Infectivity of Severe Acute Respiratory Syndrome during Its Incubation Period
Identifieur interne : 000D12 ( Pmc/Checkpoint ); précédent : 000D11; suivant : 000D13Infectivity of Severe Acute Respiratory Syndrome during Its Incubation Period
Auteurs : Guang Zeng [République populaire de Chine] ; Shu-Yun Xie [République populaire de Chine] ; Qin Li [République populaire de Chine] ; Jian-Ming Ou [République populaire de Chine]Source :
- Biomedical and Environmental Sciences [ 0895-3988 ] ; 2009.
Abstract
To evaluate the infectivity of severe acute respiratory syndrome (SARS) during its incubation period by investigating chains of transmission and individuals isolated for medical observation with a view to providing scientific evidence for updating protocols of medical isolation.
Individuals related with the two SARS chains of transmission in Beijing in 2003 and a group of individuals isolated for medical observation in Haidian district of Beijing during the SARS outbreak were selected as subjects of study. Contactors with SARS patients and those with symptom development following the contacts were investigated via questionnaire. Serum samples were collected from super transmitters and tested for SARS-CoV antibody by neutralization test and enzyme linked immunosorbent assay (ELISA).
A total of 1 112 contactors were investigated in three surveys. Of them, 669 had a history of close contact with symptomatic SARS patients, 101 developed symptoms with a rate of 15.1%, 363 had a history of close contact with patients in their incubation period, none of whom developed symptoms (0%). Serum samples were collected from 32 highly-exposed individuals, of whom 13 developing SARS symptoms after contact had serum samples positive for SARS-CoV antibody. Samples collected from the asymptomatic contactors were all negative for SARS-CoV antibody.
SARS cases are infectious only during their symptomatic period and are non-infectious during the incubation period. Isolation for medical observation should be placed for individuals who are in close contact with symptomatic SARS patients. The results of our study are of decisive significance for the Ministry of Health to the definition of SARS close contactor.
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DOI: 10.1016/S0895-3988(10)60008-6
PubMed: 20337224
PubMed Central: 7135585
Affiliations:
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and Prevention, Huangzhou 310052, Zhejiang, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Zhejiang Provincial Center for Disease Control and Prevention, Huangzhou 310052, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><affiliation wicri:level="1"><nlm:aff id="aff3">Chinese Field Epidemiology Training Program, and Chongqing Center for Disease Control and Prevention, Chongqing 400042, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Chongqing Center for Disease Control and Prevention, Chongqing 400042</wicri:regionArea><wicri:noRegion>Chongqing 400042</wicri:noRegion></affiliation></author><author><name sortKey="Ou, Jian Ming" sort="Ou, Jian Ming" uniqKey="Ou J" first="Jian-Ming" last="Ou">Jian-Ming Ou</name><affiliation wicri:level="1"><nlm:aff id="aff4">Chinese Field Epidemiology Training Program, and Fujian ProvincialCenter for Disease Control and Prevention, Fuzhou 350001, Fujian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Fujian ProvincialCenter for Disease Control and Prevention, Fuzhou 350001, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20337224</idno><idno type="pmc">7135585</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135585</idno><idno type="RBID">PMC:7135585</idno><idno type="doi">10.1016/S0895-3988(10)60008-6</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000E41</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" 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100050</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xie, Shu Yun" sort="Xie, Shu Yun" uniqKey="Xie S" first="Shu-Yun" last="Xie">Shu-Yun Xie</name><affiliation wicri:level="1"><nlm:aff id="aff2">Chinese Field Epidemiology Training Program, and Zhejiang Provincial Center for Disease Control and Prevention, Huangzhou 310052, Zhejiang, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Zhejiang Provincial Center for Disease Control and Prevention, Huangzhou 310052, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><affiliation wicri:level="1"><nlm:aff id="aff3">Chinese Field Epidemiology Training Program, and Chongqing Center for Disease Control and Prevention, Chongqing 400042, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Chongqing Center for Disease Control and Prevention, Chongqing 400042</wicri:regionArea><wicri:noRegion>Chongqing 400042</wicri:noRegion></affiliation></author><author><name sortKey="Ou, Jian Ming" sort="Ou, Jian Ming" uniqKey="Ou J" first="Jian-Ming" last="Ou">Jian-Ming Ou</name><affiliation wicri:level="1"><nlm:aff id="aff4">Chinese Field Epidemiology Training Program, and Fujian ProvincialCenter for Disease Control and Prevention, Fuzhou 350001, Fujian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Field Epidemiology Training Program, and Fujian ProvincialCenter for Disease Control and Prevention, Fuzhou 350001, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomedical and Environmental Sciences</title><idno type="ISSN">0895-3988</idno><idno type="eISSN">2214-0190</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To evaluate the infectivity of severe acute respiratory syndrome (SARS) during its incubation period by investigating chains of transmission and individuals isolated for medical observation with a view to providing scientific evidence for updating protocols of medical isolation.</p></sec><sec><title>Methods</title><p>Individuals related with the two SARS chains of transmission in Beijing in 2003 and a group of individuals isolated for medical observation in Haidian district of Beijing during the SARS outbreak were selected as subjects of study. Contactors with SARS patients and those with symptom development following the contacts were investigated via questionnaire. Serum samples were collected from super transmitters and tested for SARS-CoV antibody by neutralization test and enzyme linked immunosorbent assay (ELISA).</p></sec><sec><title>Results</title><p>A total of 1 112 contactors were investigated in three surveys. Of them, 669 had a history of close contact with symptomatic SARS patients, 101 developed symptoms with a rate of 15.1%, 363 had a history of close contact with patients in their incubation period, none of whom developed symptoms (0%). Serum samples were collected from 32 highly-exposed individuals, of whom 13 developing SARS symptoms after contact had serum samples positive for SARS-CoV antibody. Samples collected from the asymptomatic contactors were all negative for SARS-CoV antibody.</p></sec><sec><title>Conclusion</title><p>SARS cases are infectious only during their symptomatic period and are non-infectious during the incubation period. Isolation for medical observation should be placed for individuals who are in close contact with symptomatic SARS patients. The results of our study are of decisive significance for the Ministry of Health to the definition of SARS close contactor.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Yichen, Lu" uniqKey="Yichen L">Lu Yichen</name></author><author><name sortKey="Essex, M" uniqKey="Essex M">M Essex</name></author><author><name sortKey="Bryan, Roberts" uniqKey="Bryan R">Roberts Bryan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention" uniqKey="Centers For Disease Control And Prevention">Centers for Disease Control and Prevention</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Sy" uniqKey="Xie S">SY Xie</name></author><author><name sortKey="Zeng, G" uniqKey="Zeng G">G Zeng</name></author><author><name sortKey="Lei, J" uniqKey="Lei J">J Lei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Qi" uniqKey="Li Q">Qi Li</name></author><author><name sortKey="Zeng, G" uniqKey="Zeng G">G Zeng</name></author><author><name sortKey="Ou, Jm" uniqKey="Ou J">JM Ou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ou, Jm" uniqKey="Ou J">JM Ou</name></author><author><name sortKey="Dun, Z" uniqKey="Dun Z">Z Dun</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Sy" uniqKey="Xie S">SY Xie</name></author><author><name sortKey="Zeng, G" uniqKey="Zeng G">G Zeng</name></author><author><name sortKey="Chen, Jt" uniqKey="Chen J">JT Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Hl" uniqKey="Li H">HL Li</name></author><author><name sortKey="Feng, Xr" uniqKey="Feng X">XR Feng</name></author><author><name sortKey="Dai, L" uniqKey="Dai L">L Dai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author><author><name sortKey="Wang, Sx" uniqKey="Wang S">SX Wang</name></author><author><name sortKey="Gao, Hs" uniqKey="Gao H">HS Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Ch" uniqKey="Yin C">CH Yin</name></author><author><name sortKey="Li, Jl" uniqKey="Li J">JL Li</name></author><author><name sortKey="Zhang, Sw" uniqKey="Zhang S">SW Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, Js" uniqKey="Dong J">JS Dong</name></author><author><name sortKey="Cui, Ly" uniqKey="Cui L">LY Cui</name></author><author><name sortKey="Fu, Xh" uniqKey="Fu X">XH Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, Qx" uniqKey="Gu Q">QX Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Xing, Yb" uniqKey="Xing Y">YB Xing</name></author><author><name sortKey="Zhong, Gl" uniqKey="Zhong G">GL Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Yj" uniqKey="Liu Y">YJ Liu</name></author><author><name sortKey="Zhang, Yz" uniqKey="Zhang Y">YZ Zhang</name></author><author><name sortKey="Gao, Xh" uniqKey="Gao X">XH Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention" uniqKey="Centers For Disease Control And Prevention">Centers for Disease Control and Prevention</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Zhou, Dh" uniqKey="Zhou D">DH Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention" uniqKey="Centers For Disease Control And Prevention">Centers for Disease Control and Prevention</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, Sm" uniqKey="Ren S">SM Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, G" uniqKey="Zeng G">G Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Environ Sci</journal-id><journal-id journal-id-type="iso-abbrev">Biomed. Environ. Sci</journal-id><journal-title-group><journal-title>Biomedical and Environmental Sciences</journal-title></journal-title-group><issn pub-type="ppub">0895-3988</issn><issn pub-type="epub">2214-0190</issn><publisher><publisher-name>The Editorial Board of Biomedical and Environmental Sciences. Published by Elsevier (Singapore) Pte. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20337224</article-id><article-id pub-id-type="pmc">7135585</article-id><article-id pub-id-type="publisher-id">S0895-3988(10)60008-6</article-id><article-id pub-id-type="doi">10.1016/S0895-3988(10)60008-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Infectivity of Severe Acute Respiratory Syndrome during Its Incubation Period</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>ZENG</surname><given-names>Guang</given-names></name><email>zeng4605@vip.sina.com</email><xref rid="aff1" ref-type="aff">*</xref><xref rid="cor1" ref-type="corresp">1</xref></contrib><contrib contrib-type="author"><name><surname>XIE</surname><given-names>Shu-Yun</given-names></name><xref rid="aff2" ref-type="aff">#</xref></contrib><contrib contrib-type="author"><name><surname>LI</surname><given-names>Qin</given-names></name><xref rid="aff3" ref-type="aff">Δ</xref></contrib><contrib contrib-type="author"><name><surname>OU</surname><given-names>Jian-Ming</given-names></name><xref rid="aff4" ref-type="aff">†</xref></contrib></contrib-group><aff id="aff1"><label>*</label>Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China</aff><aff id="aff2"><label>#</label>Chinese Field Epidemiology Training Program, and Zhejiang Provincial Center for Disease Control and Prevention, Huangzhou 310052, Zhejiang, China</aff><aff id="aff3"><label>Δ</label>Chinese Field Epidemiology Training Program, and Chongqing Center for Disease Control and Prevention, Chongqing 400042, China</aff><aff id="aff4"><label>†</label>Chinese Field Epidemiology Training Program, and Fujian ProvincialCenter for Disease Control and Prevention, Fuzhou 350001, Fujian, China</aff><author-notes><corresp id="cor1"><label>1</label>Correspondence should be addressed to Guang ZENG, Department of Endocrinology, Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China <email>zeng4605@vip.sina.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>6</day><month>1</month><year>2010</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>12</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>6</day><month>1</month><year>2010</year></pub-date><volume>22</volume><issue>6</issue><fpage>502</fpage><lpage>510</lpage><history><date date-type="received"><day>23</day><month>1</month><year>2009</year></date><date date-type="accepted"><day>14</day><month>10</month><year>2009</year></date></history><permissions><copyright-statement>© 2009 The Editorial Board of Biomedical and Environmental Sciences</copyright-statement><copyright-year>2009</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><sec><title>Objective</title><p>To evaluate the infectivity of severe acute respiratory syndrome (SARS) during its incubation period by investigating chains of transmission and individuals isolated for medical observation with a view to providing scientific evidence for updating protocols of medical isolation.</p></sec><sec><title>Methods</title><p>Individuals related with the two SARS chains of transmission in Beijing in 2003 and a group of individuals isolated for medical observation in Haidian district of Beijing during the SARS outbreak were selected as subjects of study. Contactors with SARS patients and those with symptom development following the contacts were investigated via questionnaire. Serum samples were collected from super transmitters and tested for SARS-CoV antibody by neutralization test and enzyme linked immunosorbent assay (ELISA).</p></sec><sec><title>Results</title><p>A total of 1 112 contactors were investigated in three surveys. Of them, 669 had a history of close contact with symptomatic SARS patients, 101 developed symptoms with a rate of 15.1%, 363 had a history of close contact with patients in their incubation period, none of whom developed symptoms (0%). Serum samples were collected from 32 highly-exposed individuals, of whom 13 developing SARS symptoms after contact had serum samples positive for SARS-CoV antibody. Samples collected from the asymptomatic contactors were all negative for SARS-CoV antibody.</p></sec><sec><title>Conclusion</title><p>SARS cases are infectious only during their symptomatic period and are non-infectious during the incubation period. Isolation for medical observation should be placed for individuals who are in close contact with symptomatic SARS patients. The results of our study are of decisive significance for the Ministry of Health to the definition of SARS close contactor.</p></sec></abstract><kwd-group><title>Key words</title><kwd>Severe acute respiratory syndrome</kwd><kwd>Chain of transmission</kwd><kwd>Incubation period</kwd><kwd>Symptomatic period</kwd><kwd>Infectivity</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zeng, Guang" sort="Zeng, Guang" uniqKey="Zeng G" first="Guang" last="Zeng">Guang Zeng</name></noRegion><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><name sortKey="Ou, Jian Ming" sort="Ou, Jian Ming" uniqKey="Ou J" first="Jian-Ming" last="Ou">Jian-Ming Ou</name><name sortKey="Xie, Shu Yun" sort="Xie, Shu Yun" uniqKey="Xie S" first="Shu-Yun" last="Xie">Shu-Yun Xie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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