Bovine and human-derived passive immunization could help slow a future avian influenza pandemic.
Identifieur interne : 001A58 ( PubMed/Corpus ); précédent : 001A57; suivant : 001A59Bovine and human-derived passive immunization could help slow a future avian influenza pandemic.
Auteurs : Joseph AliskySource :
- Medical hypotheses [ 0306-9877 ] ; 2009.
English descriptors
- KwdEn :
- Animals, Birds, Cattle, Cattle Diseases (immunology), Cattle Diseases (virology), Disease Outbreaks (prevention & control), Humans, Immunization, Passive (methods), Immunization, Passive (veterinary), Influenza in Birds (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (prevention & control).
- MESH :
- epidemiology : Influenza, Human.
- immunology : Cattle Diseases, Influenza in Birds, Influenza, Human.
- methods : Immunization, Passive.
- prevention & control : Disease Outbreaks, Influenza, Human.
- veterinary : Immunization, Passive.
- virology : Cattle Diseases.
- Animals, Birds, Cattle, Humans.
Abstract
An epidemic of human transmitted avian influenza could have casualties on a scale seen in the great Spanish influenza pandemic of 1918. This paper proposes that should such occur before effective vaccines and antiviral drugs are available, the outbreak could be significantly slowed by consumption of raw milk produced by herds of pathogen-free lactating cows intranasally inoculated with heat-sterilized sputa pooled from avian influenza patients, supplemented by parenteral serum immune globulin from the same cows. Efficiency of bovine antibody production could be enhanced using cholera toxin subunit b, and milk production could be rapidly accelerated using recombinant bovine somatotropin hormone. In this way, it would be possible to quickly create and distribute large quantities of milk-based and serum-based passive immune globulin active against the strains of avian influenza present in a particular geographic area and gain time for production of human convalescent plasma and other public health measures. This novel approach might also have utility for other serious respiratory infectious diseases, including non-avian influenza, SARS, hantavirus, respiratory syncytial virus, antibiotic-resistant Streptococcus pneumoniae and pneumonia-causing Staphylococcus aureus.
DOI: 10.1016/j.mehy.2008.08.016
PubMed: 18824305
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Alisky.Joseph@marshfieldclinic.org</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:18824305</idno><idno type="pmid">18824305</idno><idno type="doi">10.1016/j.mehy.2008.08.016</idno><idno type="wicri:Area/PubMed/Corpus">001A58</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A58</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bovine and human-derived passive immunization could help slow a future avian influenza pandemic.</title><author><name sortKey="Alisky, Joseph" sort="Alisky, Joseph" uniqKey="Alisky J" first="Joseph" last="Alisky">Joseph Alisky</name><affiliation><nlm:affiliation>Marshfield Clinic Research Foundation, 1000 Oak Avenue, Marshfield, Wisconsin 54449, United States. Alisky.Joseph@marshfieldclinic.org</nlm:affiliation></affiliation></author></analytic><series><title level="j">Medical hypotheses</title><idno type="ISSN">0306-9877</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Birds</term><term>Cattle</term><term>Cattle Diseases (immunology)</term><term>Cattle Diseases (virology)</term><term>Disease Outbreaks (prevention & control)</term><term>Humans</term><term>Immunization, Passive (methods)</term><term>Immunization, Passive (veterinary)</term><term>Influenza in Birds (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cattle Diseases</term><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Disease Outbreaks</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cattle Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Birds</term><term>Cattle</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An epidemic of human transmitted avian influenza could have casualties on a scale seen in the great Spanish influenza pandemic of 1918. This paper proposes that should such occur before effective vaccines and antiviral drugs are available, the outbreak could be significantly slowed by consumption of raw milk produced by herds of pathogen-free lactating cows intranasally inoculated with heat-sterilized sputa pooled from avian influenza patients, supplemented by parenteral serum immune globulin from the same cows. Efficiency of bovine antibody production could be enhanced using cholera toxin subunit b, and milk production could be rapidly accelerated using recombinant bovine somatotropin hormone. In this way, it would be possible to quickly create and distribute large quantities of milk-based and serum-based passive immune globulin active against the strains of avian influenza present in a particular geographic area and gain time for production of human convalescent plasma and other public health measures. This novel approach might also have utility for other serious respiratory infectious diseases, including non-avian influenza, SARS, hantavirus, respiratory syncytial virus, antibiotic-resistant Streptococcus pneumoniae and pneumonia-causing Staphylococcus aureus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18824305</PMID><DateCompleted><Year>2009</Year><Month>02</Month><Day>25</Day></DateCompleted><DateRevised><Year>2008</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0306-9877</ISSN><JournalIssue CitedMedium="Print"><Volume>72</Volume><Issue>1</Issue><PubDate><Year>2009</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Medical hypotheses</Title><ISOAbbreviation>Med. Hypotheses</ISOAbbreviation></Journal><ArticleTitle>Bovine and human-derived passive immunization could help slow a future avian influenza pandemic.</ArticleTitle><Pagination><MedlinePgn>74-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.mehy.2008.08.016</ELocationID><Abstract><AbstractText>An epidemic of human transmitted avian influenza could have casualties on a scale seen in the great Spanish influenza pandemic of 1918. This paper proposes that should such occur before effective vaccines and antiviral drugs are available, the outbreak could be significantly slowed by consumption of raw milk produced by herds of pathogen-free lactating cows intranasally inoculated with heat-sterilized sputa pooled from avian influenza patients, supplemented by parenteral serum immune globulin from the same cows. Efficiency of bovine antibody production could be enhanced using cholera toxin subunit b, and milk production could be rapidly accelerated using recombinant bovine somatotropin hormone. In this way, it would be possible to quickly create and distribute large quantities of milk-based and serum-based passive immune globulin active against the strains of avian influenza present in a particular geographic area and gain time for production of human convalescent plasma and other public health measures. This novel approach might also have utility for other serious respiratory infectious diseases, including non-avian influenza, SARS, hantavirus, respiratory syncytial virus, antibiotic-resistant Streptococcus pneumoniae and pneumonia-causing Staphylococcus aureus.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alisky</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Marshfield Clinic Research Foundation, 1000 Oak Avenue, Marshfield, Wisconsin 54449, United States. 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