Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus*
Identifieur interne : 002444 ( Ncbi/Merge ); précédent : 002443; suivant : 002445Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus*
Auteurs : Kailang Wu ; Guiqing Peng ; Matthew Wilken ; Robert J. Geraghty [États-Unis] ; Fang LiSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Humains, Liaison aux protéines, Lignée cellulaire, Modèles moléculaires, Mutation, Peptidyl-Dipeptidase A (), Peptidyl-Dipeptidase A (génétique), Peptidyl-Dipeptidase A (métabolisme), Protéines virales (), Protéines virales (génétique), Protéines virales (métabolisme), Récepteurs viraux (), Récepteurs viraux (génétique), Récepteurs viraux (métabolisme), Réservoirs d'agents pathogènes (virologie), Structure tertiaire des protéines, Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (virologie), Vecteurs de maladie, Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification), Virus du SRAS (métabolisme), Viverridae (génétique), Viverridae (métabolisme), Viverridae (virologie), Évolution moléculaire.
- MESH :
- génétique : Peptidyl-Dipeptidase A, Protéines virales, Récepteurs viraux, Syndrome respiratoire aigu sévère, Virus du SRAS, Viverridae.
- isolement et purification : Virus du SRAS.
- métabolisme : Peptidyl-Dipeptidase A, Protéines virales, Récepteurs viraux, Syndrome respiratoire aigu sévère, Virus du SRAS, Viverridae.
- virologie : Réservoirs d'agents pathogènes, Syndrome respiratoire aigu sévère, Viverridae.
- Animaux, Humains, Liaison aux protéines, Lignée cellulaire, Modèles moléculaires, Mutation, Peptidyl-Dipeptidase A, Protéines virales, Récepteurs viraux, Structure tertiaire des protéines, Vecteurs de maladie, Virus du SRAS, Évolution moléculaire.
English descriptors
- KwdEn :
- Animals, Cell Line, Disease Reservoirs (virology), Disease Vectors, Evolution, Molecular, Humans, Models, Molecular, Mutation, Peptidyl-Dipeptidase A (chemistry), Peptidyl-Dipeptidase A (genetics), Peptidyl-Dipeptidase A (metabolism), Protein Binding, Protein Structure, Tertiary, Receptors, Virus (chemistry), Receptors, Virus (genetics), Receptors, Virus (metabolism), SARS Virus (chemistry), SARS Virus (genetics), SARS Virus (isolation & purification), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (metabolism), Viverridae (genetics), Viverridae (metabolism), Viverridae (virology).
- MESH :
- chemical , chemistry : Peptidyl-Dipeptidase A, Receptors, Virus, Viral Proteins.
- chemical , genetics : Peptidyl-Dipeptidase A, Receptors, Virus, Viral Proteins.
- chemical , metabolism : Peptidyl-Dipeptidase A, Receptors, Virus, Viral Proteins.
- chemistry : SARS Virus.
- genetics : SARS Virus, Severe Acute Respiratory Syndrome, Viverridae.
- isolation & purification : SARS Virus.
- metabolism : SARS Virus, Severe Acute Respiratory Syndrome, Viverridae.
- virology : Disease Reservoirs, Severe Acute Respiratory Syndrome, Viverridae.
- Animals, Cell Line, Disease Vectors, Evolution, Molecular, Humans, Models, Molecular, Mutation, Protein Binding, Protein Structure, Tertiary.
