, Ding Xiang" uniqKey="Liu D" first="Ding Xiang" last="Liu">Ding Xiang Liu</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. Electronic address: dxliu@ntu.edu.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Fung, To Sing" sort="Fung, To Sing" uniqKey="Fung T" first="To Sing" last="Fung">To Sing Fung</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Chong, Kelvin Kian Long" sort="Chong, Kelvin Kian Long" uniqKey="Chong K" first="Kelvin Kian-Long" last="Chong">Kelvin Kian-Long Chong</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Shukla, Aditi" sort="Shukla, Aditi" uniqKey="Shukla A" first="Aditi" last="Shukla">Aditi Shukla</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; German Center for Infection Research (DZIF), University of Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; German Center for Infection Research (DZIF), University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; German Center for Infection Research (DZIF), University of Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; German Center for Infection Research (DZIF), University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24995382</idno><idno type="pmid">24995382</idno><idno type="doi">10.1016/j.antiviral.2014.06.013</idno><idno type="wicri:Area/PubMed/Corpus">000F71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F71</idno><idno type="wicri:Area/PubMed/Curation">000F71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F71</idno><idno type="wicri:Area/PubMed/Checkpoint">001051</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001051</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Accessory proteins of SARS-CoV and other coronaviruses.</title><author><name sortKey="Liu, Ding Xiang" sort="Liu, Ding Xiang" uniqKey="Liu D" first="Ding Xiang" last="Liu">Ding Xiang Liu</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. Electronic address: dxliu@ntu.edu.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Fung, To Sing" sort="Fung, To Sing" uniqKey="Fung T" first="To Sing" last="Fung">To Sing Fung</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Chong, Kelvin Kian Long" sort="Chong, Kelvin Kian Long" uniqKey="Chong K" first="Kelvin Kian-Long" last="Chong">Kelvin Kian-Long Chong</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551</wicri:regionArea><wicri:noRegion>Singapore 637551</wicri:noRegion></affiliation></author><author><name sortKey="Shukla, Aditi" sort="Shukla, Aditi" uniqKey="Shukla A" first="Aditi" last="Shukla">Aditi Shukla</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; German Center for Infection Research (DZIF), University of Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; German Center for Infection Research (DZIF), University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; German Center for Infection Research (DZIF), University of Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; German Center for Infection Research (DZIF), University of Lübeck</wicri:regionArea><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral research</title><idno type="eISSN">1872-9096</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus (classification)</term><term>Coronavirus (genetics)</term><term>Coronavirus (metabolism)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Open Reading Frames</term><term>SARS Virus (genetics)</term><term>SARS Virus (metabolism)</term><term>Viral Regulatory and Accessory Proteins (genetics)</term><term>Viral Regulatory and Accessory Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Coronavirus ()</term><term>Coronavirus (génétique)</term><term>Coronavirus (métabolisme)</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Protéines virales régulatrices ou accessoires (génétique)</term><term>Protéines virales régulatrices ou accessoires (métabolisme)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Protéines virales régulatrices ou accessoires</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronavirus</term><term>Protéines virales régulatrices ou accessoires</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Open Reading Frames</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Coronavirus</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The huge RNA genome of SARS coronavirus comprises a number of open reading frames that code for a total of eight accessory proteins. Although none of these are essential for virus replication, some appear to have a role in virus pathogenesis. Notably, some SARS-CoV accessory proteins have been shown to modulate the interferon signaling pathways and the production of pro-inflammatory cytokines. The structural information on these proteins is also limited, with only two (p7a and p9b) having their structures determined by X-ray crystallography. This review makes an attempt to summarize the published knowledge on SARS-CoV accessory proteins, with an emphasis on their involvement in virus-host interaction. The accessory proteins of other coronaviruses are also briefly discussed. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses" (see Introduction by Hilgenfeld and Peiris (2013)).</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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