SrasV1, Ncbi, Curation, bibRecord, 000E35

In vitro inhibition of SARS virus replication by human interferons.

Identifieur interne : 000E35 ( Ncbi/Curation ); précédent : 000E34; suivant : 000E36

In vitro inhibition of SARS virus replication by human interferons.

Auteurs : Helena Dahl [Suède] ; Annika Linde ; Orjan Stranneg Rd

Source :

Scandinavian journal of infectious diseases [ 0036-5548 ] ; 2004.

RBID : pubmed:15764169

Descripteurs français

KwdFr :
- Animaux, Antiviraux (pharmacologie), Cellules Vero, Humains, Interféron alpha (pharmacologie), Interféron bêta (pharmacologie), Protéines recombinantes, Réplication virale (), Virus du SRAS (), Virus du SRAS (physiologie).
MESH :
- pharmacologie : Antiviraux, Interféron alpha, Interféron bêta.
- physiologie : Virus du SRAS.
- Animaux, Cellules Vero, Humains, Protéines recombinantes, Réplication virale, Virus du SRAS.

English descriptors

KwdEn :
- Animals, Antiviral Agents (pharmacology), Chlorocebus aethiops, Humans, Interferon alpha-2, Interferon-alpha (pharmacology), Interferon-beta (pharmacology), Recombinant Proteins, SARS Virus (drug effects), SARS Virus (physiology), Vero Cells, Virus Replication (drug effects).
MESH :
- chemical , pharmacology : Antiviral Agents, Interferon-alpha, Interferon-beta.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, Interferon alpha-2, Recombinant Proteins, Vero Cells.

Abstract

Four different types of human interferon, interferon-beta (IFN-beta), recombinant IFN-alpha2a and IFN-alpha2b and natural IFN-alpha were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-beta was found to be the most highly active antiviral agent, followed by natural IFN-alpha, whereas the 2 recombinant IFN-alpha2 species were poorly active in the system used. These results suggest that IFN-beta as well as natural IFN-alpha may be used for the treatment of SARS.

DOI: 10.1080/00365540410021144
PubMed: 15764169

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pubmed:15764169

Le document en format XML

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<author><name sortKey="Dahl, Helena" sort="Dahl, Helena" uniqKey="Dahl H" first="Helena" last="Dahl">Helena Dahl</name>
<affiliation wicri:level="3"><nlm:affiliation>Swedish Institute for Infectious Disease Control, Stockholm, Sweden. Helena.Dahl@smi.ki.se</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Swedish Institute for Infectious Disease Control, Stockholm</wicri:regionArea>
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<author><name sortKey="Linde, Annika" sort="Linde, Annika" uniqKey="Linde A" first="Annika" last="Linde">Annika Linde</name>
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<author><name sortKey="Stranneg Rd, Orjan" sort="Stranneg Rd, Orjan" uniqKey="Stranneg Rd O" first="Orjan" last="Stranneg Rd">Orjan Stranneg Rd</name>
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<series><title level="j">Scandinavian journal of infectious diseases</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antiviral Agents (pharmacology)</term>
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<term>Humans</term>
<term>Interferon alpha-2</term>
<term>Interferon-alpha (pharmacology)</term>
<term>Interferon-beta (pharmacology)</term>
<term>Recombinant Proteins</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (physiology)</term>
<term>Vero Cells</term>
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<term>Antiviraux (pharmacologie)</term>
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<term>Humains</term>
<term>Interféron alpha (pharmacologie)</term>
<term>Interféron bêta (pharmacologie)</term>
<term>Protéines recombinantes</term>
<term>Réplication virale ()</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (physiologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Interferon-alpha</term>
<term>Interferon-beta</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Interféron alpha</term>
<term>Interféron bêta</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chlorocebus aethiops</term>
<term>Humans</term>
<term>Interferon alpha-2</term>
<term>Recombinant Proteins</term>
<term>Vero Cells</term>
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<term>Cellules Vero</term>
<term>Humains</term>
<term>Protéines recombinantes</term>
<term>Réplication virale</term>
<term>Virus du SRAS</term>
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<front><div type="abstract" xml:lang="en">Four different types of human interferon, interferon-beta (IFN-beta), recombinant IFN-alpha2a and IFN-alpha2b and natural IFN-alpha were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-beta was found to be the most highly active antiviral agent, followed by natural IFN-alpha, whereas the 2 recombinant IFN-alpha2 species were poorly active in the system used. These results suggest that IFN-beta as well as natural IFN-alpha may be used for the treatment of SARS.</div>
</front>
</TEI>
</record>

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In vitro inhibition of SARS virus replication by human interferons.

In vitro inhibition of SARS virus replication by human interferons.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki