In vitro inhibition of SARS virus replication by human interferons.
Identifieur interne : 002C47 ( PubMed/Checkpoint ); précédent : 002C46; suivant : 002C48In vitro inhibition of SARS virus replication by human interferons.
Auteurs : Helena Dahl [Suède] ; Annika Linde ; Orjan Stranneg RdSource :
- Scandinavian journal of infectious diseases [ 0036-5548 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antiviraux, Interféron alpha, Interféron bêta.
- physiologie : Virus du SRAS.
- Animaux, Cellules Vero, Humains, Protéines recombinantes, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antiviral Agents, Interferon-alpha, Interferon-beta.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, Interferon alpha-2, Recombinant Proteins, Vero Cells.
Abstract
Four different types of human interferon, interferon-beta (IFN-beta), recombinant IFN-alpha2a and IFN-alpha2b and natural IFN-alpha were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-beta was found to be the most highly active antiviral agent, followed by natural IFN-alpha, whereas the 2 recombinant IFN-alpha2 species were poorly active in the system used. These results suggest that IFN-beta as well as natural IFN-alpha may be used for the treatment of SARS.
DOI: 10.1080/00365540410021144
PubMed: 15764169
Affiliations:
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pubmed:15764169Le document en format XML
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<term>Interferon alpha-2</term>
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<term>Virus du SRAS ()</term>
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<term>Cellules Vero</term>
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<front><div type="abstract" xml:lang="en">Four different types of human interferon, interferon-beta (IFN-beta), recombinant IFN-alpha2a and IFN-alpha2b and natural IFN-alpha were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-beta was found to be the most highly active antiviral agent, followed by natural IFN-alpha, whereas the 2 recombinant IFN-alpha2 species were poorly active in the system used. These results suggest that IFN-beta as well as natural IFN-alpha may be used for the treatment of SARS.</div>
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<Title>Scandinavian journal of infectious diseases</Title>
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<ArticleTitle>In vitro inhibition of SARS virus replication by human interferons.</ArticleTitle>
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<Abstract><AbstractText>Four different types of human interferon, interferon-beta (IFN-beta), recombinant IFN-alpha2a and IFN-alpha2b and natural IFN-alpha were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-beta was found to be the most highly active antiviral agent, followed by natural IFN-alpha, whereas the 2 recombinant IFN-alpha2 species were poorly active in the system used. These results suggest that IFN-beta as well as natural IFN-alpha may be used for the treatment of SARS.</AbstractText>
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