Determining SARS sub-clinical infection: a longitudinal seroepidemiological study in recovered SARS patients and controls after an outbreak in a general hospital.
Identifieur interne : 001921 ( PubMed/Corpus ); précédent : 001920; suivant : 001922Determining SARS sub-clinical infection: a longitudinal seroepidemiological study in recovered SARS patients and controls after an outbreak in a general hospital.
Auteurs : Zhen Yang ; Shixin Wang ; Qian Li ; Yuming Li ; Maoti Wei ; Hongsheng Gao ; Catherine Donovan ; Peizhong Peter WangSource :
- Scandinavian journal of infectious diseases [ 1651-1980 ] ; 2009.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibodies, Viral (blood), Disease Outbreaks, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Hospitals, General, Humans, Immunoglobulin G (blood), Immunoglobulin M (blood), Longitudinal Studies, Male, Middle Aged, Sensitivity and Specificity, Seroepidemiologic Studies, Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (immunology).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M.
- diagnosis : Severe Acute Respiratory Syndrome.
- epidemiology : Severe Acute Respiratory Syndrome.
- immunology : Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Disease Outbreaks, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Hospitals, General, Humans, Longitudinal Studies, Male, Middle Aged, Sensitivity and Specificity, Seroepidemiologic Studies.
Abstract
A cohort of 67 confirmed SARS patients were prospectively followed for 16 months and were compared with a control population. Serum samples taken at various times were tested for IgG and IgM; dynamic serological changes in these antibodies were described. The positive responses of IgM and IgG antibodies in sera against SARS virus from the first week to the sixth week after onset of the illness in patients with SARS were measured. The ELISA test of IgG antibody was negative in 200 community controls. The positive rate in the SARS high-risk population was 0.61% tested by ELISA and 0.21% by IFA. The high-risk population in this study was defined as those who provided health care and other services to SARS patients during the outbreak. IgG antibody in convalescent serum of patients with SARS revealed an increasing trend, peaking at the 22nd week after onset of illness followed by a slow decline. IgM appeared earlier than IgG and can be better used for early detection. IgG remained at a high level for a much longer period, serving as a good indicator for follow-up and for assessing past exposure. Our results also suggest that sub-clinical infection, if it exists, is very rare.
DOI: 10.1080/00365540902919384
PubMed: 19396666
Links to Exploration step
pubmed:19396666Le document en format XML
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<author><name sortKey="Wang, Shixin" sort="Wang, Shixin" uniqKey="Wang S" first="Shixin" last="Wang">Shixin Wang</name>
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<author><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name>
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<author><name sortKey="Li, Yuming" sort="Li, Yuming" uniqKey="Li Y" first="Yuming" last="Li">Yuming Li</name>
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<author><name sortKey="Wei, Maoti" sort="Wei, Maoti" uniqKey="Wei M" first="Maoti" last="Wei">Maoti Wei</name>
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<author><name sortKey="Gao, Hongsheng" sort="Gao, Hongsheng" uniqKey="Gao H" first="Hongsheng" last="Gao">Hongsheng Gao</name>
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<front><div type="abstract" xml:lang="en">A cohort of 67 confirmed SARS patients were prospectively followed for 16 months and were compared with a control population. Serum samples taken at various times were tested for IgG and IgM; dynamic serological changes in these antibodies were described. The positive responses of IgM and IgG antibodies in sera against SARS virus from the first week to the sixth week after onset of the illness in patients with SARS were measured. The ELISA test of IgG antibody was negative in 200 community controls. The positive rate in the SARS high-risk population was 0.61% tested by ELISA and 0.21% by IFA. The high-risk population in this study was defined as those who provided health care and other services to SARS patients during the outbreak. IgG antibody in convalescent serum of patients with SARS revealed an increasing trend, peaking at the 22nd week after onset of illness followed by a slow decline. IgM appeared earlier than IgG and can be better used for early detection. IgG remained at a high level for a much longer period, serving as a good indicator for follow-up and for assessing past exposure. Our results also suggest that sub-clinical infection, if it exists, is very rare.</div>
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<Abstract><AbstractText>A cohort of 67 confirmed SARS patients were prospectively followed for 16 months and were compared with a control population. Serum samples taken at various times were tested for IgG and IgM; dynamic serological changes in these antibodies were described. The positive responses of IgM and IgG antibodies in sera against SARS virus from the first week to the sixth week after onset of the illness in patients with SARS were measured. The ELISA test of IgG antibody was negative in 200 community controls. The positive rate in the SARS high-risk population was 0.61% tested by ELISA and 0.21% by IFA. The high-risk population in this study was defined as those who provided health care and other services to SARS patients during the outbreak. IgG antibody in convalescent serum of patients with SARS revealed an increasing trend, peaking at the 22nd week after onset of illness followed by a slow decline. IgM appeared earlier than IgG and can be better used for early detection. IgG remained at a high level for a much longer period, serving as a good indicator for follow-up and for assessing past exposure. Our results also suggest that sub-clinical infection, if it exists, is very rare.</AbstractText>
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