Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
Identifieur interne : 002612 ( Ncbi/Merge ); précédent : 002611; suivant : 002613Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
Auteurs : Dae Wook Kim ; Kyung Hye Seo ; Marcus J. Curtis-Long ; Kyeong Yeol Oh ; Jong-Won Oh ; Jung Keun Cho ; Kon Ho Lee ; Ki Hun ParkSource :
- Journal of enzyme inhibition and medicinal chemistry [ 1475-6374 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- embryologie : Psoralea.
- pharmacologie : Phénols.
- Graines, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Phenols.
- chemistry : Seeds.
- drug effects : SARS Virus.
- embryology : Psoralea.
Abstract
Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) is a key enzyme that plays an important role in SARS virus replication. The ethanol extract of the seeds of Psoralea corylifolia showed high activity against the SARS-CoV PLpro with an IC50 of value of 15 µg/ml. Due to its potency, subsequent bioactivity-guided fractionation of the ethanol extract led to six aromatic compounds (1-6), which were identified as bavachinin (1), neobavaisoflavone (2), isobavachalcone (3), 4'-O-methylbavachalcone (4), psoralidin (5) and corylifol A (6). All isolated flavonoids (1-6) inhibited PLpro in a dose-dependent manner with IC50 ranging between 4.2 and 38.4 µM. Lineweaver-Burk and Dixon plots and their secondary replots indicated that inhibitors (1-6) were mixed inhibitors of PLpro. The analysis of KI and KIS values proved that the two most promising compounds (3 and 5) had reversible mixed type I mechanisms.
DOI: 10.3109/14756366.2012.753591
PubMed: 23323951
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pubmed:23323951Le document en format XML
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Curtis-Long</name></author><author><name sortKey="Oh, Kyeong Yeol" sort="Oh, Kyeong Yeol" uniqKey="Oh K" first="Kyeong Yeol" last="Oh">Kyeong Yeol Oh</name></author><author><name sortKey="Oh, Jong Won" sort="Oh, Jong Won" uniqKey="Oh J" first="Jong-Won" last="Oh">Jong-Won Oh</name></author><author><name sortKey="Cho, Jung Keun" sort="Cho, Jung Keun" uniqKey="Cho J" first="Jung Keun" last="Cho">Jung Keun Cho</name></author><author><name sortKey="Lee, Kon Ho" sort="Lee, Kon Ho" uniqKey="Lee K" first="Kon Ho" last="Lee">Kon Ho Lee</name></author><author><name sortKey="Park, Ki Hun" sort="Park, Ki Hun" uniqKey="Park K" first="Ki Hun" last="Park">Ki Hun Park</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:23323951</idno><idno type="pmid">23323951</idno><idno type="doi">10.3109/14756366.2012.753591</idno><idno type="wicri:Area/PubMed/Corpus">001259</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001259</idno><idno type="wicri:Area/PubMed/Curation">001259</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001259</idno><idno type="wicri:Area/PubMed/Checkpoint">000F54</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F54</idno><idno type="wicri:Area/Ncbi/Merge">002612</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.</title><author><name sortKey="Kim, Dae Wook" sort="Kim, Dae Wook" uniqKey="Kim D" first="Dae Wook" last="Kim">Dae Wook Kim</name><affiliation><nlm:affiliation>Division of Applied Life Science (BK21 Program), IALS and.</nlm:affiliation><wicri:noCountry code="subField">IALS and</wicri:noCountry></affiliation></author><author><name sortKey="Seo, Kyung Hye" sort="Seo, Kyung Hye" uniqKey="Seo K" first="Kyung Hye" last="Seo">Kyung Hye Seo</name></author><author><name sortKey="Curtis Long, Marcus J" sort="Curtis Long, Marcus J" uniqKey="Curtis Long M" first="Marcus J" last="Curtis-Long">Marcus J. Curtis-Long</name></author><author><name sortKey="Oh, Kyeong Yeol" sort="Oh, Kyeong Yeol" uniqKey="Oh K" first="Kyeong Yeol" last="Oh">Kyeong Yeol Oh</name></author><author><name sortKey="Oh, Jong Won" sort="Oh, Jong Won" uniqKey="Oh J" first="Jong-Won" last="Oh">Jong-Won Oh</name></author><author><name sortKey="Cho, Jung Keun" sort="Cho, Jung Keun" uniqKey="Cho J" first="Jung Keun" last="Cho">Jung Keun Cho</name></author><author><name sortKey="Lee, Kon Ho" sort="Lee, Kon Ho" uniqKey="Lee K" first="Kon Ho" last="Lee">Kon Ho Lee</name></author><author><name sortKey="Park, Ki Hun" sort="Park, Ki Hun" uniqKey="Park K" first="Ki Hun" last="Park">Ki Hun Park</name></author></analytic><series><title level="j">Journal of enzyme inhibition and medicinal chemistry</title><idno type="eISSN">1475-6374</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Phenols (pharmacology)</term><term>Psoralea (embryology)</term><term>SARS Virus (drug effects)</term><term>Seeds (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Graines ()</term><term>Phénols (pharmacologie)</term><term>Psoralea (embryologie)</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Phenols</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Seeds</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Psoralea</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Psoralea</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Phénols</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Graines</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) is