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Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

Identifieur interne : 002440 ( PubMed/Curation ); précédent : 002439; suivant : 002441

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

Auteurs : Linqi Zhang [États-Unis] ; Fengwen Zhang ; Wenjie Yu ; Tian He ; Jian Yu ; Christopher E. Yi ; Lei Ba ; Wenhui Li ; Michael Farzan ; Zhiwei Chen ; Kwok-Yung Yuen ; David Ho

Source :

RBID : pubmed:16299724

Descripteurs français

English descriptors

Abstract

Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.

DOI: 10.1002/jmv.20499
PubMed: 16299724

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pubmed:16299724

Le document en format XML

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<term>Humans</term>
<term>Membrane Glycoproteins (immunology)</term>
<term>Neutralization Tests</term>
<term>Nucleocapsid Proteins (immunology)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
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<term>Anticorps antiviraux (immunologie)</term>
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<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (immunologie)</term>
<term>Humains</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>Protéines nucléocapside (immunologie)</term>
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<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Tests de neutralisation</term>
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<div type="abstract" xml:lang="en">Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.</div>
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