The protein X4 of severe acute respiratory syndrome-associated coronavirus is expressed on both virus-infected cells and lung tissue of severe acute respiratory syndrome patients and inhibits growth of Balb/c 3T3 cell line.
Identifieur interne : 000E06 ( Ncbi/Curation ); précédent : 000E05; suivant : 000E07The protein X4 of severe acute respiratory syndrome-associated coronavirus is expressed on both virus-infected cells and lung tissue of severe acute respiratory syndrome patients and inhibits growth of Balb/c 3T3 cell line.
Auteurs : Ying-Yu Chen [République populaire de Chine] ; Bao Shuang ; Ya-Xia Tan ; Min-Jie Meng ; Pu Han ; Xiao-Ning Mo ; Quan-Sheng Song ; Xiao-Yan Qiu ; Xin Luo ; Qi-Ni Gan ; Xin Zhang ; Ying Zheng ; Shun-Ai Liu ; Xiao-Ning Wang ; Nan-Shan Zhong ; Da-Long MaSource :
- Chinese medical journal [ 0366-6999 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Cellules BALB 3T3, Cellules HeLa, Cellules Vero, Données de séquences moléculaires, Humains, Immunohistochimie, Inhibiteurs de croissance (analyse), Inhibiteurs de croissance (physiologie), Poumon (), Protéines virales structurales (analyse), Protéines virales structurales (physiologie), Souris, Syndrome respiratoire aigu sévère (métabolisme), Séquence d'acides aminés, Virus du SRAS ().
- MESH :
- analyse : Inhibiteurs de croissance, Protéines virales structurales.
- métabolisme : Syndrome respiratoire aigu sévère.
- physiologie : Inhibiteurs de croissance, Protéines virales structurales.
- Animaux, Cellules BALB 3T3, Cellules HeLa, Cellules Vero, Données de séquences moléculaires, Humains, Immunohistochimie, Poumon, Souris, Séquence d'acides aminés, Virus du SRAS.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, BALB 3T3 Cells, Chlorocebus aethiops, Growth Inhibitors (analysis), Growth Inhibitors (physiology), HeLa Cells, Humans, Immunohistochemistry, Lung (chemistry), Mice, Molecular Sequence Data, SARS Virus (chemistry), Severe Acute Respiratory Syndrome (metabolism), Vero Cells, Viral Structural Proteins (analysis), Viral Structural Proteins (physiology).
- MESH :
- chemical , analysis : Growth Inhibitors, Viral Structural Proteins.
- chemical , physiology : Growth Inhibitors, Viral Structural Proteins.
- chemistry : Lung, SARS Virus.
- metabolism : Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Animals, BALB 3T3 Cells, Chlorocebus aethiops, HeLa Cells, Humans, Immunohistochemistry, Mice, Molecular Sequence Data, Vero Cells.
Abstract
The genome of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) includes sequences encoding the putative protein X4 (ORF8, ORF7a), consisting of 122 amino acids. The deduced sequence contains a probable cleaved signal peptide sequence and a C-terminal transmembrane helix, indicating that protein X4 is likely to be a type I membrane protein. This study was conducted to demonstrate whether the protein X4 was expressed and its essential function in the process of SARS-CoV infection.
