SrasV1, Ncbi, Curation, bibRecord, 001272

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

Identifieur interne : 001272 ( Ncbi/Curation ); précédent : 001271; suivant : 001273

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

Auteurs : Linqi Zhang [États-Unis] ; Fengwen Zhang ; Wenjie Yu ; Tian He ; Jian Yu ; Christopher E. Yi ; Lei Ba ; Wenhui Li ; Michael Farzan ; Zhiwei Chen ; Kwok-Yung Yuen ; David Ho

Source :

Journal of medical virology [ 0146-6615 ] ; 2006.

RBID : pubmed:16299724

Descripteurs français

English descriptors

KwdEn :
- Antibodies, Viral (blood), Antibodies, Viral (immunology), Disease Progression, Humans, Membrane Glycoproteins (immunology), Neutralization Tests, Nucleocapsid Proteins (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (physiopathology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (immunology).
MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Antibodies, Viral, Membrane Glycoproteins, Nucleocapsid Proteins, Viral Envelope Proteins.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- physiopathology : Severe Acute Respiratory Syndrome.
- Disease Progression, Humans, Neutralization Tests, Spike Glycoprotein, Coronavirus.

Abstract

Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.

DOI: 10.1002/jmv.20499
PubMed: 16299724

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pubmed:16299724

Le document en format XML

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<front><div type="abstract" xml:lang="en">Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.</div>
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Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki