Determining SARS sub-clinical infection: a longitudinal seroepidemiological study in recovered SARS patients and controls after an outbreak in a general hospital.
Identifieur interne : 001E96 ( Ncbi/Merge ); précédent : 001E95; suivant : 001E97Determining SARS sub-clinical infection: a longitudinal seroepidemiological study in recovered SARS patients and controls after an outbreak in a general hospital.
Auteurs : Zhen Yang [République populaire de Chine] ; Shixin Wang ; Qian Li ; Yuming Li ; Maoti Wei ; Hongsheng Gao ; Catherine Donovan ; Peizhong Peter WangSource :
- Scandinavian journal of infectious diseases [ 1651-1980 ] ; 2009.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Femelle, Flambées de maladies, Humains, Hôpitaux généraux, Immunoglobuline G (sang), Immunoglobuline M (sang), Mâle, Sensibilité et spécificité, Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (épidémiologie), Technique d'immunofluorescence, Test ELISA, Études longitudinales, Études séroépidémiologiques.
- MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- immunologie : Syndrome respiratoire aigu sévère.
- sang : Anticorps antiviraux, Immunoglobuline G, Immunoglobuline M.
- épidémiologie : Syndrome respiratoire aigu sévère.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Flambées de maladies, Humains, Hôpitaux généraux, Mâle, Sensibilité et spécificité, Technique d'immunofluorescence, Test ELISA, Études longitudinales, Études séroépidémiologiques.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibodies, Viral (blood), Disease Outbreaks, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Hospitals, General, Humans, Immunoglobulin G (blood), Immunoglobulin M (blood), Longitudinal Studies, Male, Middle Aged, Sensitivity and Specificity, Seroepidemiologic Studies, Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (immunology).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M.
- diagnosis : Severe Acute Respiratory Syndrome.
- epidemiology : Severe Acute Respiratory Syndrome.
- immunology : Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Disease Outbreaks, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Hospitals, General, Humans, Longitudinal Studies, Male, Middle Aged, Sensitivity and Specificity, Seroepidemiologic Studies.
Abstract
A cohort of 67 confirmed SARS patients were prospectively followed for 16 months and were compared with a control population. Serum samples taken at various times were tested for IgG and IgM; dynamic serological changes in these antibodies were described. The positive responses of IgM and IgG antibodies in sera against SARS virus from the first week to the sixth week after onset of the illness in patients with SARS were measured. The ELISA test of IgG antibody was negative in 200 community controls. The positive rate in the SARS high-risk population was 0.61% tested by ELISA and 0.21% by IFA. The high-risk population in this study was defined as those who provided health care and other services to SARS patients during the outbreak. IgG antibody in convalescent serum of patients with SARS revealed an increasing trend, peaking at the 22nd week after onset of illness followed by a slow decline. IgM appeared earlier than IgG and can be better used for early detection. IgG remained at a high level for a much longer period, serving as a good indicator for follow-up and for assessing past exposure. Our results also suggest that sub-clinical infection, if it exists, is very rare.
DOI: 10.1080/00365540902919384
PubMed: 19396666
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compared with a control population. Serum samples taken at various times were tested for IgG and IgM; dynamic serological changes in these antibodies were described. The positive responses of IgM and IgG antibodies in sera against SARS virus from the first week to the sixth week after onset of the illness in patients with SARS were measured. The ELISA test of IgG antibody was negative in 200 community controls. The positive rate in the SARS high-risk population was 0.61% tested by ELISA and 0.21% by IFA. The high-risk population in this study was defined as those who provided health care and other services to SARS patients during the outbreak. IgG antibody in convalescent serum of patients with SARS revealed an increasing trend, peaking at the 22nd week after onset of illness followed by a slow decline. IgM appeared earlier than IgG and can be better used for early detection. IgG remained at a high level for a much longer period, serving as a good indicator for follow-up and for assessing past exposure. 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Dis.</ISOAbbreviation></Journal><ArticleTitle>Determining SARS sub-clinical infection: a longitudinal seroepidemiological study in recovered SARS patients and controls after an outbreak in a general hospital.</ArticleTitle><Pagination><MedlinePgn>507-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/00365540902919384</ELocationID><Abstract><AbstractText>A cohort of 67 confirmed SARS patients were prospectively followed for 16 months and were compared with a control population. Serum samples taken at various times were tested for IgG and IgM; dynamic serological changes in these antibodies were described. The positive responses of IgM and IgG antibodies in sera against SARS virus from the first week to the sixth week after onset of the illness in patients with SARS were measured. The ELISA test of IgG antibody was negative in 200 community controls. The positive rate in the SARS high-risk population was 0.61% tested by ELISA and 0.21% by IFA. The high-risk population in this study was defined as those who provided health care and other services to SARS patients during the outbreak. IgG antibody in convalescent serum of patients with SARS revealed an increasing trend, peaking at the 22nd week after onset of illness followed by a slow decline. IgM appeared earlier than IgG and can be better used for early detection. IgG remained at a high level for a much longer period, serving as a good indicator for follow-up and for assessing past exposure. Our results also suggest that sub-clinical infection, if it exists, is very rare.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Zhen</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Science Research, Medical College of Chinese People's Armed Police Force, Tianjin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Shixin</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Qian</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yuming</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Maoti</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Hongsheng</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Donovan</LastName><ForeName>Catherine</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Peizhong Peter</ForeName><Initials>PP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Scand J Infect Dis</MedlineTA><NlmUniqueID>0215333</NlmUniqueID><ISSNLinking>0036-5548</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007075">Immunoglobulin 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Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>4</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>4</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19396666</ArticleId><ArticleId IdType="pii">910696428</ArticleId><ArticleId IdType="doi">10.1080/00365540902919384</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Tianjin</li></settlement></list><tree><noCountry><name sortKey="Donovan, Catherine" sort="Donovan, Catherine" uniqKey="Donovan C" first="Catherine" last="Donovan">Catherine Donovan</name><name sortKey="Gao, Hongsheng" sort="Gao, Hongsheng" uniqKey="Gao H" first="Hongsheng" last="Gao">Hongsheng Gao</name><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name><name sortKey="Li, Yuming" sort="Li, Yuming" uniqKey="Li Y" first="Yuming" last="Li">Yuming Li</name><name sortKey="Wang, Peizhong Peter" sort="Wang, Peizhong Peter" uniqKey="Wang P" first="Peizhong Peter" last="Wang">Peizhong Peter Wang</name><name sortKey="Wang, Shixin" sort="Wang, Shixin" uniqKey="Wang S" first="Shixin" last="Wang">Shixin Wang</name><name sortKey="Wei, Maoti" sort="Wei, Maoti" uniqKey="Wei M" first="Maoti" last="Wei">Maoti Wei</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Zhen" sort="Yang, Zhen" uniqKey="Yang Z" first="Zhen" last="Yang">Zhen Yang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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