SrasV1, Ncbi, Curation, bibRecord, 000B92

SARS coronavirus E protein forms cation-selective ion channels.

Identifieur interne : 000B92 ( Ncbi/Curation ); précédent : 000B91; suivant : 000B93

SARS coronavirus E protein forms cation-selective ion channels.

Auteurs : Lauren Wilson [Australie] ; Carolyn Mckinlay ; Peter Gage ; Gary Ewart

Source :

Virology [ 0042-6822 ] ; 2004.

RBID : pubmed:15527857

Descripteurs français

KwdFr :
- Canaux ioniques (physiologie), Données de séquences moléculaires, Double couche lipidique, Fragments peptidiques (), Potentiels de membrane, Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (physiologie), Séquence d'acides aminés, Virus du SRAS (physiologie).
MESH :
- physiologie : Canaux ioniques, Protéines de l'enveloppe virale, Virus du SRAS.
- Données de séquences moléculaires, Double couche lipidique, Fragments peptidiques, Potentiels de membrane, Protéines de l'enveloppe virale, Séquence d'acides aminés.

English descriptors

KwdEn :
- Amino Acid Sequence, Ion Channels (physiology), Lipid Bilayers, Membrane Potentials, Molecular Sequence Data, Peptide Fragments (chemistry), SARS Virus (physiology), Viral Envelope Proteins (chemistry), Viral Envelope Proteins (physiology).
MESH :
- chemical , chemistry : Peptide Fragments, Viral Envelope Proteins.
- chemical , physiology : Ion Channels, Viral Envelope Proteins.
- physiology : SARS Virus.
- Amino Acid Sequence, Lipid Bilayers, Membrane Potentials, Molecular Sequence Data.

Abstract

Severe Acute Respiratory Syndrome (SARS) is caused by a novel coronavirus (SARS-CoV). Coronaviruses including SARS-CoV encode an envelope (E) protein, a small, hydrophobic membrane protein. We report that, in planar lipid bilayers, synthetic peptides corresponding to the SARS-CoV E protein forms ion channels that are more permeable to monovalent cations than to monovalent anions. Affinity-purified polyclonal antibodies recognizing the N-terminal 19 residues of SARS-CoV E protein were used to establish the specificity of channel formation by inhibiting the ion currents generated in the presence of the E protein peptides.

DOI: 10.1016/j.virol.2004.09.033
PubMed: 15527857

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pubmed:15527857

Le document en format XML

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<author><name sortKey="Wilson, Lauren" sort="Wilson, Lauren" uniqKey="Wilson L" first="Lauren" last="Wilson">Lauren Wilson</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical School, Frank Fenner Building 42, ANU, Canberra, ACT 2601, Australia. lwilson@biotron.com.au</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Medical School, Frank Fenner Building 42, ANU, Canberra, ACT 2601</wicri:regionArea>
<wicri:noRegion>ACT 2601</wicri:noRegion>
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<author><name sortKey="Mckinlay, Carolyn" sort="Mckinlay, Carolyn" uniqKey="Mckinlay C" first="Carolyn" last="Mckinlay">Carolyn Mckinlay</name>
</author>
<author><name sortKey="Gage, Peter" sort="Gage, Peter" uniqKey="Gage P" first="Peter" last="Gage">Peter Gage</name>
</author>
<author><name sortKey="Ewart, Gary" sort="Ewart, Gary" uniqKey="Ewart G" first="Gary" last="Ewart">Gary Ewart</name>
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<author><name sortKey="Gage, Peter" sort="Gage, Peter" uniqKey="Gage P" first="Peter" last="Gage">Peter Gage</name>
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<author><name sortKey="Ewart, Gary" sort="Ewart, Gary" uniqKey="Ewart G" first="Gary" last="Ewart">Gary Ewart</name>
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<series><title level="j">Virology</title>
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<term>Lipid Bilayers</term>
<term>Membrane Potentials</term>
<term>Molecular Sequence Data</term>
<term>Peptide Fragments (chemistry)</term>
<term>SARS Virus (physiology)</term>
<term>Viral Envelope Proteins (chemistry)</term>
<term>Viral Envelope Proteins (physiology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Canaux ioniques (physiologie)</term>
<term>Données de séquences moléculaires</term>
<term>Double couche lipidique</term>
<term>Fragments peptidiques ()</term>
<term>Potentiels de membrane</term>
<term>Protéines de l'enveloppe virale ()</term>
<term>Protéines de l'enveloppe virale (physiologie)</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS (physiologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptide Fragments</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Ion Channels</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Canaux ioniques</term>
<term>Protéines de l'enveloppe virale</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Lipid Bilayers</term>
<term>Membrane Potentials</term>
<term>Molecular Sequence Data</term>
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<term>Double couche lipidique</term>
<term>Fragments peptidiques</term>
<term>Potentiels de membrane</term>
<term>Protéines de l'enveloppe virale</term>
<term>Séquence d'acides aminés</term>
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<front><div type="abstract" xml:lang="en">Severe Acute Respiratory Syndrome (SARS) is caused by a novel coronavirus (SARS-CoV). Coronaviruses including SARS-CoV encode an envelope (E) protein, a small, hydrophobic membrane protein. We report that, in planar lipid bilayers, synthetic peptides corresponding to the SARS-CoV E protein forms ion channels that are more permeable to monovalent cations than to monovalent anions. Affinity-purified polyclonal antibodies recognizing the N-terminal 19 residues of SARS-CoV E protein were used to establish the specificity of channel formation by inhibiting the ion currents generated in the presence of the E protein peptides.</div>
</front>
</TEI>
</record>

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SARS coronavirus E protein forms cation-selective ion channels.

SARS coronavirus E protein forms cation-selective ion channels.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki