Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS)1
Identifieur interne : 001218 ( Ncbi/Merge ); précédent : 001217; suivant : 001219Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS)1
Auteurs : Jian Xu [République populaire de Chine] ; Lihua Qi [République populaire de Chine] ; Xiaochun Chi [République populaire de Chine] ; Jingjing Yang [République populaire de Chine] ; Xiaohong Wei [République populaire de Chine] ; Encong Gong [République populaire de Chine] ; Suatcheng Peh [République populaire de Chine] ; Jiang Gu [République populaire de Chine]Source :
- Biology of Reproduction [ 0006-3363 ] ; 2006.
Descripteurs français
- KwdFr :
- Antigènes CD (immunologie), Antigènes de différenciation des myélomonocytes (immunologie), Apoptose, Humains, Leucocytes (cytologie), Mâle, Orchite (anatomopathologie), Orchite (virologie), Orchite (étiologie), Syndrome respiratoire aigu sévère (), Testicule (anatomopathologie), Testicule (immunologie), Testicule (virologie), Virus du SRAS (isolement et purification).
- MESH :
- anatomopathologie : Orchite, Testicule.
- cytologie : Leucocytes.
- immunologie : Antigènes CD, Antigènes de différenciation des myélomonocytes, Testicule.
- isolement et purification : Virus du SRAS.
- virologie : Orchite, Testicule.
- étiologie : Orchite.
- Apoptose, Humains, Mâle, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Antigens, CD (immunology), Antigens, Differentiation, Myelomonocytic (immunology), Apoptosis, Humans, Leukocytes (cytology), Male, Orchitis (etiology), Orchitis (pathology), Orchitis (virology), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (complications), Testis (immunology), Testis (pathology), Testis (virology).
- MESH :
- chemical , immunology : Antigens, CD, Antigens, Differentiation, Myelomonocytic.
- complications : Severe Acute Respiratory Syndrome.
- cytology : Leukocytes.
- etiology : Orchitis.
- immunology : Testis.
- isolation & purification : SARS Virus.
- pathology : Orchitis, Testis.
- virology : Orchitis, Testis.
- Apoptosis, Humans, Male.
Abstract
Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (
Url:
DOI: 10.1095/biolreprod.105.044776
PubMed: 16237152
PubMed Central: 7109827
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PMC:7109827Le document en format XML
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<series><title level="j">Biology of Reproduction</title>
<idno type="ISSN">0006-3363</idno>
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<term>Antigens, Differentiation, Myelomonocytic (immunology)</term>
<term>Apoptosis</term>
<term>Humans</term>
<term>Leukocytes (cytology)</term>
<term>Male</term>
<term>Orchitis (etiology)</term>
<term>Orchitis (pathology)</term>
<term>Orchitis (virology)</term>
<term>SARS Virus (isolation & purification)</term>
<term>Severe Acute Respiratory Syndrome (complications)</term>
<term>Testis (immunology)</term>
<term>Testis (pathology)</term>
<term>Testis (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes CD (immunologie)</term>
<term>Antigènes de différenciation des myélomonocytes (immunologie)</term>
<term>Apoptose</term>
<term>Humains</term>
<term>Leucocytes (cytologie)</term>
<term>Mâle</term>
<term>Orchite (anatomopathologie)</term>
<term>Orchite (virologie)</term>
<term>Orchite (étiologie)</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Testicule (anatomopathologie)</term>
<term>Testicule (immunologie)</term>
<term>Testicule (virologie)</term>
<term>Virus du SRAS (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, CD</term>
<term>Antigens, Differentiation, Myelomonocytic</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Orchite</term>
<term>Testicule</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Leucocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Leukocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Orchitis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes CD</term>
<term>Antigènes de différenciation des myélomonocytes</term>
<term>Testicule</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Testis</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Orchitis</term>
<term>Testis</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Orchite</term>
<term>Testicule</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orchitis</term>
<term>Testis</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Orchite</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term>
<term>Humains</term>
<term>Mâle</term>
<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (<italic>P</italic>
< 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.</p>
</div>
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<double pmid="16237152"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS)<xref ref-type="author-notes" rid="fn1"><sup>1</sup>
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<author><name sortKey="Yang, Jingjing" sort="Yang, Jingjing" uniqKey="Yang J" first="Jingjing" last="Yang">Jingjing Yang</name>
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</author>
<author><name sortKey="Wei, Xiaohong" sort="Wei, Xiaohong" uniqKey="Wei X" first="Xiaohong" last="Wei">Xiaohong Wei</name>
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<placeName><settlement type="city">Pékin</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Gong, Encong" sort="Gong, Encong" uniqKey="Gong E" first="Encong" last="Gong">Encong Gong</name>
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<placeName><settlement type="city">Pékin</settlement>
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<placeName><settlement type="city">Pékin</settlement>
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<author><name sortKey="Peh, Suatcheng" sort="Peh, Suatcheng" uniqKey="Peh S" first="Suatcheng" last="Peh">Suatcheng Peh</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
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</affiliation>
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<idno type="pmid">16237152</idno>
<idno type="pmc">7109827</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109827</idno>
<idno type="RBID">PMC:7109827</idno>
<idno type="doi">10.1095/biolreprod.105.044776</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS)<xref ref-type="author-notes" rid="fn1"><sup>1</sup>
</xref>
</title>
<author><name sortKey="Xu, Jian" sort="Xu, Jian" uniqKey="Xu J" first="Jian" last="Xu">Jian Xu</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qi, Lihua" sort="Qi, Lihua" uniqKey="Qi L" first="Lihua" last="Qi">Lihua Qi</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chi, Xiaochun" sort="Chi, Xiaochun" uniqKey="Chi X" first="Xiaochun" last="Chi">Xiaochun Chi</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Jingjing" sort="Yang, Jingjing" uniqKey="Yang J" first="Jingjing" last="Yang">Jingjing Yang</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wei, Xiaohong" sort="Wei, Xiaohong" uniqKey="Wei X" first="Xiaohong" last="Wei">Xiaohong Wei</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gong, Encong" sort="Gong, Encong" uniqKey="Gong E" first="Encong" last="Gong">Encong Gong</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peh, Suatcheng" sort="Peh, Suatcheng" uniqKey="Peh S" first="Suatcheng" last="Peh">Suatcheng Peh</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology of Reproduction</title>
<idno type="ISSN">0006-3363</idno>
<idno type="eISSN">1529-7268</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
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</profileDesc>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (<italic>P</italic>
< 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.</p>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Orchitis: a complication of severe acute respiratory syndrome (SARS).</title>
<author><name sortKey="Xu, Jian" sort="Xu, Jian" uniqKey="Xu J" first="Jian" last="Xu">Jian Xu</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy, School of Basic Medical Sciences, Peking University, Beijing 100083, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Anatomy, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qi, Lihua" sort="Qi, Lihua" uniqKey="Qi L" first="Lihua" last="Qi">Lihua Qi</name>
</author>
<author><name sortKey="Chi, Xiaochun" sort="Chi, Xiaochun" uniqKey="Chi X" first="Xiaochun" last="Chi">Xiaochun Chi</name>
</author>
<author><name sortKey="Yang, Jingjing" sort="Yang, Jingjing" uniqKey="Yang J" first="Jingjing" last="Yang">Jingjing Yang</name>
</author>
<author><name sortKey="Wei, Xiaohong" sort="Wei, Xiaohong" uniqKey="Wei X" first="Xiaohong" last="Wei">Xiaohong Wei</name>
</author>
<author><name sortKey="Gong, Encong" sort="Gong, Encong" uniqKey="Gong E" first="Encong" last="Gong">Encong Gong</name>
</author>
<author><name sortKey="Peh, Suatcheng" sort="Peh, Suatcheng" uniqKey="Peh S" first="Suatcheng" last="Peh">Suatcheng Peh</name>
</author>
<author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name>
</author>
</titleStmt>
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<date when="2006">2006</date>
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<idno type="pmid">16237152</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Orchitis: a complication of severe acute respiratory syndrome (SARS).</title>
<author><name sortKey="Xu, Jian" sort="Xu, Jian" uniqKey="Xu J" first="Jian" last="Xu">Jian Xu</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy, School of Basic Medical Sciences, Peking University, Beijing 100083, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Anatomy, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qi, Lihua" sort="Qi, Lihua" uniqKey="Qi L" first="Lihua" last="Qi">Lihua Qi</name>
</author>
<author><name sortKey="Chi, Xiaochun" sort="Chi, Xiaochun" uniqKey="Chi X" first="Xiaochun" last="Chi">Xiaochun Chi</name>
</author>
<author><name sortKey="Yang, Jingjing" sort="Yang, Jingjing" uniqKey="Yang J" first="Jingjing" last="Yang">Jingjing Yang</name>
</author>
<author><name sortKey="Wei, Xiaohong" sort="Wei, Xiaohong" uniqKey="Wei X" first="Xiaohong" last="Wei">Xiaohong Wei</name>
</author>
<author><name sortKey="Gong, Encong" sort="Gong, Encong" uniqKey="Gong E" first="Encong" last="Gong">Encong Gong</name>
</author>
<author><name sortKey="Peh, Suatcheng" sort="Peh, Suatcheng" uniqKey="Peh S" first="Suatcheng" last="Peh">Suatcheng Peh</name>
</author>
<author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name>
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</analytic>
<series><title level="j">Biology of reproduction</title>
<idno type="ISSN">0006-3363</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, CD (immunology)</term>
<term>Antigens, Differentiation, Myelomonocytic (immunology)</term>
<term>Apoptosis</term>
<term>Humans</term>
<term>Leukocytes (cytology)</term>
<term>Male</term>
<term>Orchitis (etiology)</term>
<term>Orchitis (pathology)</term>
<term>Orchitis (virology)</term>
<term>SARS Virus (isolation & purification)</term>
<term>Severe Acute Respiratory Syndrome (complications)</term>
<term>Testis (immunology)</term>
<term>Testis (pathology)</term>
<term>Testis (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes CD (immunologie)</term>
<term>Antigènes de différenciation des myélomonocytes (immunologie)</term>
<term>Apoptose</term>
<term>Humains</term>
<term>Leucocytes (cytologie)</term>
<term>Mâle</term>
<term>Orchite (anatomopathologie)</term>
<term>Orchite (virologie)</term>
<term>Orchite (étiologie)</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Testicule (anatomopathologie)</term>
<term>Testicule (immunologie)</term>
<term>Testicule (virologie)</term>
<term>Virus du SRAS (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, CD</term>
<term>Antigens, Differentiation, Myelomonocytic</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Orchite</term>
<term>Testicule</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Leucocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Leukocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Orchitis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes CD</term>
<term>Antigènes de différenciation des myélomonocytes</term>
<term>Testicule</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Testis</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Orchitis</term>
<term>Testis</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Orchite</term>
<term>Testicule</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orchitis</term>
<term>Testis</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Orchite</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term>
<term>Humains</term>
<term>Mâle</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (P < 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.</div>
</front>
</TEI>
</pubmed>
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