Renal hypouricemia is an ominous sign in patients with severe acute respiratory syndrome
Identifieur interne : 000D69 ( Ncbi/Merge ); précédent : 000D68; suivant : 000D70Renal hypouricemia is an ominous sign in patients with severe acute respiratory syndrome
Auteurs : Vin-Cent Wu [Taïwan] ; Jenq-Wen Huang [Taïwan] ; Po-Ren Hsueh [Taïwan] ; Ya-Fei Yang [Taïwan] ; Hung-Bin Tsai [Taïwan] ; Wei-Chih Kan [Taïwan] ; Hong-Wei Chang [Taïwan] ; Kwan-Dun Wu [Taïwan]Source :
- American Journal of Kidney Diseases [ 0272-6386 ] ; 2005.
Abstract
Url:
DOI: 10.1053/j.ajkd.2004.09.031
PubMed: 15696447
PubMed Central: 7115701
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Renal hypouricemia is an ominous sign in patients with severe acute respiratory syndrome</title><author><name sortKey="Wu, Vin Cent" sort="Wu, Vin Cent" uniqKey="Wu V" first="Vin-Cent" last="Wu">Vin-Cent Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Jenq Wen" sort="Huang, Jenq Wen" uniqKey="Huang J" first="Jenq-Wen" last="Huang">Jenq-Wen Huang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Laboratory Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Ya Fei" sort="Yang, Ya Fei" uniqKey="Yang Y" first="Ya-Fei" last="Yang">Ya-Fei Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Hung Bin" sort="Tsai, Hung Bin" uniqKey="Tsai H" first="Hung-Bin" last="Tsai">Hung-Bin Tsai</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Kan, Wei Chih" sort="Kan, Wei Chih" uniqKey="Kan W" first="Wei-Chih" last="Kan">Wei-Chih Kan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Hong Wei" sort="Chang, Hong Wei" uniqKey="Chang H" first="Hong-Wei" last="Chang">Hong-Wei Chang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Kwan Dun" sort="Wu, Kwan Dun" uniqKey="Wu K" first="Kwan-Dun" last="Wu">Kwan-Dun Wu</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15696447</idno><idno type="pmc">7115701</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115701</idno><idno type="RBID">PMC:7115701</idno><idno type="doi">10.1053/j.ajkd.2004.09.031</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000D74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D74</idno><idno type="wicri:Area/Pmc/Curation">000D74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D74</idno><idno type="wicri:Area/Pmc/Checkpoint">001256</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001256</idno><idno type="wicri:Area/Ncbi/Merge">000D69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Renal hypouricemia is an ominous sign in patients with severe acute respiratory syndrome</title><author><name sortKey="Wu, Vin Cent" sort="Wu, Vin Cent" uniqKey="Wu V" first="Vin-Cent" last="Wu">Vin-Cent Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Jenq Wen" sort="Huang, Jenq Wen" uniqKey="Huang J" first="Jenq-Wen" last="Huang">Jenq-Wen Huang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Laboratory Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Ya Fei" sort="Yang, Ya Fei" uniqKey="Yang Y" first="Ya-Fei" last="Yang">Ya-Fei Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Hung Bin" sort="Tsai, Hung Bin" uniqKey="Tsai H" first="Hung-Bin" last="Tsai">Hung-Bin Tsai</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Kan, Wei Chih" sort="Kan, Wei Chih" uniqKey="Kan W" first="Wei-Chih" last="Kan">Wei-Chih Kan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Hong Wei" sort="Chang, Hong Wei" uniqKey="Chang H" first="Hong-Wei" last="Chang">Hong-Wei Chang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Kwan Dun" sort="Wu, Kwan Dun" uniqKey="Wu K" first="Kwan-Dun" last="Wu">Kwan-Dun Wu</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></analytic><series><title level="j">American Journal of Kidney Diseases</title><idno type="ISSN">0272-6386</idno><idno type="eISSN">1523-6838</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic><underline>Background:</underline></italic> The purpose of this study is to determine the incidence and significance of hypouricemia in patients with severe acute respiratory syndrome (SARS). Pulmonary lesions in patients with SARS are thought to result from proinflammatory cytokine dysregulation. Acute renal failure has been reported in patients with SARS, but whether cytokines can injure renal tubules is unknown. <italic><underline>Methods:</underline></italic> Sixty patients diagnosed with SARS in Taiwan in April 2003 were studied. Patients were identified as hypouricemic when their