Bovine and human-derived passive immunization could help slow a future avian influenza pandemic.
Identifieur interne : 001D59 ( Ncbi/Curation ); précédent : 001D58; suivant : 001D60Bovine and human-derived passive immunization could help slow a future avian influenza pandemic.
Auteurs : Joseph Alisky [États-Unis]Source :
- Medical hypotheses [ 0306-9877 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Bovins, Flambées de maladies (), Grippe chez les oiseaux (immunologie), Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Immunisation passive (), Immunisation passive (médecine vétérinaire), Maladies des bovins (immunologie), Maladies des bovins (virologie), Oiseaux.
- MESH :
- immunologie : Grippe chez les oiseaux, Grippe humaine, Maladies des bovins.
- médecine vétérinaire : Immunisation passive.
- virologie : Maladies des bovins.
- épidémiologie : Grippe humaine.
- Animaux, Bovins, Flambées de maladies, Grippe humaine, Humains, Immunisation passive, Oiseaux.
English descriptors
- KwdEn :
- Animals, Birds, Cattle, Cattle Diseases (immunology), Cattle Diseases (virology), Disease Outbreaks (prevention & control), Humans, Immunization, Passive (methods), Immunization, Passive (veterinary), Influenza in Birds (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (prevention & control).
- MESH :
- epidemiology : Influenza, Human.
- immunology : Cattle Diseases, Influenza in Birds, Influenza, Human.
- methods : Immunization, Passive.
- prevention & control : Disease Outbreaks, Influenza, Human.
- veterinary : Immunization, Passive.
- virology : Cattle Diseases.
- Animals, Birds, Cattle, Humans.
Abstract
An epidemic of human transmitted avian influenza could have casualties on a scale seen in the great Spanish influenza pandemic of 1918. This paper proposes that should such occur before effective vaccines and antiviral drugs are available, the outbreak could be significantly slowed by consumption of raw milk produced by herds of pathogen-free lactating cows intranasally inoculated with heat-sterilized sputa pooled from avian influenza patients, supplemented by parenteral serum immune globulin from the same cows. Efficiency of bovine antibody production could be enhanced using cholera toxin subunit b, and milk production could be rapidly accelerated using recombinant bovine somatotropin hormone. In this way, it would be possible to quickly create and distribute large quantities of milk-based and serum-based passive immune globulin active against the strains of avian influenza present in a particular geographic area and gain time for production of human convalescent plasma and other public health measures. This novel approach might also have utility for other serious respiratory infectious diseases, including non-avian influenza, SARS, hantavirus, respiratory syncytial virus, antibiotic-resistant Streptococcus pneumoniae and pneumonia-causing Staphylococcus aureus.
DOI: 10.1016/j.mehy.2008.08.016
PubMed: 18824305
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pubmed:18824305Le document en format XML
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Alisky.Joseph@marshfieldclinic.org</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Marshfield Clinic Research Foundation, 1000 Oak Avenue, Marshfield, Wisconsin 54449</wicri:regionArea><wicri:noRegion>Wisconsin 54449</wicri:noRegion></affiliation></author></analytic><series><title level="j">Medical hypotheses</title><idno type="ISSN">0306-9877</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Birds</term><term>Cattle</term><term>Cattle Diseases (immunology)</term><term>Cattle Diseases (virology)</term><term>Disease Outbreaks (prevention & control)</term><term>Humans</term><term>Immunization, Passive (methods)</term><term>Immunization, Passive (veterinary)</term><term>Influenza in Birds (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Bovins</term><term>Flambées de maladies ()</term><term>Grippe chez les oiseaux (immunologie)</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Immunisation passive ()</term><term>Immunisation passive (médecine vétérinaire)</term><term>Maladies des bovins (immunologie)</term><term>Maladies des bovins (virologie)</term><term>Oiseaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Grippe humaine</term><term>Maladies des bovins</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cattle Diseases</term><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Immunisation passive</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Disease Outbreaks</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies des bovins</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cattle Diseases</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Birds</term><term>Cattle</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Bovins</term><term>Flambées de maladies</term><term>Grippe humaine</term><term>Humains</term><term>Immunisation passive</term><term>Oiseaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An epidemic of human transmitted avian influenza could have casualties on a scale seen in the great Spanish influenza pandemic of 1918. This paper proposes that should such occur before effective vaccines and antiviral drugs are available, the outbreak could be significantly slowed by consumption of raw milk produced by herds of pathogen-free lactating cows intranasally inoculated with heat-sterilized sputa pooled from avian influenza patients, supplemented by parenteral serum immune globulin from the same cows. Efficiency of bovine antibody production could be enhanced using cholera toxin subunit b, and milk production could be rapidly accelerated using recombinant bovine somatotropin hormone. In this way, it would be possible to quickly create and distribute large quantities of milk-based and serum-based passive immune globulin active against the strains of avian influenza present in a particular geographic area and gain time for production of human convalescent plasma and other public health measures. This novel approach might also have utility for other serious respiratory infectious diseases, including non-avian influenza, SARS, hantavirus, respiratory syncytial virus, antibiotic-resistant Streptococcus pneumoniae and pneumonia-causing Staphylococcus aureus.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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