SrasV1, Ncbi, Curation, bibRecord, 001114

A Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific Protein Enhances Virulence of an Attenuated Murine Coronavirus

Identifieur interne : 001114 ( Ncbi/Curation ); précédent : 001113; suivant : 001115

A Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific Protein Enhances Virulence of an Attenuated Murine Coronavirus

Auteurs : Lecia Pewe ; Haixia Zhou ; Jason Netland ; Chandra Tangudu ; Heidi Olivares ; Lei Shi ; Dwight Look ; Thomas Gallagher ; Stanley Perlman

Source :

Journal of Virology [ 0022-538X ] ; 2005.

RBID : PMC:1193615

Descripteurs français

KwdFr :
- Animaux, Cadres ouverts de lecture (génétique), Encéphalite (virologie), Humains, Infections à coronavirus (virologie), Lignée cellulaire, Modèles animaux de maladie humaine, Protéines virales non structurales (génétique), Protéines virales non structurales (métabolisme), Réplication virale, Souris, Souris de lignée C57BL, Virulence, Virus de l'hépatite murine (génétique), Virus de l'hépatite murine (pathogénicité), Virus du SRAS (), Virus du SRAS (pathogénicité), Virus du SRAS (physiologie), Virus recombinants (pathogénicité).
MESH :
- génétique : Cadres ouverts de lecture, Protéines virales non structurales, Virus de l'hépatite murine.
- métabolisme : Protéines virales non structurales.
- pathogénicité : Virus de l'hépatite murine, Virus du SRAS, Virus recombinants.
- physiologie : Virus du SRAS.
- virologie : Encéphalite, Infections à coronavirus.
- Animaux, Humains, Lignée cellulaire, Modèles animaux de maladie humaine, Réplication virale, Souris, Souris de lignée C57BL, Virulence, Virus du SRAS.

English descriptors

KwdEn :
- Animals, Cell Line, Coronavirus Infections (virology), Disease Models, Animal, Encephalitis (virology), Humans, Mice, Mice, Inbred C57BL, Murine hepatitis virus (genetics), Murine hepatitis virus (pathogenicity), Open Reading Frames (genetics), Reassortant Viruses (pathogenicity), SARS Virus (chemistry), SARS Virus (pathogenicity), SARS Virus (physiology), Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism), Virulence, Virus Replication.
MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- chemistry : SARS Virus.
- genetics : Murine hepatitis virus, Open Reading Frames.
- chemical , metabolism : Viral Nonstructural Proteins.
- pathogenicity : Murine hepatitis virus, Reassortant Viruses, SARS Virus.
- physiology : SARS Virus.
- virology : Coronavirus Infections, Encephalitis.
- Animals, Cell Line, Disease Models, Animal, Humans, Mice, Mice, Inbred C57BL, Virulence, Virus Replication.

Abstract

Most animal species that can be infected with the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) do not reproducibly develop clinical disease, hindering studies of pathogenesis. To develop an alternative system for the study of SARS-CoV, we introduced individual SARS-CoV genes (open reading frames [ORFs]) into the genome of an attenuated murine coronavirus. One protein, the product of SARS-CoV ORF6, converted a sublethal infection to a uniformly lethal encephalitis and enhanced virus growth in tissue culture cells, indicating that SARS-CoV proteins function in the context of a heterologous coronavirus infection. Furthermore, these results suggest that the attenuated murine coronavirus lacks a virulence gene residing in SARS-CoV. Recombinant murine coronaviruses cause a reproducible and well-characterized clinical disease, offer virtually no risk to laboratory personnel, and should be useful for elucidating the role of SARS-CoV nonstructural proteins in viral replication and pathogenesis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193615

DOI: 10.1128/JVI.79.17.11335-11342.2005
PubMed: 16103185
PubMed Central: 1193615

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PMC:1193615

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Most animal species that can be infected with the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) do not reproducibly develop clinical disease, hindering studies of pathogenesis. To develop an alternative system for the study of SARS-CoV, we introduced individual SARS-CoV genes (open reading frames [ORFs]) into the genome of an attenuated murine coronavirus. One protein, the product of SARS-CoV ORF6, converted a sublethal infection to a uniformly lethal encephalitis and enhanced virus growth in tissue culture cells, indicating that SARS-CoV proteins function in the context of a heterologous coronavirus infection. Furthermore, these results suggest that the attenuated murine coronavirus lacks a virulence gene residing in SARS-CoV. Recombinant murine coronaviruses cause a reproducible and well-characterized clinical disease, offer virtually no risk to laboratory personnel, and should be useful for elucidating the role of SARS-CoV nonstructural proteins in viral replication and pathogenesis.</p>
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A Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific Protein Enhances Virulence of an Attenuated Murine Coronavirus

A Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific Protein Enhances Virulence of an Attenuated Murine Coronavirus

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Descripteurs français

English descriptors

Abstract

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