a key enzyme that plays an important role in SARS virus replication. The ethanol extract of the seeds of Psoralea corylifolia showed high activity against the SARS-CoV PLpro with an IC50 of value of 15 µg/ml. Due to its potency, subsequent bioactivity-guided fractionation of the ethanol extract led to six aromatic compounds (1-6), which were identified as bavachinin (1), neobavaisoflavone (2), isobavachalcone (3), 4'-O-methylbavachalcone (4), psoralidin (5) and corylifol A (6). All isolated flavonoids (1-6) inhibited PLpro in a dose-dependent manner with IC50 ranging between 4.2 and 38.4 µM. Lineweaver-Burk and Dixon plots and their secondary replots indicated that inhibitors (1-6) were mixed inhibitors of PLpro. The analysis of KI and KIS values proved that the two most promising compounds (3 and 5) had reversible mixed type I mechanisms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23323951</PMID><DateCompleted><Year>2014</Year><Month>10</Month><Day>06</Day></DateCompleted><DateRevised><Year>2014</Year><Month>02</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1475-6374</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>1</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Journal of enzyme inhibition and medicinal chemistry</Title><ISOAbbreviation>J Enzyme Inhib Med Chem</ISOAbbreviation></Journal><ArticleTitle>Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.</ArticleTitle><Pagination><MedlinePgn>59-63</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3109/14756366.2012.753591</ELocationID><Abstract><AbstractText>Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) is a key enzyme that plays an important role in SARS virus replication. The ethanol extract of the seeds of Psoralea corylifolia showed high activity against the SARS-CoV PLpro with an IC50 of value of 15 µg/ml. Due to its potency, subsequent bioactivity-guided fractionation of the ethanol extract led to six aromatic compounds (1-6), which were identified as bavachinin (1), neobavaisoflavone (2), isobavachalcone (3), 4'-O-methylbavachalcone (4), psoralidin (5) and corylifol A (6). All isolated flavonoids (1-6) inhibited PLpro in a dose-dependent manner with IC50 ranging between 4.2 and 38.4 µM. Lineweaver-Burk and Dixon plots and their secondary replots indicated that inhibitors (1-6) were mixed inhibitors of PLpro. The analysis of KI and KIS values proved that the two most promising compounds (3 and 5) had reversible mixed type I mechanisms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Dae Wook</ForeName><Initials>DW</Initials><AffiliationInfo><Affiliation>Division of Applied Life Science (BK21 Program), IALS and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seo</LastName><ForeName>Kyung Hye</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Curtis-Long</LastName><ForeName>Marcus J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Kyeong Yeol</ForeName><Initials>KY</Initials></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Jong-Won</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Jung Keun</ForeName><Initials>JK</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Kon Ho</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Ki Hun</ForeName><Initials>KH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>01</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Enzyme Inhib Med Chem</MedlineTA><NlmUniqueID>101150203</NlmUniqueID><ISSNLinking>1475-6366</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010636">Phenols</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029907" MajorTopicYN="N">Psoralea</DescriptorName><QualifierName UI="Q000196" MajorTopicYN="Y">embryology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012639" MajorTopicYN="N">Seeds</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23323951</ArticleId><ArticleId IdType="doi">10.3109/14756366.2012.753591</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Cho, Jung Keun" sort="Cho, Jung Keun" uniqKey="Cho J" first="Jung Keun" last="Cho">Jung Keun Cho</name><name sortKey="Curtis Long, Marcus J" sort="Curtis Long, Marcus J" uniqKey="Curtis Long M" first="Marcus J" last="Curtis-Long">Marcus J. Curtis-Long</name><name sortKey="Kim, Dae Wook" sort="Kim, Dae Wook" uniqKey="Kim D" first="Dae Wook" last="Kim">Dae Wook Kim</name><name sortKey="Lee, Kon Ho" sort="Lee, Kon Ho" uniqKey="Lee K" first="Kon Ho" last="Lee">Kon Ho Lee</name><name sortKey="Oh, Jong Won" sort="Oh, Jong Won" uniqKey="Oh J" first="Jong-Won" last="Oh">Jong-Won Oh</name><name sortKey="Oh, Kyeong Yeol" sort="Oh, Kyeong Yeol" uniqKey="Oh K" first="Kyeong Yeol" last="Oh">Kyeong Yeol Oh</name><name sortKey="Park, Ki Hun" sort="Park, Ki Hun" uniqKey="Park K" first="Ki Hun" last="Park">Ki Hun Park</name><name sortKey="Seo, Kyung Hye" sort="Seo, Kyung Hye" uniqKey="Seo K" first="Kyung Hye" last="Seo">Kyung Hye Seo</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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