Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase
Identifieur interne : 000E61 ( Ncbi/Merge ); précédent : 000E60; suivant : 000E62Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase
Auteurs : D. Xu [République populaire de Chine] ; Z. Zhang [République populaire de Chine] ; L. Jin [République populaire de Chine] ; F. Chu [République populaire de Chine] ; Y. Mao [République populaire de Chine] ; H. Wang [République populaire de Chine] ; M. Liu [République populaire de Chine] ; M. Wang [République populaire de Chine] ; L. Zhang [République populaire de Chine] ; G. F. Gao [République populaire de Chine] ; F. S. Wang [République populaire de Chine]Source :
- European Journal of Clinical Microbiology & Infectious Diseases [ 0934-9723 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN viral (isolement et purification), ARN viral (sang), ARN viral (urine), Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Convalescence, Facteurs temps, Femelle, Fèces (virologie), Humains, Immunoglobuline G (sang), Immunoglobuline M (sang), Mâle, Sujet âgé, Syndrome respiratoire aigu sévère (urine), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification).
- MESH :
- isolement et purification : ARN viral, Virus du SRAS.
- sang : ARN viral, Anticorps antiviraux, Immunoglobuline G, Immunoglobuline M.
- virologie : Fèces, Syndrome respiratoire aigu sévère.
- urine : ARN viral, Adulte, Adulte d'âge moyen, Convalescence, Facteurs temps, Femelle, Humains, Mâle, Sujet âgé, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Adult, Aged, Antibodies, Viral (blood), Convalescence, Feces (virology), Female, Humans, Immunoglobulin G (blood), Immunoglobulin M (blood), Male, Middle Aged, RNA, Viral (blood), RNA, Viral (isolation & purification), RNA, Viral (urine), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (urine), Severe Acute Respiratory Syndrome (virology), Time Factors.
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M, RNA, Viral.
- chemical , isolation & purification : RNA, Viral.
- chemical , urine : RNA, Viral.
- isolation & purification : SARS Virus.
- urine : Severe Acute Respiratory Syndrome.
- virology : Feces, Severe Acute Respiratory Syndrome.
- Adult, Aged, Convalescence, Female, Humans, Male, Middle Aged, Time Factors.
Abstract
In order to further the present knowledge of the emerging severe acute respiratory syndrome-associated coronavirus (SARS-CoV), 486 different specimens from 54 patients with a clinical diagnosis of SARS were investigated for the presence of viral RNA, and 314 plasma specimens of 73 patients were examined for IgM and IgG antibodies specific against SARS-CoV using an indirect ELISA. Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29–36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.
Url:
DOI: 10.1007/s10096-005-1299-5
PubMed: 15789222
PubMed Central: 7088045
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PMC:7088045Le document en format XML
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Wang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">European Journal of Clinical Microbiology & Infectious Diseases</title><idno type="ISSN">0934-9723</idno><idno type="eISSN">1435-4373</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antibodies, Viral (blood)</term><term>Convalescence</term><term>Feces (virology)</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin M (blood)</term><term>Male</term><term>Middle Aged</term><term>RNA, Viral (blood)</term><term>RNA, Viral (isolation & purification)</term><term>RNA, Viral (urine)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (urine)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (isolement et purification)</term><term>ARN viral (sang)</term><term>ARN viral (urine)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Convalescence</term><term>Facteurs temps</term><term>Femelle</term><term>Fèces (virologie)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Immunoglobuline M (sang)</term><term>Mâle</term><term>Sujet âgé</term><term>Syndrome respiratoire aigu sévère (urine)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>ARN viral</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term><term>Anticorps antiviraux</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fèces</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Feces</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Convalescence</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>ARN viral</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Convalescence</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In order to further the present knowledge of the emerging severe acute respiratory syndrome-associated coronavirus (SARS-CoV), 486 different specimens from 54 patients with a clinical diagnosis of SARS were investigated for the presence of viral RNA, and 314 plasma specimens of 73 patients were examined for IgM and IgG antibodies specific against SARS-CoV using an indirect ELISA. Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29–36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tambyah, Pa" uniqKey="Tambyah P">PA Tambyah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author><author><name sortKey="Brodt, Hr" uniqKey="Brodt H">HR Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M Panning</name></author><author><name 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pmid="15789222"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase</title><author><name sortKey="Xu, D" sort="Xu, D" uniqKey="Xu D" first="D." last="Xu">D. Xu</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Z" sort="Zhang, Z" uniqKey="Zhang Z" first="Z." last="Zhang">Z. Zhang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jin, L" sort="Jin, L" uniqKey="Jin L" first="L." last="Jin">L. Jin</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chu, F" sort="Chu, F" uniqKey="Chu F" first="F." last="Chu">F. Chu</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Mao, Y" sort="Mao, Y" uniqKey="Mao Y" first="Y." last="Mao">Y. Mao</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, H" sort="Wang, H" uniqKey="Wang H" first="H." last="Wang">H. Wang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, M" sort="Liu, M" uniqKey="Liu M" first="M." last="Liu">M. Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Beijing Genomics Institute,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Wang, M" sort="Wang, M" uniqKey="Wang M" first="M." last="Wang">M. Wang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, L" sort="Zhang, L" uniqKey="Zhang L" first="L." last="Zhang">L. Zhang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Gao, G F" sort="Gao, G F" uniqKey="Gao G" first="G. F." last="Gao">G. F. Gao</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Institute of Microbiology,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Wang, F S" sort="Wang, F S" uniqKey="Wang F" first="F. S." last="Wang">F. S. Wang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15789222</idno><idno type="pmc">7088045</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088045</idno><idno type="RBID">PMC:7088045</idno><idno type="doi">10.1007/s10096-005-1299-5</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000371</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000371</idno><idno type="wicri:Area/Pmc/Curation">000371</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000371</idno><idno type="wicri:Area/Pmc/Checkpoint">001281</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001281</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase</title><author><name sortKey="Xu, D" sort="Xu, D" uniqKey="Xu D" first="D." last="Xu">D. Xu</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Z" sort="Zhang, Z" uniqKey="Zhang Z" first="Z." last="Zhang">Z. Zhang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jin, L" sort="Jin, L" uniqKey="Jin L" first="L." last="Jin">L. Jin</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chu, F" sort="Chu, F" uniqKey="Chu F" first="F." last="Chu">F. Chu</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Mao, Y" sort="Mao, Y" uniqKey="Mao Y" first="Y." last="Mao">Y. Mao</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, H" sort="Wang, H" uniqKey="Wang H" first="H." last="Wang">H. Wang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, M" sort="Liu, M" uniqKey="Liu M" first="M." last="Liu">M. Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Beijing Genomics Institute,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Wang, M" sort="Wang, M" uniqKey="Wang M" first="M." last="Wang">M. Wang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, L" sort="Zhang, L" uniqKey="Zhang L" first="L." last="Zhang">L. Zhang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Gao, G F" sort="Gao, G F" uniqKey="Gao G" first="G. F." last="Gao">G. F. Gao</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Institute of Microbiology,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Wang, F S" sort="Wang, F S" uniqKey="Wang F" first="F. S." last="Wang">F. S. Wang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">European Journal of Clinical Microbiology & Infectious Diseases</title><idno type="ISSN">0934-9723</idno><idno type="eISSN">1435-4373</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In order to further the present knowledge of the emerging severe acute respiratory syndrome-associated coronavirus (SARS-CoV), 486 different specimens from 54 patients with a clinical diagnosis of SARS were investigated for the presence of viral RNA, and 314 plasma specimens of 73 patients were examined for IgM and IgG antibodies specific against SARS-CoV using an indirect ELISA. Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29–36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tambyah, Pa" uniqKey="Tambyah P">PA Tambyah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author><author><name sortKey="Brodt, Hr" uniqKey="Brodt H">HR Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M Panning</name></author><author><name 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xml:lang="en">Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase.</title><author><name sortKey="Xu, D" sort="Xu, D" uniqKey="Xu D" first="D" last="Xu">D. Xu</name><affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing, 100039, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing, 100039</wicri:regionArea><wicri:noRegion>100039</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Z" sort="Zhang, Z" uniqKey="Zhang Z" first="Z" last="Zhang">Z. Zhang</name></author><author><name sortKey="Jin, L" sort="Jin, L" uniqKey="Jin L" first="L" last="Jin">L. Jin</name></author><author><name sortKey="Chu, F" sort="Chu, F" uniqKey="Chu F" first="F" last="Chu">F. Chu</name></author><author><name sortKey="Mao, Y" sort="Mao, Y" uniqKey="Mao Y" first="Y" last="Mao">Y. Mao</name></author><author><name sortKey="Wang, H" sort="Wang, H" uniqKey="Wang H" first="H" last="Wang">H. Wang</name></author><author><name sortKey="Liu, M" sort="Liu, M" uniqKey="Liu M" first="M" last="Liu">M. Liu</name></author><author><name sortKey="Wang, M" sort="Wang, M" uniqKey="Wang M" first="M" last="Wang">M. Wang</name></author><author><name sortKey="Zhang, L" sort="Zhang, L" uniqKey="Zhang L" first="L" last="Zhang">L. Zhang</name></author><author><name sortKey="Gao, G F" sort="Gao, G F" uniqKey="Gao G" first="G F" last="Gao">G F Gao</name></author><author><name sortKey="Wang, F S" sort="Wang, F S" uniqKey="Wang F" first="F S" last="Wang">F S Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15789222</idno><idno type="pmid">15789222</idno><idno type="doi">10.1007/s10096-005-1299-5</idno><idno type="wicri:Area/PubMed/Corpus">002821</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002821</idno><idno type="wicri:Area/PubMed/Curation">002821</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002821</idno><idno type="wicri:Area/PubMed/Checkpoint">002583</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002583</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase.</title><author><name sortKey="Xu, D" sort="Xu, D" uniqKey="Xu D" first="D" last="Xu">D. Xu</name><affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing, 100039, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing, 100039</wicri:regionArea><wicri:noRegion>100039</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Z" sort="Zhang, Z" uniqKey="Zhang Z" first="Z" last="Zhang">Z. Zhang</name></author><author><name sortKey="Jin, L" sort="Jin, L" uniqKey="Jin L" first="L" last="Jin">L. Jin</name></author><author><name sortKey="Chu, F" sort="Chu, F" uniqKey="Chu F" first="F" last="Chu">F. Chu</name></author><author><name sortKey="Mao, Y" sort="Mao, Y" uniqKey="Mao Y" first="Y" last="Mao">Y. Mao</name></author><author><name sortKey="Wang, H" sort="Wang, H" uniqKey="Wang H" first="H" last="Wang">H. Wang</name></author><author><name sortKey="Liu, M" sort="Liu, M" uniqKey="Liu M" first="M" last="Liu">M. Liu</name></author><author><name sortKey="Wang, M" sort="Wang, M" uniqKey="Wang M" first="M" last="Wang">M. Wang</name></author><author><name sortKey="Zhang, L" sort="Zhang, L" uniqKey="Zhang L" first="L" last="Zhang">L. Zhang</name></author><author><name sortKey="Gao, G F" sort="Gao, G F" uniqKey="Gao G" first="G F" last="Gao">G F Gao</name></author><author><name sortKey="Wang, F S" sort="Wang, F S" uniqKey="Wang F" first="F S" last="Wang">F S Wang</name></author></analytic><series><title level="j">European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</title><idno type="ISSN">0934-9723</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antibodies, Viral (blood)</term><term>Convalescence</term><term>Feces (virology)</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin M (blood)</term><term>Male</term><term>Middle Aged</term><term>RNA, Viral (blood)</term><term>RNA, Viral (isolation & purification)</term><term>RNA, Viral (urine)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (urine)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (isolement et purification)</term><term>ARN viral (sang)</term><term>ARN viral (urine)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Convalescence</term><term>Facteurs temps</term><term>Femelle</term><term>Fèces (virologie)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Immunoglobuline M (sang)</term><term>Mâle</term><term>Sujet âgé</term><term>Syndrome respiratoire aigu sévère (urine)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>ARN viral</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term><term>Anticorps antiviraux</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fèces</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Feces</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Convalescence</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>ARN viral</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Convalescence</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to further the present knowledge of the emerging severe acute respiratory syndrome-associated coronavirus (SARS-CoV), 486 different specimens from 54 patients with a clinical diagnosis of SARS were investigated for the presence of viral RNA, and 314 plasma specimens of 73 patients were examined for IgM and IgG antibodies specific against SARS-CoV using an indirect ELISA. Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29-36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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