Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice
Identifieur interne : 002874 ( Ncbi/Curation ); précédent : 002873; suivant : 002875Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice
Auteurs : Christopher M. Coleman [États-Unis] ; Ye V. Liu [États-Unis] ; Haiyan Mu [États-Unis] ; Justin K. Taylor [États-Unis] ; Michael Massare [États-Unis] ; David C. Flyer [États-Unis] ; Gregory M. Glenn [États-Unis] ; Gale E. Smith [États-Unis] ; Matthew B. Frieman [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2014.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Coronavirus, Glycoprotéine de spicule des coronavirus (biosynthèse), Glycoprotéine de spicule des coronavirus (immunologie), Infections à coronavirus (), Nanoparticules, Protection croisée, Protéines recombinantes (biosynthèse), Protéines recombinantes (immunologie), Souris, Souris de lignée BALB C, Tests de neutralisation, Vaccins antiviraux (immunologie).
- MESH :
- administration et posologie : Adjuvants immunologiques.
- biosynthèse : Glycoprotéine de spicule des coronavirus, Protéines recombinantes.
- immunologie : Glycoprotéine de spicule des coronavirus, Protéines recombinantes, Vaccins antiviraux.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Animaux, Coronavirus, Infections à coronavirus, Nanoparticules, Protection croisée, Souris, Souris de lignée BALB C, Tests de neutralisation.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Coronavirus, Coronavirus Infections (prevention & control), Cross Protection, Mice, Mice, Inbred BALB C, Nanoparticles, Neutralization Tests, Recombinant Proteins (biosynthesis), Recombinant Proteins (immunology), Spike Glycoprotein, Coronavirus (biosynthesis), Spike Glycoprotein, Coronavirus (immunology), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic.
- chemical , biosynthesis : Recombinant Proteins, Spike Glycoprotein, Coronavirus.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , immunology : Recombinant Proteins, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- prevention & control : Coronavirus Infections.
- Animals, Coronavirus, Cross Protection, Mice, Mice, Inbred BALB C, Nanoparticles, Neutralization Tests.
Abstract
Emergence of MERS-CoV demonstrates the need for novel vaccine strategies against coronaviruses. Production of novel nanoparticle vaccine containing full spike protein of MERS-CoV and SARS-CoV. Higher titer neutralizing antibody produced in vaccinated mice. Vaccination in combination with a new adjuvant, Matrix M1, boosts neutralizing antibody titer.
Url:
DOI: 10.1016/j.vaccine.2014.04.016
PubMed: 24736006
PubMed Central: 4058772
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PMC:4058772Le document en format XML
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Flyer</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Novavax, Inc. 22 Firstfield Rd, Gaithersburg, MD 20852, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc. 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Glenn, Gregory M" sort="Glenn, Gregory M" uniqKey="Glenn G" first="Gregory M." last="Glenn">Gregory M. Glenn</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Novavax, Inc. 22 Firstfield Rd, Gaithersburg, MD 20852, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc. 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Smith, Gale E" sort="Smith, Gale E" uniqKey="Smith G" first="Gale E." last="Smith">Gale E. Smith</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Novavax, Inc. 22 Firstfield Rd, Gaithersburg, MD 20852, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc. 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B." last="Frieman">Matthew B. Frieman</name><affiliation wicri:level="4"><nlm:aff id="aff0005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic (administration & dosage)</term><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Coronavirus</term><term>Coronavirus Infections (prevention & control)</term><term>Cross Protection</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Nanoparticles</term><term>Neutralization Tests</term><term>Recombinant Proteins (biosynthesis)</term><term>Recombinant Proteins (immunology)</term><term>Spike Glycoprotein, Coronavirus (biosynthesis)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques (administration et posologie)</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Coronavirus</term><term>Glycoprotéine de spicule des coronavirus (biosynthèse)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Infections à coronavirus ()</term><term>Nanoparticules</term><term>Protection croisée</term><term>Protéines recombinantes (biosynthèse)</term><term>Protéines recombinantes (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tests de neutralisation</term><term>Vaccins antiviraux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Recombinant Proteins</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Recombinant Proteins</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term><term>Protéines recombinantes</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Coronavirus</term><term>Cross Protection</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Nanoparticles</term><term>Neutralization Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus</term><term>Infections à coronavirus</term><term>Nanoparticules</term><term>Protection croisée</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Emergence of MERS-CoV demonstrates the need for novel vaccine strategies against coronaviruses.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Production of novel nanoparticle vaccine containing full spike protein of MERS-CoV and SARS-CoV.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Higher titer neutralizing antibody produced in vaccinated mice.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Vaccination in combination with a new adjuvant, Matrix M1, boosts neutralizing antibody titer.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jackwood, M W" uniqKey="Jackwood M">M.W. 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Devitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, C M" uniqKey="Coleman C">C.M. Coleman</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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