The immune gene repertoire of an important viral reservoir, the Australian black flying fox.
Identifieur interne : 002519 ( Ncbi/Curation ); précédent : 002518; suivant : 002520The immune gene repertoire of an important viral reservoir, the Australian black flying fox.
Auteurs : Anthony T. Papenfuss [Australie] ; Michelle L. Baker ; Zhi-Ping Feng ; Mary Tachedjian ; Gary Crameri ; Chris Cowled ; Justin Ng ; Vijaya Janardhana ; Hume E. Field ; Lin-Fa WangSource :
- BMC genomics [ 1471-2164 ] ; 2012.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Alignement de séquences, Animaux, Annotation de séquence moléculaire, Antigènes d'histocompatibilité (), Antigènes d'histocompatibilité (génétique), Australie, Chiroptera (génétique), Chiroptera (immunologie), Chiroptera (virologie), Données de séquences moléculaires, Equus caballus (génétique), Humains, Immunité acquise (génétique), Immunité innée (génétique), Phylogénie, Récepteurs immunologiques (), Récepteurs immunologiques (génétique), Récepteurs immunologiques (métabolisme), Réservoirs d'agents pathogènes (virologie), Similitude de séquences d'acides nucléiques, Système immunitaire (métabolisme), Séquence conservée (génétique), Séquence d'acides aminés, Transcriptome (génétique), Vecteurs de maladie.
- MESH :
- génétique : ARN messager, Antigènes d'histocompatibilité, Chiroptera, Equus caballus, Immunité acquise, Immunité innée, Récepteurs immunologiques, Séquence conservée, Transcriptome.
- immunologie : Chiroptera.
- métabolisme : ARN messager, Récepteurs immunologiques, Système immunitaire.
- virologie : Chiroptera, Réservoirs d'agents pathogènes.
- Alignement de séquences, Animaux, Annotation de séquence moléculaire, Antigènes d'histocompatibilité, Australie, Données de séquences moléculaires, Humains, Phylogénie, Récepteurs immunologiques, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Vecteurs de maladie.
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
- Adaptive Immunity (genetics), Amino Acid Sequence, Animals, Australia, Chiroptera (genetics), Chiroptera (immunology), Chiroptera (virology), Conserved Sequence (genetics), Disease Reservoirs (virology), Disease Vectors, Histocompatibility Antigens (chemistry), Histocompatibility Antigens (genetics), Horses (genetics), Humans, Immune System (metabolism), Immunity, Innate (genetics), Molecular Sequence Annotation, Molecular Sequence Data, Phylogeny, RNA, Messenger (genetics), RNA, Messenger (metabolism), Receptors, Immunologic (chemistry), Receptors, Immunologic (genetics), Receptors, Immunologic (metabolism), Sequence Alignment, Sequence Homology, Nucleic Acid, Transcriptome (genetics).
- MESH :
- chemical , chemistry : Histocompatibility Antigens, Receptors, Immunologic.
- chemical , genetics : Histocompatibility Antigens, RNA, Messenger, Receptors, Immunologic.
- chemical , metabolism : RNA, Messenger, Receptors, Immunologic.
- geographic : Australia.
- genetics : Adaptive Immunity, Chiroptera, Conserved Sequence, Horses, Immunity, Innate, Transcriptome.
- immunology : Chiroptera.
- metabolism : Immune System.
- virology : Chiroptera, Disease Reservoirs.
- Amino Acid Sequence, Animals, Disease Vectors, Humans, Molecular Sequence Annotation, Molecular Sequence Data, Phylogeny, Sequence Alignment, Sequence Homology, Nucleic Acid.
Abstract
Bats are the natural reservoir host for a range of emerging and re-emerging viruses, including SARS-like coronaviruses, Ebola viruses, henipaviruses and Rabies viruses. However, the mechanisms responsible for the control of viral replication in bats are not understood and there is little information available on any aspect of antiviral immunity in bats. Massively parallel sequencing of the bat transcriptome provides the opportunity for rapid gene discovery. Although the genomes of one megabat and one microbat have now been sequenced to low coverage, no transcriptomic datasets have been reported from any bat species. In this study, we describe the immune transcriptome of the Australian flying fox, Pteropus alecto, providing an important resource for identification of genes involved in a range of activities including antiviral immunity.
DOI: 10.1186/1471-2164-13-261
PubMed: 22716473
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pubmed:22716473Le document en format XML
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<term>Chiroptera (immunology)</term>
<term>Chiroptera (virology)</term>
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<term>Disease Reservoirs (virology)</term>
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<term>Histocompatibility Antigens (chemistry)</term>
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<term>Immune System (metabolism)</term>
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<term>RNA, Messenger (metabolism)</term>
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<term>Vecteurs de maladie</term>
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<term>Annotation de séquence moléculaire</term>
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<term>Données de séquences moléculaires</term>
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<term>Phylogénie</term>
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<front><div type="abstract" xml:lang="en">Bats are the natural reservoir host for a range of emerging and re-emerging viruses, including SARS-like coronaviruses, Ebola viruses, henipaviruses and Rabies viruses. However, the mechanisms responsible for the control of viral replication in bats are not understood and there is little information available on any aspect of antiviral immunity in bats. Massively parallel sequencing of the bat transcriptome provides the opportunity for rapid gene discovery. Although the genomes of one megabat and one microbat have now been sequenced to low coverage, no transcriptomic datasets have been reported from any bat species. In this study, we describe the immune transcriptome of the Australian flying fox, Pteropus alecto, providing an important resource for identification of genes involved in a range of activities including antiviral immunity.</div>
</front>
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