Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase
Identifieur interne : 001281 ( Pmc/Checkpoint ); précédent : 001280; suivant : 001282Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase
Auteurs : D. Xu [République populaire de Chine] ; Z. Zhang [République populaire de Chine] ; L. Jin [République populaire de Chine] ; F. Chu [République populaire de Chine] ; Y. Mao [République populaire de Chine] ; H. Wang [République populaire de Chine] ; M. Liu [République populaire de Chine] ; M. Wang [République populaire de Chine] ; L. Zhang [République populaire de Chine] ; G. F. Gao [République populaire de Chine] ; F. S. Wang [République populaire de Chine]Source :
- European Journal of Clinical Microbiology & Infectious Diseases [ 0934-9723 ] ; 2005.
Abstract
In order to further the present knowledge of the emerging severe acute respiratory syndrome-associated coronavirus (SARS-CoV), 486 different specimens from 54 patients with a clinical diagnosis of SARS were investigated for the presence of viral RNA, and 314 plasma specimens of 73 patients were examined for IgM and IgG antibodies specific against SARS-CoV using an indirect ELISA. Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29–36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.
Url:
DOI: 10.1007/s10096-005-1299-5
PubMed: 15789222
PubMed Central: 7088045
Affiliations:
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Gao</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Institute of Microbiology,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Wang, F S" sort="Wang, F S" uniqKey="Wang F" first="F. S." last="Wang">F. S. Wang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>100 Xi Si Huan Middle Road, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">European Journal of Clinical Microbiology & Infectious Diseases</title><idno type="ISSN">0934-9723</idno><idno type="eISSN">1435-4373</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In order to further the present knowledge of the emerging severe acute respiratory syndrome-associated coronavirus (SARS-CoV), 486 different specimens from 54 patients with a clinical diagnosis of SARS were investigated for the presence of viral RNA, and 314 plasma specimens of 73 patients were examined for IgM and IgG antibodies specific against SARS-CoV using an indirect ELISA. Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29–36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tambyah, Pa" uniqKey="Tambyah P">PA Tambyah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author><author><name sortKey="Brodt, Hr" uniqKey="Brodt H">HR Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M Panning</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur J Clin Microbiol Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Eur. J. Clin. Microbiol. Infect. Dis</journal-id><journal-title-group><journal-title>European Journal of Clinical Microbiology & Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0934-9723</issn><issn pub-type="epub">1435-4373</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15789222</article-id><article-id pub-id-type="pmc">7088045</article-id><article-id pub-id-type="publisher-id">1299</article-id><article-id pub-id-type="doi">10.1007/s10096-005-1299-5</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Xu</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Z.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jin</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mao</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>G. F.</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Wang</surname><given-names>F. S.</given-names></name><address><phone>+86-10-66933332</phone><fax>+86-10-63831870</fax><email>fswang@public.bta.net.cn</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.413135.1</institution-id><institution-id institution-id-type="ISNI">0000000417643045</institution-id><institution>Beijing Institute of Infectious Diseases,</institution><institution>Beijing 302 Hospital,</institution></institution-wrap>100 Xi Si Huan Middle Road, Beijing, 100039 China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Beijing Genomics Institute,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>Beijing, China</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Institute of Microbiology,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>Beijing, China</aff></contrib-group><pub-date pub-type="epub"><day>24</day><month>3</month><year>2005</year></pub-date><pub-date pub-type="ppub"><year>2005</year></pub-date><volume>24</volume><issue>3</issue><fpage>165</fpage><lpage>171</lpage><permissions><copyright-statement>© Springer-Verlag 2005</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>In order to further the present knowledge of the emerging severe acute respiratory syndrome-associated coronavirus (SARS-CoV), 486 different specimens from 54 patients with a clinical diagnosis of SARS were investigated for the presence of viral RNA, and 314 plasma specimens of 73 patients were examined for IgM and IgG antibodies specific against SARS-CoV using an indirect ELISA. Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29–36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Severe Acute Respiratory Syndrome</kwd><kwd>Urine Specimen</kwd><kwd>Stool Specimen</kwd><kwd>Severe Acute Respiratory Syndrome</kwd><kwd>Severe Acute Respiratory Syndrome Patient</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag 2005</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, D" sort="Xu, D" uniqKey="Xu D" first="D." last="Xu">D. Xu</name></noRegion><name sortKey="Chu, F" sort="Chu, F" uniqKey="Chu F" first="F." last="Chu">F. Chu</name><name sortKey="Gao, G F" sort="Gao, G F" uniqKey="Gao G" first="G. F." last="Gao">G. F. Gao</name><name sortKey="Jin, L" sort="Jin, L" uniqKey="Jin L" first="L." last="Jin">L. Jin</name><name sortKey="Liu, M" sort="Liu, M" uniqKey="Liu M" first="M." last="Liu">M. Liu</name><name sortKey="Mao, Y" sort="Mao, Y" uniqKey="Mao Y" first="Y." last="Mao">Y. Mao</name><name sortKey="Wang, F S" sort="Wang, F S" uniqKey="Wang F" first="F. S." last="Wang">F. S. Wang</name><name sortKey="Wang, H" sort="Wang, H" uniqKey="Wang H" first="H." last="Wang">H. Wang</name><name sortKey="Wang, M" sort="Wang, M" uniqKey="Wang M" first="M." last="Wang">M. Wang</name><name sortKey="Zhang, L" sort="Zhang, L" uniqKey="Zhang L" first="L." last="Zhang">L. Zhang</name><name sortKey="Zhang, Z" sort="Zhang, Z" uniqKey="Zhang Z" first="Z." last="Zhang">Z. 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