Antiviral activity of nucleoside analogues against SARS-coronavirus (SARS-coV).
Identifieur interne : 001809 ( Ncbi/Merge ); précédent : 001808; suivant : 001810Antiviral activity of nucleoside analogues against SARS-coronavirus (SARS-coV).
Auteurs : Chung K. Chu [États-Unis] ; Srinivas Gadthula ; Xin Chen ; Hyunah Choo ; Sureyya Olgen ; Dale L. Barnard ; Robert W. SidwellSource :
- Antiviral chemistry & chemotherapy [ 0956-3202 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Chlorocebus aethiops, Microbial Sensitivity Tests, Molecular Structure, Nucleosides (chemistry), Nucleosides (pharmacology), SARS Virus (drug effects), Structure-Activity Relationship, Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , chemistry : Antiviral Agents, Nucleosides.
- chemical , pharmacology : Antiviral Agents, Nucleosides.
- drug effects : SARS Virus, Virus Replication.
- Animals, Chlorocebus aethiops, Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship, Vero Cells.
Abstract
The recent outbreak of severe acute respiratory syndrome (SARS), which is an acute respiratory illness, is caused by newly discovered SARS coronavirus (SARS-CoV). Herein we describe the antiviral activity of several classes of nucleoside analogues evaluated against SARS-CoV in Vero 76 cells, some of which exhibited moderate activity.
DOI: 10.1177/095632020601700506
PubMed: 17176633
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pubmed:17176633Le document en format XML
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<wicri:regionArea>The University of Georgia, College of Pharmacy, Athens, GA</wicri:regionArea>
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<author><name sortKey="Gadthula, Srinivas" sort="Gadthula, Srinivas" uniqKey="Gadthula S" first="Srinivas" last="Gadthula">Srinivas Gadthula</name>
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<author><name sortKey="Chen, Xin" sort="Chen, Xin" uniqKey="Chen X" first="Xin" last="Chen">Xin Chen</name>
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<author><name sortKey="Choo, Hyunah" sort="Choo, Hyunah" uniqKey="Choo H" first="Hyunah" last="Choo">Hyunah Choo</name>
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<author><name sortKey="Olgen, Sureyya" sort="Olgen, Sureyya" uniqKey="Olgen S" first="Sureyya" last="Olgen">Sureyya Olgen</name>
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<term>Microbial Sensitivity Tests</term>
<term>Molecular Structure</term>
<term>Nucleosides (chemistry)</term>
<term>Nucleosides (pharmacology)</term>
<term>SARS Virus (drug effects)</term>
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<term>Vero Cells</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
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<term>Tests de sensibilité microbienne</term>
<term>Virus du SRAS ()</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term>
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<term>Antiviraux</term>
<term>Cellules Vero</term>
<term>Nucléosides</term>
<term>Relation structure-activité</term>
<term>Réplication virale</term>
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<term>Tests de sensibilité microbienne</term>
<term>Virus du SRAS</term>
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<front><div type="abstract" xml:lang="en">The recent outbreak of severe acute respiratory syndrome (SARS), which is an acute respiratory illness, is caused by newly discovered SARS coronavirus (SARS-CoV). Herein we describe the antiviral activity of several classes of nucleoside analogues evaluated against SARS-CoV in Vero 76 cells, some of which exhibited moderate activity.</div>
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