serum uric acid (UA) level was less than 2.5 mg/dL (<149 μmol/L) within 15 days after fever onset. Urine UA and creatinine levels were available for 43 patients; the serum cytokines interleukin-6 (IL-6), IL-8, and tumor necrosis factor-α (TNF-α) were measured in 16 patients. <italic><underline>Results:</underline></italic> Sixteen patients (26.7%) had hypouricemia (UA, 1.68 ± 0.52 mg/dL [100 ± 31 μmol/L]). No differences in age, sex, symptoms, vital signs, hemogram, or other biochemistry data existed between the hypouricemic and normouricemic groups. Fractional excretion (FE) of UA (FE<sub>UA</sub>) in 12 hypouricemic patients was 39.6% ± 23.4%, significantly greater than that of 31 normouricemic patients (16.4% ± 11.4%; <italic>P</italic> < 0.0001). After adjustments for age and sex, high FE<sub>UA</sub> was significantly associated with the lowest blood oxygenation (<italic>P</italic> = 0.001; <italic>r</italic> = −0.624). The number of catastrophic outcomes (endotracheal intubation and/or death) adjusted for older age and sex showed that hypouremic patients had an odds ratio of 10.57 (confidence interval, 2.33 to 47.98; <italic>P</italic> = 0.002). Kaplan-Meier curves for catastrophic outcome–free results showed significant differences between patients with normouricemia or hypouricemia (<italic>P</italic> = 0.01). Serum IL-8 levels correlated significantly with FE<sub>UA</sub> (<italic>P</italic> < 0.001; <italic>r</italic> = 0.785) and inversely with serum UA level (<italic>P</italic> = 0.044; <italic>r</italic> = −0.509); neither IL-6 nor TNF-α level showed such correlations. <italic><underline>Conclusion:</underline></italic> One fourth of patients with SARS developed hypouricemia, which might result from a defect in renal UA handling and was associated with a high serum IL-8 level. Renal hypouricemia is an ominous sign in patients with SARS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D. Erdman</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Kidney Dis</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Kidney Dis</journal-id><journal-title-group><journal-title>American Journal of Kidney Diseases</journal-title></journal-title-group><issn pub-type="ppub">0272-6386</issn><issn pub-type="epub">1523-6838</issn><publisher><publisher-name>National Kidney Foundation, Inc. Published by Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15696447</article-id><article-id pub-id-type="pmc">7115701</article-id><article-id pub-id-type="publisher-id">S0272-6386(04)01418-0</article-id><article-id pub-id-type="doi">10.1053/j.ajkd.2004.09.031</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Renal hypouricemia is an ominous sign in patients with severe acute respiratory syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Vin-Cent</given-names></name><degrees>MD</degrees><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Jenq-Wen</given-names></name><degrees>MD</degrees><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Hsueh</surname><given-names>Po-Ren</given-names></name><degrees>MD</degrees><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Ya-Fei</given-names></name><degrees>MD</degrees><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Tsai</surname><given-names>Hung-Bin</given-names></name><degrees>MD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Kan</surname><given-names>Wei-Chih</given-names></name><degrees>MD</degrees><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Hong-Wei</given-names></name><degrees>MD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Kwan-Dun</given-names></name><degrees>MD, PhD</degrees><email>kdw@ntumc.org</email><xref rid="aff2" ref-type="aff">b</xref><xref rid="cor1" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><collab>SARS Research Group of National Taiwan University College of Medicine and National Taiwan University Hospital</collab></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan</aff><aff id="aff2"><label>b</label>Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan</aff><aff id="aff3"><label>c</label>Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan</aff><author-notes><corresp id="cor1"><label>*</label>Address reprint requests to Kwan-Dun Wu, MD, PhD, Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Rd, Taipei, Taiwan <email>kdw@ntumc.org</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>21</day><month>2</month><year>2008</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>1</month><year>2005</year></pub-date><pub-date pub-type="epub"><day>21</day><month>2</month><year>2008</year></pub-date><volume>45</volume><issue>1</issue><fpage>88</fpage><lpage>95</lpage><history><date date-type="received"><day>16</day><month>6</month><year>2004</year></date><date date-type="accepted"><day>9</day><month>9</month><year>2004</year></date></history><permissions><copyright-statement>Copyright © 2004 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2004</copyright-year><copyright-holder>National Kidney Foundation, Inc.