Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV).
Identifieur interne : 002445 ( Ncbi/Merge ); précédent : 002444; suivant : 002446Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV).
Auteurs : Hye Ri Park [Corée du Sud] ; Hyunjun Yoon ; Mi Kyoung Kim ; Sung Dae Lee ; Youhoon ChongSource :
- Archives of pharmacal research [ 0253-6269 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antiviraux, Quercétine.
- physiologie : Hepacivirus, Virus du SRAS.
- synthèse chimique : Antiviraux, Quercétine.
- Hepacivirus, Humains, Lignée cellulaire tumorale, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Antiviral Agents, Quercetin.
- chemical , pharmacology : Antiviral Agents, Quercetin.
- drug effects : Hepacivirus, SARS Virus, Virus Replication.
- physiology : Hepacivirus, SARS Virus.
- Cell Line, Tumor, Humans.
Abstract
Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV.
DOI: 10.1007/s12272-012-0108-9
PubMed: 22297745
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pubmed:22297745Le document en format XML
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<term>Hepacivirus (physiology)</term>
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<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Quercétine (pharmacologie)</term>
<term>Quercétine (synthèse chimique)</term>
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<term>Virus du SRAS (physiologie)</term>
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<front><div type="abstract" xml:lang="en">Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV.</div>
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