A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus.
Identifieur interne : 002853 ( PubMed/Checkpoint ); précédent : 002852; suivant : 002854A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus.
Auteurs : Lecia Pewe [États-Unis] ; Haixia Zhou ; Jason Netland ; Chandra Tangudu ; Heidi Olivares ; Lei Shi ; Dwight Look ; Thomas Gallagher ; Stanley PerlmanSource :
- Journal of virology [ 0022-538X ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Cadres ouverts de lecture (génétique), Encéphalite (virologie), Humains, Infections à coronavirus (virologie), Lignée cellulaire, Modèles animaux de maladie humaine, Protéines virales non structurales (génétique), Protéines virales non structurales (métabolisme), Réplication virale, Souris, Souris de lignée C57BL, Virulence, Virus de l'hépatite murine (génétique), Virus de l'hépatite murine (pathogénicité), Virus du SRAS (), Virus du SRAS (pathogénicité), Virus du SRAS (physiologie), Virus recombinants (pathogénicité).
- MESH :
- génétique : Cadres ouverts de lecture, Protéines virales non structurales, Virus de l'hépatite murine.
- métabolisme : Protéines virales non structurales.
- pathogénicité : Virus de l'hépatite murine, Virus du SRAS, Virus recombinants.
- physiologie : Virus du SRAS.
- virologie : Encéphalite, Infections à coronavirus.
- Animaux, Humains, Lignée cellulaire, Modèles animaux de maladie humaine, Réplication virale, Souris, Souris de lignée C57BL, Virulence, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Cell Line, Coronavirus Infections (virology), Disease Models, Animal, Encephalitis (virology), Humans, Mice, Mice, Inbred C57BL, Murine hepatitis virus (genetics), Murine hepatitis virus (pathogenicity), Open Reading Frames (genetics), Reassortant Viruses (pathogenicity), SARS Virus (chemistry), SARS Virus (pathogenicity), SARS Virus (physiology), Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism), Virulence, Virus Replication.
- MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- chemistry : SARS Virus.
- genetics : Murine hepatitis virus, Open Reading Frames.
- chemical , metabolism : Viral Nonstructural Proteins.
- pathogenicity : Murine hepatitis virus, Reassortant Viruses, SARS Virus.
- physiology : SARS Virus.
- virology : Coronavirus Infections, Encephalitis.
- Animals, Cell Line, Disease Models, Animal, Humans, Mice, Mice, Inbred C57BL, Virulence, Virus Replication.
Abstract
Most animal species that can be infected with the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) do not reproducibly develop clinical disease, hindering studies of pathogenesis. To develop an alternative system for the study of SARS-CoV, we introduced individual SARS-CoV genes (open reading frames [ORFs]) into the genome of an attenuated murine coronavirus. One protein, the product of SARS-CoV ORF6, converted a sublethal infection to a uniformly lethal encephalitis and enhanced virus growth in tissue culture cells, indicating that SARS-CoV proteins function in the context of a heterologous coronavirus infection. Furthermore, these results suggest that the attenuated murine coronavirus lacks a virulence gene residing in SARS-CoV. Recombinant murine coronaviruses cause a reproducible and well-characterized clinical disease, offer virtually no risk to laboratory personnel, and should be useful for elucidating the role of SARS-CoV nonstructural proteins in viral replication and pathogenesis.
DOI: 10.1128/JVI.79.17.11335-11342.2005
PubMed: 16103185
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:16103185Le document en format XML
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<front><div type="abstract" xml:lang="en">Most animal species that can be infected with the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) do not reproducibly develop clinical disease, hindering studies of pathogenesis. To develop an alternative system for the study of SARS-CoV, we introduced individual SARS-CoV genes (open reading frames [ORFs]) into the genome of an attenuated murine coronavirus. One protein, the product of SARS-CoV ORF6, converted a sublethal infection to a uniformly lethal encephalitis and enhanced virus growth in tissue culture cells, indicating that SARS-CoV proteins function in the context of a heterologous coronavirus infection. Furthermore, these results suggest that the attenuated murine coronavirus lacks a virulence gene residing in SARS-CoV. Recombinant murine coronaviruses cause a reproducible and well-characterized clinical disease, offer virtually no risk to laboratory personnel, and should be useful for elucidating the role of SARS-CoV nonstructural proteins in viral replication and pathogenesis.</div>
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<ReferenceList><Reference><Citation>J Virol. 2004 May;78(10):5486-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15113927</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2004 Mar 12;303(5664):1666-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14752165</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Aug;78(15):7863-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15254158</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2004 Jul 30;341(1):271-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15312778</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2004 Nov 10;329(1):11-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15476870</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Virol. 1984;82(1-2):19-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6208879</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1986 Jun;58(3):869-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3701929</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1992 Feb;186(2):742-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1310195</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1992 Apr;187(2):443-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1347668</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1995 Dec;69(12):8127-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7494335</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1996 Feb;77 ( Pt 2 ):315-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8627236</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurovirol. 1996 Apr;2(2):101-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8799201</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 1996 Sep;5(3):253-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8808680</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Virus Res. 1997;48:1-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9233431</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1999 Aug;73(8):6862-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10400784</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1999 Oct;73(10):8771-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10482631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2005 Jan;107(1):93-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15567038</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2004 Dec;10(12 Suppl):S88-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15577937</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Jan;79(2):1036-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15613332</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Structure. 2005 Jan;13(1):75-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15642263</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Feb;79(4):2079-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15681410</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Mar;79(5):3182-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15709039</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2430-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15695582</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2005 Mar;166(3):801-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15743792</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2004 Feb;10(2):317-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15030704</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2004 Apr 1;189(7):1164-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15031783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1999 Dec 1;163(11):6106-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10570300</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Feb;74(3):1393-406</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10627550</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2000 Aug 15;165(4):2278-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10925317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Microbiol. 2001 Aug;4(4):462-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11495812</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2001 Oct 25;289(2):230-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11689046</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1995 Apr 1;208(1):173-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11831697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2002 Oct;161(4):1255-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12368199</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2003 Jul 26;362(9380):293-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12892961</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2003 Aug 15;171(4):2006-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12902505</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 Dec 18;349(25):2431-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14681510</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Apr;78(7):3572-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15016880</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Jul;78(13):6723-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15194747</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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