Infectivity of Severe Acute Respiratory Syndrome during Its Incubation Period
Identifieur interne : 002102 ( Ncbi/Curation ); précédent : 002101; suivant : 002103Infectivity of Severe Acute Respiratory Syndrome during Its Incubation Period
Auteurs : Guang Zeng [République populaire de Chine] ; Shu-Yun Xie [République populaire de Chine] ; Qin Li [République populaire de Chine] ; Jian-Ming Ou [République populaire de Chine]Source :
- Biomedical and Environmental Sciences [ 0895-3988 ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- épidémiologie : Chine, Syndrome respiratoire aigu sévère.
- Flambées de maladies, Humains, Période d'incubation de maladie infectieuse.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : China.
- epidemiology : Severe Acute Respiratory Syndrome.
- physiology : SARS Virus.
- transmission : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Disease Outbreaks, Humans, Infectious Disease Incubation Period.
Abstract
To evaluate the infectivity of severe acute respiratory syndrome (SARS) during its incubation period by investigating chains of transmission and individuals isolated for medical observation with a view to providing scientific evidence for updating protocols of medical isolation.
Individuals related with the two SARS chains of transmission in Beijing in 2003 and a group of individuals isolated for medical observation in Haidian district of Beijing during the SARS outbreak were selected as subjects of study. Contactors with SARS patients and those with symptom development following the contacts were investigated via questionnaire. Serum samples were collected from super transmitters and tested for SARS-CoV antibody by neutralization test and enzyme linked immunosorbent assay (ELISA).
A total of 1 112 contactors were investigated in three surveys. Of them, 669 had a history of close contact with symptomatic SARS patients, 101 developed symptoms with a rate of 15.1%, 363 had a history of close contact with patients in their incubation period, none of whom developed symptoms (0%). Serum samples were collected from 32 highly-exposed individuals, of whom 13 developing SARS symptoms after contact had serum samples positive for SARS-CoV antibody. Samples collected from the asymptomatic contactors were all negative for SARS-CoV antibody.
SARS cases are infectious only during their symptomatic period and are non-infectious during the incubation period. Isolation for medical observation should be placed for individuals who are in close contact with symptomatic SARS patients. The results of our study are of decisive significance for the Ministry of Health to the definition of SARS close contactor.
Url:
DOI: 10.1016/S0895-3988(10)60008-6
PubMed: 20337224
PubMed Central: 7135585
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000E41
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000E41
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000D12
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001727
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001727
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001856
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002102
Links to Exploration step
PMC:7135585Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Infectivity of Severe Acute Respiratory Syndrome during Its Incubation Period</title><author><name sortKey="Zeng, Guang" sort="Zeng, Guang" uniqKey="Zeng G" first="Guang" last="Zeng">Guang Zeng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xie, Shu Yun" sort="Xie, Shu Yun" uniqKey="Xie S" first="Shu-Yun" last="Xie">Shu-Yun Xie</name><affiliation wicri:level="1"><nlm:aff id="aff2">Chinese Field Epidemiology Training Program, and Zhejiang Provincial Center for Disease Control and Prevention, Huangzhou 310052, Zhejiang, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Zhejiang Provincial Center for Disease Control and Prevention, Huangzhou 310052, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><affiliation wicri:level="1"><nlm:aff id="aff3">Chinese Field Epidemiology Training Program, and Chongqing Center for Disease Control and Prevention, Chongqing 400042, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Chongqing Center for Disease Control and Prevention, Chongqing 400042</wicri:regionArea><wicri:noRegion>Chongqing 400042</wicri:noRegion></affiliation></author><author><name sortKey="Ou, Jian Ming" sort="Ou, Jian Ming" uniqKey="Ou J" first="Jian-Ming" last="Ou">Jian-Ming Ou</name><affiliation wicri:level="1"><nlm:aff id="aff4">Chinese Field Epidemiology Training Program, and Fujian ProvincialCenter for Disease Control and Prevention, Fuzhou 350001, Fujian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Fujian ProvincialCenter for Disease Control and Prevention, Fuzhou 350001, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20337224</idno><idno type="pmc">7135585</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135585</idno><idno type="RBID">PMC:7135585</idno><idno type="doi">10.1016/S0895-3988(10)60008-6</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000E41</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E41</idno><idno type="wicri:Area/Pmc/Curation">000E41</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E41</idno><idno type="wicri:Area/Pmc/Checkpoint">000D12</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D12</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:20337224</idno><idno type="wicri:Area/PubMed/Corpus">001727</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001727</idno><idno type="wicri:Area/PubMed/Curation">001727</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001727</idno><idno type="wicri:Area/PubMed/Checkpoint">001856</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001856</idno><idno type="wicri:Area/Ncbi/Merge">002102</idno><idno type="wicri:Area/Ncbi/Curation">002102</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Infectivity of Severe Acute Respiratory Syndrome during Its Incubation Period</title><author><name sortKey="Zeng, Guang" sort="Zeng, Guang" uniqKey="Zeng G" first="Guang" last="Zeng">Guang Zeng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xie, Shu Yun" sort="Xie, Shu Yun" uniqKey="Xie S" first="Shu-Yun" last="Xie">Shu-Yun Xie</name><affiliation wicri:level="1"><nlm:aff id="aff2">Chinese Field Epidemiology Training Program, and Zhejiang Provincial Center for Disease Control and Prevention, Huangzhou 310052, Zhejiang, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Zhejiang Provincial Center for Disease Control and Prevention, Huangzhou 310052, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><affiliation wicri:level="1"><nlm:aff id="aff3">Chinese Field Epidemiology Training Program, and Chongqing Center for Disease Control and Prevention, Chongqing 400042, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Chongqing