PubMed: 15740663
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pubmed:15740663Le document en format XML
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uniqKey="Chen Y" first="Ying-Yu" last="Chen">Ying-Yu Chen</name><affiliation wicri:level="4"><nlm:affiliation>Center for Human Disease Genomics, Peking University, Beijing 100083, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Human Disease Genomics, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Shuang, Bao" sort="Shuang, Bao" uniqKey="Shuang B" first="Bao" last="Shuang">Bao Shuang</name></author><author><name sortKey="Tan, Ya Xia" sort="Tan, Ya Xia" uniqKey="Tan Y" first="Ya-Xia" last="Tan">Ya-Xia Tan</name></author><author><name sortKey="Meng, Min Jie" sort="Meng, Min Jie" uniqKey="Meng M" first="Min-Jie" last="Meng">Min-Jie Meng</name></author><author><name sortKey="Han, Pu" sort="Han, Pu" uniqKey="Han P" first="Pu" last="Han">Pu Han</name></author><author><name sortKey="Mo, Xiao Ning" sort="Mo, Xiao Ning" uniqKey="Mo X" first="Xiao-Ning" last="Mo">Xiao-Ning Mo</name></author><author><name sortKey="Song, Quan Sheng" sort="Song, Quan Sheng" uniqKey="Song Q" first="Quan-Sheng" last="Song">Quan-Sheng Song</name></author><author><name sortKey="Qiu, Xiao Yan" sort="Qiu, Xiao Yan" uniqKey="Qiu X" first="Xiao-Yan" last="Qiu">Xiao-Yan Qiu</name></author><author><name sortKey="Luo, Xin" sort="Luo, Xin" uniqKey="Luo X" first="Xin" last="Luo">Xin Luo</name></author><author><name sortKey="Gan, Qi Ni" sort="Gan, Qi Ni" uniqKey="Gan Q" first="Qi-Ni" last="Gan">Qi-Ni Gan</name></author><author><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name></author><author><name sortKey="Zheng, Ying" sort="Zheng, Ying" uniqKey="Zheng Y" first="Ying" last="Zheng">Ying Zheng</name></author><author><name sortKey="Liu, Shun Ai" sort="Liu, Shun Ai" uniqKey="Liu S" first="Shun-Ai" last="Liu">Shun-Ai Liu</name></author><author><name sortKey="Wang, Xiao Ning" sort="Wang, Xiao Ning" uniqKey="Wang X" first="Xiao-Ning" last="Wang">Xiao-Ning Wang</name></author><author><name sortKey="Zhong, Nan Shan" sort="Zhong, Nan Shan" uniqKey="Zhong N" first="Nan-Shan" last="Zhong">Nan-Shan Zhong</name></author><author><name sortKey="Ma, Da Long" sort="Ma, Da Long" uniqKey="Ma D" first="Da-Long" last="Ma">Da-Long Ma</name></author></analytic><series><title level="j">Chinese medical journal</title><idno type="ISSN">0366-6999</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>BALB 3T3 Cells</term><term>Chlorocebus aethiops</term><term>Growth Inhibitors (analysis)</term><term>Growth Inhibitors (physiology)</term><term>HeLa Cells</term><term>Humans</term><term>Immunohistochemistry</term><term>Lung (chemistry)</term><term>Mice</term><term>Molecular Sequence Data</term><term>SARS Virus (chemistry)</term><term>Severe Acute Respiratory Syndrome (metabolism)</term><term>Vero Cells</term><term>Viral Structural Proteins (analysis)</term><term>Viral Structural Proteins (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules BALB 3T3</term><term>Cellules HeLa</term><term>Cellules Vero</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Immunohistochimie</term><term>Inhibiteurs de croissance (analyse)</term><term>Inhibiteurs de croissance (physiologie)</term><term>Poumon ()</term><term>Protéines virales structurales (analyse)</term><term>Protéines virales structurales (physiologie)</term><term>Souris</term><term>Syndrome respiratoire aigu sévère (métabolisme)</term><term>Séquence d'acides aminés</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Growth Inhibitors</term><term>Viral Structural Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Growth Inhibitors</term><term>Viral Structural Proteins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Inhibiteurs de croissance</term><term>Protéines virales structurales</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lung</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Inhibiteurs de croissance</term><term>Protéines virales structurales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>BALB 3T3 Cells</term><term>Chlorocebus aethiops</term><term>HeLa Cells</term><term>Humans</term><term>Immunohistochemistry</term><term>Mice</term><term>Molecular Sequence Data</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules BALB 3T3</term><term>Cellules HeLa</term><term>Cellules Vero</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Immunohistochimie</term><term>Poumon</term><term>Souris</term><term>Séquence d'acides aminés</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The genome of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) includes sequences encoding the putative protein X4 (ORF8, ORF7a), consisting of 122 amino acids. The deduced sequence contains a probable cleaved signal peptide sequence and a C-terminal transmembrane helix, indicating that protein X4 is likely to be a type I membrane protein. This study was conducted to demonstrate whether the protein X4 was expressed and its essential function in the process of SARS-CoV infection.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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