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><p><italic><underline>Background:</underline></italic> The purpose of this study is to determine the incidence and significance of hypouricemia in patients with severe acute respiratory syndrome (SARS). Pulmonary lesions in patients with SARS are thought to result from proinflammatory cytokine dysregulation. Acute renal failure has been reported in patients with SARS, but whether cytokines can injure renal tubules is unknown. <italic><underline>Methods:</underline></italic> Sixty patients diagnosed with SARS in Taiwan in April 2003 were studied. Patients were identified as hypouricemic when their serum uric acid (UA) level was less than 2.5 mg/dL (<149 μmol/L) within 15 days after fever onset. Urine UA and creatinine levels were available for 43 patients; the serum cytokines interleukin-6 (IL-6), IL-8, and tumor necrosis factor-α (TNF-α) were measured in 16 patients. <italic><underline>Results:</underline></italic> Sixteen patients (26.7%) had hypouricemia (UA, 1.68 ± 0.52 mg/dL [100 ± 31 μmol/L]). No differences in age, sex, symptoms, vital signs, hemogram, or other biochemistry data existed between the hypouricemic and normouricemic groups. Fractional excretion (FE) of UA (FE<sub>UA</sub>) in 12 hypouricemic patients was 39.6% ± 23.4%, significantly greater than that of 31 normouricemic patients (16.4% ± 11.4%; <italic>P</italic> < 0.0001). After adjustments for age and sex, high FE<sub>UA</sub> was significantly associated with the lowest blood oxygenation (<italic>P</italic> = 0.001; <italic>r</italic> = −0.624). The number of catastrophic outcomes (endotracheal intubation and/or death) adjusted for older age and sex showed that hypouremic patients had an odds ratio of 10.57 (confidence interval, 2.33 to 47.98; <italic>P</italic> = 0.002). Kaplan-Meier curves for catastrophic outcome–free results showed significant differences between patients with normouricemia or hypouricemia (<italic>P</italic> = 0.01). Serum IL-8 levels correlated significantly with FE<sub>UA</sub> (<italic>P</italic> < 0.001; <italic>r</italic> = 0.785) and inversely with serum UA level (<italic>P</italic> = 0.044; <italic>r</italic> = −0.509); neither IL-6 nor TNF-α level showed such correlations. <italic><underline>Conclusion:</underline></italic> One fourth of patients with SARS developed hypouricemia, which might result from a defect in renal UA handling and was associated with a high serum IL-8 level. Renal hypouricemia is an ominous sign in patients with SARS.</p></abstract><kwd-group><title>Index words</title><kwd>Hypouricemia</kwd><kwd>severe acute respiratory syndrome (SARS)</kwd><kwd>uric acid (UA)</kwd><kwd>fraction excretion (FE)</kwd><kwd>renal tubule</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Wu, Vin Cent" sort="Wu, Vin Cent" uniqKey="Wu V" first="Vin-Cent" last="Wu">Vin-Cent Wu</name></noRegion><name sortKey="Chang, Hong Wei" sort="Chang, Hong Wei" uniqKey="Chang H" first="Hong-Wei" last="Chang">Hong-Wei Chang</name><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name><name sortKey="Huang, Jenq Wen" sort="Huang, Jenq Wen" uniqKey="Huang J" first="Jenq-Wen" last="Huang">Jenq-Wen Huang</name><name sortKey="Kan, Wei Chih" sort="Kan, Wei Chih" uniqKey="Kan W" first="Wei-Chih" last="Kan">Wei-Chih Kan</name><name sortKey="Tsai, Hung Bin" sort="Tsai, Hung Bin" uniqKey="Tsai H" first="Hung-Bin" last="Tsai">Hung-Bin Tsai</name><name sortKey="Wu, Kwan Dun" sort="Wu, Kwan Dun" uniqKey="Wu K" first="Kwan-Dun" last="Wu">Kwan-Dun Wu</name><name sortKey="Wu, Vin Cent" sort="Wu, Vin Cent" uniqKey="Wu V" first="Vin-Cent" last="Wu">Vin-Cent Wu</name><name sortKey="Yang, Ya Fei" sort="Yang, Ya Fei" uniqKey="Yang Y" first="Ya-Fei" last="Yang">Ya-Fei Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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