Center for Disease Control and Prevention, Chongqing 400042</wicri:regionArea><wicri:noRegion>Chongqing 400042</wicri:noRegion></affiliation></author><author><name sortKey="Ou, Jian Ming" sort="Ou, Jian Ming" uniqKey="Ou J" first="Jian-Ming" last="Ou">Jian-Ming Ou</name><affiliation wicri:level="1"><nlm:aff id="aff4">Chinese Field Epidemiology Training Program, and Fujian ProvincialCenter for Disease Control and Prevention, Fuzhou 350001, Fujian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Fujian ProvincialCenter for Disease Control and Prevention, Fuzhou 350001, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomedical and Environmental Sciences</title><idno type="ISSN">0895-3988</idno><idno type="eISSN">2214-0190</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>China (epidemiology)</term><term>Disease Outbreaks</term><term>Humans</term><term>Infectious Disease Incubation Period</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (transmission)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Chine (épidémiologie)</term><term>Flambées de maladies</term><term>Humains</term><term>Période d'incubation de maladie infectieuse</term><term>Syndrome respiratoire aigu sévère (transmission)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Outbreaks</term><term>Humans</term><term>Infectious Disease Incubation Period</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Flambées de maladies</term><term>Humains</term><term>Période d'incubation de maladie infectieuse</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To evaluate the infectivity of severe acute respiratory syndrome (SARS) during its incubation period by investigating chains of transmission and individuals isolated for medical observation with a view to providing scientific evidence for updating protocols of medical isolation.</p></sec><sec><title>Methods</title><p>Individuals related with the two SARS chains of transmission in Beijing in 2003 and a group of individuals isolated for medical observation in Haidian district of Beijing during the SARS outbreak were selected as subjects of study. Contactors with SARS patients and those with symptom development following the contacts were investigated via questionnaire. Serum samples were collected from super transmitters and tested for SARS-CoV antibody by neutralization test and enzyme linked immunosorbent assay (ELISA).</p></sec><sec><title>Results</title><p>A total of 1 112 contactors were investigated in three surveys. Of them, 669 had a history of close contact with symptomatic SARS patients, 101 developed symptoms with a rate of 15.1%, 363 had a history of close contact with patients in their incubation period, none of whom developed symptoms (0%). Serum samples were collected from 32 highly-exposed individuals, of whom 13 developing SARS symptoms after contact had serum samples positive for SARS-CoV antibody. Samples collected from the asymptomatic contactors were all negative for SARS-CoV antibody.</p></sec><sec><title>Conclusion</title><p>SARS cases are infectious only during their symptomatic period and are non-infectious during the incubation period. Isolation for medical observation should be placed for individuals who are in close contact with symptomatic SARS patients. The results of our study are of decisive significance for the Ministry of Health to the definition of SARS close contactor.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Yichen, Lu" uniqKey="Yichen L">Lu Yichen</name></author><author><name sortKey="Essex, M" uniqKey="Essex M">M Essex</name></author><author><name sortKey="Bryan, Roberts" uniqKey="Bryan R">Roberts Bryan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention" uniqKey="Centers For Disease Control And Prevention">Centers for Disease Control and Prevention</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Sy" uniqKey="Xie S">SY Xie</name></author><author><name sortKey="Zeng, G" uniqKey="Zeng G">G Zeng</name></author><author><name sortKey="Lei, J" uniqKey="Lei J">J Lei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Qi" uniqKey="Li Q">Qi Li</name></author><author><name sortKey="Zeng, G" uniqKey="Zeng G">G Zeng</name></author><author><name sortKey="Ou, Jm" uniqKey="Ou J">JM Ou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ou, Jm" uniqKey="Ou J">JM Ou</name></author><author><name sortKey="Dun, Z" uniqKey="Dun Z">Z Dun</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Sy" uniqKey="Xie S">SY Xie</name></author><author><name sortKey="Zeng, G" uniqKey="Zeng G">G Zeng</name></author><author><name sortKey="Chen, Jt" uniqKey="Chen J">JT Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Hl" uniqKey="Li H">HL Li</name></author><author><name sortKey="Feng, Xr" uniqKey="Feng X">XR Feng</name></author><author><name sortKey="Dai, L" uniqKey="Dai L">L Dai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author><author><name sortKey="Wang, Sx" uniqKey="Wang S">SX Wang</name></author><author><name sortKey="Gao, Hs" uniqKey="Gao H">HS Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Ch" uniqKey="Yin C">CH Yin</name></author><author><name sortKey="Li, Jl" uniqKey="Li J">JL Li</name></author><author><name sortKey="Zhang, Sw" uniqKey="Zhang S">SW Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, Js" uniqKey="Dong J">JS Dong</name></author><author><name sortKey="Cui, Ly" uniqKey="Cui L">LY Cui</name></author><author><name sortKey="Fu, Xh" uniqKey="Fu X">XH Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, Qx" uniqKey="Gu Q">QX Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Xing, Yb" uniqKey="Xing Y">YB Xing</name></author><author><name sortKey="Zhong, Gl" uniqKey="Zhong G">GL Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Yj" uniqKey="Liu Y">YJ Liu</name></author><author><name sortKey="Zhang, Yz" uniqKey="Zhang Y">YZ Zhang</name></author><author><name sortKey="Gao, Xh" uniqKey="Gao X">XH Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention" uniqKey="Centers For Disease Control And Prevention">Centers for Disease Control and Prevention</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Zhou, Dh" uniqKey="Zhou D">DH Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention" uniqKey="Centers For Disease Control And Prevention">Centers for Disease Control and Prevention</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, Sm" uniqKey="Ren S">SM Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, G" uniqKey="Zeng G">G Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002102 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 002102 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:7135585
|texte= Infectivity of Severe Acute Respiratory Syndrome during Its Incubation Period
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:20337224" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |