SrasV1, Ncbi, Merge, bibRecord, 001152

Screening and identification of linear B-cell epitopes and entry-blocking peptide of severe acute respiratory syndrome (SARS)-associated coronavirus using synthetic overlapping peptide library.

Identifieur interne : 001152 ( Ncbi/Merge ); précédent : 001151; suivant : 001153

Screening and identification of linear B-cell epitopes and entry-blocking peptide of severe acute respiratory syndrome (SARS)-associated coronavirus using synthetic overlapping peptide library.

Auteurs : Hongbo Hu [République populaire de Chine] ; Li Li ; Richard Y. Kao ; Binbin Kou ; Zhanguo Wang ; Liang Zhang ; Huiyuan Zhang ; Zhiyong Hao ; Wayne H. Tsui ; Anping Ni ; Lianxian Cui ; Baoxing Fan ; Feng Guo ; Shuan Rao ; Chengyu Jiang ; Qian Li ; Manji Sun ; Wei He ; Gang Liu

Source :

Journal of combinatorial chemistry [ 1520-4766 ]

RBID : pubmed:16153058

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Antigens, Viral (chemistry), Antigens, Viral (genetics), Antigens, Viral (immunology), Combinatorial Chemistry Techniques, Epitopes, B-Lymphocyte (chemistry), Epitopes, B-Lymphocyte (genetics), Epitopes, B-Lymphocyte (immunology), Molecular Sequence Data, Peptide Library, SARS Virus (chemistry), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology).
MESH :
- chemical , chemistry : Antigens, Viral, Epitopes, B-Lymphocyte.
- chemical , genetics : Antigens, Viral, Epitopes, B-Lymphocyte.
- chemical , immunology : Antigens, Viral, Epitopes, B-Lymphocyte.
- chemistry : SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Combinatorial Chemistry Techniques, Molecular Sequence Data, Peptide Library.

Abstract

A 10-mer overlapping peptide library has been synthesized for screening and identification of linear B-cell epitopes of severe acute respiratory syndrome associated coronavirus (SARS-CoV), which spanned the major structural proteins of SARS-CoV. One hundred and eleven candidate peptides were positive according to the result of PEPscan, which were assembled into 22 longer peptides. Five of these peptides showed high cross-immunoreactivities (approximately 66.7 to 90.5%) to SARS convalescent patients' sera from the severest epidemic regions of the China mainland. Most interestingly, S(471-503), a peptide located at the receptor binding domain (RBD) of SARS-CoV, could specifically block the binding between the RBD and angiotensin-converting enzyme 2, resulting in the inhibition of SARS-CoV entrance into host cells in vitro. The study demonstrated that S(471-503) peptide was a potential immunoantigen for the development of peptide-based vaccine or a candidate for further drug evaluation against the SARS-CoV virus-cell fusion.

DOI: 10.1021/cc0500607
PubMed: 16153058

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002550
to stream PubMed, to step Curation: 002550
to stream PubMed, to step Checkpoint: 003519

Links to Exploration step

pubmed:16153058

Le document en format XML

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<front><div type="abstract" xml:lang="en">A 10-mer overlapping peptide library has been synthesized for screening and identification of linear B-cell epitopes of severe acute respiratory syndrome associated coronavirus (SARS-CoV), which spanned the major structural proteins of SARS-CoV. One hundred and eleven candidate peptides were positive according to the result of PEPscan, which were assembled into 22 longer peptides. Five of these peptides showed high cross-immunoreactivities (approximately 66.7 to 90.5%) to SARS convalescent patients' sera from the severest epidemic regions of the China mainland. Most interestingly, S(471-503), a peptide located at the receptor binding domain (RBD) of SARS-CoV, could specifically block the binding between the RBD and angiotensin-converting enzyme 2, resulting in the inhibition of SARS-CoV entrance into host cells in vitro. The study demonstrated that S(471-503) peptide was a potential immunoantigen for the development of peptide-based vaccine or a candidate for further drug evaluation against the SARS-CoV virus-cell fusion.</div>
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<Abstract><AbstractText>A 10-mer overlapping peptide library has been synthesized for screening and identification of linear B-cell epitopes of severe acute respiratory syndrome associated coronavirus (SARS-CoV), which spanned the major structural proteins of SARS-CoV. One hundred and eleven candidate peptides were positive according to the result of PEPscan, which were assembled into 22 longer peptides. Five of these peptides showed high cross-immunoreactivities (approximately 66.7 to 90.5%) to SARS convalescent patients' sera from the severest epidemic regions of the China mainland. Most interestingly, S(471-503), a peptide located at the receptor binding domain (RBD) of SARS-CoV, could specifically block the binding between the RBD and angiotensin-converting enzyme 2, resulting in the inhibition of SARS-CoV entrance into host cells in vitro. The study demonstrated that S(471-503) peptide was a potential immunoantigen for the development of peptide-based vaccine or a candidate for further drug evaluation against the SARS-CoV virus-cell fusion.</AbstractText>
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<name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name>
<name sortKey="Kao, Richard Y" sort="Kao, Richard Y" uniqKey="Kao R" first="Richard Y" last="Kao">Richard Y. Kao</name>
<name sortKey="Kou, Binbin" sort="Kou, Binbin" uniqKey="Kou B" first="Binbin" last="Kou">Binbin Kou</name>
<name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name>
<name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name>
<name sortKey="Liu, Gang" sort="Liu, Gang" uniqKey="Liu G" first="Gang" last="Liu">Gang Liu</name>
<name sortKey="Ni, Anping" sort="Ni, Anping" uniqKey="Ni A" first="Anping" last="Ni">Anping Ni</name>
<name sortKey="Rao, Shuan" sort="Rao, Shuan" uniqKey="Rao S" first="Shuan" last="Rao">Shuan Rao</name>
<name sortKey="Sun, Manji" sort="Sun, Manji" uniqKey="Sun M" first="Manji" last="Sun">Manji Sun</name>
<name sortKey="Tsui, Wayne H" sort="Tsui, Wayne H" uniqKey="Tsui W" first="Wayne H" last="Tsui">Wayne H. Tsui</name>
<name sortKey="Wang, Zhanguo" sort="Wang, Zhanguo" uniqKey="Wang Z" first="Zhanguo" last="Wang">Zhanguo Wang</name>
<name sortKey="Zhang, Huiyuan" sort="Zhang, Huiyuan" uniqKey="Zhang H" first="Huiyuan" last="Zhang">Huiyuan Zhang</name>
<name sortKey="Zhang, Liang" sort="Zhang, Liang" uniqKey="Zhang L" first="Liang" last="Zhang">Liang Zhang</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Hu, Hongbo" sort="Hu, Hongbo" uniqKey="Hu H" first="Hongbo" last="Hu">Hongbo Hu</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001152 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001152 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:16153058
   |texte=   Screening and identification of linear B-cell epitopes and entry-blocking peptide of severe acute respiratory syndrome (SARS)-associated coronavirus using synthetic overlapping peptide library.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:16153058" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
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Serveur d'exploration SRAS

Screening and identification of linear B-cell epitopes and entry-blocking peptide of severe acute respiratory syndrome (SARS)-associated coronavirus using synthetic overlapping peptide library.

Screening and identification of linear B-cell epitopes and entry-blocking peptide of severe acute respiratory syndrome (SARS)-associated coronavirus using synthetic overlapping peptide library.

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Pour mettre un lien sur cette page dans le réseau Wicri

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