Abstract
Url:
DOI: 10.1074/jbc.M111.325803
PubMed: 22291007
PubMed Central: 3308800
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PMC:3308800Le document en format XML
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Syndrome Coronavirus<xref ref-type="fn" rid="FN1">*</xref><xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic></sup></xref></title><author><name sortKey="Wu, Kailang" sort="Wu, Kailang" uniqKey="Wu K" first="Kailang" last="Wu">Kailang Wu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Peng, Guiqing" sort="Peng, Guiqing" uniqKey="Peng G" first="Guiqing" last="Peng">Guiqing Peng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wilken, Matthew" sort="Wilken, Matthew" uniqKey="Wilken M" first="Matthew" last="Wilken">Matthew Wilken</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Geraghty, Robert J" sort="Geraghty, Robert J" uniqKey="Geraghty R" first="Robert J." last="Geraghty">Robert J. Geraghty</name><affiliation wicri:level="2"><nlm:aff id="aff2">Center for Drug Design, University of Minnesota Medical School, Minneapolis, Minnesota 55455</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Center for Drug Design, University of Minnesota Medical School, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22291007</idno><idno type="pmc">3308800</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308800</idno><idno type="RBID">PMC:3308800</idno><idno type="doi">10.1074/jbc.M111.325803</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001111</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001111</idno><idno type="wicri:Area/Pmc/Curation">001111</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001111</idno><idno type="wicri:Area/Pmc/Checkpoint">000A49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A49</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:22291007</idno><idno type="wicri:Area/PubMed/Corpus">001413</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001413</idno><idno type="wicri:Area/PubMed/Curation">001413</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001413</idno><idno type="wicri:Area/PubMed/Checkpoint">001325</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001325</idno><idno type="wicri:Area/Ncbi/Merge">002444</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory
Syndrome Coronavirus<xref ref-type="fn" rid="FN1">*</xref><xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic></sup></xref></title><author><name sortKey="Wu, Kailang" sort="Wu, Kailang" uniqKey="Wu K" first="Kailang" last="Wu">Kailang Wu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Peng, Guiqing" sort="Peng, Guiqing" uniqKey="Peng G" first="Guiqing" last="Peng">Guiqing Peng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wilken, Matthew" sort="Wilken, Matthew" uniqKey="Wilken M" first="Matthew" last="Wilken">Matthew Wilken</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Geraghty, Robert J" sort="Geraghty, Robert J" uniqKey="Geraghty R" first="Robert J." last="Geraghty">Robert J. Geraghty</name><affiliation wicri:level="2"><nlm:aff id="aff2">Center for Drug Design, University of Minnesota Medical School, Minneapolis, Minnesota 55455</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Center for Drug Design, University of Minnesota Medical School, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Disease Reservoirs (virology)</term><term>Disease Vectors</term><term>Evolution, Molecular</term><term>Humans</term><term>Models, Molecular</term><term>Mutation</term><term>Peptidyl-Dipeptidase A (chemistry)</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Protein Binding</term><term>Protein Structure, Tertiary</term><term>Receptors, Virus (chemistry)</term><term>Receptors, Virus (genetics)</term><term>Receptors, Virus (metabolism)</term><term>SARS Virus (chemistry)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>SARS Virus (metabolism)</term><term>Severe Acute Respiratory Syndrome (genetics)</term><term>Severe Acute Respiratory Syndrome (metabolism)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term><term>Viverridae (genetics)</term><term>Viverridae (metabolism)</term><term>Viverridae (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles moléculaires</term><term>Mutation</term><term>Peptidyl-Dipeptidase A ()</term><term>Peptidyl-Dipeptidase A (génétique)</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Protéines virales ()</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Récepteurs viraux ()</term><term>Récepteurs viraux (génétique)</term><term>Récepteurs viraux (métabolisme)</term><term>Réservoirs d'agents pathogènes (virologie)</term><term>Structure tertiaire des protéines</term><term>Syndrome respiratoire aigu sévère (génétique)</term><term>Syndrome respiratoire aigu sévère (métabolisme)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Vecteurs de maladie</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (isolement et purification)</term><term>Virus du SRAS (métabolisme)</term><term>Viverridae (génétique)</term><term>Viverridae (métabolisme)</term><term>Viverridae (virologie)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term><term>Protéines virales</term><term>Récepteurs viraux</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term><term>Protéines virales</term><term>Récepteurs viraux</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Réservoirs d'agents pathogènes</term><term>Syndrome respiratoire aigu sévère</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Disease Reservoirs</term><term>Severe Acute Respiratory Syndrome</term><term>Viverridae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Disease Vectors</term><term>Evolution, Molecular</term><term>Humans</term><term>Models, Molecular</term><term>Mutation</term><term>Protein Binding</term><term>Protein Structure, Tertiary</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles moléculaires</term><term>Mutation</term><term>Peptidyl-Dipeptidase A</term><term>Protéines virales</term><term>Récepteurs viraux</term><term>Structure tertiaire des protéines</term><term>Vecteurs de maladie</term><term>Virus du SRAS</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> The severe acute respiratory syndrome (SARS) virus has
undergone mutations in its receptor-binding domain.</p><p><bold>Results:</bold> We used biochemical, functional, and crystallographic
methods to investigate these mutations.</p><p><bold>Conclusion:</bold> These mutations were viral adaptations to either the
human or palm civet receptor.</p><p><bold>Significance:</bold> This research elucidates detailed mechanisms of host
receptor adaptation by the SARS virus and can help predict and monitor future
evolution of the SARS virus in animals.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N. Lee</name></author><author><name sortKey="Hui, D" uniqKey="Hui D">D. Hui</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A. Wu</name></author><author><name sortKey="Chan, P" uniqKey="Chan P">P. Chan</name></author><author><name sortKey="Cameron, P" uniqKey="Cameron P">P. Cameron</name></author><author><name sortKey="Joynt, G M" uniqKey="Joynt G">G. M. Joynt</name></author><author><name sortKey="Ahuja, A" uniqKey="Ahuja A">A. Ahuja</name></author><author><name sortKey="Yung, M Y" uniqKey="Yung M">M. Y. Yung</name></author><author><name sortKey="Leung, C B" uniqKey="Leung C">C. B. Leung</name></author><author><name sortKey="To, K F" uniqKey="To K">K. F. To</name></author><author><name sortKey="Lui, S F" uniqKey="Lui S">S. F. Lui</name></author><author><name sortKey="Szeto, C C" uniqKey="Szeto C">C. C. 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Murshudov</name></author><author><name sortKey="Vagin, A A" uniqKey="Vagin A">A. A. Vagin</name></author><author><name sortKey="Lebedev, A" uniqKey="Lebedev A">A. Lebedev</name></author><author><name sortKey="Wilson, K S" uniqKey="Wilson K">K. S. Wilson</name></author><author><name sortKey="Dodson, E J" uniqKey="Dodson E">E. J. Dodson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fenn, T D" uniqKey="Fenn T">T. D. Fenn</name></author><author><name sortKey="Ringe, D" uniqKey="Ringe D">D. Ringe</name></author><author><name sortKey="Petsko, G A" uniqKey="Petsko G">G. A. Petsko</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="22291007"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory
Syndrome Coronavirus<xref ref-type="fn" rid="FN1">*</xref><xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic></sup></xref></title><author><name sortKey="Wu, Kailang" sort="Wu, Kailang" uniqKey="Wu K" first="Kailang" last="Wu">Kailang Wu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Peng, Guiqing" sort="Peng, Guiqing" uniqKey="Peng G" first="Guiqing" last="Peng">Guiqing Peng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wilken, Matthew" sort="Wilken, Matthew" uniqKey="Wilken M" first="Matthew" last="Wilken">Matthew Wilken</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Geraghty, Robert J" sort="Geraghty, Robert J" uniqKey="Geraghty R" first="Robert J." last="Geraghty">Robert J. Geraghty</name><affiliation wicri:level="2"><nlm:aff id="aff2">Center for Drug Design, University of Minnesota Medical School, Minneapolis, Minnesota 55455</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Center for Drug Design, University of Minnesota Medical School, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22291007</idno><idno type="pmc">3308800</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308800</idno><idno type="RBID">PMC:3308800</idno><idno type="doi">10.1074/jbc.M111.325803</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001111</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001111</idno><idno type="wicri:Area/Pmc/Curation">001111</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001111</idno><idno type="wicri:Area/Pmc/Checkpoint">000A49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A49</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory
Syndrome Coronavirus<xref ref-type="fn" rid="FN1">*</xref><xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic></sup></xref></title><author><name sortKey="Wu, Kailang" sort="Wu, Kailang" uniqKey="Wu K" first="Kailang" last="Wu">Kailang Wu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Peng, Guiqing" sort="Peng, Guiqing" uniqKey="Peng G" first="Guiqing" last="Peng">Guiqing Peng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wilken, Matthew" sort="Wilken, Matthew" uniqKey="Wilken M" first="Matthew" last="Wilken">Matthew Wilken</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Geraghty, Robert J" sort="Geraghty, Robert J" uniqKey="Geraghty R" first="Robert J." last="Geraghty">Robert J. Geraghty</name><affiliation wicri:level="2"><nlm:aff id="aff2">Center for Drug Design, University of Minnesota Medical School, Minneapolis, Minnesota 55455</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Center for Drug Design, University of Minnesota Medical School, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> The severe acute respiratory syndrome (SARS) virus has
undergone mutations in its receptor-binding domain.</p><p><bold>Results:</bold> We used biochemical, functional, and crystallographic
methods to investigate these mutations.</p><p><bold>Conclusion:</bold> These mutations were viral adaptations to either the
human or palm civet receptor.</p><p><bold>Significance:</bold> This research elucidates detailed mechanisms of host
receptor adaptation by the SARS virus and can help predict and monitor future
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Geraghty</name></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22291007</idno><idno type="pmid">22291007</idno><idno type="doi">10.1074/jbc.M111.325803</idno><idno type="wicri:Area/PubMed/Corpus">001413</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001413</idno><idno type="wicri:Area/PubMed/Curation">001413</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001413</idno><idno type="wicri:Area/PubMed/Checkpoint">001325</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001325</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus.</title><author><name sortKey="Wu, Kailang" sort="Wu, Kailang" uniqKey="Wu K" first="Kailang" last="Wu">Kailang Wu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology,University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology,University of Minnesota Medical School, Minneapolis, Minnesota 55455</wicri:regionArea><wicri:noRegion>Minnesota 55455</wicri:noRegion></affiliation></author><author><name sortKey="Peng, Guiqing" sort="Peng, Guiqing" uniqKey="Peng G" first="Guiqing" last="Peng">Guiqing Peng</name></author><author><name sortKey="Wilken, Matthew" sort="Wilken, Matthew" uniqKey="Wilken M" first="Matthew" last="Wilken">Matthew Wilken</name></author><author><name sortKey="Geraghty, Robert J" sort="Geraghty, Robert J" uniqKey="Geraghty R" first="Robert J" last="Geraghty">Robert J. Geraghty</name></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name></author></analytic><series><title level="j">The Journal of biological chemistry</title><idno type="eISSN">1083-351X</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Disease Reservoirs (virology)</term><term>Disease Vectors</term><term>Evolution, Molecular</term><term>Humans</term><term>Models, Molecular</term><term>Mutation</term><term>Peptidyl-Dipeptidase A (chemistry)</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Protein Binding</term><term>Protein Structure, Tertiary</term><term>Receptors, Virus (chemistry)</term><term>Receptors, Virus (genetics)</term><term>Receptors, Virus (metabolism)</term><term>SARS Virus (chemistry)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>SARS Virus (metabolism)</term><term>Severe Acute Respiratory Syndrome (genetics)</term><term>Severe Acute Respiratory Syndrome (metabolism)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term><term>Viverridae (genetics)</term><term>Viverridae (metabolism)</term><term>Viverridae (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles moléculaires</term><term>Mutation</term><term>Peptidyl-Dipeptidase A ()</term><term>Peptidyl-Dipeptidase A (génétique)</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Protéines virales ()</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Récepteurs viraux ()</term><term>Récepteurs viraux (génétique)</term><term>Récepteurs viraux (métabolisme)</term><term>Réservoirs d'agents pathogènes (virologie)</term><term>Structure tertiaire des protéines</term><term>Syndrome respiratoire aigu sévère (génétique)</term><term>Syndrome respiratoire aigu sévère (métabolisme)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Vecteurs de maladie</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (isolement et purification)</term><term>Virus du SRAS (métabolisme)</term><term>Viverridae (génétique)</term><term>Viverridae (métabolisme)</term><term>Viverridae (virologie)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term><term>Protéines virales</term><term>Récepteurs viraux</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term><term>Protéines virales</term><term>Récepteurs viraux</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Réservoirs d'agents pathogènes</term><term>Syndrome respiratoire aigu sévère</term><term>Viverridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Disease Reservoirs</term><term>Severe Acute Respiratory Syndrome</term><term>Viverridae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Disease Vectors</term><term>Evolution, Molecular</term><term>Humans</term><term>Models, Molecular</term><term>Mutation</term><term>Protein Binding</term><term>Protein Structure, Tertiary</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles moléculaires</term><term>Mutation</term><term>Peptidyl-Dipeptidase A</term><term>Protéines virales</term><term>Récepteurs viraux</term><term>Structure tertiaire des protéines</term><term>Vecteurs de maladie</term><term>Virus du SRAS</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The severe acute respiratory syndrome coronavirus (SARS-CoV) from palm civets has twice evolved the capacity to infect humans by gaining binding affinity for human receptor angiotensin-converting enzyme 2 (ACE2). Numerous mutations have been identified in the receptor-binding domain (RBD) of different SARS-CoV strains isolated from humans or civets. Why these mutations were naturally selected or how SARS-CoV evolved to adapt to different host receptors has been poorly understood, presenting evolutionary and epidemic conundrums. In this study, we investigated the impact of these mutations on receptor recognition, an important determinant of SARS-CoV infection and pathogenesis. Using a combination of biochemical, functional, and crystallographic approaches, we elucidated the molecular and structural mechanisms of each of these naturally selected RBD mutations. These mutations either strengthen favorable interactions or reduce unfavorable interactions with two virus-binding hot spots on ACE2, and by doing so, they enhance viral interactions with either human (hACE2) or civet (cACE2) ACE2. Therefore, these mutations were viral adaptations to either hACE2 or cACE2. To corroborate the above analysis, we designed and characterized two optimized RBDs. The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2. The civet-optimized RBD contains all of the cACE2-adapted residues (Tyr-442, Pro-472, Arg-479, Gly-480, and Thr-487) and possesses exceptionally high affinity for cACE2 and also substantial affinity for hACE2. These results not only illustrate the detailed mechanisms of host receptor adaptation by SARS-CoV but also provide a molecular and structural basis for tracking future SARS-CoV evolution in animals.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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